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31

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31162	Cysteinyltyrosine N-L-Cysteinyl-L-tyrosine,Cys-tyr
	Cysteinyltyrosine is a dipeptide composed of cysteine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T1677L	Montelukast sodium MK0476,孟鲁司特钠	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T1677	Montelukast 孟鲁司特,Singular	Leukotriene Receptor; Lipoxygenase; LTR	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T4233L	Cysteinylglycine acetate Cys-Gly Acetate,Cysteinylglycine acetate（19246-18-5 Free base）	Endogenous Metabolite	Metabolism
	Cysteinylglycine acetate (Cys-Gly Acetate) 是Cysteinylglycine 的醋酸盐形式。Cysteinylglycine 是一种内源性代谢产物，可用于疾病诊断。
T32099	Homocysteinylpropachlor Homo-cys-ipa
	Homocysteinylpropachlor is a bioactive chemical.
T15036	Cysteinylglycine TFA	Others	Others
	Cysteinylglycine TFA is an endogenous metabolite. It is used in disease diagnosis.
T38206	3-Cysteinylacetaminophen (trifluoroacetate salt) APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)
	3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.[3],[4] In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin.
T31161	Cysteinyllysine
	Cysteinyllysine is a dipeptide composed of cysteine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T31160	Cysteinylcysteine Cys-cys
	Cysteinylcysteine is a bioactive chemical.
T19699	Triciribine phosphate TCN-P,VD 002,VQD-002	Apoptosis; Akt	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Triciribine phosphate (VD 002) 是一种高选择性的 AKT 抑制剂，可诱导细胞周期停滞和半胱天冬酶依赖性细胞凋亡，抑制新生血管的生成，可用于研究白血病。
T36333	Z-IETD-AFC
	Z-IETD-AFC 是 caspase-8 和颗粒酶 B 的荧光底物，可用于定量半胱天冬酶-8 或颗粒酶 B 的活性。
T0694	Pranlukast 普鲁司特,ONO-1078,普仑司特	Leukotriene Receptor; IL Receptor; Others; TNF; NF-κB; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
	Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂，可拮抗或减少支气管痉挛，用于哮喘研究。
T68130	Pobilukast SKF 104353 Z2,SKF 104353	Leukotriene Receptor	GPCR/G Protein
	Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂，可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成，可用于研究过度心肌再灌注损伤（MI/R）大鼠限制心肌损伤。
T11388	Gemilukast ONO-6950	Others	Others
	Gemilukast（ONO-6950）是一种具有口服活性和有效性的半胱氨酰白三烯 1 和 2 受体 (CysLT1 和CysLT2) 双重抑制剂，抑制 LTC 4 诱导的支气管收缩，对人 CysLT1 和 CysLT2 有抑制作用，可用于治疗哮喘。
T27912	LY 290324 LY-290324,LY290324
	LY 290324 is an orally active, potent and selective antagonist of cysteinyl leukotriene (LTD4) receptor.
T31080	CP-85958 (+)-Cp 85958,UNII-CU98Q2IL7P
	CP-85958 is a cysteinyl leukotriene antagonist.
T28481	Q8 hydrochloride Q8
	Q8 is an antagonist of cysteinyl leukotreine receptor. Q8 inhibits VEGF-independent angiogenesis.
T37016	Iralukast (CGP 45715A)
	Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.
T38129	Leukotriene F4 LTF4
	LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
T15463	(Rac)-HAMI 3379 HAMI 3379	Others	Others
	HAMI 3379 is a potent and selective antagonist of the Cysteinyl leukotriene (CysLT2) receptor. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury. It also attenuates microglia-related inflammation.
T37386	Dihydro Montelukast
	Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis.
T21864	BAY-u 9773
	BAY-u 9773 是 CysLT 受体(半胱氨酸白三烯受体)的非选择性拮抗剂，对于 CysLT1和 CysLT2的 IC50值大致相同，用于抑制白三烯反应。
TP1816	Urotensin II, mouse
	Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En
T72145	Montelukast dicyclohexylamine MK0476 dicyclohexylamine
	Montelukast (MK0476) dicyclohexylamine 是一种有效、选择性且具口服活性的半胱氨酸白三烯受体1 (CysLT1) 拮抗剂，用于哮喘和肝损伤预防研究。它在肠缺血-再灌注损伤中展现抗氧化作用，减轻心脏损伤，并降低嗜酸性粒细胞对哮喘气道的浸润。此外，亦被用于COVID-19的研究。
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
T60439	CAY10789
	CAY10789 (化合物 6) 是有效的CysLT1R 拮抗剂，IC50值为2.80 μM。CAY10789 也是一种GPBAR1激动剂，EC50为3 μM。CAY10789 显著降低 U937 细胞对 HAEC 的粘附并降低 TNF-α 的表达。CAY10789 表现出有前途的代谢稳定性和出色的药代动力学。 CAY10789 可用于结肠炎、代谢综合征和其他 GPBAR1/CysLT1R 相关疾病的研究。
T37980	N-methyl Leukotriene C4 N-methyl Leukotriene C4
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot...
T83926	S-Geranylgeranyl-L-glutathione GGG
	S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体（GPCR）P2RY8的配体。该化合物在100 nM浓度下，选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2（S1P2）、GPR55、半胱氨酸白三烯受体1（CysLT1 receptor）以及CysLT2 receptor的内吞作用。在10 nM浓度下，S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子（C-X-C motif）配体12（CXCL12）诱导的迁移。
T38128	Leukotriene D4 Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of...

化合物

Cysteinyltyrosine

Cat.No: T31162

Synonym: N-L-Cysteinyl-L-tyrosine,Cys-tyr

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Montelukast sodium

Cat.No: T1677L

Synonym: MK0476,孟鲁司特钠

Target: Leukotriene Receptor, LTR

Cat.No: T1677

Synonym: 孟鲁司特,Singular

Target: Leukotriene Receptor, Lipoxygenase, LTR

Cysteinylglycine acetate

Cat.No: T4233L

Synonym: Cys-Gly Acetate,Cysteinylglycine acetate（19246-18-5 Free base）

Target: Endogenous Metabolite

Homocysteinylpropachlor

Cat.No: T32099

Synonym: Homo-cys-ipa

Cysteinylglycine TFA

Cat.No: T15036

Target: Others

3-Cysteinylacetaminophen (trifluoroacetate salt)

Cat.No: T38206

Synonym: APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)

Cysteinyllysine

Cat.No: T31161

Cysteinylcysteine

Cat.No: T31160

Synonym: Cys-cys

Triciribine phosphate

Cat.No: T19699

Synonym: TCN-P,VD 002,VQD-002

Target: Apoptosis, Akt

Cat.No: T36333

Cat.No: T0694

Synonym: 普鲁司特,ONO-1078,普仑司特

Target: Leukotriene Receptor, IL Receptor, Others, TNF, NF-κB, LTR

Cat.No: T68130

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Cat.No: T11388

Synonym: ONO-6950

Target: Others

Cat.No: T27912

Synonym: LY-290324,LY290324

Cat.No: T31080

Synonym: (+)-Cp 85958,UNII-CU98Q2IL7P

Q8 hydrochloride

Cat.No: T28481

Synonym: Q8

Iralukast (CGP 45715A)

Cat.No: T37016

Cat.No: T38129

Synonym: LTF4

(Rac)-HAMI 3379

Cat.No: T15463

Synonym: HAMI 3379

Target: Others

Dihydro Montelukast

Cat.No: T37386

Cat.No: T21864

Urotensin II, mouse

Cat.No: TP1816

Montelukast dicyclohexylamine

Cat.No: T72145

Synonym: MK0476 dicyclohexylamine

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

Leukotriene C4 methyl ester

Cat.No: T37620

Cat.No: T60439

N-methyl Leukotriene C4

Cat.No: T37980

Synonym: N-methyl Leukotriene C4

S-Geranylgeranyl-L-glutathione

Cat.No: T83926

Synonym: GGG

Cat.No: T38128

Synonym: Leukotriene D4 MaxSpec® Standard,LTD4

Cat. No.	Product Name	Target	Signaling Pathways
T1085	L-Glutathione reduced 谷胱甘肽,GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,还原型谷胱甘肽,Tathion	Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite; Glutathione reductase	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	L-Glutathione reduced (Glutathione) 属于天然三肽，存在与细胞中，是一种内源性抗氧化剂，可以清除氧自由基。L-Glutathione reduced 是某些酶的辅助因子，参与蛋白质二硫键重排并减少过氧化物。
T4233	Cysteinylglycine 半胱氨酰甘氨酸,Cys-Gly	Others; Endogenous Metabolite	Metabolism; Others
	Cysteinylglycine (Cys-Gly) 是内源性代谢产物的一种，能够用于疾病诊断。
TN4675	Nortrachelogenin (-)-Wikstromol,(-)-Nortrachelogenin	Apoptosis; Antifungal	Apoptosis; Microbiology/Virology
	Nortrachelogenin ((-)-Wikstromol) 可从 Partrinia scabiosaefolia 提取得到，具有抗真菌活性，可诱导膜破坏和半胱天冬酶依赖性细胞凋亡.
TN2554	1-Monopalmitin Glyceryl palmitate	Apoptosis	Apoptosis
	1-Monopalmitin (Glyceryl palmitate) 是一种从Mougeotia nummuloides 和 Spirulina major 提取出来的小分子化合物，具有潜在的抗肿瘤活性，抑制A549和SPC-A1细胞增殖，诱导G2/M阻滞和半胱天冬酶依赖性细胞凋亡。

天然产物

L-Glutathione reduced

Cat.No: T1085

Synonym: 谷胱甘肽,GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,还原型谷胱甘肽,Tathion

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite, Glutathione reductase

Cysteinylglycine

Cat.No: T4233

Synonym: 半胱氨酰甘氨酸,Cys-Gly

Target: Others, Endogenous Metabolite

Nortrachelogenin

Cat.No: TN4675

Synonym: (-)-Wikstromol,(-)-Nortrachelogenin

Target: Apoptosis, Antifungal

Cat.No: TN2554

Synonym: Glyceryl palmitate

Target: Apoptosis

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