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Search Results for " endocrine "

58

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0695	Avobenzone 阿伏苯宗,Butyl methoxydibenzoylmethane,BF2AVB	Apoptosis; Estrogen Receptor/ERR; Others	Apoptosis; Endocrinology/Hormones; Others
	Avobenzone (Butyl methoxydibenzoylmethane) 是一种二苯甲酰甲烷内分泌干扰物，可直接与雌激素受体 β 结合，起到雌激素激动剂的作用。它是紫外线波段皮肤光防护防晒霜中应用最广泛的滤光剂之一。
T4504	Triclocarban Solubacter,Cutisan,Procutene,3,4,4′-Trichlorocarbanilide,三氯卡班	Antibacterial	Microbiology/Virology
	Triclocarban (Cutisan) 是一种抗菌剂，用于个人清洁产品。它有潜在干扰内分泌的作用，具有调节雄激素和雌激素活性以及其他激素介导的生物过程的能力。
T7839	Lasofoxifene Tartrate CP-336156,酒石酸拉索昔芬	Estrogen Receptor/ERR	Endocrinology/Hormones
	Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。
T0787	Butylhydroxyanisole BHA,丁基羟基茴香醚,丁基大茴香醚,E320,Butylated hydroxyanisole	Antioxidant; Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Butylhydroxyanisole (BHA) 是一种抗氧化剂，能介导肝毒性、生殖器官发育和学习迟缓以及睡眠不足，用作食品防腐剂。它也是一种铁死亡诱导剂，能导致大脑和神经发育中断，具有神经毒性。
T34385	Ronacaleret HCl SB 751689,SB 751689A,SB-751689A,SB-751689,SB751689A,SB751689	CaSR	GPCR/G Protein
	Ronacaleret HCl (SB-751689) 是一种小分子 CaSR 拮抗剂，可用于治疗内分泌与代谢疾病、皮肤和肌肉骨骼疾病。
T41244	Triticonazole	Antifungal	Microbiology/Virology
	Triticonazole 是一种三唑类农药。它具有杀菌和干扰内分泌作用。
TP1035L	Cyclic somatostatin Acetate(38916-34-6(free base)) Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt)	Others	Others
	Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽，可调节许多内分泌和神经系统功能。
T5627	Methoxychlor	Others	Others
	Methoxychlor 是一种有机氯农药，被认为是一种内分泌干扰物，会影响不同细胞模型中的 Ca²⁺ 稳态和细胞活力。
TP1035	Cyclic somatostatin SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14	Others	Others
	Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子，可用于研究胃十二指肠溃疡出血。
T31611	Eldacimibe WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147	Acyltransferase	Metabolism
	Eldacimibe (WAY-ACA-147) 是一种ACAT2抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，研究动脉粥样硬化和高胆固醇血症。
T16090	MK-0773 PF-05314882	Androgen Receptor	Endocrinology/Hormones
	MK-0773 (PF-05314882) 是一种选择性雄激素受体调节剂，能与 AR 结合（IC50：6.6 nM），可用于研究内分泌异常引起的疾病。
T13435	TR antagonist 1	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	TR antagonist 1 是一种高效甲状腺激素受体（TR）拮抗剂（对 TRα 和 TRβ 的 IC50 分别为 36 和 22 nM），可用于研究内分泌异常引起的疾病。
T72042	Acetylsulfamerazine N-Acetylsulfamerazine
	Acetylsulfamerazine (N-Acetylsulfamerazine) 是磺胺甲基嗪的次级代谢产物，对纤维素消化和瘤胃内分泌的活性有轻微的抑制作用,具有抗微生物活性。
T5626	Atrazine Aktikon,Chromozin,Gesaprim,莠去津,Oleogesaprim,阿特拉津	Others	Others
	Atrazine (Oleogesaprim) 能够抑制光磷酸化，但通不会在短期内导致致命性或永久性细胞损伤，常用于控制一年生阔叶杂草。
T72049	4-N-Nonyloxyphenol 4-nonoxyphenol,p-Nonyloxyphenol
	4-N-Nonyloxyphenol (4-nonoxyphenol) 是一种基于高岭土纳米管的杂化光敏剂，是一种广泛使用的农药和内分泌干扰剂，可用于苯酚基农药的光降解。
TP2026L	GRP (porcine) acetate GRP (porcine) acetate(74815-57-9 Free base)	Others	Others
	GRP (porcine) acetate 是从猪胰腺中提取的胃泌素释放肽。 GRP (porcine) acetate 可能在猪胰腺内分泌和外分泌的副交感神经调节中起作用。
T68053	Denagliptin GW823093	DPP-4	Proteases/Proteasome
	Denagliptin是一种小分子二肽基肽酶IV（DPP-4）抑制剂，可用于治疗内分泌于代谢疾病，可用于研究2型糖尿病。
T27245L	Eflucimibe L0081,F-12511	Acyltransferase	Metabolism
	Eflucimibe (L0081) 是一种酰基辅酶A：胆固醇酰基转移酶抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，可用于研究动脉粥样硬化和高脂血症。
TP2296L	TLQP 21 acetate	Complement System	Immunology/Inflammation
	TLQP 21 acetate 是 G 蛋白偶联受体补体 3a 受体 1 (C3aR1) 的有效激动剂。小鼠的 EC50 值为 10.3 μM，人的 EC50 值为 68.8 μM。它是一种 VGF 衍生肽，具有内分泌和内分泌特性。
T68043	Ciamexon Ciamexone,BM 41332,BM41332,BM-41332	Others	Others
	Ciamexon (Ciamexone) 是一种新型的免疫调节剂，在自身免疫性疾病的实验模型中具有良好的效果，几乎没有显示出细胞毒性。Ciamexon 可用于研究内分泌眼病和糖尿病，在短时间给药后眼科疾病得到轻微改善。
T14226	Amino-PEG11-amine 氨基-十二聚乙二醇-氨基	Others; PROTAC Linker	Others; PROTAC
	Amino-PEG11-amine 是一种基于 PEG（12 个单位）的 PROTAC 接头，能够结合两种基于单乙基雌酚的配体，是制备用于乳腺癌内分泌治疗的更具选择性和活性的 ER 拮抗剂的替代策略。
T61932	Nesuparib JPI-547/OCN-201	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	Nesuparib (JPI-547/OCN-201) 是一种有效的PARP抑制剂，对PARP 和TNKS1具有抑制作用。Nesuparib 具有抗肿瘤活性，可用于治疗肿瘤、内分泌与代谢疾病、泌尿生殖系统疾病，可用于研究神经性疼痛、神经退行性疾病和心血管疾病。
TP2236L	Cortistatin-8 acetate Cortistatin-8 acetate(485803-62-1 Free base)	GHSR	GPCR/G Protein
	Cortistatin-8 acetate 是一种皮质抑素类似物，是一种GHS-R拮抗剂，对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体，不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。
T67791	BMS-903452	GPR	Endocrinology/Hormones; GPCR/G Protein
	BMS-903452是一种有效的、具有选择性的 GPR119激动剂，EC50为14 nM。BMS-903452可用于治疗急性和慢性啮齿动物糖尿病。GPR119主要在胰腺 b 细胞和胃肠道肠内分泌细胞中表达，对9种不同的细胞色素 P450酶没有显著的抑制作用(IC50 > 40 μM)，不激活 PXR (EC50>50 μM)，并且对肝脏(HEPG2)细胞系没有毒性。
T38272	Thiacloprid	AChR; Parasite	Microbiology/Virology; Neuroscience
	Thiacloprid 属于氯烟碱类杀虫剂，主要用于防治蔬菜和果园中的蚜虫。它会破坏 DNA 的稳定性，通过疏水或氢相互作用，结合到小沟槽中，改变 DNA 的结构和稳定性。
T26553	Aclatonium Napadisilate Acaltonium napadisilate
	Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.
T30837	Cgp 47645 Leflutrozole,Cgp-47645,Cgp47645
	CGP 47645 (Leflurozole) is an oral active non-steroidal aromatase inhibitor and antitumor agent with anti-tumor and endocrine effects.
T30834	Cgp 45688 Cgp45688,Cgp-45688
	CGP 45688 is an oral active non-steroidal aromatase inhibitor with anti-tumor and endocrine effects on rat breast tumors.
T20274	Dibenzyl phthalate AI300364,AI3-00364
	Dibenzyl phthalate is an endocrine-disrupting chemical. It also interferes with different cell signaling pathways involved in weight and glucose homeostasis.
T33607	NBI-34041 NBI34041,SB 723620,SB-723620,SB723620
	NBI-34041 is an effective and high-affinity CRF1 receptor antagonist that effectively reduces endocrine responses to CRF(1) receptor-mediated pharmacological and behavioral challenges.
TP1306	GLP-1(7-37)
	GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.
T39306	7-Oxodehydroabietic acid
	7-Oxodehydroabietic acid is a diterpene resin acid found in the roots of Pinus densiflora pine. It acts as a defensive compound against herbivorous insects by disrupting their endocrine system.
TP1863	Glucagon (19-29), human
	Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing endocrine pancreas.
T38379	4-tert-Octylphenol diethoxylate
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.
T26200	Somatostatin RC 102 Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102
	Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
T39244	Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
	Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research.
T14223	Amino-PEG10-amine	Others	Others
	Amino-PEG10-amine is a PEG-based PROTAC linker employed for the conjugation of two mono diethylstilbestrol (DES)-based ligands. This compound offers an alternative approach to the synthesis of highly selective and active ER antagonists, which are crucial for the advancement of endocrine therapy in breast cancer treatment[1].
TP1232	Amylin, amide, rat Amylin (rat)
	Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac
TP1732	Galanin (1-30), human
	Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been shown to have an action on intestinal
TP1610	Secretin, canine
	Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
T38077	TLQP-21 TFA
	TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions[1][2]. TLQP-21 TFA is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of th...
T82447	Ergtoxin-1 ErgTx1
	Ergtoxin-1为钾离子通道阻断剂，源于墨西哥毒蝎Centruroides noxius的毒液。该化合物具有阻断神经、心脏及内分泌细胞ERG-K+通道的功能。
T80985	Thyrotropin Pretiron,TSH
	Thyrotropin (TSH)为促甲状腺激素，由垂体前叶的促甲状腺细胞分泌，主要功能是调节甲状腺的内分泌活动。
T76538	Pancreatic polypeptide
	Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽，具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。
T81919	Locustatachykinin II Lom-TK II
	Locustachykinin II (Lom-TK II)为具有同源性的昆虫神经肽，与脊椎动物的tachykinin肽家族相似。此化合物适用于研究昆虫的内分泌系统。
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco
T36469	Atrazine Mercapturate
	Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples.
T78039	Acetyl-(D-Arg2)-GRF (1-29) amide (human)
	Acetyl-(D-Arg2)-GRF (1-29) amide (human) 是一种针对人体的生长激素释放因子(GRF)拮抗剂，其主要作用是抑制生长激素(GH)的释放，广泛应用于内分泌学领域的研究。
T63572	Org 43553
	Org 43553 是口服具有活力的低分子量 (LMW) 促黄体生成素受体(LH-R)激动剂，能够激动人 LH (EC50: 3.7 nM)和 FSH 受体(EC50: 110 nM) 。Org 43553 能够用于研究内分泌。
T75894	Sauvagine TFA
	Sauvagine TFA，是一种来自青蛙皮肤的 40 个氨基酸的神经肽，是哺乳动物 CRF 激动剂。Sauvagine TFA 可有效从大鼠垂体细胞释放 ACTH。Sauvagine TFA 在利尿，心血管系统和内分泌腺体方面具有许多药理作用。

化合物

Cat.No: T0695

Synonym: 阿伏苯宗,Butyl methoxydibenzoylmethane,BF2AVB

Target: Apoptosis, Estrogen Receptor/ERR, Others

Cat.No: T4504

Synonym: Solubacter,Cutisan,Procutene,3,4,4′-Trichlorocarbanilide,三氯卡班

Target: Antibacterial

Lasofoxifene Tartrate

Cat.No: T7839

Synonym: CP-336156,酒石酸拉索昔芬

Target: Estrogen Receptor/ERR

Butylhydroxyanisole

Cat.No: T0787

Synonym: BHA,丁基羟基茴香醚,丁基大茴香醚,E320,Butylated hydroxyanisole

Target: Antioxidant, Ferroptosis, Reactive Oxygen Species

Ronacaleret HCl

Cat.No: T34385

Synonym: SB 751689,SB 751689A,SB-751689A,SB-751689,SB751689A,SB751689

Target: CaSR

Cat.No: T41244

Target: Antifungal

Cyclic somatostatin Acetate(38916-34-6(free base))

Cat.No: TP1035L

Synonym: Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt)

Target: Others

Cat.No: T5627

Target: Others

Cyclic somatostatin

Cat.No: TP1035

Synonym: SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14

Target: Others

Cat.No: T31611

Synonym: WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147

Target: Acyltransferase

Cat.No: T16090

Synonym: PF-05314882

Target: Androgen Receptor

TR antagonist 1

Cat.No: T13435

Target: Thyroid hormone receptor(THR)

Acetylsulfamerazine

Cat.No: T72042

Synonym: N-Acetylsulfamerazine

Cat.No: T5626

Synonym: Aktikon,Chromozin,Gesaprim,莠去津,Oleogesaprim,阿特拉津

Target: Others

4-N-Nonyloxyphenol

Cat.No: T72049

Synonym: 4-nonoxyphenol,p-Nonyloxyphenol

GRP (porcine) acetate

Cat.No: TP2026L

Synonym: GRP (porcine) acetate(74815-57-9 Free base)

Target: Others

Cat.No: T68053

Synonym: GW823093

Target: DPP-4

Cat.No: T27245L

Synonym: L0081,F-12511

Target: Acyltransferase

TLQP 21 acetate

Cat.No: TP2296L

Target: Complement System

Cat.No: T68043

Synonym: Ciamexone,BM 41332,BM41332,BM-41332

Target: Others

Amino-PEG11-amine

Cat.No: T14226

Synonym: 氨基-十二聚乙二醇-氨基

Target: Others, PROTAC Linker

Cat.No: T61932

Synonym: JPI-547/OCN-201

Target: PARP, Wnt/beta-catenin

Cortistatin-8 acetate

Cat.No: TP2236L

Synonym: Cortistatin-8 acetate(485803-62-1 Free base)

Target: GHSR

Cat.No: T67791

Target: GPR

Cat.No: T38272

Target: AChR, Parasite

Aclatonium Napadisilate

Cat.No: T26553

Synonym: Acaltonium napadisilate

Cat.No: T30837

Synonym: Leflutrozole,Cgp-47645,Cgp47645

Cat.No: T30834

Synonym: Cgp45688,Cgp-45688

Dibenzyl phthalate

Cat.No: T20274

Synonym: AI300364,AI3-00364

Cat.No: T33607

Synonym: NBI34041,SB 723620,SB-723620,SB723620

Cat.No: TP1306

7-Oxodehydroabietic acid

Cat.No: T39306

Glucagon (19-29), human

Cat.No: TP1863

4-tert-Octylphenol diethoxylate

Cat.No: T38379

Somatostatin RC 102

Cat.No: T26200

Synonym: Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled

Cat.No: T39244

Amino-PEG10-amine

Cat.No: T14223

Target: Others

Amylin, amide, rat

Cat.No: TP1232

Synonym: Amylin (rat)

Galanin (1-30), human

Cat.No: TP1732

Secretin, canine

Cat.No: TP1610

Cat.No: T38077

Cat.No: T82447

Synonym: ErgTx1

Cat.No: T80985

Synonym: Pretiron,TSH

Pancreatic polypeptide

Cat.No: T76538

Locustatachykinin II

Cat.No: T81919

Synonym: Lom-TK II

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Atrazine Mercapturate

Cat.No: T36469

Acetyl-(D-Arg2)-GRF (1-29) amide (human)

Cat.No: T78039

Cat.No: T63572

Cat.No: T75894

Cat. No.	Product Name	Target	Signaling Pathways
T5623	Bisphenol A	Others; Endogenous Metabolite	Metabolism; Others
	Bisphenol A 是酚类内源性代谢合成物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
T4797	DEHP Bis(2-ethylhexyl) phthalate,邻苯二甲酸二(2-乙基己)酯	Others; Endogenous Metabolite	Metabolism; Others
	DEHP (Bis(2-ethylhexyl) phthalate) 是内源性代谢产物的一种。
TN6982	Diethyl phthalate 邻苯二甲酸二乙酯,1,2-diethyl benzene-1,2-dicarboxylate	Apoptosis	Apoptosis
	Diethyl phthalate (1,2-diethyl benzene-1,2-dicarboxylate) 是一种内分泌干扰物，影响 PC12 细胞凋亡系统。Diethyl phthalate 广泛用于许多塑料和个人护理产品。
T64353	4-tert-Octylphenol	Endogenous Metabolite	Metabolism
	4-tert-Octylphenol 是一种干扰内分泌的化学物质及雌激素药物，能诱导子代小鼠脑神经元祖细胞的凋亡，并通过减少溴脱氧尿苷（BrdU）、有丝分裂标志物Ki67以及磷酸组蛋白H3（p-Histone-H3）的表达，导致神经元祖细胞的增殖减少。这种物质不仅会干扰小鼠的大脑发育，还会影响其行为。
T20273	Diamyl phthalate NSC 4720,NSC-4720,NSC4720
	Diamyl phthalate is an agent of endocrine disruptor.
TN1550	Danshenxinkun A 丹参新醌甲,丹参新醌A	Others	Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental ada
T31536	Ditridecyl phthalate DTDP,Phthalic acid, ditridecyl ester,Nuoplaz,BRN 2023076,Polycizer 962BPA
	Ditridecyl phthalate is a kind of phthalate ester. Phthalate esters are esters of phthalic acid and are mainly used as plasticizers to soften polyvinyl chloride. They can be found in many different kind if products, including glues, building materials, pe

天然产物

Cat.No: T5623

Target: Others, Endogenous Metabolite

Cat.No: T4797

Synonym: Bis(2-ethylhexyl) phthalate,邻苯二甲酸二(2-乙基己)酯

Target: Others, Endogenous Metabolite

Diethyl phthalate

Cat.No: TN6982

Synonym: 邻苯二甲酸二乙酯,1,2-diethyl benzene-1,2-dicarboxylate

Target: Apoptosis

4-tert-Octylphenol

Cat.No: T64353

Target: Endogenous Metabolite

Diamyl phthalate

Cat.No: T20273

Synonym: NSC 4720,NSC-4720,NSC4720

Danshenxinkun A

Cat.No: TN1550

Synonym: 丹参新醌甲,丹参新醌A

Target: Others

Ditridecyl phthalate

Cat.No: T31536

Synonym: DTDP,Phthalic acid, ditridecyl ester,Nuoplaz,BRN 2023076,Polycizer 962BPA

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