38
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83756 |
S1H TFA
Site 1-binding Helix |
||
S1H是一种人造肽类模拟物,模仿人类生长激素的第36至51个氨基酸,且为生长激素受体的拮抗剂。在溶液中呈现α-螺旋结构,并在100和200纳摩尔(nM)的浓度下,能降低SK-MEL-28和MALME-3M黑色素瘤细胞系以及IM-9 B细胞淋巴细胞中,由人类生长激素及泌乳素诱导的STAT5磷酸化。 | |||
TP1057 |
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa
Phe-Met-Arg-Phe Like Peptide |
||
Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1]. | |||
T81356 |
PTBP1-RNA-binding inhibitor P6 TFA
PTBP1 α3-helix derived peptide P6 TFA |
||
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA 为剪接因子PTBP1的特定钉合肽抑制剂,用于抑制PTBP1调控的RNA选择性剪接事件。该抑制剂通过与PTBP1的RNA识别基序相结合,从而发挥其作用。 | |||
T80546 |
Thioether-cyclized helix B peptide, CHBP
|
mTOR | PI3K/Akt/mTOR signaling |
Thioether-cyclized helix B peptide (CHBP) 通过抑制 mTORC1 及激活 mTORC2 诱导的自噬增强代谢稳定和肾脏保护效应。 | |||
T10860 |
Col003
|
HSP | Cytoskeletal Signaling; Metabolism |
Col003 是一种选择性和有效的 Hsp47 抑制剂,可竞争性结合 Hsp47 上的胶原蛋白结合位点,IC50为1.8 μM。它通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌,可用于肺纤维化的相关研究。 | |||
T80547 |
Thioether-cyclized helix B peptide, CHBP TFA
|
mTOR | PI3K/Akt/mTOR signaling |
Thioether-cyclized helix B peptide, CHBP(TFA)为Thioether-cyclized helix B peptide, CHBP的三氟乙酸盐形式,通过抑制mTORC1及激活mTORC2来诱导自噬(autophagy),进而增强代谢稳定性及肾脏保护效果。 | |||
T81357 |
PTBP1 α3-helix derived peptide P1 TFA
|
||
PTBP1 α3-螺旋衍生的多肽P1是一种多肽,具有抑制RNA结合的能力。 | |||
T16670 |
PS210
|
PDK | PI3K/Akt/mTOR signaling |
PS210 是针对 PDK1的 PIF 结合口袋的、选择性的、有效的 PDK1激活剂,对其他蛋白激酶无活性。在细胞中,它的前药 PS423 可作为 PDK1的底物选择性抑制剂,抑制 S6K 的磷酸化和活化。 | |||
TP2311 |
C-MYC PEPTIDE EPITOPE TFA
|
Others | Others |
C-MYC PEPTIDE EPITOPE TFA 是 c-myc 原癌基因的产物,是一种螺旋-环-螺旋亮氨酸拉链磷蛋白,可调节细胞增殖、细胞分化和凋亡中的基因转录。该肽是人类 c-myc 表位。 | |||
TP1057L |
Phe-Met-Arg-Phe Like Peptide acetate
Pqdpflrfamide acetate,Phe-Met-Arg-Phe Like Peptide acetate(98495-35-3 free base) |
Others | Others |
Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate)(98495-35-3 free base) 是一种来自蜗牛 Helix aspersa 的内脏和躯体肌肉的 FMRF 样肽。 FMRF (Phe-Met-Arg-Phe) 是一种由 4 个氨基酸残基组成的神经肽肽。 | |||
T20511 |
6-Thioguanosine
6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422 |
Others | Others |
6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷,是 Azathioprine 的代谢物,是低分子量凝胶剂。6-Thioguanosine 具有免疫抑制作用,可用于研究RNA 双螺旋结构的形成。 | |||
T1779 |
SAG
Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM),具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性,可以活化 Hedgehog 信号通路。 | |||
T14834 |
BT2
3,6-二氯-2-苯并噻吩羧酸 |
BCL | Apoptosis |
BT2 是 BCKDC 激酶(BDK)抑制剂,IC50值为 3.19 μM。它也是一种选择性的Mcl-1抑制剂,Ki 值为 59 μM。BT2 与 BDK 结合触发 N 端结构域的螺旋运动,导致 BDK 从支链 α-酮酸脱氢酶复合物 (BCKDC) 中解离。 | |||
T1006 |
Propantheline bromide
Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl |
AChR | Neuroscience |
Propantheline bromide (Pro-Banthine) 是一种抗毒蕈碱剂,用于研究多汗症,遗尿,胃肠和膀胱痉挛。 | |||
T28133 |
NB-64
|
||
NB-64 is a HIV-1 entry inhibitor. NB-64 interferes the gp41 six-helix bundle formation and blocks virus fusion. | |||
TP2346 |
Peptide 399
(Leu-lys-lys-leu-leu-lys-leu)2 |
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Peptide 399 is an antimicrobial peptide with an idealized amphiphilic alpha helix. | |||
T32344 |
JY-1-106
JY-1 106,JY-1106 |
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JY-1-106 is a BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. | |||
T25051 |
Allotrap
Peptide Bc-1nl |
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Allotrap is a small synthetic peptide derived from the alpha1 helix of the heavy chain of HLA class I proteins. It suppresses human T cell responses in vitro. It prolongs allograft survival in rats and mice. | |||
T29453 |
5-Formylcytosine
|
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5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymerase II. | |||
TP1811 |
LAH4
|
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The a-helix of the amphipathic peptide antibiotic LAH4 (KKALLALALHHLAHLALHLALALKKA-NH2) strongly interacts with phospholipid membranes, demonstrating in vitro transfection efficiencies comparable to those of commercially available reagents. | |||
T34807 |
Terephthalamidine
terephthalimidamide |
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Terephthalamidine is a derivative of the phthalanilide compounds. Terephthalamidine belongs to a family of compounds which appear to reversibly bind to the minor groove of the DNA double helix but not intercalate DNA. This agent also has been suggested to | |||
T76438 |
QEQLERALNSS TFA
|
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QEQLERALNSS TFA 是一种衍生自促红细胞生成素的HBSP,具有组织保护活性,能够保护心肌细胞免受凋亡(apoptosis)。 | |||
TP1576 |
SNAP-25 187-203
|
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This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT/E)-treated cells, albeit at higher concentrations | |||
TP2301 |
type II collagen fragment
|
Others | Others |
Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), ma | |||
T76470 |
GVLSNVIGYLKKLGTGALNAVLKQ
|
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GVLSNVIGYLKKLGTGALNAVLKQ 是一种具有 24 个氨基酸的抗菌肽。 GVLSNVIGYLKKLGTGALNAVLKQ 可能形成 α 螺旋。GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) 对革兰氏阴性菌、革兰氏阳性菌和酵母Candida albicans 具有抗性。 | |||
T78949 | AM841 | Cannabinoid Receptor | GPCR/G Protein |
AM841是一种高亲和力的亲电子配体,能与CB1大麻素受体中第六螺旋的半胱氨酸发生共价作用并激活该受体。此外,AM841能减少Forskolin刺激下的cAMP积累,并且减缓胃肠蠕动。 | |||
T75762 |
LAH4 TFA
|
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LAH4 TFA是一种两亲性肽抗生素,以α螺旋形式表现出显著的抗菌(antimicrobial)、核酸转染(nucleic acid transfection)及细胞穿透能力。它在传递质粒DNA方面显示出较高效能,并对细菌外膜中的阴离子脂质展现强烈亲和力。 | |||
T75831 |
NTR 368 TFA
|
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NTR 368 TFA, 衍生自p75神经营养蛋白受体(p75NTR),对应人类受体残基368-381,胶束脂质存在促使其倾向形成螺旋结构。该肽为神经细胞凋亡(apoptosis)的有效诱导剂。 | |||
T80264 |
C34 peptide
|
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C34 peptide是一种生物活性肽,亦名HR2,为HIV gp41螺旋区的C端七肽重复2(HR2),亦称C螺旋或C肽。该肽是HIV-1细胞膜融合过程的有效抑制剂,从而阻断病毒入侵细胞。 | |||
T83703 |
BLP-3 TFA
Bombin-like Peptide 3 |
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BLP-3是一种在X. laevis皮肤中表达的内源性多肽,具有抗菌特性。在20 µg/ml的浓度下对N. meningitidis、N. gonorrhoeae、N. lactamica和N. cinerea有效。BLP-3折叠成α-螺旋结构,能插入并破坏类细菌膜。 | |||
T61911 |
Antibacterial agent 98
|
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Antibacterial agent 98 (compound g37) 是口服有效的抗菌剂,可以抑制 Gyrase B 的 ATP 酶活性并削弱金黄色葡萄球菌 (S. aureus )的DNA 超螺旋。Antibacterial agent 98 不会诱导 MRSA (耐甲氧西林金黄色葡萄球菌 (S. aureus)) 的耐药性发展。 | |||
TD0003L |
CelGreen nucleic acid gel stain *10,000× concentrate in DMSO*
|
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CelGreen nucleic acid gel stain *10,000× concentrate in DMSO* is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak fluorescence, but the fluorescence is greatly enhanced once they are combined with the double-stranded DNA. Therefore, the fluorescence signal strength of CelGreen is related to the amount of double-stranded DNA, and the amount of double-stranded DNA in the PCR system can be detec... | |||
TP1130 |
β-CGRP, human
CGRP-II (Human),Human β-CGRP |
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β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascular and nervous systems. β-CGRP contains a disulphide bridge at the N-terminus, a C-terminal phenylal | |||
T81640 |
NSC15520
|
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NSC15520是一种小分子RPA抑制剂,特异性结合RPA的N端DNA结合域(DBD),阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性,影响DNA复制、修复、重组及损伤反应信号。 | |||
T73576 | EP39 | ||
EP39 是一种有效的HIV-1成熟抑制剂。EP39 与 Gag 的 SP1 结构域相互作用。EP39 通过与 SP1 结构域的 QVT 基序结合来降低 CA-SP1 连接的动力学,并通过稳定瞬态 α 螺旋结构来扰乱 SP1 结构域两侧的自然螺旋平衡。EP39 通过阻止HIV-1的成熟而起作用,从而阻断其感染性。 | |||
T38303 |
Apramycin (Nebramycin II)
|
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Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A bas... | |||
TD0003 |
CelGreen nucleic acid gel stain *10,000× concentrate in water*
|
Others | Others |
CelGreen 是一种具有独特参与性的荧光染料,可与所有 dsDNA 双螺旋沟区域结合。在游离状态下,侧链和 CelGreen 发出微弱的荧光,但一旦与双链DNA 结合,荧光就会大大增强。因此,CelGreen 的荧光信号强度与双链DNA 的量有关,可以根据荧光信号检测PCR 系统中双链DNA 的量。 | |||
T83683 |
st-Ht31 ammonium
sHt31 |
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st-Ht31是一种由A-kinase锚定蛋白(AKAPs)的两亲螺旋域衍生的、可穿透细胞的硬脂化肽,它能够结合蛋白激酶A (PKA)。在使用50 µM浓度时,能降低PKA在细胞膜上的锚定,但不影响其在使用BHK-21成纤维细胞进行的报告基因分析中的活性。st-Ht31 (1和3 µM)能减少小鼠精子的电容和超活化,同时阻止体外受精。当使用50 µM浓度时,它还能促进表达ATP结合盒转运蛋白1 (ABCA1)的BHK-21细胞和RAW 264.7巨噬细胞中的胆固醇排出。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3790 |
Hederacoside D
常春藤苷 D,常春藤苷D;常春藤皂苷D |
TNF | Apoptosis |
Hederacoside D 是从常春藤中分离到的皂苷,具有很高的生物活性。 | |||
T21498 |
Phleomycin
|
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Phleomycin 是在链霉菌中发现的,引起 DNA 切割的抗癌糖肽抗生素之一。 它类似于博来霉素,它结合并插入 DNA 以破坏双螺旋的完整性。 | |||
T6654 |
Saponins
Sapogenins Glycosides,皂素,Saponin |
Others | Others |
Saponins (Sapogenins Glycosides) 是一种苷类的化合物,多发现于多种植物中,可保护植物免受微生物和真菌的破坏。 | |||
T3345 |
Hederasaponin B
常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B |
Others; Virus Protease | Microbiology/Virology; Others |
Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的,有广谱抗病毒活性。 | |||
T3S0205 |
β-Hederin
Beta-Hederin,β-常春藤素 |
Parasite | Microbiology/Virology |
β-Hederin 是从 Hedera helix L.(Araliaceae) 分离得到的一种皂苷,具有抗利什曼虫活性。它对乳腺癌细胞有凋亡作用,有望成为乳腺癌化疗的候选药物。 |