首页工具

登录

搜索结果

Search Results for " neonatal "

35

抑制剂 & 化合物

6

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T21793	CGP 35348	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T23283	2-Methoxyidazoxan monohydrochloride RX 821002 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) 是高效的 alpha 2r 肾上腺素受体选择性拮抗剂，对 imidazoline 拮抗作用很小或没有。它对 (豚鼠) alpha 2D 肾上腺素受体 (pKd9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd8.2)。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T11339L	Furegrelate	PPAR	DNA Damage/DNA Repair; Metabolism
	FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂，可减缓新生仔猪肺动脉高压的发展。
T29670	ADR-925 ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925	Endogenous Metabolite	Metabolism
	ADR-925 (ICRF 198) 是右雷佐生的一种活性螯合铁代谢物，具有使新生大鼠心肌细胞免受阿霉素诱导的损伤的能力。
T28607	Rocepafant LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation	Others
	Rocepafant (LAU8080) 是一种血小板活化因子(PAF)拮抗剂，可减轻新生大鼠缺氧缺血性脑损伤。Rocepafant 抑制肿瘤坏死因子-Afa 介导的小鼠 L929 肿瘤细胞的细胞毒性。
T23215L	(R)-3,4-DCPG HCl (R)-3,4-DCPG HCl(201730-10-1 Free base)	GluR	Neuroscience
	(R)-3,4-DCPG HCl 是一种强效和选择性的mGlu8a 受体激动剂，可激活新生大鼠脊髓初级传入终端上的代谢性谷氨酸受体。
T7578	REVERSE T3 碘塞罗宁,3,3',5'-triiodo-L-thyronine	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Reverse T3 (3,3',5'-triiodo-L-thyronine) 是由甲状腺素原脱碘后产生的甲状腺激素。它可抑制由其它甲状腺激素类似物引起的新生大鼠心肌细胞中钠电流增加的作用。
T7284	Argipressin acetate (113-79-1(free base))	Others	Others
	Vasopressin acetate (113-79-1(free base)) 是一种具有血管收缩和抗利尿活性的肽激素，可与血管精氨酸加压素受体 V1 结合，在 A7r5 大鼠主动脉平滑肌细胞和新生大鼠心肌细胞中的 Kd 值分别为 1.31 和 1.44 nM。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T0005	Aspirin 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA	Mitophagy; Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂，具有多种药理活性。它是组蛋白去乙酰化酶抑制剂，可上调细胞周期阻滞蛋白 p21，抑制携带 COX-1 的卵巢 Y 细胞。它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达，分别减少 PG 的产生和 ERK 和 NF-KB 的下调。
T63715	hIgG–hFc receptor-IN-1
	hIgG–hFc receptor-IN-1 是一种人免疫球蛋白G -人新生儿Fc 受体(hIgG-hFcRn)蛋白-蛋白相互作用抑制剂 (IC50: 2 μM)。
T7434	Argipressin Arg8-vasopressin,Vasopressin,醋酸精氨酸加压素,精氨加压素,AVP	Vasopressin Receptor	GPCR/G Protein
	Argipressin (Vasopressin) 是一种具有血管收缩和抗利尿活性的肽激素，可与血管精氨酸加压素受体 V1 结合，在 A7r5 大鼠主动脉平滑肌细胞和新生大鼠心肌细胞中的 Kd 值分别为 1.31 和 1.44 nM。
T79549	Antifungal agent 67
	Antifungalagent 67 (compound 9) 是一种抑制念珠菌有效的咪唑类抗真菌剂，其对健康新生大鼠成心肌细胞的 CC50 值为 33.6 μM。
T39717	VGSC blocker-1
	VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.
TP1171	Apraglutide TFA (1295353-98-8 free base) Apraglutide TFA,FE 203799e (TFA)
	Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.
TP2012	JMV 449
	Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analg
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T75868	JMV 449 acetate
	JMV 449 acetate 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 acetate 显示抑制125I-neurotensin 与新生小鼠脑结合的 IC50为 0.15 nM，对收缩豚鼠回肠的 EC50为 1.9 nM。JMV 449 acetate 对小鼠具有高效、持久的降温和缓解疼痛作用。
T64266	KR-39038
	KR-39038 是一种口服具有活力的 GRK5 (G 蛋白偶联受体激酶 5) 抑制剂 (IC50: 0.02 μM)。KR-39038 能够抑制新生儿心肌细胞的 HDAC5 通路，明显抑制血管紧张素 II 诱导的细胞肥大，具有显著的抗心肌肥厚和改善心功能作用。KR-39038 能够用于进行心力衰竭的研究。
T76001	Apraglutide TFA
	Apraglutide TFA (FE 203799 TFA) 是一种合成的、含33个氨基酸的肽类药物，为长效GLP-2类似物。它能在全回肠切除后导致的新生短肠综合征小猪中增强适应性和线性肠生长。
T37210	5-hydroxy Indomethacin
	5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981)
T37409	DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants...
T36336	Burnettramic Acid A
	Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic aci...
T36218	19R(20S)-EpDPA
	19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.219R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).3 1.Cinelli, M.A., Yang, J., Scharmen, A., et al.Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acidsJ. Lipid Res.59(11)2237-2252(2018) 2.Lucas...
T63793	Tauro-ω-muricholic acid sodium
	Tauro-ω-muricholic acid sodium (TωMCA sodium) 是一种tauro-α-muricholic acid 的类似物，是来源于肝脏的胆汁酸。Tauro-ω-muricholic acid sodium 能用作早发性新生儿败血症 (EOS) 和胆汁淤积的血清标志物。
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ...
T71145	Racecadotril-d5
	Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu...
T83766	Moexiprilat RS 10029
	Moexiprilat是一种血管紧张素转换酶(ACE; IC50 = 2.1 nM)的抑制剂，也是前药moexipril的一种活性代谢产物。通过侧链酯水解作用，在体内从moexipril转化而来。Moexiprilat (10 nM)能防止初生大鼠心脏成纤维细胞在雌激素或血管紧张素II刺激下的增殖。在以每天50 mg/kg剂量给药的去卵巢小鼠中，降低平均动脉血压，并增加心房钠尿肽水平，这是高血压的一个标志。
TP2012L	JMV 449 acetate(139026-66-7 Free bsae)
	JMV 449 acetate(139026-66-7 Free bsae) 是一种有效的、代谢稳定的神经降压素受体激动剂肽（抑制[125I]-NT与新生小鼠大脑的结合的IC50 = 0.15 nM；对于豚鼠收缩的EC50 = 1.9 nM 回肠）。 JMV 449 acetate 在小鼠体内中枢给药后产生持久的低温、神经保护和镇痛作用。
T36055	Nitisinone-13C6 Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F...
T83721	Hexafluoropropylene Oxide Dimer Acid FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA
	Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA)，于HepG2细胞中以250 µM的浓度使用时，可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量，会减少孵化鸡右心室壁厚度，增加心率，并诱导肝脏脂肪积累，这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下，HFPO-DA（250 mg/kg）降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平，并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T37347	6'-Sialyllactose Sodium Salt 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose
	6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.[1],[2],[3],[4],[5],[6] These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylne...

化合物

Cat.No: T21793

Target: GABA Receptor

2-Methoxyidazoxan monohydrochloride

Cat.No: T23283

Synonym: RX 821002 hydrochloride

Target: Adrenergic Receptor

Cat.No: T7714

Target: Tyrosinase

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Cat.No: T11339L

Target: PPAR

Cat.No: T29670

Synonym: ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925

Target: Endogenous Metabolite

Cat.No: T28607

Synonym: LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730

Target: Platelet aggregation

(R)-3,4-DCPG HCl

Cat.No: T23215L

Synonym: (R)-3,4-DCPG HCl(201730-10-1 Free base)

Target: GluR

Cat.No: T7578

Synonym: 碘塞罗宁,3,3',5'-triiodo-L-thyronine

Target: Thyroid hormone receptor(THR)

Argipressin acetate (113-79-1(free base))

Cat.No: T7284

Target: Others

Cat.No: T68123

Target: Calcium Channel

Cat.No: T0005

Synonym: 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

hIgG–hFc receptor-IN-1

Cat.No: T63715

Cat.No: T7434

Synonym: Arg8-vasopressin,Vasopressin,醋酸精氨酸加压素,精氨加压素,AVP

Target: Vasopressin Receptor

Antifungal agent 67

Cat.No: T79549

Cat.No: T39717

Apraglutide TFA (1295353-98-8 free base)

Cat.No: TP1171

Synonym: Apraglutide TFA,FE 203799e (TFA)

Cat.No: TP2012

Cat.No: T70421

JMV 449 acetate

Cat.No: T75868

Cat.No: T64266

Apraglutide TFA

Cat.No: T76001

5-hydroxy Indomethacin

Cat.No: T37210

DPC-AJ1951 (trifluoroacetate salt)

Cat.No: T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Burnettramic Acid A

Cat.No: T36336

Cat.No: T36218

Tauro-ω-muricholic acid sodium

Cat.No: T63793

Cat.No: T36215

Racecadotril-d5

Cat.No: T71145

Cat.No: T83766

Synonym: RS 10029

JMV 449 acetate(139026-66-7 Free bsae)

Cat.No: TP2012L

Nitisinone-13C6

Cat.No: T36055

Synonym: Nitisinone-13C6

Hexafluoropropylene Oxide Dimer Acid

Cat.No: T83721

Synonym: FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

6'-Sialyllactose Sodium Salt

Cat.No: T37347

Synonym: 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose

Cat. No.	Product Name	Target	Signaling Pathways
T5252	Tridecanedioic acid 十三烷二酸,1,11-Undecanedicarboxylic acid,1,13-Tridecanedioic acid,Brassilic acid	Others; Endogenous Metabolite	Metabolism; Others
	Tridecanedioic acid (Brassilic acid) 是内源性代谢产物的一种。
T4762	L-Pipecolic acid L-哌啶酸,L-Homoproline,H-HoPro-OH	Endogenous Metabolite	Metabolism
	L-Pipecolic acid (L-Homoproline) 是赖氨酸的分解产物，它能在患有常染色体遗传性疾病的婴儿体液中积累，比如新生儿肾上腺机能障碍， Zellweger 综合征等。
T36337	Burnettramic Acid A aglycone
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus...
T82545	Disialyllacto-N-tetraose
	Disialyllacto-N-tetraose，一种人乳低聚糖，能预防新生大鼠坏死性小肠结肠炎。
T72734	3-Fucosyllactose 3-Fucosyl-D-lactose
	3-Fucosyllactose (3-Fucosyl-D-lactose) 是人类母乳中的主要焦糖之一，具益生元、免疫调节、促进新生儿大脑发育及抗菌功能。
TN6453	Nardoaristolone B
	Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes. The novel mosquito-repellentsynthetic hydrindanesbased on noreremophilanes and nardoaristolone B which s

天然产物

Tridecanedioic acid

Cat.No: T5252

Synonym: 十三烷二酸,1,11-Undecanedicarboxylic acid,1,13-Tridecanedioic acid,Brassilic acid

Target: Others, Endogenous Metabolite

L-Pipecolic acid

Cat.No: T4762

Synonym: L-哌啶酸,L-Homoproline,H-HoPro-OH

Target: Endogenous Metabolite

Burnettramic Acid A aglycone

Cat.No: T36337

Disialyllacto-N-tetraose

Cat.No: T82545

3-Fucosyllactose

Cat.No: T72734

Synonym: 3-Fucosyl-D-lactose

Nardoaristolone B

Cat.No: TN6453

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼