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Search Results for " kidney disease "

56

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7802	M1001	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	M1001 是较弱的HIF-2α激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd=667 nM，能够提高 HIF-2α-ARNT 复合体之间的稳定性。
T9022	AZD9977 AZD 9977	Glucocorticoid Receptor	Endocrinology/Hormones
	AZD9977 是一种选择性的，有效的，具有口服活性的盐皮质激素受体 (MR) 调节剂，可用于研究心力衰竭和慢性肾病。
T8528	AC1903	TRP/TRPV Channel	Membrane transporter/Ion channel
	AC1903是一种选择性的TRPC5抑制剂，具有足细胞保护特性，对 TRPC4 或 TRPC6没有影响，并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化大鼠模型中，AC1903抑制严重蛋白尿，并且防止足细胞丢失。
T11394	GFB-8438	TRP/TRPV Channel	Membrane transporter/Ion channel
	GFB-8438 是有效的TRPC5选择性抑制剂，对 hTRPC5 和 hTRPC4 的IC50分别为 0.18 和 0.29 μM。它对 TRPC6、其他 TRP 家族成员、NaV1.5 具有良好的选择性，对 hERG 通道的活性也有限。它对小鼠足细胞的保护作用。
T1874	PPQ-102 PPQ102,CFTR Inhibitor,PPQ 102	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂，可以完全抑制CFTR 氯化物电流，IC50为90 nM。
T4583	PFI-2 hydrochloride (R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) 是一种有效的、高度选择性的、具有细胞活性的 SETD7 甲基转移酶抑制剂，IC50值为2nM，活性是 (S)-PFI-2 的 500 倍。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T4651	Vadadustat N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂，是一种促红细胞生成剂，在动物慢性肾脏疾病模型中，有用于贫血的研究潜力。
T21395	Finerenone BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862	Glucocorticoid Receptor	Endocrinology/Hormones
	Finerenone (BAY-948862) 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
T6666	Sevelamer Carbonate	Others	Others
	Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂，能有效降低体内血清磷水平，但对体内血清钙、氯水平影响极小，可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。
T1987	PFI-2 PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂，Ki 和 IC50值分别为 0.33 和 2 nM。
T40108	Inaxaplin VX-147	Others	Others
	Inaxaplin 是一种载脂蛋白L1（APOL1）功能抑制剂。Inaxaplin 可用于肾脏疾病的研究。
T13591	Calcium polystyrene sulfonate Poly(styrenesulfonic acid) calcium salt,聚苯乙烯磺酸钙	Others	Others
	Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) 是一种离子交换树脂。 Calcium polystyrene sulfonate 可降低血钾水平，可用于治疗慢性肾病患者高钾血症的研究。
T0080	Trapidil 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR; PDE	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T77364	Sibeprenlimab VIS649,VIS-649	Others	Others
	Sibeprenlimab (VIS649) 是一种抑制 APRIL 的人源化IgG 2单克隆抗体。Sibeprenlimab 对 APRIL 有抑制作用，可用于研究预防和治疗肾病（IgAN）。
T60170	BLU2864	Others	Others
	BLU2864 是一种具有口服活性的、高选择性的、ATP 竞争性的 PRKACA 抑制剂，IC50值为0.3 nM。BLU2864 具有抗肿瘤活性，具有用于癌症和多囊肾的研究潜力。
T50000	2-Iodohippuric Acid	Others	Others
	2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究，也用于某些疾病的诊断，如肝病和肾病。此外，它还用于某些药物的合成。
T40109	APOL1-IN-1 APOL1-IN-1	Others	Others
	APOL1-IN-1是一种有效的载脂蛋白 L1(APOL1) 的抑制剂，可用于研究局灶节段性肾小球硬化 (FSGS) 和非糖尿病肾病 (NDKD) 的发病原理，促进对此类疾病的研究。
T30479	Bis-T-23 Bis T-23,Bis-T 23,AG1717	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bis-T-23是一种肌动蛋白依赖性达纳敏低聚物的促进剂，是一种 HIV-I 整合酶抑制剂，是泰尔普斯丁衍生物。Bis-T-23可以促进肌动蛋白依赖性的dynamin 寡聚化。Bis-T-23可用于HIV 和慢性肾脏疾病（CKD）的研究。
T13604	CDDO-dhTFEA	Others; NF-κB; Nrf2	Immunology/Inflammation; NF-κB; Others
	CDDO-dhTFEA 是合成的齐墩果烷三萜化合物，可有效激活Nrf2并抑制促炎转录因子NF-κB。它可以恢复高血压 (MAP)，提高 Nrf2 及其靶基因的表达，抑制 NF-κB 的活化和转化生长因子-β 途径，并减少慢性肾病 (CKD) 大鼠的肾小球硬化，间质纤维化和炎症。
T28222	5-Hydroxy-1-methylhydantoin HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor	GPCR/G Protein
	5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物，是一种羟基自由基清除剂，此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。它是一种新型抗氧化药物，可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应，并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明，它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
T38768	Ocedurenone
	Ocedurenone, a corticosteroid receptor antagonist, is a compound utilized in the investigation of kidney disease (WO2018054357, compound I).
T34107	Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
	Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T32193	Iron sorbitex Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit
T39105	Ibiglustat succinate GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate
	Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
T1605L	Enalapril sodium (-)-Enalapril sodium
	Enalapril sodium is used to treat high blood pressure, diabetic kidney disease, and heart failure and can be generally used with a diuretic such as furosemide for heart failure.
T39410	Zevaquenabant (S)-MRI-1867
	Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).
T60937	TRPC5-IN-1
	TRPC5-IN-1是一种TRPC5抑制剂，在各种慢性肾病动物模型中均具有活性。
T73332	BI-685509
	BI-685509 是一种口服有效的sGC 激活剂。BI-685509 可恢复环磷酸鸟苷 (cGMP) 并改善一氧化氮 (NO) 通路的功能。BI-685509 可用于慢性肾病 (CKD) 和糖尿病肾病 (DKD) 的研究。
T38419	Difelikefalin CR-845,FE-202845
	Difelikefalin (CR-845; FE-202845) is a peripherally restricted, selective agonist of the kappa opioid receptor (KOR). It exhibits anti-inflammatory properties and holds promise for modulating pruritus in conditions associated with chronic kidney disease.
T20118	L-Penicillamine
	L-Penicillamine is a medication primarily. It is used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, copper poisoning, and lead poisoning.
T64174	Vasopressin V2 receptor antagonist 1
	Vasopressin V2 receptor antagonist 1 (Compound 4g) 是一种 vasopressin V2receptor (V2R) 拮抗剂 (Ki: 3.8 nM)。Vasopressin V2 receptor antagonist 1 可以用于研究常染色体显性多囊肾病 (ADPKD)。
T39712	RGLS4326 RG4326,RGLS4326
	RGLS4326 (RG4326) is a short oligonucleotide inhibitor of microRNA-17 (miR-17), with a pioneering role in its class. This compound, with a research focus on autosomal dominant polycystic kidney disease (ADPKD), effectively suppresses the activity of miR-17 in HeLa cells, displaying an EC50 value of 28.3 nM.
T62589	TRPC5-IN-4
	TRPC5-IN-4 是一种有效且安全的TRPC 抑制剂，对TRPC5和TRPC4的IC50分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。
T80220	OK2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	OK2为CCN2/EGFR交互作用的特异性抑制剂，其通过结合CCN2的CT结构域，有效阻断了CCN2/EGFR的交互作用。该化合物适用于肾纤维化与慢性肾脏疾病研究。
T61362	CDK5-IN-3
	CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1].
T77074	Lulizumab pegol
	Lulizumab pegol (BMS-931699) 为一种抗CD28抗体拮抗剂，能有效抑制T细胞增殖。其主要应用于肾移植和自身免疫性疾病的研究。
T69294	UK‑396082
	UK-396082为一有效的TAFI抑制剂，能增进纤溶酶活性并促使ECM水平下降，适用于CKD研究。
T63293	Axl-IN-7
	Axl-IN-7 是 AXL 的有效抑制剂。Axl-IN-7 能够用于研究 Axl 相关疾病，如癌症(如急性髓系白血病、乳腺癌、黑色素瘤、胰腺癌和神经胶质肿瘤)、免疫系统紊乱、肾脏疾病和心血管疾病。
T74097	THX-B
	THX-B为一高效非多肽类p75NTR（神经营养蛋白受体p75）拮抗剂，适用于糖尿病、肾病、神经退行性及炎症性疾病研究。
T76947	Ziltivekimab
	Ziltivekimab (COR-001) 是一种人源化抗IL-6单克隆抗体，具有降低血清CRP的效能，并展现出抗炎活性。该化合物在CKD相关的慢性全身性炎症及心血管疾病研究中有潜在应用。
T83872	Oleoyl-L-carnitine chloride L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1
	Oleoyl-L-carnitine是一种长链酰基肉碱，也是一种糖苷转运体2（GlyT2；IC50 = 340 nM）的抑制剂，对GlyT2比对GlyT1（IC50 = >10,000 nM）具有选择性。慢性肾脏病或接受初始血液透析的终末期肾脏病患者的血浆中Oleoyl-L-carnitine水平增高，这与心血管死亡率相关。
T78513	Sodium zirconium cyclosilicate	Others	Others
	Sodium zirconium cyclosilicate 是一种新型口服、不吸收的无机微孔硅酸盐锆化合物，高选择性地作为阳离子交换剂，专门用于去除体内过量的K+。该化合物适用于慢性肾脏疾病（CKD）的研究。
T69035	Camostat free base
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces...
T60909	SSAO inhibitor-3
	SSAO inhibitor-3 (Compound 2) 可用于研究动脉粥样硬化、糖尿病及其并发症、肥胖症、中风、慢性肾病、视网膜病变、慢性阻塞性肺病 (COPD)、自身免疫性疾病、多发性硬化等。SSAO inhibitor-3 是一种氨基脲敏感性胺氧化酶 (SSAO) 的抑制剂，对人 AOC1 和SSAO 的IC50分别为 0.1-10 μM 和 <10 nM 。
T37439	C18 Globotriaosylceramide (d18:1/18:0)
	C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma...
T36384	DL-Tyrosine-13C9,15N L-Tyrosine-13C9,15N
	L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...
T60640	SSAO inhibitor-2
	SSAO inhibitor-2 (Compound 1) 可用于动脉粥样硬化、糖尿病及其并发症、肥胖、中风、慢性肾病、视网膜病变、慢性阻塞性肺病 (COPD)、自身免疫性疾病、多发性硬化等的研究。SSAO inhibitor-2 是氨基脲敏感性胺氧化酶 (SSAO) 抑制剂，其对人 SSAO 和 MAO-A 的IC50分别为 <10 nM 和 10-100 μM。
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T73163	CDK7-IN-20
	CDK7-IN-20 是一种有效的、选择性的、不可逆的 CDK7(CDK) 抑制剂，IC50值为 4 nM。CDK7-IN-20 对 CDK7的选择性超过 CDK1、CDK2、CDK3、CDK5、CDK6、CDK9 和 CDK12的 206 倍以上。CDK7-IN-20 具有用于常染色体显性多囊肾病 (ADPKD) 研究的潜力。

化合物

Cat.No: T7802

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T9022

Synonym: AZD 9977

Target: Glucocorticoid Receptor

Cat.No: T8528

Target: TRP/TRPV Channel

Cat.No: T11394

Target: TRP/TRPV Channel

Cat.No: T1874

Synonym: PPQ102,CFTR Inhibitor,PPQ 102

Target: CFTR, Autophagy

PFI-2 hydrochloride

Cat.No: T4583

Synonym: (R)-PFI-2 hydrochloride,PFI-2 HCl

Target: Histone Methyltransferase

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Cat.No: T4651

Synonym: N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T21395

Synonym: BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862

Target: Glucocorticoid Receptor

Sevelamer Carbonate

Cat.No: T6666

Target: Others

Cat.No: T1987

Synonym: PFI2,PFI 2,(R)-PFI-2

Target: Histone Methyltransferase

Cat.No: T40108

Synonym: VX-147

Target: Others

Calcium polystyrene sulfonate

Cat.No: T13591

Synonym: Poly(styrenesulfonic acid) calcium salt,聚苯乙烯磺酸钙

Target: Others

Cat.No: T0080

Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Cat.No: T77364

Synonym: VIS649,VIS-649

Target: Others

Cat.No: T60170

Target: Others

2-Iodohippuric Acid

Cat.No: T50000

Target: Others

Cat.No: T40109

Synonym: APOL1-IN-1

Target: Others

Cat.No: T30479

Synonym: Bis T-23,Bis-T 23,AG1717

Target: HIV Protease

Cat.No: T13604

Target: Others, NF-κB, Nrf2

5-Hydroxy-1-methylhydantoin

Cat.No: T28222

Synonym: HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419

Target: Bradykinin Receptor

Cat.No: T38768

Cat.No: T34107

Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Cat.No: T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Ibiglustat succinate

Cat.No: T39105

Synonym: GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate

Enalapril sodium

Cat.No: T1605L

Synonym: (-)-Enalapril sodium

Cat.No: T39410

Synonym: (S)-MRI-1867

Cat.No: T60937

Cat.No: T73332

Cat.No: T38419

Synonym: CR-845,FE-202845

L-Penicillamine

Cat.No: T20118

Vasopressin V2 receptor antagonist 1

Cat.No: T64174

Cat.No: T39712

Synonym: RG4326,RGLS4326

Cat.No: T62589

Cat.No: T80220

Target: EGFR

Cat.No: T61362

Lulizumab pegol

Cat.No: T77074

Cat.No: T69294

Cat.No: T63293

Cat.No: T74097

Cat.No: T76947

Oleoyl-L-carnitine chloride

Cat.No: T83872

Synonym: L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1

Sodium zirconium cyclosilicate

Cat.No: T78513

Target: Others

Camostat free base

Cat.No: T69035

SSAO inhibitor-3

Cat.No: T60909

C18 Globotriaosylceramide (d18:1/18:0)

Cat.No: T37439

DL-Tyrosine-13C9,15N

Cat.No: T36384

Synonym: L-Tyrosine-13C9,15N

SSAO inhibitor-2

Cat.No: T60640

Cat.No: T35881

Cat.No: T73163

Cat. No.	Product Name	Target	Signaling Pathways
T2S1837	Steviol 甜菊醇,NSC 226902,Hydroxydehydrostevic acid	Others	Others
	Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。
T14002	12-Ketodeoxycholic acid	Endogenous Metabolite	Metabolism
	12-Ketodeoxycholic acid 是一种胆汁酸，由肾脏代谢产生。它是肾脏损伤的标志物。
T21977	p-Cresyl sulfate	Others	Others
	p-Cresyl Sulfate 是主要的尿毒症毒素，存在于慢性肾病患者的血液，来源于肝脏中酪氨酸和苯丙氨酸的代谢物。
T5623	Bisphenol A	Others; Endogenous Metabolite	Metabolism; Others
	Bisphenol A 是酚类内源性代谢合成物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T77988	Phenyl sulfate Phenyl hydrogen sulfate	Endogenous Metabolite	Metabolism
	Phenyl sulfate为肠道微生物衍生的口服活性代谢物，能在糖尿病实验模型中诱发蛋白尿及足细胞损伤，其可能成为糖尿病肾病的疾病标志物和未来治疗靶点。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

Cat.No: T2S1837

Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Target: Others

12-Ketodeoxycholic acid

Cat.No: T14002

Target: Endogenous Metabolite

p-Cresyl sulfate

Cat.No: T21977

Target: Others

Cat.No: T5623

Target: Others, Endogenous Metabolite

Potassium 1H-indol-3-yl sulfate

Cat.No: T4938

Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: T77988

Synonym: Phenyl hydrogen sulfate

Target: Endogenous Metabolite

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

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