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Search Results for " osteogenic differentiation "

7

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4205	AG-494 Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR; CDK	Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-494 (Tyrphostin B48) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂，IC50为0.7 μM。它阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。它抑制 EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化，IC50为 1.1、39、45 和 6 μM。
T19389	L-Ascorbic acid 2-phosphate magnesium 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁	Phosphatase; Phosphorylase	Metabolism
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物，能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。
T35694	OD36 OD 36,OD 36 hydrochloride,OD-36	ALK; RIP kinase	Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	OD36 是一种选择性强效 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 可抑制 ALK2 信号传导和成骨分化（KD：37 nM），并能与 ALK2 激酶 ATP 袋有效结合。
T19390	L-Ascorbic acid 2-phosphate 维生素C磷酸酯,2-Phospho-L-ascorbic acid	Others	Others
	L-ascorbic acid 2-phosphate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that can stimulate collagen formation and expression.
T76798	Bimekizumab
	Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) 是一种人源化单克隆抗体，可选择性中和 IL-17A 和 IL-17F。这两种细胞因子都能够促进成骨的人骨膜衍生细胞 (hPDC) 分化。因此，Bimekizumab 的应用，可以阻断炎症驱动的成骨分化。
T31124	CW 008 CW-008,CW008
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice.
T82851	BMP2-derived peptide
	BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序，具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。

化合物

Cat.No: T4205

Synonym: Tyrphostin AG-494,AG 494,Tyrphostin B48

Target: EGFR, CDK

L-Ascorbic acid 2-phosphate magnesium

Cat.No: T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁

Target: Phosphatase, Phosphorylase

Cat.No: T35694

Synonym: OD 36,OD 36 hydrochloride,OD-36

Target: ALK, RIP kinase

L-Ascorbic acid 2-phosphate

Cat.No: T19390

Synonym: 维生素C磷酸酯,2-Phospho-L-ascorbic acid

Target: Others

Cat.No: T76798

Cat.No: T31124

Synonym: CW-008,CW008

BMP2-derived peptide

Cat.No: T82851

Cat. No.	Product Name	Target	Signaling Pathways
TN1124	Neoeriocitrin	AChE	Neuroscience
	Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂，分离于自百日草，在 MC3T3-E1 中显示出对增殖和成骨分化的活性。
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
T2185	L-Ascorbic acid 2-phosphate trisodium L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐	Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors
	L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物，能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达，因此，能够促进人脂肪干细胞的成骨分化。
T3808	Icariside I 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I	Others	Others
	Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物，具有调节骨重塑的作用，可用于研究骨质疏松。
T3924	Astragaloside II 黄芪皂苷 II,Astrasieversianin VIII	TGF-beta/Smad	Stem Cells
	Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。
T3925	Astragaloside I 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化，可用于成骨活性研究。
TN1918	Medicarpin 美迪紫檀素	Apoptosis; BCL; ROS; JNK	Apoptosis; Immunology/Inflammation; MAPK
	Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流，诱导白血病 P388 细胞凋亡并克服多药耐药性。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
TN3215	7,4'-Dihydroxy-8-methylflavan	Others	Others
	7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].

天然产物

Cat.No: TN1124

Target: AChE

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

L-Ascorbic acid 2-phosphate trisodium

Cat.No: T2185

Synonym: L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐

Target: Reactive Oxygen Species, c-Met/HGFR, Endogenous Metabolite

Cat.No: T3808

Synonym: 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I

Target: Others

Astragaloside II

Cat.No: T3924

Synonym: 黄芪皂苷 II,Astrasieversianin VIII

Target: TGF-beta/Smad

Astragaloside I

Cat.No: T3925

Synonym: 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV

Target: Wnt/beta-catenin

Cat.No: TN1918

Synonym: 美迪紫檀素

Target: Apoptosis, BCL, ROS, JNK

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Cat.No: TN6568

7,4'-Dihydroxy-8-methylflavan

Cat.No: TN3215

Target: Others

Cat.No: T14368

Target: Others

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