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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0314 |
Hexylresorcinol
己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol |
Apoptosis; Tyrosinase; Antibacterial; Parasite | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物,具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂,有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。 | |||
T2008 |
LY294002
LY 294002,NSC 697286,SF 1101 |
Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂,抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。 | |||
T4079 |
LY-294002 hydrochloride
SF 1101,LY 294002,NSC 697286 |
PI3K | PI3K/Akt/mTOR signaling |
LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂(IC50:0.5/0.57/0.97 μM,在无细胞试验中);在溶液中比 Wortmannin 更稳定,也是自噬体形成的阻断剂。 | |||
T29165 |
XC-302 free base
XC 302,Puquitinib,XC-302,XC302 |
||
XC-302 is a multi-targeted inhibitor, it induces autophagy of nasopharyngeal cancer cells via inhibiting the PI3K/AKT/mTOR signaling pathway. | |||
T69201 |
Lophenol
|
||
Lophenol has potent inhibitory activity against human cancer cell lines such as liver cancer, nasopharyngeal and colon cancer cells. | |||
T81720 |
N,N'-Dinitrosopiperazine
1,4-Dinitrosopiperazine,DNP |
||
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物,与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路,特别是通过蛋白磷酸化作用于丝氨酸568位,发挥作用。 | |||
T30095 |
APG-1387
SM 1387,SM-1387,SM1387,APG 1387l |
||
APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's CDDP and 5-FU enhance chemoresensit | |||
T76970 | Tagitanlimab | ||
Tagitanlimab (HBM-9167),一种人源化抗PD-L1抗体(IgG1κ型),通过选择性阻断PD-L1与PD-1的相互作用,展现出对研究复发性或转移性鼻咽癌(NPC)的潜力。 | |||
T77117 | Toripalimab | ||
Toripalimab 是一个国产抗肿瘤 PD-1抗体。Toripalimab 是一种靶向 PD-1的选择性人源化单克隆抗体。Toripalimab 能够与 PD-1结合并阻断与其配体相互作用。Toripalimab 具有强效抗肿瘤作用,可用于黑色素瘤、肺癌、消化道肿瘤、肝胆和胰腺肿瘤、神经内分泌肿瘤、鼻咽癌和尿路上皮癌等肿瘤的研究。 | |||
T83667 |
A11 TFA
CPP-EYVQTVKSSKG |
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A11是一种细胞穿透肽,由HIV-1 Tat蛋白质转导域与对应于脂联素A1 N末端第20至30残基的11氨基酸肽连接而成。它减少脂联素A1与Eph受体酪氨酸激酶A2(EphA2)的结合,并在HK1鼻咽癌(NPC)细胞中增加EphA2的泛素化。A11(10 µM)抑制HK1和5-8F NPC细胞的增殖、迁移和侵袭。在体内,A11减少5-8F和HK1 NPC小鼠异种移植模型中的肿瘤体积。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4569 |
Minimolide F
|
Others | Others |
Minimolide F 是从 Centipeda minima 中分离得到的,对人鼻咽癌细胞具有抗增殖活性,IC50 为 17.4 μM。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 是β1选择性的肾上腺素能受体激动剂,EC50值为 5.37 μM。它可上调鼻咽癌肿瘤细胞中血管内皮生长因子、基质金属蛋白酶MMP-2和MMP-9的表达。 | |||
TN1854 |
Lasiodin
毛栲利素,Lasiokaurin |
P450; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物,可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性,可诱导细胞周期组长和凋亡,诱导细胞迁移和侵袭,可用于研究鼻咽癌 | |||
TN1405 |
Arnicolide D
山金车内酯 D,山金车内酯D |
Akt; Caspase; PI3K; STAT; mTOR | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯,以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期,激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。 | |||
T5S2347 |
Deoxyshikonin
去氧紫草素,Arnebin 7 |
Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others |
Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物,具有抗肿瘤活性,在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。 | |||
TN5171 |
Tricetin
|
Apoptosis; Others; Nrf2 | Apoptosis; Immunology/Inflammation; Others |
Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用(PPI)的强效竞争性抑制剂,通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路,保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1(PS-1)表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症,保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。 | |||
T73067 |
Isodispar B
|
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Isodispar B,一种抗癌剂,能够抑制鼻咽癌和乳腺癌细胞的增殖,并诱导(apoptosis)。它对多种癌细胞系展示出了细胞毒性作用。 | |||
TN1324 |
6-O-Nicotinoylscutebarbatine G
|
Others | Others |
6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1 5.7 μM. | |||
TN3812 |
Dehydrovomifoliol
|
AChR | Neuroscience |
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and the IC(50) values in the range 3.7-8.1 microM. | |||
T66078 | Cardamonin | ||
Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin(15μM) in CNE-2 cells.In vivo, cardamonin (25 mg/kg ... |