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155

抑制剂 & 化合物

42

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。
T4017	Relebactam 瑞来巴坦,MK-7655	Antibacterial	Microbiology/Virology
	Relebactam (MK-7655) 是一种有广谱抗β内酰胺酶活性的二氮杂双环辛烷抑制剂。
T19794	Temafloxacin 替马沙星,Omniflox	Antibiotic	Microbiology/Virology
	Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂，对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。
T0396	Pipemidic acid 吡哌酸,Acido pipemidico	Antibacterial; Antibiotic	Microbiology/Virology
	Pipemidic acid (Acido pipemidico) 是一种新型抗菌剂，对革兰氏阴性菌和某些革兰氏阳性细菌具有活性，可研究肠道、泌尿和胆道感染。
T0827	Cefsulodin sodium Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。
T4201	Avibactam sodium 阿维巴坦,AVE-1330A,阿维巴坦钠,NXL-104	Antibacterial; Antibiotic	Microbiology/Virology
	Avibactam sodium (NXL-104) 是一种可逆的 β-内酰胺酶抑制剂，抑制 TEM-1，P99和KPC-2 β-内酰胺酶，IC50分别为8、80和38 nM。
T6179	Moxalactam sodium salt Latamoxef sodium,6059 S,拉氧头孢钠,Moxalactam Disodium,LY-127935,Antibiotic 6059S,Shiomarin,FestamoxinLy	Antibacterial; Antibiotic	Microbiology/Virology
	Moxalactam sodium salt (LY-127935) 是一种抗生素, 对大肠杆菌和绿脓杆菌有作用。
T1293	Gatifloxacin BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中，它有抗细菌性结膜炎作用。
T20711	Hemipyocyanine 1-羟基吩嗪,528-71-2	Amylase	Metabolism
	Hemipyocyanine (528-71-2) 是一种 α-淀粉酶抑制剂。
T8533	ML318	Others; Antibiotic	Microbiology/Virology; Others
	ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂，可以结合在酰基结合位点上，IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。
T38173	Propargylcholine Propargylcholine (bromide)	Antibacterial	Microbiology/Virology
	Propargylcholine (Propargylcholine (bromide)) 是一种炔烃修饰的胆碱类似物，在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。
T67912	PA3552-IN-1
	PA3552-IN-1 是一种抗生素佐剂，可以降低 PA3552 的表达，恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。
T65309	S-Methyl methanesulfonothioate	Antibacterial	Microbiology/Virology
	S-Methyl methanesulfonothioate 是一种生物原料，具有细胞毒性和潜在的抗菌活性，可用于研究铜绿假单胞菌感染。
T7495	Hexa-D-arginine	Others	Others
	Hexa-D-arginine 是稳定的furin 抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
T9119	SU0268	Others	Others
	SU0268 是有效的 8-8-氧鸟嘌呤 DNA 糖基化酶1的选择性抑制剂，具有调控铜绿假单胞杆菌感染免疫反应的能力。
T77686	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone	Antifungal	Microbiology/Virology
	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 具有广谱的抗真菌活性，对白色念珠菌、黑曲霉、铜绿假单胞菌、金黄色葡萄球菌等具有抑制作用。
TP1663L	CysHHC10 acetate CysHHC10 acetate(1408311-03-4 free base)	Antibacterial	Microbiology/Virology
	CysHHC10 acetate 对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性，对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌的 MIC 分别为 10.1、20.2、2.5 和 1.3 mM。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T78226	Methyl 2-amino-5-bromobenzoate Methyl 5-Bromoanthranilate	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) 是一种丙型肝炎病毒 NS5b RNA 聚合酶抑制剂，具有抗菌活性，可抑制铜绿假单胞菌感染，参与许多毒力因子的产生和生物膜的形成。
TP1050L	Murepavadin acetate(944252-63-5 free base)	Antibacterial; Antibiotic	Microbiology/Virology
	Murepavadin acetate(944252-63-5 free base) 是一种有效且特异性的抗生素，用于治疗由铜绿假单胞菌引起的细菌感染。 Murepavadin acetate 靶向脂多糖转运蛋白 D。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T4998L	Cefpodoxime (free acid)	Others	Others
	Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外，它对大多数革兰氏阳性和革兰氏阴性微生物均有效。
T23858	WCK-5153 WCK 5153,WCK5153	Antibacterial	Microbiology/Virology
	WCK-5153 是 β-Lactamase 的增强剂和 PBP2 的抑制剂，对铜绿假单胞菌具有抗菌活性。 WCK-5153 可用于治疗由高度耐药的革兰氏阴性病原体引起的严重感染的研究。
T7858	Ceftezole sodium Celoslin,Falomesin,头孢替唑钠,Alomen	Anti-infection; Antibacterial; Antibiotic; Glucosidase	Metabolism; Microbiology/Virology
	Ceftezole sodium (Falomesin) 是一种广谱 cephem 抗生素，具有抑制多种革兰氏阳性菌和革兰氏阴性菌活性。它是一种α-葡萄糖苷酶抑制剂，具有体内抗糖尿病活性。
T124492	Imipenem N-Formimidoyl thienamycin,MK0787	Antifungal	Microbiology/Virology
	Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。
T60247	Diethylamine NONOate diethylammonium salt NOC-18 Diethylamine,DEA NONOate diethylamine	Antibiotic	Microbiology/Virology
	Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) 是一种一氧化氮供体，具有抗菌活性，是铜绿假单胞菌生物膜预形成生物膜的分散剂，可抑制大肠杆菌的生长。Diethylamine NONOate diethylammonium salt 可用于离体大鼠心脏的保存。
T41275	PF-04753299	Others	Others
	PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用，对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。
T13789	N-dodecanoyl-L-Homoserine lactone C12-HSL,十二烷酰-L-高丝氨酸内酯	Others	Others
	N-dodecanoyl-L-Homoserine lactone (C12-HSL) 是群体感应 (QS) 信号分子的一种。它适配体可用于阻止群体感应，并能够阻碍铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成。
T35449	α-(difluoromethyl)-DL-Arginine DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时，它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时，能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长，并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。
T13395L	Zidebactam 齐德巴坦,WCK-5107	Antibacterial	Microbiology/Virology
	Zidebactam (WCK-5107) 是一种β-内酰胺酶抑制剂。它也是一种青霉素结合蛋白 2 抑制剂，IC50值为 0.26 μg/ml。
T14492	BAL-30072	Others	Others
	BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli
T14043	4-(tert-Butyl)-benzhydroxamic Acid	Others	Others
	4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].
T33857	PA Autoinducer 3O-C12 autoinducer,PA-Autoinducer
	PA Autoinducer is a Pseudomonas aeruginosa autoinducer.
T39983	SPR206 acetate
	SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301.
T25280	Cyanopeptolin 954 Cyanopeptolin-954,Cyanopeptolin954
	Cyanopeptolin 954 is a chlorine-containing Microcystis aeruginosa NIVA Cya 43 chymotrypsin Inhibitor.
T62773	OX11
	OX11 是一种 S. pneumoniae、P. aeruginosa 和 E. coli 细菌的选择性抑制剂。
T13788	N-Butanoyl-DL-homoserine lactone (Rac)-C4-HSL	Others	Others
	N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
T25810	Micropeptin 478A Micropeptin 478 A,Micropeptin 478-A
	Micropeptin 478A is a plasmin inhibitor from the Cyanobacterium Microcystis aeruginosa.
T25811	Micropeptin 478B
	Micropeptin 478B is a plasmin inhibitor from the Cyanobacterium Microcystis aeruginosa.
T39296	DS86760016
	DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
T61368	FPI-1602
	FPI-1602 is a β-lactamase inhibitor with strong antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, and Enterobacter species [1].
T15142	Vebufloxacin OPC7241,Flumenique,DM8966	Antibacterial	Microbiology/Virology
	Vebufloxacin (OPC-7251) shows potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. It has potent activity characteristically against Propionibacterium acnes.
T76903	Alvircept sudotox
	Alvircept sudotox 是一种重组CD4，来源于Pneumonas aeruginosaexotoxin A。Alvircept sudotox 可用于HIV 感染的研究。
T25136	Aztreonam lysine Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate
	Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF).
T37912	Furanone C-30
	Synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing in vivo and promotes bacterial clearance in a mouse pulmonary infection model. Hentzer et al (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22 3803 PMID:12881415
T78537	Cefetamet pivoxyl Ro 15-8075 free base	Antibiotic	Microbiology/Virology
	Cefetamet pivoxyl为头孢类抗生素，能抑制355种肠道病原体Keime、革兰氏阴性菌（ausgenommenPseudomonas aeruginosa）及嗜肺军团菌。
T77029	Gremubamab
	Gremubamab (MEDI3902) 是一种人源化 IgG1kappa 抗PcrV/Psl 单克隆抗体。Gremubamab 结合 PA PcrV 蛋白和 Psl 胞外多糖 Gremubamab 具有研究铜绿假单胞菌感染的潜力。
T10944	D13-9001	Others	Others
	The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
T73531	SABA1
	SABA1 具有抗菌活性，比如铜绿假单胞菌和大肠杆菌，其对大肠杆菌的IC50值为 4.0 µM。
T80285	KAMP-19
	KAMP-19，一款角蛋白衍生的抗菌肽，展示出对铜绿假单胞菌 (P. aeruginosa) 的有效抗菌作用。

化合物

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Cat.No: T4017

Synonym: 瑞来巴坦,MK-7655

Target: Antibacterial

Cat.No: T19794

Synonym: 替马沙星,Omniflox

Target: Antibiotic

Cat.No: T0396

Synonym: 吡哌酸,Acido pipemidico

Target: Antibacterial, Antibiotic

Cefsulodin sodium

Cat.No: T0827

Synonym: Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠

Target: Antibacterial, Antibiotic

Avibactam sodium

Cat.No: T4201

Synonym: 阿维巴坦,AVE-1330A,阿维巴坦钠,NXL-104

Target: Antibacterial, Antibiotic

Moxalactam sodium salt

Cat.No: T6179

Synonym: Latamoxef sodium,6059 S,拉氧头孢钠,Moxalactam Disodium,LY-127935,Antibiotic 6059S,Shiomarin,FestamoxinLy

Target: Antibacterial, Antibiotic

Cat.No: T1293

Synonym: BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T20711

Synonym: 1-羟基吩嗪,528-71-2

Target: Amylase

Cat.No: T8533

Target: Others, Antibiotic

Propargylcholine

Cat.No: T38173

Synonym: Propargylcholine (bromide)

Target: Antibacterial

Cat.No: T67912

S-Methyl methanesulfonothioate

Cat.No: T65309

Target: Antibacterial

Hexa-D-arginine

Cat.No: T7495

Target: Others

Cat.No: T9119

Target: Others

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Cat.No: T77686

Target: Antifungal

CysHHC10 acetate

Cat.No: TP1663L

Synonym: CysHHC10 acetate(1408311-03-4 free base)

Target: Antibacterial

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

Methyl 2-amino-5-bromobenzoate

Cat.No: T78226

Synonym: Methyl 5-Bromoanthranilate

Target: HCV Protease, Antifungal

Murepavadin acetate(944252-63-5 free base)

Cat.No: TP1050L

Target: Antibacterial, Antibiotic

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Cefpodoxime (free acid)

Cat.No: T4998L

Target: Others

Cat.No: T23858

Synonym: WCK 5153,WCK5153

Target: Antibacterial

Ceftezole sodium

Cat.No: T7858

Synonym: Celoslin,Falomesin,头孢替唑钠,Alomen

Target: Anti-infection, Antibacterial, Antibiotic, Glucosidase

Cat.No: T124492

Synonym: N-Formimidoyl thienamycin,MK0787

Target: Antifungal

Diethylamine NONOate diethylammonium salt

Cat.No: T60247

Synonym: NOC-18 Diethylamine,DEA NONOate diethylamine

Target: Antibiotic

Cat.No: T41275

Target: Others

N-dodecanoyl-L-Homoserine lactone

Cat.No: T13789

Synonym: C12-HSL,十二烷酰-L-高丝氨酸内酯

Target: Others

α-(difluoromethyl)-DL-Arginine

Cat.No: T35449

Synonym: DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine

Target: Others

Cat.No: T13395L

Synonym: 齐德巴坦,WCK-5107

Target: Antibacterial

Cat.No: T14492

Target: Others

4-(tert-Butyl)-benzhydroxamic Acid

Cat.No: T14043

Target: Others

Cat.No: T33857

Synonym: 3O-C12 autoinducer,PA-Autoinducer

Cat.No: T39983

Cyanopeptolin 954

Cat.No: T25280

Synonym: Cyanopeptolin-954,Cyanopeptolin954

Cat.No: T62773

N-Butanoyl-DL-homoserine lactone

Cat.No: T13788

Synonym: (Rac)-C4-HSL

Target: Others

Micropeptin 478A

Cat.No: T25810

Synonym: Micropeptin 478 A,Micropeptin 478-A

Micropeptin 478B

Cat.No: T25811

Cat.No: T39296

Cat.No: T61368

Cat.No: T15142

Synonym: OPC7241,Flumenique,DM8966

Target: Antibacterial

Alvircept sudotox

Cat.No: T76903

Aztreonam lysine

Cat.No: T25136

Synonym: Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate

Cat.No: T37912

Cefetamet pivoxyl

Cat.No: T78537

Synonym: Ro 15-8075 free base

Target: Antibiotic

Cat.No: T77029

Cat.No: T10944

Target: Others

Cat.No: T73531

Cat.No: T80285

Cat. No.	Product Name	Target	Signaling Pathways
T5779	MOSLOFLAVONE	IL Receptor; Virus Protease; TNF; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成，有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。
TN1544	D-Menthol Menthol,(+)-MENTHOL,D-薄荷醇	Calcium Channel; 5-HT Receptor; AChR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	D-Menthol ((+)-MENTHOL) 是药物和商业产品中的一种常见化合物，也是一种流行的香烟添加剂，它可以减弱细胞体和神经突中 α±7 介导的 Ca 2+ 瞬变，表明薄荷醇以非竞争性方式抑制 α±7-nACh 受体.
TN1877	Lonicerin 忍冬苦苷,金银花	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物，对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
T2904	Sclareolide 香紫苏内酯,Norambreinolide	Others; Antibacterial	Microbiology/Virology; Others
	Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物，具有抗菌和细胞毒性作用。
T1505	Imipenem monohydrate N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物	Antibacterial; Antibiotic	Microbiology/Virology
	Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素，是一种用于静脉注射的β 内酰胺类抗生素，作用于细菌细胞壁，能广泛有效抑制多种革兰氏阳性和阴性菌。
TQ0251	(Z)-2-decenoic acid (Z)-dec-2-enoic acid,(Z)-2-癸烯酸,cis-2-Decenoic acid,cis-dec-2-enoic acid	Others	Others
	(Z)-2-decenoic acid (cis-dec-2-enoic acid) 是一种由铜绿假单胞菌产生的不饱和脂肪酸。它能够诱导一系列革兰氏阴性细菌(包括铜绿假单胞菌)和革兰氏阳性细菌形成的生物膜发生分散反应。它能够抑制生物膜发育。
T8384	Gatifloxacin hydrochloride AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素，有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中，可研究细菌性结膜炎。
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
T8185	(+)-Viroallosecurinine 别一叶萩碱,Viroallosecurinine	Antibacterial	Microbiology/Virology
	(+)-Viroallosecurinine (Viroallosecurinine) 是一种具有抗菌活性的天然生物碱，抑制Ps. Aeruginosa 和Staph. aureus，MIC 为 0.48 μg/mL。
T4816	6-Hydroxynicotinic acid 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) 用于核磁共振波谱或气相色谱-质谱法诊断尿路感染中的铜绿假单胞菌。在引起尿液感染的常见细菌中，只有铜绿假单胞菌从烟酸中产生6-羟基烟酸。
T38373	2-heptyl-3-hydroxy-4(1H)-Quinolone 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal	Others	Others
	2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。它增加了铜绿假单胞菌中lasB 基因的表达，增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌，以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时，它还会降低铜绿假单胞菌生长介质中的铁含量，并在硫酸铁溶液中充当一种铁螯合剂。
T5707	3-O-Methylgalangin 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚	Antibacterial	Microbiology/Virology
	3-O-Methylgalangin (GALANGIN-3-METHYLETHER) 是一种来源于高良姜根茎的天然黄酮，具有抗菌活性，抑制胰腺脂肪酶。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T37341	N-Acetyltyramine	Antibacterial	Microbiology/Virology
	N-Acetyltyramine 是一种群体感应抑制剂，由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。
T8066	Sulbenicillin disodium 磺苄西林钠,Sulbenicillin Sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbenicillin disodium (Sulbenicillin Sodium) 是 Sulbenicillin 的二钠盐。Sulbenicillin 是一种青霉素抗生素，对Pseudomonas aeruginosa 的许多粘液型和非粘液型菌株具有抗菌活性。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
TN1203	2,3,8-Tri-O-methylellagic acid 2,3,8-三邻甲基鞣花酸	Antifection	Microbiology/Virology
	2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
TN4851	Pterodondiol	Antifection	Microbiology/Virology
	Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
TN5229	Vibralactone B	Antifection	Microbiology/Virology
	Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively.
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
TN4852	Pterodontic acid	Antifection	Microbiology/Virology
	Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.
T11219	Equisetin	Others	Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...
T72250	4aα,7α,7aα-Nepetalactone
	4aα,7α,7aα-Nepetalactone 具有抗菌 (antibacterial) 活性，抑制Escherichia coli，Pseudomonas aeruginosa，Staphylococcus aureus，Salmonella typhi 和Enterococcus faecalis。
TN2032	Pachypodol 霍香黃酮醇	Antifection	Microbiology/Virology
	Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
TN5930	Ocotillone
	Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only
T83902	Polymyxin E1 sulfate Colistin A sulfate
	Polymyxin E1，是一种肽类抗生素，也是原初从B. polymyxa分离得到的阳离子脂肽抗生素colistin的主要成分。对P. aeruginosa和E. coli具有活性（MICs分别为2和0.8 µg/ml）。
T83245	7-Desmethylmicrocystin-LR
	7-Desmethylmicrocystin-LR为有毒七肽类化合物，可自无菌铜绿微囊藻菌株（K-139）中提取。
T83903	Polymyxin B2 sulfate
	Polymyxin B2是一种抗生素，并且是从B. polymyxa分离出的阳离子脂肽抗生素polymyxin B的主要成分。该化合物对P. aeruginosa、A. baumannii、K. pneumoniae和E. cloacae菌株具有活性（MICs分别为1-2、0.5-1、0.25-0.5和0.25-1 µg/ml）。在体内实验中，以4 mg/kg剂量的Polymyxin B2能显著降低P. aeruginosa血液感染小鼠模型中的血液集落形成单位(CFUs)数量。
TN2124	Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside Quercetin 3-O-(6''-galloyl)-beta-D-glucopyranoside,槲皮素3-O-(6''-没食子酰基)-Β-D-葡萄糖苷	Others	Others
	Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Quercetin 3-O-(6''-galloyl)-beta-D-glucopyranoside) 是一种天然产物，对铜绿微囊藻的生长具有很强的抑制活性。
T83918	Clazamycin A hydrochloride NSC 332188
	Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性，包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa（MICs分别为100、6.25、100、50和25 µg/ml）。
T75635	Microcystin-LY
	Microcystin-LY 是一种铜绿微囊藻蓝藻的环状七肽毒素，可作为 Nrf2通路的激活剂引起氧化应激反应,在3μM 时诱导效果非常明显。
T75439	Angustifoline hydrochloride
	Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱，展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用，证明了其抗菌活性。
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T36403	Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate
	Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T38086	Neohydroxyaspergillic Acid
	Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
TN1991	Norchelerythrine	Antifection	Microbiology/Virology
	Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm.

天然产物

Cat.No: T5779

Target: IL Receptor, Virus Protease, TNF, Antibacterial

Cat.No: TN1544

Synonym: Menthol,(+)-MENTHOL,D-薄荷醇

Target: Calcium Channel, 5-HT Receptor, AChR

Cat.No: TN1877

Synonym: 忍冬苦苷,金银花

Target: Apoptosis, Antibacterial

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: T2904

Synonym: 香紫苏内酯,Norambreinolide

Target: Others, Antibacterial

Imipenem monohydrate

Cat.No: T1505

Synonym: N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物

Target: Antibacterial, Antibiotic

(Z)-2-decenoic acid

Cat.No: TQ0251

Synonym: (Z)-dec-2-enoic acid,(Z)-2-癸烯酸,cis-2-Decenoic acid,cis-dec-2-enoic acid

Target: Others

Gatifloxacin hydrochloride

Cat.No: T8384

Synonym: AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T8433

Target: Mitochondrial Metabolism

(+)-Viroallosecurinine

Cat.No: T8185

Synonym: 别一叶萩碱,Viroallosecurinine

Target: Antibacterial

6-Hydroxynicotinic acid

Cat.No: T4816

Synonym: 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid

Target: Others, Endogenous Metabolite

2-heptyl-3-hydroxy-4(1H)-Quinolone

Cat.No: T38373

Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Target: Others

3-O-Methylgalangin

Cat.No: T5707

Synonym: 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚

Target: Antibacterial

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

N-Acetyltyramine

Cat.No: T37341

Target: Antibacterial

Sulbenicillin disodium

Cat.No: T8066

Synonym: 磺苄西林钠,Sulbenicillin Sodium

Target: Antibacterial, Antibiotic

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

2,3,8-Tri-O-methylellagic acid

Cat.No: TN1203

Synonym: 2,3,8-三邻甲基鞣花酸

Target: Antifection

Cat.No: TN4851

Target: Antifection

Cat.No: TN5229

Target: Antifection

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

Pterodontic acid

Cat.No: TN4852

Target: Antifection

Cat.No: T11219

Target: Others

4aα,7α,7aα-Nepetalactone

Cat.No: T72250

Cat.No: TN2032

Synonym: 霍香黃酮醇

Target: Antifection

Cat.No: TN3978

Target: Antifection

Cat.No: TN5930

Polymyxin E1 sulfate

Cat.No: T83902

Synonym: Colistin A sulfate

7-Desmethylmicrocystin-LR

Cat.No: T83245

Polymyxin B2 sulfate

Cat.No: T83903

Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside

Cat.No: TN2124

Synonym: Quercetin 3-O-(6''-galloyl)-beta-D-glucopyranoside,槲皮素3-O-(6''-没食子酰基)-Β-D-葡萄糖苷

Target: Others

Clazamycin A hydrochloride

Cat.No: T83918

Synonym: NSC 332188

Cat.No: T75635

Angustifoline hydrochloride

Cat.No: T75439

Cat.No: T38016

Antibacterial synergist 2

Cat.No: T72235

Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

Cat.No: T36403

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

Cat.No: TN5014

Target: Antifection, HSV

Neohydroxyaspergillic Acid

Cat.No: T38086

Cat.No: T36329

Norchelerythrine

Cat.No: TN1991

Target: Antifection

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