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Search Results for " a-1 protease inhibitor "

130

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4578	Tipranavir PNU-140690	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tipranavir 是一种蛋白酶抑制剂，对1种以上蛋白酶抑制剂耐药的HIV-1具有抑制作用。Tipranavir 可有效抑制 HIV-1 蛋白酶酶活性和二聚化，对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性（IC50 为 66-410 nM）。Tipranavir 对SARS-CoV-2 3CLpro 活性有抑制作用。
T80672	1,4-Dihydroxynaphthalene Naphthalene-1,4-diol	HSV	Microbiology/Virology
	1,4-Dihydroxynaphthalene 一种有效的 HSV-1蛋白酶抑制剂，对HCMV蛋白酶有抑制作用，可用于研究疱疹病毒。
T13268	USP7-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP7-IN-1 是泛素蛋白特异性蛋白酶的选择性、可逆性抑制剂，IC50为 77 μM，可用于癌症研究。
T4338	USP7/USP47 inhibitor USP7/47 inhibitor-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP7/USP47 inhibitor (USP7/47 inhibitor-1) 是一种选择性泛素特异性蛋白酶 7/47 抑制剂，EC50值分别为 0.42 μM 和 1.0 μM。
T4317	PF 429242	NPC1L1; Lipid	Membrane transporter/Ion channel; Metabolism
	PF 429242 是甾醇调节元件结合蛋白 (SREBP) 位点 1 蛋白酶的竞争性抑制剂 (IC50 = 0.175 μM)。它对位点 1 蛋白酶对一组丝氨酸蛋白酶具有选择性。 PF-429242 抑制 CHO 细胞中胆固醇的合成速率 (IC50 = 0.53 μM)。
T1623	Lopinavir ABT-378,洛匹那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用，从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。
T9216	MLT-943 MLT943	MALT	Immunology/Inflammation
	ML-943 是选择性的、口服活性的MALT1 protease 抑制剂。它可抑制 PBMC 或全血中 IL-2 的分泌，PBMC 中抑制的IC50值为 0.07~0.09 μM，全血中抑制的IC50值为 0.6~0.8 μM)。它具有抗炎作用，可用于研究 FcgR 介导的炎症。
T22168	Vialinin A Terrestrin A	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Vialinin A (Terrestrin A) (Terrestrin A) 是一种具有抗氧化性质的对三苯化合物。Vialinin A (Terrestrin A) 是 TNF-α，USP4, USP5 和 SENP1 特异性蛋白酶 1 的有效抑制剂。Vialinin A (Terrestrin A) 可用于自身免疫疾病和癌症研究。
T9458	PF-00835231	SARS-CoV	Microbiology/Virology
	PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。
T12926	SJB3-019A	Others; DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
	SJB3-019A 是一种有效的、有效的和新型的泛素特异性蛋白酶1（USP1）抑制剂，在 K562细胞中促进 ID1降解和细胞毒性的作用是 SJB2-043的5倍，IC50为0.0781 μM。SJB3-019A 抑制细胞增殖，使细胞凋亡。
T24362	L 756423 L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	L 756423 (L756423) 是一种新型有效且具有选择性和竞争性的HIV蛋白酶抑制剂，对 HIV-1 PR 的 Ki 值为0.049 nM。L 756423 能阻止HIV(IIIb)感染的 MT25 淋巴细胞在0.50-0.1nM处的扩散，可用于研究获得性免疫缺陷综合征(AIDS)。
T3226	Paritaprevir free base ABT-450,Veruprevir,帕利瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir free base (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂，可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物，由非结构蛋白 3 和 4A (NS3/NS4A) 组成，对 HCV 基因型 1 具有潜在活性。给药后，paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点，并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成，从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶，对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要，并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒，感染与肝细胞癌 (HCC) 的发展有关。
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.53 μM). MProinhibitor 11a also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM. 1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-...
T9574	PF-07304814 Lufotrelvir,卢夫特韦
	Lufotrelvir (PF-07304814) 是 PF-00835231 的磷酸盐前药，是一种有效的3CLpro 蛋白酶 (Mpro) 抑制剂，具有抗SARS-CoV-2 病毒活性。Lufotrelvir 结合并抑制 SARS-CoV-2 3CLpro 活性，Ki 为 174nM。Lufotrelvir 是一种很有前途的单一抗病毒试剂，也可用于与针对冠状病毒生命周期其他关键阶段的其他抗病毒试剂的联合研究。
T36682	USP30 inhibitor 18	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP30 inhibitor 18 是有效的USP30选择性抑制剂，IC50为 0.02 μM。它增加蛋白质泛素化并加速线粒体自噬。
T26446	A 77003 A-77003,Abbott 77003,A77003
	A 77003 is a HIV-1 protease inhibitor. A77003 impairs HIV-1 protease-mediated Gag processing.
T26445	A 76889 A76889,A-76889
	A 76889 is an inhibitor of HIV-1 protease.
T24008	DMP 323 JCR424,DMP-323,JCR-424,JCR 424,DMP323
	DMP 323 is a potent inhibitor of HIV-1 protease.
T70518	CGP-53437
	CGP-53437 is a novel HIV-1 protease inhibitor, also potently inhibiting major aspartyl peptidase 1 (May1), a secreted Cryptococcus neoformans protease.
T15683	L-689502	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
T24266	KNI-1657
	KNI-1657 is a potent and selective HIV-1 protease inhibitor (Anti-HIV-1 pNL4-3, EC50: 3 nM). KNI-1657 is a highly potent HIV-1 Protease Inhibitor against Lopinavir.
T36306	FT206
	FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].
T26451	A 80987 A80987,A-80987
	A 80987 is an inhibitor of HIV-1 protease.
T24737	Rpi 856 A Rpi856 A,Rpi 856 B,Rpi-856 A,Rpi-856 B,Rpi856 B
	Rpi 856 A is a retrovirus protease inhibitor. It is effective against HIV-1 and HTLV-1 proteases.
T30839	Cgp 53820 Cgp53820,Cgp-53820
	CGP 53820 is a pseudosymmetric inhibitor of HIV-1 Protease.
T26440	A 74704 A-74704,A74704
	A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog.
T13417	ZYZ-488	Others	Others
	ZYZ-488 is a competitive inhibitor of apoptotic protease activating factor-1 (Apaf-1).
T26128	Rpi 856 C Rpi-856 C,Rpi856 C,Rpi-856 D,Rpi856 D,Rpi 856 D
	Rpi 856 C is a retrovirus protease inhibitor from Streptomyces that is effective against HIV-1 and HTLV-1 proteases.
T30841	Cgp 57813 Cgp-57813,Cgp57813
	CGP 57813 is a lipophilic compound, which can be used as an inhibitor of HIV-1 protease.
T40068	SENP1-IN-1 SENP1-IN-1
	SENP1-IN-1 is a distinct inhibitor of the deSUMOylation protease 1 (SENP1), designed to enhance tumor radiosensitivity.
T10082	DPP-IV-IN-1	Others	Others
	DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).
T63949	HIV-1 protease-IN-2
	HIV-1 protease-IN-2 是 HIV-1 protease 的有效抑制剂 (IC50: 2.53 nM)。HIV-1 protease-IN-2 对 DRV (达芦那韦)敏感或耐药性 HIV-1 突变体均表现出抗病毒效果。
T70717	KNI 174
	KNI 174 is a new type of anti‐AIDS drug used as an HIV‐1 protease inhibitor
T28306	PD 099560 PD099560,PD-099560
	PD 099560 is a non-peptide inhibitor of HIV-1 protease, a significant target enzyme in AIDS research.
T40067	SENP1-IN-4 SENP1-IN-4
	SENP1-IN-4, a distinct inhibitor of the deSUMOylation protease 1 (SENP1), is designed to enhance tumor radiosensitivity.
T40066	SENP1-IN-3 SENP1-IN-3
	SENP1-IN-3 is a distinct inhibitor of the deSUMOylation protease 1 (SENP1), designed to enhance tumor radiosensitivity.
T40069	SENP1-IN-2 SENP1-IN-2
	SENP1-IN-2, a distinct inhibitor of the deSUMOylation protease 1 (SENP1), is designed to enhance tumor radiosensitivity.
T14295	Antipain	Others	Others
	Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations[1][2].
T30585	Brecanavir GW-640385,GW-640385X,UNII-E367I8C7FI,CHEMBL206031,GW-0385
	Brecanavir is a tyrosyl-based arylsulfonamide, high affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type 1.
T15163	DPC-681 DPH-153893	Others	Others
	DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).
T74939	HIV protease-IN-1
	HIVprotease-IN-1 (compound 1·succinate) 是一种有效的HIV 蛋白酶 (HIV protease) 非肽抑制剂，可用于艾滋病的研究。
T63453	HIV-1 protease-IN-1
	HIV-1 protease-IN-1 是 HIV-1 蛋白酶的有效抑制剂 (IC50: 90 pM)。HIV-1 protease-IN-1 对 B-HIV 具有抗病毒活性 (EC50: 89 nM)。HIV-1 protease-IN-1 能够作用于 C-HIV 毒株 ZM246 (EC50: 13.59 nM) 以及 C-HIV 株 Indie (EC50: 8.23 nM)。
T14187	ALLM Calpain inhibitor II	Others	Others
	ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
T35043	Vedroprevir GS9451,GS 9451,GS-9451
	Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in the development of the treatment of genotype 1 (GT1) HCV infection.
T63733	HIV-1 protease-IN-6
	HIV-1 protease-IN-6 (compound 17d) 是 HIV-1 蛋白酶 (HIV-1 protease) 的有效抑制剂 (IC50: 21 pM, Ki: 4.7 pM)。HIV-1 protease-IN-6 对 DRV (darunavir) 耐药病毒突变体具有显著的抗病毒效果 (antiviral activity)，抑制强度甚至超过对野生型病毒。
T8675	Vaniprevir	Others	Others
	Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure in multiple species.
T76603	HIV-IN petide
	HIV-IN petide 是HIV-1蛋白酶 (Ki=50 nM) 的竞争性抑制剂。
T38931	Calpain Inhibitor-1
	Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM.
T75871	FSLLRY-NH2 TFA
	FSLLRY-NH2 TFA 是蛋白酶激活受体2(PAR2)抑制剂。
T79295	HIV-1 protease-IN-9	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1protease-IN-9 (compound 5b)为HIV-1蛋白酶抑制剂，具有0.028 nM的Ki值和66.8 nM的IC50，表现出显著的抗病毒活性。

化合物

Cat.No: T4578

Synonym: PNU-140690

Target: SARS-CoV, HIV Protease

1,4-Dihydroxynaphthalene

Cat.No: T80672

Synonym: Naphthalene-1,4-diol

Target: HSV

Cat.No: T13268

Target: DUB

USP7/USP47 inhibitor

Cat.No: T4338

Synonym: USP7/47 inhibitor-1

Target: DUB

Cat.No: T4317

Target: NPC1L1, Lipid

Cat.No: T1623

Synonym: ABT-378,洛匹那韦

Target: SARS-CoV, HIV Protease

Cat.No: T9216

Synonym: MLT943

Target: MALT

Cat.No: T22168

Synonym: Terrestrin A

Target: DUB

Cat.No: T9458

Target: SARS-CoV

Cat.No: T12926

Target: Others, DUB

Cat.No: T24362

Synonym: L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a

Target: HIV Protease

Paritaprevir free base

Cat.No: T3226

Synonym: ABT-450,Veruprevir,帕利瑞韦

Target: HCV Protease

MPro Inhibitor 11a

Cat.No: T37173

Cat.No: T9574

Synonym: Lufotrelvir,卢夫特韦

USP30 inhibitor 18

Cat.No: T36682

Target: DUB

Cat.No: T26446

Synonym: A-77003,Abbott 77003,A77003

Cat.No: T26445

Synonym: A76889,A-76889

Cat.No: T24008

Synonym: JCR424,DMP-323,JCR-424,JCR 424,DMP323

Cat.No: T70518

Cat.No: T15683

Target: HIV Protease

Cat.No: T24266

Cat.No: T36306

Cat.No: T26451

Synonym: A80987,A-80987

Cat.No: T24737

Synonym: Rpi856 A,Rpi 856 B,Rpi-856 A,Rpi-856 B,Rpi856 B

Cat.No: T30839

Synonym: Cgp53820,Cgp-53820

Cat.No: T26440

Synonym: A-74704,A74704

Cat.No: T13417

Target: Others

Cat.No: T26128

Synonym: Rpi-856 C,Rpi856 C,Rpi-856 D,Rpi856 D,Rpi 856 D

Cat.No: T30841

Synonym: Cgp-57813,Cgp57813

Cat.No: T40068

Synonym: SENP1-IN-1

Cat.No: T10082

Target: Others

HIV-1 protease-IN-2

Cat.No: T63949

Cat.No: T70717

Cat.No: T28306

Synonym: PD099560,PD-099560

Cat.No: T40067

Synonym: SENP1-IN-4

Cat.No: T40066

Synonym: SENP1-IN-3

Cat.No: T40069

Synonym: SENP1-IN-2

Cat.No: T14295

Target: Others

Cat.No: T30585

Synonym: GW-640385,GW-640385X,UNII-E367I8C7FI,CHEMBL206031,GW-0385

Cat.No: T15163

Synonym: DPH-153893

Target: Others

HIV protease-IN-1

Cat.No: T74939

HIV-1 protease-IN-1

Cat.No: T63453

Cat.No: T14187

Synonym: Calpain inhibitor II

Target: Others

Cat.No: T35043

Synonym: GS9451,GS 9451,GS-9451

HIV-1 protease-IN-6

Cat.No: T63733

Cat.No: T8675

Target: Others

Cat.No: T76603

Calpain Inhibitor-1

Cat.No: T38931

Cat.No: T75871

HIV-1 protease-IN-9

Cat.No: T79295

Target: HIV Protease

Cat. No.	Product Name	Target	Signaling Pathways
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
TN1059	Ganoderic acid B	IL Receptor; HIV Protease; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T5S0983	Absinthin Absinthiin,Absynthin,洋艾素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Absinthin (Absynthin) 是结构独特的三萜类化合物，是艾草苦味高的原因。它是苦味受体hTAS2R46的激动剂，它利用 hTAS2R46 介导的受体特异性机制抑制组胺诱导的细胞内 Ca2+升高。
TN4347	Jacoumaric acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
T10928	Cytochalasin A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy
T73900	(±)-Alliin
	(±)-Alliin 是大蒜的主要活性成分。(±)-Alliin 被认为是SARS-CoV-2 (Mpro)的虚拟抑制剂。
T75648	Rivulariapeptolides 1155
	Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂，对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。
T79947	10-Hydroxyaloin A	SARS-CoV	Microbiology/Virology
	10-Hydroxyaloin A有效抑制SARS-CoV-2，与SARS-CoV-2 Mpro活性位点显著结合。
T75649	Rivulariapeptolides 1185
	Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂，其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。
T75651	Rivulariapeptolides 988
	Rivulariapeptolides 988作为一种高效选择性丝氨酸蛋白酶抑制剂，对胰凝蛋白酶、弹性蛋白酶和蛋白酶K的IC50分别为95.46 nM、15.29 nM和85.50 nM。
T75652	Molassamide B
	Molassamide B，丝氨酸蛋白酶抑制剂，对胰凝乳蛋白酶、弹性蛋白酶及蛋白酶 K 具有显著抑制活性，其IC50值分别为24.65、11.69和5.42 nM。
T75650	Rivulariapeptolides 1121
	Rivulariapeptolides 1121，作为一种高效的选择性丝氨酸蛋白酶抑制剂，对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性，其IC50值分别为35.52 nM、13.24 nM和48.05 nM。
T72508	Palmatine hydroxide
	Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。

天然产物

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

Ganoderic acid B

Cat.No: TN1059

Target: IL Receptor, HIV Protease, JAK, STAT

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Cat.No: T5S0983

Synonym: Absinthiin,Absynthin,洋艾素

Target: HIV Protease

Jacoumaric acid

Cat.No: TN4347

Target: HIV Protease

Cat.No: T10928

Target: HIV Protease

Cat.No: T73900

Rivulariapeptolides 1155

Cat.No: T75648

10-Hydroxyaloin A

Cat.No: T79947

Target: SARS-CoV

Rivulariapeptolides 1185

Cat.No: T75649

Rivulariapeptolides 988

Cat.No: T75651

Cat.No: T75652

Rivulariapeptolides 1121

Cat.No: T75650

Palmatine hydroxide

Cat.No: T72508

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