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Cat. No. | Product Name | Target | Signaling Pathways |
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T21543 |
AP 18
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活,在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。 | |||
T15358 |
Funapide
TV 45070,XEN402 |
Sodium Channel | Membrane transporter/Ion channel |
Funapide (TV 45070) 是一个有效的钠通 Nav1.7 抑制剂,据有潜在的抗炎活性,可用来治疗红斑性肢痛症、肌肉骨骼疼痛、膝关节炎以及疱疹后神经。 | |||
T0217L |
(+)-Dropropizine
(+)-Dropropizine,左羟丙哌嗪 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
(+)-Dropropizine 可以抑制组胺受体,抗过敏,并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。 | |||
T2196 |
Fipronil
氟虫腈,Fluocyanobenpyrazole,Termidor |
P450; GluCls; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Fipronil (Fluocyanobenpyrazole) 是昆虫GABA 受体的选择性拮抗剂,可抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏。在分离的大鼠肝微粒体中,它诱导细胞色素 P450 (CYP) 亚型CYP1A1/2、CYP2B1/2和CYP3A1/2的活性。 | |||
TP1650 |
Myelin Basic Protein
Myelin Basic Protein MBP |
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Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. | |||
T15449 |
GW-406381
|
COX | Immunology/Inflammation; Neuroscience |
GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats following chronic constriction injury. | |||
T38964 |
Peripheral Myelin P0 Protein (180-199), mouse
Peripheral Myelin P0 Protein (180-199), mouse |
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Peripheral Myelin P0 Protein (180-199), derived from mice, is a purified component of the myelin found in the peripheral nerves. This protein serves as a neuritogenic peptide, initiating the growth of neuronal processes. | |||
T70282 |
Drofenine
|
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Drofenin is an anticonvulsant. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers (neurotropic musculotropic effect). Drofenin also acts as FIASMA (functional inhibitor of acid sphingomyelinase ) | |||
T80513 |
YVAD-CHO
|
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YVAD-CHO为白细胞介素-1β转换酶(ICE,caspase 1)的抑制剂,能够在一定程度上减缓面神经损伤小鼠运动神经元死亡速率。 | |||
T60493 |
Guaiacol Carbonate
|
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Guaiacol Carbonate 是一种祛痰剂,其作用是通过胃的反射作用,通过胃神经到达延髓中枢,然后再通过外周进入呼吸道,从而起到祛痰作用。 | |||
T37953 |
Sphingomyelins (buttermilk)
|
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Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling... | |||
T74645 | Eplontersen | ||
Eplontersen 是一种三触角的、N-乙酰半乳糖胺 (GalNAc3)-缀合的反义寡核苷酸,能够靶向 甲状腺素运载蛋白 TTR 的 mRNA,抑制变体和野生型 TTR 产生。错误折叠的 TTR 诱导心脏和周围神经的淀粉样原纤维形成,并介导淀粉样 TTR (ATTR) 蛋白变性疾病。 | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S1720 |
Huperzine B
|
AChE | Neuroscience |
Huperzine B 是一种从 Huperzia serrata 中分离出的石蒜生物碱,也是一种高度选择性的乙酰胆碱酯酶抑制剂,可以用于改善阿尔茨海默氏病。 | |||
T5S1389 |
Escin IB
七叶皂苷B,七叶皂苷 IB |
5-HT Receptor; NO Synthase | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Escin IB 是一种皂苷,分离自马栗子种子的皮和胚乳中,能够抑制 pancreatic lipase 的活性。 | |||
T7040 |
Angiotensin II human
DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Angiotensin II human (Ang II) 是一种生物活性肽,一种血管收缩剂。Angiotensin II 可以与 AT1R 和 AT2R 相互作用,调节人类血压,刺激交感神经,增加醛固酮生物合成和肾脏活动。 | |||
T6805 |
Choline bitartrate
2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱 |
Others; AChR | Neuroscience; Others |
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱,可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体,作为甲基供体参与各种代谢过程和脂质代谢。 | |||
T64812 |
Collagenase Type I
Collagenase I,Collagenase Type I (From microorganisms) |
Others | Others |
Collagenase Type I 是一种蛋白水解酶,能分解胶原蛋白中的肽键(胶原蛋白是结缔组织的主要结构蛋白)。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质,从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组,潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。 | |||
T34885 |
Tinyatoxin
TNX,TTN,TTX |
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Tinyatoxin is a neurotoxin that works through vanillin receptors on sensory nerves. |