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Search Results for " osteoblasts "

14

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T9988	Wnt/β-catenin agonist 3	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。
T25859	Necrostatin-7 Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis	Apoptosis
	Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂，具有心脏保护作用，可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。
T1641	Strontium ranelate Distrontium renelate,S12911,雷尼酸锶	Calcium Channel; CaSR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Strontium ranelate (S12911) 是抗骨质疏松的药物，能够抑制骨吸收，促进骨形成，进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR)，进而促进肌醇 1，4，5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。
T21460	Teriparatide acetate hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽	Others	Others
	Teriparatide acetate (Forteo) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢（即骨骼生长）剂，用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞，从而导致骨骼整体增加。
T1210	Sodium etidronate 依替膦酸钠,Didronel	Phosphatase	Metabolism
	Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员，etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量，从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。
T11048	DIPQUO	Others	Others
	DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. The EC50 in C2C12 cells was 6.27 μM.
T74871	ODN BW001
	ODN BW001 是一种寡核苷酸。ODN BW001 在成骨细胞增殖和激活中起调节作用。
T40498	Dentonin AC-100
	Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells. It does not have a significant effect on mature osteoblasts. Dentonin is useful for research on phosphate homeostasis and bone metabolism.
T80529	VnP-16	Integrin	Cytoskeletal Signaling
	VnP-16 通过直接作用于β1整合素 (β1 integrin)，激活FAK，促进成骨细胞分化和活性，加速骨形成。
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption.
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...
T83827	Adenosine-5'-O-(3-thiotriphosphate) sodium ATPγS,Adenosine 5'-(γ-thio)-triphosphate
	Adenosine-5'-O-(3-thiotriphosphate)（ATPγS）是一种purinergic P2Y11受体的激动剂。在表达人类或犬类P2Y11受体的CHO-K1细胞中，能够诱导肌醇磷酸累积（EC50s分别为1.2和19.3 µM）。ATPγS（10 µM）能抑制Junin病毒导致的编码骨形态生成蛋白6（BMP6）的mRNA水平增加，并减少Junin病毒感染的初代大鼠成骨细胞中的粒子形成单位（PFUs）。使用25 µM浓度时，可以诱导MIN6胰岛β细胞分泌胰岛素。
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...

化合物

Cat.No: T22814

Target: Hedgehog/Smoothened

Wnt/β-catenin agonist 3

Cat.No: T9988

Target: Wnt/beta-catenin

Cat.No: T25859

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: Apoptosis

Strontium ranelate

Cat.No: T1641

Synonym: Distrontium renelate,S12911,雷尼酸锶

Target: Calcium Channel, CaSR

Teriparatide acetate

Cat.No: T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽

Target: Others

Sodium etidronate

Cat.No: T1210

Synonym: 依替膦酸钠,Didronel

Target: Phosphatase

Cat.No: T11048

Target: Others

Cat.No: T74871

Cat.No: T40498

Synonym: AC-100

Cat.No: T80529

Target: Integrin

N-Oleoyl-L-Serine

Cat.No: T36065

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Adenosine-5'-O-(3-thiotriphosphate) sodium

Cat.No: T83827

Synonym: ATPγS,Adenosine 5'-(γ-thio)-triphosphate

Cat.No: T37441

Cat. No.	Product Name	Target	Signaling Pathways
T3397	Epmedin C 淫羊霍定C,Baohuoside-VI,Epimedin C	Others	Others
	Epmedin C (Baohuoside-VI) 是天然化合物，在切除卵巢的小鼠体内与雌性激素作用相似。
T6S2146	Epimedin B 朝藿定B,Epmedin B	Others	Others
	Epimedin B (Epmedin B) 是一种天然活性成分，来自淫羊藿，据报道其就有抗骨质疏松症的潜能。
T6S2252	Sweroside	Others	Others
	Sweroside 是分离自Lonicera japonica 中，具有细胞保护、抗骨质疏松和保护肝脏活性。
T2820	Glycitin 黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside	Others; Influenza Virus; Antibacterial	Microbiology/Virology; Others
	Glycitin (Glycitein 7-O-β-glucoside) 是一种从豆类中分离出来的天然异黄酮，有抗菌，抗病毒和雌激素作用，还有促进骨髓基质细胞和成骨细胞的增殖和抑制骨转换的生物学功能。
T3900	Emodin-8-glucoside 大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B	Others	Others
	Emodin-8-glucoside (Anthraglycoside B) 是从芦荟中分离出的蒽醌衍生物，与 DNA 的小沟结合。它具有保护缺血和再灌注引起的局灶性脑损伤的作用。它直接刺激成骨细胞的细胞增殖和分化。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
T5S2129	Sciadopitysin	TNF; NF-κB	Apoptosis; NF-κB
	Sciadopitysin 是一种双黄酮类化合物，来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
TN1711	Gossypetin	Antioxidant; p38 MAPK; MAPK; Antibacterial	MAPK; Microbiology/Virology; oxidation-reduction
	Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮，是一种有效的 MKK3 和 MKK6 抑制剂，可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用，它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。
TN3547	Bullatantriol	Antifection	Microbiology/Virology
	Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN4999	Serratenediol	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote

天然产物

Cat.No: T3397

Synonym: 淫羊霍定C,Baohuoside-VI,Epimedin C

Target: Others

Cat.No: T6S2146

Synonym: 朝藿定B,Epmedin B

Target: Others

Cat.No: T6S2252

Target: Others

Cat.No: T2820

Synonym: 黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside

Target: Others, Influenza Virus, Antibacterial

Emodin-8-glucoside

Cat.No: T3900

Synonym: 大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B

Target: Others

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: TN5888

Target: Others

Cat.No: T5S2129

Target: TNF, NF-κB

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Cat.No: TN1711

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Cat.No: TN3547

Target: Antifection

Cat.No: TN4716

Target: Influenza Virus

Cat.No: TN4999

Target: BCL, PARP, Caspase

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