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65

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61114	Anti-Trypanosoma cruzi agent-2
	Anti-Trypanosoma cruzi agent-1 (Compd 3b) 对NINOA trypomastigote (IC50= 0.51 μM) 和 INC-5 epimastigote (IC50= 3.06 μM) 锥虫具有选择性，具有有效的抗弓形虫活性。
T63869	Anti-Trypanosoma cruzi agent-3
	Anti-Trypanosoma cruzi agent-3 是一种抗原虫 (antiprotozoal) 剂。
T72134	Anti-Trypanosoma cruzi agent-4
	Anti-Trypanosoma cruzi agent-4是克氏锥虫抑制剂。Anti-Trypanosoma cruzi agent-4 可用于感染的研究。
T62333	Anti-Trypanosoma cruzi agent-1
	Anti-Trypanosoma cruzi agent-1 (Compd E5) 具有有效的抗弓形虫效果。
T27135	DDD85646 DDD 85646,DDD-85646	Parasite	Microbiology/Virology
	DDD85646 是 T. brucei N-myristoyltransferase 的抑制剂，Ki 为 1.44 nM，IC50 为 2 nM，EC50 为 2 nM。 hNMT 的 IC50 为 4 nM。
T4198	T.cruzi-IN-1 MDK1088,T.cruzi Inhibitor	Antibiotic; Parasite	Microbiology/Virology
	T.cruzi-IN-1 (MDK1088) 是一种克氏锥虫抑制剂，IC50为 8 nM。它是一种 4-三氟甲基取代的类似物，有潜力治疗南美锥虫病的急性和慢性阶段。
T10340	Antitrypanosomal agent 2	Parasite	Microbiology/Virology
	Antitrypanosomal agent 2 显示出针对布氏锥虫的有效且特异性的抗寄生虫活性。
T10339	Antitrypanosomal agent 1	Parasite	Microbiology/Virology
	Antitrypanosomal agent 1 是一种有效的选择性锥虫硫酮还原酶抑制剂，IC50为 3.3 μM。它抑制谷胱甘肽还原酶，IC50为 64.8 μM，抑制布氏锥虫，EC50为 1 μM。
T72228	Antitrypanosomal agent 10
	Antitrypanosomal agent 10，一种针对克氏锥虫 (Trypanosoma cruzi) 有抑制作用的抗锥虫药物，IC50 值达到 0.28 μM。
T72229	Antitrypanosomal agent 11
	Antitrypanosomal agent 11，抑制克氏锥虫(Trypanosoma cruzi)，IC50值为0.23 μM，具有显著的抗锥虫活性。
T62372	Antitrypanosomal agent 8
	Antitrypanosomal agent 8 (compound 3b) 对布氏锥虫 (Trypanosoma brucei) 表现出较强的抗锥虫体作用 (IC50: 0.79 μM)。Antitrypanosomal agent 8 对 L6 细胞具有一定的细胞毒性，其 IC50 值为 80.95 μM。
T79316	Antitrypanosomal agent 15	Proteasome	Proteases/Proteasome; Ubiquitination
	Antitrypanosomal agent 15 (compound 26) 是一种具有口服活性、能穿透血脑屏障、对克氏锥虫蛋白酶体具有高选择性的抑制剂，其对克氏锥虫蛋白酶体的pIC50值为7.4，而对人蛋白酶体的pIC50值小于4。该化合物展现出良好的ADME性质，适合用于恰加斯病研究。
T62212	Antitrypanosomal agent 4
	Antitrypanosomal agent 4 (compound 19) 是一种有效的、能够透过血脑屏障的抗锥体虫剂，对克氏锥 (T. cruzi) 和布氏锥虫 (T. b. brucei) 表现出良好的抗性，其 IC50 值分别为 1.2 μM 和 70 nM。
T62710	Antitrypanosomal agent 6
	Antitrypanosomal agent 6 (compound 18a) 是一种有效的抗锥体虫剂，表现出良好的 ADME 特性。Antitrypanosomal agent 6 抗布氏锥虫 (T. brucei) 的活性比 Nifurtimox 高两倍以上，IC50为 0.47 μM。Antitrypanosomal agent 6 与 DNA 具有很强的相互作用，可以选择性的结合富含 AT 碱基的 DNA。
T83012	Antitrypanosomal agent 18
	Antitrypanosomal agent 18 (compound 8b)，一硝基呋喃衍生物，显示出卓越的锥虫杀灭活性，IC50值仅为0.03 μM。
T83013	Antitrypanosomal agent 17	Parasite	Microbiology/Virology
	Antitrypanosomal agent 17 (Compd 7a) 具有针对T. congolense的显著抗锥虫效应，表现出低至0.03 μM的半抑制浓度(IC50)。
T72267	Antitrypanosomal agent 9
	Antitrypanosomal agent 9 是一种有效的抗锥虫体剂。Antitrypanosomal agent 9 显示出对T. b. brucei 的抑制活性，其IC50为 1.15 μM。Antitrypanosomal agent 9 可用于人类非洲锥虫病 (HAT) 研究。
T79254	Antitrypanosomal agent 14	Parasite	Microbiology/Virology
	Antitrypanosomal agent 14（Compound 1）是一种针对T. brucei的有效抑制剂，其EC50为0.47 μM。它对TbGSK3的抑制作用表现在IC50为12 μM。该化合物主要用于非洲人类锥虫病的研究。
T78978	Antitrypanosomal agent 13	Parasite	Microbiology/Virology
	Antitrypanosomal agent 13 (compound 4b) 是一种高效的抗锥虫剂，具备显著的杀锥虫活性和细胞毒性。针对 T. brucei 和 HL-60，Antitrypanosomal agent 13 的 GI50 值分别为 0.18 μM 和 8.4 μM。
T63167	Antitrypanosomal agent 7
	Antitrypanosomal agent 7 (compound 18c) 是一种有效的抗锥体虫剂，显示出良好的 ADME 特性。Antitrypanosomal agent 7 的抗布氏锥虫 (T. brucei) 的活性 (IC50: 0.71 μM)，比 Nifurtimox 高两倍以上。Antitrypanosomal agent 7 与 DNA 有很强的相互作用，且能够选择性结合富含 AT 碱基的 DNA。
T64035	Antitrypanosomal agent 5
	Antitrypanosal agent 5 是一种选择性的抗锥虫剂，能够作用于 T. brucei (IC50: 1 nM) 和 HEK293 细胞 (IC50: 483.3 μM)。
T83014	Antitrypanosomal agent 16	Parasite	Microbiology/Virology
	Antitrypanosomal agent 16，作为一种杀锥虫剂，其对刚果锥虫T. congolense IL3000的IC50值仅为0.04μM。
T78977	Antitrypanosomal agent 12	Parasite	Microbiology/Virology
	Antitrypanosomal agent 12 是 C20-苯基硫脲化合物，显示出杀锥虫和细胞毒性。该化合物在实现 50% 生长抑制(GI50)时所需浓度为0.22 μM，能在血流形式的锥虫中引起细胞肿胀。
T23973	DDD100097 DDD 100097,DDD-100097	Others	Others
	DDD100097 是一种有效的 N-肉豆蔻醇转移酶抑制剂，对布氏锥虫具有潜在的抑制作用，可用于研究神经系统疾病。
T63727	CRK12-IN-2	Parasite	Microbiology/Virology
	CRK12-IN-2 是一种有效的 CRK12 的抑制剂。CRK12-IN-2 对寄生虫具有抑制作，对Trypanosoma congolense 和 Trypanosoma vivax 的 EC50 值分别为 3.2 和 0.08 nM。CRK12-IN-2 可用于预防和治疗动物锥体虫病。
T4248	T.cruzi Inhibitor (1350920-22-7(free base))	Antibiotic	Microbiology/Virology
	T.cruzi Inhibitor (1350920-22-7(free base)) 是一种克氏锥虫抑制剂。
T63059	CRK12-IN-1	Antibiotic	Microbiology/Virology
	CRK12-IN-1 是一种有效的CRK12抑制剂。CRK12-IN-1具有杀虫活性，对布氏锥虫 (T.b. brucei) 和刚果锥虫 (T. congolense) 具有抑制作用EC50分别为1.3和18 nM。CRK12-IN-1能迅速杀死病原细胞。
T2112	Fexinidazole 非昔硝唑,HOE 239	Others; Parasite	Microbiology/Virology; Others
	Fexinidazole (HOE 239) 是具有口服活性的硝基咪唑抗锥虫药物。它显示出对布鲁氏杆菌亚种和菌株的杀锥虫活性，IC50值为 0.7-3.3 μM (0.2-0.9 μg/ml)。它具有用于因感染布鲁氏菌引起的人类昏睡病的潜力。
T77551	6'-hydroxydihydrocinchonidine	Antibiotic; Drug Metabolite	Metabolism; Microbiology/Virology
	6'-hydroxydihydrocinchonidine 是奎宁的代谢产物,具有抗菌和抗肿瘤活性，对布氏锥虫和肺炎链球菌有抑制作用。
T77645	JC-229	TRP/TRPV Channel	Membrane transporter/Ion channel
	JC-229 是一种具有有效性和选择性的 TbRPA1 抑制剂，对布氏锥虫中的 RPA1 有抑制作用。 JC-229 可用于研究人类非洲锥虫病 (HAT) 。
T68109	Moxipraquine	Antibiotic	Microbiology/Virology
	Moxipraquine 是一种新型的8-氨基喹诺酮类化合物，对克氏锥虫具有抗感染活性。Moxipraquine 能有效抑制寄生虫血症，但不能根除小鼠或豚鼠的感染。Moxipraquine 对重度利什曼原虫、墨西哥乳杆菌和巴西乳杆菌的实验性感染有效，但对巴西乳杆菌无效。
T35449	α-(difluoromethyl)-DL-Arginine DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时，它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时，能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长，并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T25156	BiPNQ
	BiPNQ is a Trypanosoma cruzi inhibitor. Trypanosoma cruzi is the etiological agent of Chagas disease (American trypanosomiasis).
T68828	Chinifur
	Chinifur is a selective inhibitor and subversive substrate" for Trypanosoma congolense trypanothione reductase"
T34350	Ro 15-0216 Ro-15-0216,Ro15-0216
	RO 15-0216, a nitroimidazole compound, is active against human and animal pathogenic trypanosoma africanum in vitro.
T25200	CA-IN-5g CAIN5g
	CA-IN-5g is an effective carbonic anhydrase (CA) inhibitor. Carbonic anhydrase is isolated from Trypanosoma cruzi (TcCA).
T24096	GNF7686 GNF-7686,GNF 7686
	GNF7686 is a novel Trypanosoma cruzi inhibitor.
T27848	LP10 LP-10,LP 10
	LP10 is a reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1 and a Potent type II inhibitor of Trypanosoma cruzi CYP51.
T27851	LP8 LP 8,LP-8
	LP8 is a novel inhibitor of Trypanosoma cruzi CYP51.
T33434	MK436 MK 436,MK-436
	MK436 is a therapeutic agent and an antigenic animal drug that is effective in the treatment of Trypanosoma cruzonii infection.
T13223	Tuberculosis inhibitor 1	Others	Others
	Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM).
T69765	NPD-039
	NPD-039 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
T69764	NPD-008
	NPD-008 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
T61912	TbPTR1 inhibitor 1
	TbPTR1 inhibitor 1 (compound 5d) 是有效的动基体蝶啶还原酶 1 (PTR1)抑制剂。TbPTR1 inhibitor 1抑制布氏锥虫 PTR1 (TbPTR1) 的 IC50<0.1 nM，抑制布氏锥虫 (Trypanosoma brucei) 活性的 EC50=0.66 μM。
T83025	Antiparasitic agent-19
	Antiparasitic agent-19 (compound 40) 是一种化合物，具备广泛的抗寄生虫活性，且对布氏锥虫、婴儿利什曼原虫和克氏锥虫具有较低的毒性。
T39397	S-MGB-234
	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.
T69313	Ascofuranone
	Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH.
T6769	Elaiophylin 洋橄榄叶素,Efomycin E,Gopalamicin,Salbomycin,Azalomycin B	Others; Autophagy	Autophagy; Others
	Elaiophylin (Salbomycin) 是一种自噬抑制剂，在卵巢癌细胞中有抗肿瘤活性。它对 Plasmodium falciparum K1a 和 Trypanosoma brucei brucei GUTat 3.1 菌株具有抗原生动物活性，IC50 分别为 0.36 μM 和 0.45 μM。
T79390	Antileishmanial agent-23	Parasite	Microbiology/Virology
	Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著，展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。

化合物

Anti-Trypanosoma cruzi agent-2

Cat.No: T61114

Anti-Trypanosoma cruzi agent-3

Cat.No: T63869

Anti-Trypanosoma cruzi agent-4

Cat.No: T72134

Anti-Trypanosoma cruzi agent-1

Cat.No: T62333

Cat.No: T27135

Synonym: DDD 85646,DDD-85646

Target: Parasite

Cat.No: T4198

Synonym: MDK1088,T.cruzi Inhibitor

Target: Antibiotic, Parasite

Antitrypanosomal agent 2

Cat.No: T10340

Target: Parasite

Antitrypanosomal agent 1

Cat.No: T10339

Target: Parasite

Antitrypanosomal agent 10

Cat.No: T72228

Antitrypanosomal agent 11

Cat.No: T72229

Antitrypanosomal agent 8

Cat.No: T62372

Antitrypanosomal agent 15

Cat.No: T79316

Target: Proteasome

Antitrypanosomal agent 4

Cat.No: T62212

Antitrypanosomal agent 6

Cat.No: T62710

Antitrypanosomal agent 18

Cat.No: T83012

Antitrypanosomal agent 17

Cat.No: T83013

Target: Parasite

Antitrypanosomal agent 9

Cat.No: T72267

Antitrypanosomal agent 14

Cat.No: T79254

Target: Parasite

Antitrypanosomal agent 13

Cat.No: T78978

Target: Parasite

Antitrypanosomal agent 7

Cat.No: T63167

Antitrypanosomal agent 5

Cat.No: T64035

Antitrypanosomal agent 16

Cat.No: T83014

Target: Parasite

Antitrypanosomal agent 12

Cat.No: T78977

Target: Parasite

Cat.No: T23973

Synonym: DDD 100097,DDD-100097

Target: Others

Cat.No: T63727

Target: Parasite

T.cruzi Inhibitor (1350920-22-7(free base))

Cat.No: T4248

Target: Antibiotic

Cat.No: T63059

Target: Antibiotic

Cat.No: T2112

Synonym: 非昔硝唑,HOE 239

Target: Others, Parasite

6'-hydroxydihydrocinchonidine

Cat.No: T77551

Target: Antibiotic, Drug Metabolite

Cat.No: T77645

Target: TRP/TRPV Channel

Cat.No: T68109

Target: Antibiotic

α-(difluoromethyl)-DL-Arginine

Cat.No: T35449

Synonym: DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine

Target: Others

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T25156

Cat.No: T68828

Cat.No: T34350

Synonym: Ro-15-0216,Ro15-0216

Cat.No: T25200

Synonym: CAIN5g

Cat.No: T24096

Synonym: GNF-7686,GNF 7686

Cat.No: T27848

Synonym: LP-10,LP 10

Cat.No: T27851

Synonym: LP 8,LP-8

Cat.No: T33434

Synonym: MK 436,MK-436

Tuberculosis inhibitor 1

Cat.No: T13223

Target: Others

Cat.No: T69765

Cat.No: T69764

TbPTR1 inhibitor 1

Cat.No: T61912

Antiparasitic agent-19

Cat.No: T83025

Cat.No: T39397

Cat.No: T69313

Cat.No: T6769

Synonym: 洋橄榄叶素,Efomycin E,Gopalamicin,Salbomycin,Azalomycin B

Target: Others, Autophagy

Antileishmanial agent-23

Cat.No: T79390

Target: Parasite

Cat. No.	Product Name	Target	Signaling Pathways
T4S0590	Columbin	Phospholipase; COX; Parasite	Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Columbin 是有口服活性的二萜呋喃内酯，选择性抑制COX-1和COX-2，EC50值为 327 μM 和 53.1 μM，具有抗炎和抗锥虫体作用。
T3792	Ajugol 益母草苷,益母草苷A,Leonuride	Parasite	Microbiology/Virology
	Ajugol (Leonuride) 是从Sideritis germanicopolitana 分离得到的一种环烯醚糖苷。它有抗原生动物活性，对Trypanosoma b. rhodesiense 锥虫的 IC50为 31.8 μg/mL。
TN1375	α-Lapachone ALPHA-拉杷醌,alpha-Lapachone	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	α-Lapachone 具有杀锥虫作用。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T26288	Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa	Apoptosis; Influenza Virus; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Clovamide (trans-Clovamide) 是一种天然存在的咖啡酰结合物，具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。
T12286	Obtusifoliol	Others	Others
	Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively).
TN2485	1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Antifection	Microbiology/Virology
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
TN3220	7',8'-Dihydroobolactone	Antifection	Microbiology/Virology
	7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
TN4041	Eupatoriopicrin	Others	Others
	Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capacity in guinea pigs.
TN4227	Horminone	NADPH-oxidase; DNA/RNA Synthesis; Antifection	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. After administration of plant extracts containing Horminone has possibility of toxic effect.
TN1930	Methylenetanshinquinone	Antifection	Microbiology/Virology
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
TN5588	Kolavenol
	Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
TN4578	Monomethyl kolavate	Antifection	Microbiology/Virology
	Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.
T72234	3β-Hydroxy-hop-22(29)-ene
	3β-Hydroxy-hop-22(29)-ene 是一种有效的抗寄生虫剂 (antiparasiticagent)。3β-Hydroxy-hop-22(29)-ene 对克氏锥虫和墨西哥利什曼原虫具有一定的抑制活性。
TN4664	Norarmepavine	Others	Others
	N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa
TN6501	Isololiolide
	Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 μM and 40 μM, respectively. I
TN3549	Burchellin	Antifection	Microbiology/Virology
	Burchellin has larvicidal activity, it can interfer with the development cycle of the mosquito, where its strongest toxic effect is 100% mortality in larvae (L3) at concentrations ¥ 30 ppm. Burchellin and licarin A have activity against Trypanosoma cruzi
T73068	Mammea A/BA
	Mammea A/BA 对克氏锥虫 (T. cruzi) 显示出有效抗性。通过诱导线粒体功能障碍、产生活性氧 (ROS)、DNA 片段化以及增加酸性液泡数量，Mammea A/BA 触发细胞死亡机制，包括细胞凋亡 (apoptosis)、细胞自噬 (autophagy) 和细胞坏死，对于南美锥虫病的研究具有潜在应用价值。
TN5243	Vitexilactone	NADPH-oxidase; HIV Protease; Antifection	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...
T36448	(E)-Ajoene
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

Cat.No: T4S0590

Target: Phospholipase, COX, Parasite

Cat.No: T3792

Synonym: 益母草苷,益母草苷A,Leonuride

Target: Parasite

Cat.No: TN1375

Synonym: ALPHA-拉杷醌,alpha-Lapachone

Target: Topoisomerase, Antifection

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

Cat.No: T26288

Synonym: trans-Clovamide,N-trans-Caffeoy-L-dopa

Target: Apoptosis, Influenza Virus, ROS, Antibacterial

Cat.No: T12286

Target: Others

1,2-Dihydrotanshinone

Cat.No: TN2485

Synonym: 1,2-Dihydrotanshinquinone

Target: Antifection

7',8'-Dihydroobolactone

Cat.No: TN3220

Target: Antifection

Eupatoriopicrin

Cat.No: TN4041

Target: Others

Cat.No: TN4227

Target: NADPH-oxidase, DNA/RNA Synthesis, Antifection

Methylenetanshinquinone

Cat.No: TN1930

Target: Antifection

Cat.No: TN5588

Monomethyl kolavate

Cat.No: TN4578

Target: Antifection

3β-Hydroxy-hop-22(29)-ene

Cat.No: T72234

Cat.No: TN4664

Target: Others

Cat.No: TN6501

Cat.No: TN3549

Target: Antifection

Cat.No: T73068

Cat.No: TN5243

Target: NADPH-oxidase, HIV Protease, Antifection

Cat.No: T35750

Cat.No: T36448

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