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8

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10526	β-NF-JQ1	Others	Others
	β-NF-JQ1是一种PROTAC，可将芳烃受体E3 （AhR E3）连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain（BRD）的蛋白，诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性。
T2320	Indacaterol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol 是一种超长效β-肾上腺素受体激动剂。
T1239	Indacaterol maleate 马来酸茚达特罗,QAB149	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。
T13981	β-Naphthoflavone-CH2-Br β-NF-CH2-Br	Others	Others
	β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
T17363	β-Naphthoflavone-CH2-OH β-NF-CH2-OH	Others	Others
	β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1].
T9010	IMM-H007	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
TP2177	Amyloid Precursor C-Terminal Peptide	Others	Others
	Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am
T35438	(5E)-7-Oxozeaenol
	(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 μM, respectively.2 \|1. Fakhouri, L., El-Elimat, T., Hurst, D.P., et al. Isolation, semisynthesis, covalent docking and transforming growt...

化合物

Cat.No: T10526

Target: Others

Cat.No: T2320

Target: Adrenergic Receptor

Indacaterol maleate

Cat.No: T1239

Synonym: 马来酸茚达特罗,QAB149

Target: Adrenergic Receptor

β-Naphthoflavone-CH2-Br

Cat.No: T13981

Synonym: β-NF-CH2-Br

Target: Others

β-Naphthoflavone-CH2-OH

Cat.No: T17363

Synonym: β-NF-CH2-OH

Target: Others

Cat.No: T9010

Target: Others, AMPK

Amyloid Precursor C-Terminal Peptide

Cat.No: TP2177

Target: Others

(5E)-7-Oxozeaenol

Cat.No: T35438

Cat. No.	Product Name	Target	Signaling Pathways
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T2P2870	Damascenone trans-damascenone,Beta-Damascenone,大马烯酮,大马酮	Others; NF-κB; Endogenous Metabolite	Metabolism; NF-κB; Others
	Damascenone (trans-damascenone) 是一种 E-和 Z-异构体大马士革酮的混合物，源于 Epipremnum pinnatum 的具有抗炎特性的特性化合物。
T0607	Dihydroartemisinin 双氢青蒿素,β-Dihydroartemisinin,Dihydroqinghaosu,Artenimol,DHA	Apoptosis; NF-κB; Parasite; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; NF-κB
	Dihydroartemisinin (Artenimol) 是一种抗疟疾药物。
T2775	Baicalin 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide	NF-κB; HIV Protease; GABA Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Baicalin (Baicalein 7-O-β-D-glucuronide) 是一种从黄芩中分离出来的脯氨酰内肽酶抑制剂，具有抗氧化、抗肿瘤、抗 HIV 的特性。
T3138	Astaxanthin β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素	Reactive Oxygen Species; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB
	Astaxanthin (trans-Astaxanthin) 是可从雨生红球藻等多种海洋生物中提取得到的红色类胡萝卜素，是过氧化物酶体增殖物活化受体γ 的调节剂，具有抗增殖、神经保护作用和抗炎活性。它是一种抗氧化剂，有用于癌症和心血管疾病的研究潜力，作为颜色添加剂用于动物食品中。
TN2165	Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷	ERK; NF-κB; TGF-beta/Smad	MAPK; NF-κB; Stem Cells
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) 一种分离自决明子的、具有清除自由基作用的化合物。
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
T3849	Kinsenoside 金线莲苷,(+)-Kinsenoside	Apoptosis; Nrf2	Apoptosis; Immunology/Inflammation
	Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分，以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力，防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。

天然产物

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: T2P2870

Synonym: trans-damascenone,Beta-Damascenone,大马烯酮,大马酮

Target: Others, NF-κB, Endogenous Metabolite

Dihydroartemisinin

Cat.No: T0607

Synonym: 双氢青蒿素,β-Dihydroartemisinin,Dihydroqinghaosu,Artenimol,DHA

Target: Apoptosis, NF-κB, Parasite, Autophagy

Cat.No: T2775

Synonym: 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide

Target: NF-κB, HIV Protease, GABA Receptor, Autophagy

Cat.No: T3138

Synonym: β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素

Target: Reactive Oxygen Species, PPAR

Rubrofusarin gentiobioside

Cat.No: TN2165

Synonym: Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷

Target: ERK, NF-κB, TGF-beta/Smad

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

Cat.No: T3849

Synonym: 金线莲苷,(+)-Kinsenoside

Target: Apoptosis, Nrf2

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