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Search Results for " calcium ions "

22

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16014	Mavatrep JNJ-39439335	TRP/TRPV Channel	Membrane transporter/Ion channel
	Mavatrep (JNJ-39439335) 是一种特异性的 TRPV1 拮抗剂，Ki 为 6.5 nM，可用于炎症性疼痛的研究。
T13911	Tacalcitol monohydrate Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate	Cysteine Protease	Proteases/Proteasome
	Tacalcitol monohydrate(Curatoderm monohydrate) 是一种维生素 D3 类似物，能通过调节钙离子促进骨发育，可用于研究银屑病。
T21469	Cyclopenthiazide Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪	Others	Others
	Cyclopenthiazide (Cyclomethiazide) 是一种噻嗪类利尿剂，用于治疗高血压和心力衰竭。减少钙离子和尿酸的排泄，增加钠和钾离子的排泄。
T13219	TTA-Q6	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	TTA-Q6 是一种选择性 T 型 Ca2+ 通道拮抗剂，具有潜在的抗肿瘤和免疫调节活性，可抑制肿瘤细胞摄取细胞外钙离子，诱导细胞内钙缺乏和内质网（ER）应激，用于治疗神经系统疾病。
T14855	Calcein Fluorexon,钙黄绿素	Others	Others
	Calcein (Fluorexon) 是一种荧光染料和自灭探针，是一种脂囊泡渗漏的指示剂，也是一种 EDTA 钙离子滴定和荧光测定钙离子的络合指示剂。
T3465L	Vesnarinone HCl Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel; Calcium Channel; PDE	Membrane transporter/Ion channel; Metabolism
	Vesnarinone HCl (OPC-8212 HCl) 是一种具有口服活性的 phosphodiesterase 3 (PDE3) 抑制剂。Vesnarinone HCl 可对钙离子和钾离子进行调节，增加钙通量，减少钾通量。Vesnarinone HCl 是一种新的正性肌力化合物，可增强心肌收缩力，可用于心力衰竭的研究。
T1146	Nifedipine BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat	CaMK; Potassium Channel; Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂，可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞，导致主要冠状动脉和全身动脉扩张，降低心肌收缩力。它常用于心肌功能不全的相关研究。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T30691	Calcium diglutamate Calcium di-L-glutamate,Glutamic acid, calcium salt (2:1), L-
	Calcium diglutamate(CDG), calcium acid salt of glutamic acid. As a soluble source of calcium ions, this chemical is used as a first-aid treatment for exposure to hydrofluoric acid.
T21229	Pirenoxine Catalin,PRX
	Pirenoxine is an agent with anti-cataractogenesis activity by interacting with calcium ions or selenite which could lead to the formation of lens cataract.
T82363	Fura Red
	Fura Red为荧光指示剂，其特性为随[Ca2+]浓度增加，荧光强度反比降低。
T19266	Ins(1,4,5)-P3 hexapotassium salt 1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt	Others	Others
	D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.
T82147	Hydroxy naphthol blue disodium
	Hydroxy naphthol blue disodium 作为一种钙离子金属指示剂和碱土金属离子比色试剂(λmax = 650 nm)，在pH值介于12至13的环境中表现出明显的颜色变化；该指示剂在钙离子存在时显淡红色，在EDTA二钠作用下则转为深蓝色。
T71295	SOR-C13
	SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in t...
T35731	Deethylindanomycin
	Deethylindanomycin is a polyether antibiotic that has been found in S. setonii. It is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae (MICs = 4, 4, and 2 μg/ml, respectively). It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when administered at a dose of 200 μg/g in the diet. Deethylindanomycin acts as an ionop...
T62272	TRPC6-IN-3
	TRPC6-IN-3 (compound 17) 是一种口服具有活力的瞬时受体电位 C6 离子通道 (TRPC6) 抑制剂。TRPC6-IN-3 能够调节细胞内钙浓度，也能够调节包括钙离子和钠离子在内的阳离子通量来调节膜电位。TRPC6-IN-3 可以用于研究呼吸系统。
T11042	Dihydrocytochalasin B	Others	Others
	Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth
T76488	Calmodulin Dependent Protein Kinase Substrate
	CalmodulinDependent Protein Kinase Substrate 为Ca2+及钙调蛋白(CaM)依赖的CaMK底物肽，属合成肽底物类。
T22014	8-CPT-2Me-cAMP, sodium salt
	8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for activating small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium specifically activates Epac1 with an EC50 value of 2.2 μM, while showing no activation of PKA with an EC50 value greater than 10 μM [1]. Additionally, 8-CPT-2Me-cAMP sodium stimulates the Epac-mediated release of calcium ...
T83941	Mag-Fura-2 AM
	Mag-Fura-2 AM是一种可渗透细胞的荧光镁离子(Mg2+)指示剂，对Mg2+具有高度选择性，相较于其他二价离子(Zn2+、Cu2+和Ca2+)。其对Mg2+的选择性超过13,000倍（Mg2+Kd为1.9 nM，相对于Ca2+Kd的25 μM）。激发和发射峰值（λ）分别为369 nm和511 nm。Mag-Fura-2 AM可作为间接指示ATP消耗/产生的指标。
TD0055	Fluo-8, AM
	Fluo-8,AM is one of the most commonly used fluorescent probes to detect intracellular calcium concentration.Fluo-8, which penetrates the cell membrane and enters the cell, is cut by the intracellular esterase to form fluO-8, and thus is trapped in the cel

化合物

Cat.No: T16014

Synonym: JNJ-39439335

Target: TRP/TRPV Channel

Tacalcitol monohydrate

Cat.No: T13911

Synonym: Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate

Target: Cysteine Protease

Cyclopenthiazide

Cat.No: T21469

Synonym: Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪

Target: Others

Cat.No: T13219

Target: Calcium Channel

Cat.No: T14855

Synonym: Fluorexon,钙黄绿素

Target: Others

Vesnarinone HCl

Cat.No: T3465L

Synonym: Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)

Target: Potassium Channel, Calcium Channel, PDE

Cat.No: T1146

Synonym: BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Calcium diglutamate

Cat.No: T30691

Synonym: Calcium di-L-glutamate,Glutamic acid, calcium salt (2:1), L-

Cat.No: T21229

Synonym: Catalin,PRX

Cat.No: T82363

Ins(1,4,5)-P3 hexapotassium salt

Cat.No: T19266

Synonym: 1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt

Target: Others

Hydroxy naphthol blue disodium

Cat.No: T82147

Cat.No: T71295

Deethylindanomycin

Cat.No: T35731

Cat.No: T62272

Dihydrocytochalasin B

Cat.No: T11042

Target: Others

Calmodulin Dependent Protein Kinase Substrate

Cat.No: T76488

8-CPT-2Me-cAMP, sodium salt

Cat.No: T22014

Cat.No: T83941

Cat.No: TD0055

Cat. No.	Product Name	Target	Signaling Pathways
T7285	Ionomycin	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ionomycin 是一种钙离子载体和一种结合钙离子(Ca2+)的抗生素。它是由联合链霉菌(Streptomyces conglobatus)产生的。它在研究中用于提高细胞内钙水平(Ca2+)，并作为了解 Ca2+跨生物膜运输的研究工具。Ionomycin 可促进细胞凋亡，诱导蛋白激酶 C (PKC)活化。
T7963	2,4-Dihydroxypyridine	Others	Others
	2,4-Dihydroxypyridine 是一种吡啶衍生物，作为螯合剂与金属离子结合并形成络合物。它被用作测定各种离子浓度的试剂，如钙、镁和磷酸盐；也用于测量酶催化反应的速率；还用于蛋白质、碳水化合物和其他生物分子的检测和定量。
T5075	Phytic acid potassium 植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt	Others; Endogenous Metabolite	Metabolism; Others
	Phytic acid potassium (Inositol polyphosphate dipotassium salt) 是内源性代谢产物的一种。

天然产物

Cat.No: T7285

Target: Calcium Channel

2,4-Dihydroxypyridine

Cat.No: T7963

Target: Others

Phytic acid potassium

Cat.No: T5075

Synonym: 植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt

Target: Others, Endogenous Metabolite

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