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Search Results for " nonpeptide "

71

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11857	LIT-001	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	LIT-001 是非肽类催产素受体激动剂，EC50为55 nM，Ki 为226 nM。它可改善孤独症小鼠模型的社交互动。
T11696	Ivachtin Caspase-3 Inhibitor VII	Caspase	Apoptosis; Proteases/Proteasome
	Ivachtin (Caspase-3 Inhibitor VII) 是一种非肽，非竞争性和可逆的caspase-3抑制剂，IC50为 23 nM。它是其余胱天蛋白酶的适度抑制剂。
T16850	SB-265610 GSK-CXCR2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂，可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 和 70 nM。
T6288	Mozavaptan 莫扎伐坦,OPC31260l,OPC-31260	Vasopressin Receptor	GPCR/G Protein
	Mozavaptan (OPC-31260) 是 benzazepine 衍生物，是一种竞争性加压素受体拮抗剂，作用于 V1 和 V2 受体，IC50 分别为 1.2 μM 和 14 nM。它可在体内拮抗精氨酸加压素的抗利尿作用，可用于低钠血症、抗利尿激素不适当综合征和充血性心力衰竭的研究。
T12870	SCH79797 dihydrochloride	Apoptosis; Others; Protease-activated Receptor	Apoptosis; GPCR/G Protein; Others
	SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂，IC50 为 70 nM，Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。
T21790	BMS 182874 hydrochloride	Endothelin Receptor	GPCR/G Protein
	BMS 182874 hydrochloride 是一种非肽内皮素 (El) 受体拮抗剂。
T1520	Aliskiren hemifumarate 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂，IC50为1.5 nM，具有抗高血压活性。
T26594	Allisartan Isoproxil	RAAS	Endocrinology/Hormones
	Allisartan Isoproxil 是一种非肽类的血管紧张素 II 受体拮抗剂，可用于有关高血压和心脏疾病的研究。
T3525	PD150606	Cysteine Protease	Proteases/Proteasome
	PD150606 是一种具有选择性的非肽 calpain 抑制剂，具有神经保护活性，抑制 μ-calpains 和 m-calpains ，抑制红藻氨酸诱导的 Ca2+ 内流，干扰兴奋性毒性依赖性运动神经元死亡。
T27762	L-162,313 L-162313,L 162,313,L162,313	RAAS	Endocrinology/Hormones
	L-162,313是一种ANG II受体激动剂，是一种模仿血管紧张素II生物学作用的非肽，可诱导MAP增加。
T3347	PF3274167 PF 3274167,Cligosiban,PF-3274167	OX Receptor	GPCR/G Protein; Neuroscience
	PF3274167 (Cligosiban) 是一种有效的、选择性的、高亲和力的非肽催产素受体拮抗剂。
T39229	YNT-185	OX Receptor	GPCR/G Protein; Neuroscience
	YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
T6281	TW-37 TW 37	BCL	Apoptosis
	TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂，Ki 值分别为 0.26、0.29和1.11μM
TQ0057	AVE 0991	Others	Others
	AVE 0991 是血管紧张素-(1-7) [Ang-(1-7)] 的非肽类似物，是一种具有口服活性的 Mas 激动剂，对 [125I]-Ang-(1-7) 结合到牛主动脉内皮细胞膜有抑制作用，通过增强自噬来抑制星形胶质细胞介导的阿尔茨海默病神经炎症。
TQ0075	ML314	Neurotensin Receptor	GPCR/G Protein
	ML314 是一种具有脑渗透性非肽 β-抑制素偏向神经降压素 NTR1 受体激动剂（EC50：1.9 μM），是一种用于甲基苯丙胺滥用的偏向神经降压素受体配体，抑制 NTR2 和 GPR35。
T8691	PD 168368 PD168368	Bombesin Receptor	GPCR/G Protein
	PD 168368 是一种新型有效且具有竞争性和选择性的非肽类神经调节蛋白 B 受体 (NMB-R) 拮抗剂，对胃泌素释放肽受体 (GRPR)具有抑制作用。PD 168368 是一种高效的 FPR1/FPR2/FPR3 的混合激动剂。
T25615	Lanepitant LY303870,LY-303870,LY 303870	Others	Others
	Lanepitant (LY303870) 是一种非肽类神经激肽-1（NK-1）拮抗剂,具有镇痛活性，可抑制神经源性硬脑膜炎症,可用于预防偏头痛。
T9692	Paltusotine	Somatostatin	GPCR/G Protein
	Paltusotine 是一种口服有效的，非肽选择性生长抑素 2 型受体激动剂。在长效生长抑素受体配体作用后，Paltusotine 仍可维持 GH 和 IGF-1 水平。
T11174	(R)-Elagolix 恶拉戈利,NBI-56418	GNRH Receptor	GPCR/G Protein
	(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。
T6825	Eltrombopag Olamine Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR	Thrombin	Proteases/Proteasome
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) 是 Eltrombopag 的口服活性乙醇胺盐，是一种血小板生成素(TPO)受体激动剂，用于血小板减少的某些病症研究。
T2531L	Eprosartan KF-108566J free base,Teveten	RAAS	Endocrinology/Hormones
	Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂，对AT1受体亚型具有高亲和力，可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
T29177	YM 218 YM218,YM-218
	YM 218 is a novel, potent, selective antagonist of nonpeptide vasopressin V1A receptor.
T70225	L-159884
	L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging
T29234	ZM 253270 ZM253270,ZM-253270
	ZM 253270 is an nonpeptide neurokinin A antagonist.
T27940	LY301875 LY 301875,LY-301875
	LY301875 is an antagonist of nonpeptide angiotensin receptor.
T70137	CAM 4515
	CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist.
T70136	CAM 4750
	CAM 4750 is a nonpeptide tachykinin NK1 receptor antagonist.
T12331	OT-R antagonist 2 Oxytocin receptor antagonist 2	Others	Others
	OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R .
T28322	PD 123177 PD-123177,PD123177,Exp-655,Exp655,Exp 655
	PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2.
T70272	L-162782
	L-162782 is a nonpeptide agonist of angiotensin AT1 receptor.
T69097	ARD-353
	ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects.
T28814	SM19712 free acid SM 19712,SM-19712,SM19712
	SM19712 is an inhibitor of nonpeptide endothelin converting enzyme.
T16895	SL910102	Others	Others
	SL910102 is a nonpeptide angiotensin antagonist of the AT1 receptor.
T28813	SM19712 sodium SM 19712,SM19712,SM-19712
	SM19712 is an inhibitor of nonpeptide endothelin converting enzyme.
T16935	SR 146131	Others	Others
	SR 146131 is a potent and selective agonist of the nonpeptide receptor.
T25895	NVP-SAA164 SAA 164,SAA164,SAA-164,NVP SAA164
	NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.
T25608	Lamifiban trifluoroacetate Lamifiban trifluoroacetate salt
	Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).
T70295	MDL-105212A HCl
	MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist.
T68486	Fasitibant
	Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.
T11862	LMD-009	Others	Others
	LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 nonpeptide agonist.
T3178	BIBS 39	RAAS	Endocrinology/Hormones
	BIBS 39是新型的非肽类血管紧张素II（AII）受体拮抗剂。
T16085	MK-0429 L-000845704	Others	Others
	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
T25607	Lamifiban Ro-44-9883/000,Ro 44-9883/000,Ro44-9883/000
	Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.
T61079	RXFP3 agonist 1
	RXFP3 agonist 1 是一种非肽的RXFP3激动剂 (EC50=6937 nM)。
T14354	AVE 0991 sodium salt	Others	Others
	AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes, with IC50 of 21±35 nM. AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist.
T70658	Ici D8731
	Ici D8731 is a nonpeptide angiotensin II antagonist with potential as a treatment for hypertension and heart failure.
T36481	BIIE 0246 hydrochloride
	Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.
T16772	Ro 64-6198	Others	Others
	Ro 64-6198 is a nonpeptide, high-affinity, and brain penetration N/OFQ receptor (NOP) agonist (EC50: 25.6 nM). Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors.
T16358	NTRC-824	Others	Others
	NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM).
T11856	LIT-001 free base	Others	Others
	LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).

化合物

Cat.No: T11857

Target: Oxytocin Receptor

Cat.No: T11696

Synonym: Caspase-3 Inhibitor VII

Target: Caspase

Cat.No: T16850

Synonym: GSK-CXCR2

Target: CXCR

Cat.No: T6288

Synonym: 莫扎伐坦,OPC31260l,OPC-31260

Target: Vasopressin Receptor

SCH79797 dihydrochloride

Cat.No: T12870

Target: Apoptosis, Others, Protease-activated Receptor

BMS 182874 hydrochloride

Cat.No: T21790

Target: Endothelin Receptor

Aliskiren hemifumarate

Cat.No: T1520

Synonym: 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Allisartan Isoproxil

Cat.No: T26594

Target: RAAS

Cat.No: T3525

Target: Cysteine Protease

Cat.No: T27762

Synonym: L-162313,L 162,313,L162,313

Target: RAAS

Cat.No: T3347

Synonym: PF 3274167,Cligosiban,PF-3274167

Target: OX Receptor

Cat.No: T39229

Target: OX Receptor

Cat.No: T6281

Synonym: TW 37

Target: BCL

Cat.No: TQ0057

Target: Others

Cat.No: TQ0075

Target: Neurotensin Receptor

Cat.No: T8691

Synonym: PD168368

Target: Bombesin Receptor

Cat.No: T25615

Synonym: LY303870,LY-303870,LY 303870

Target: Others

Cat.No: T9692

Target: Somatostatin

Cat.No: T11174

Synonym: 恶拉戈利,NBI-56418

Target: GNRH Receptor

Eltrombopag Olamine

Cat.No: T6825

Synonym: Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR

Target: Thrombin

Cat.No: T2531L

Synonym: KF-108566J free base,Teveten

Target: RAAS

Cat.No: T29177

Synonym: YM218,YM-218

Cat.No: T70225

Cat.No: T29234

Synonym: ZM253270,ZM-253270

Cat.No: T27940

Synonym: LY 301875,LY-301875

Cat.No: T70137

Cat.No: T70136

OT-R antagonist 2

Cat.No: T12331

Synonym: Oxytocin receptor antagonist 2

Target: Others

Cat.No: T28322

Synonym: PD-123177,PD123177,Exp-655,Exp655,Exp 655

Cat.No: T70272

Cat.No: T69097

SM19712 free acid

Cat.No: T28814

Synonym: SM 19712,SM-19712,SM19712

Cat.No: T16895

Target: Others

Cat.No: T28813

Synonym: SM 19712,SM19712,SM-19712

Cat.No: T16935

Target: Others

Cat.No: T25895

Synonym: SAA 164,SAA164,SAA-164,NVP SAA164

Lamifiban trifluoroacetate

Cat.No: T25608

Synonym: Lamifiban trifluoroacetate salt

MDL-105212A HCl

Cat.No: T70295

Cat.No: T68486

Cat.No: T11862

Target: Others

Cat.No: T3178

Target: RAAS

Cat.No: T16085

Synonym: L-000845704

Target: Others

Cat.No: T25607

Synonym: Ro-44-9883/000,Ro 44-9883/000,Ro44-9883/000

RXFP3 agonist 1

Cat.No: T61079

AVE 0991 sodium salt

Cat.No: T14354

Target: Others

Cat.No: T70658

BIIE 0246 hydrochloride

Cat.No: T36481

Cat.No: T16772

Target: Others

Cat.No: T16358

Target: Others

LIT-001 free base

Cat.No: T11856

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4954L	Smilagenin PYM50028,Cogane,AI3-44895,PYM 50028
	Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.

天然产物

Cat.No: T4954L

Synonym: PYM50028,Cogane,AI3-44895,PYM 50028

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