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Search Results for " taxol "

12

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28289	Paclitaxel-SMCC SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate.
	Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies, antigens and other biopolymers. Pa
T70005	LY3325656
	LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.
T0226	Betaxolol hydrochloride 盐酸倍他洛尔,SL75212,SL 75212 HCl,Betaxolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Betaxolol hydrochloride (SL 75212 HCl) 是一种 β1 肾上腺素受体阻断剂，可用于研究高血压和青光眼。
T6565	Levobetaxolol hydrochloride Betaxon,左旋倍他洛尔,(S)-Betaxolol hydrochloride,AL-1577A,Levobetaxolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) 是 β-肾上腺素能受体抑制剂 (β阻滞剂) 。它具有降低眼压的作用，可用于研究青光眼。
T6408	Betaxolol Kerlone,SL 75212,Betoptic,倍他洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Betaxolol (Kerlone) 是 β1 肾上腺素受体阻断剂，可用于研究高血压和青光眼。
T19682	Levobetaxolol (S)-(-)-Betaxolol,(S)-Betaxolol
	Levobetaxolol, also known as AL-1577A and Betaxon, is a cardioselective β-adrenergic receptor inhibitor. It has been demonstrated to reduce intraocular pressure in patients affected by ocular hypertension and primary open-angle glaucoma.
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)	Protease-activated Receptor	GPCR/G Protein
	FSLLRY-NH2 TFA(245329-02-6 free base) 是一种蛋白酶激活受体 2 (PAR2) 抑制剂。在 ICR 小鼠中逆转紫杉醇诱导的机械异常性疼痛、热痛觉过敏和 PKC 激活。阻断分离的心脏成纤维细胞中的 ERK 活化和胶原蛋白生成。还可以减轻皮肤癣菌相关瘙痒小鼠模型的症状。
T36364	Flutax-2
	Green fluorescent taxol derivative. Used for microtubule imaging. Binds microtubules with high affinity (Ka ~ 107M-1). Excitation/emission maximum λ ~ 496/526 nm. Lillo et al (2002) Location and properties of the Tax. binding center in microtubules: a picosecond laser study with fluorescent taxoids. Biochemistry. 41 12436 PMID:12369834 \|Diaz et al (2000) Molecular recognition of Tax. by microtubules. Kinetics and thermodynamics of binding of fluorescent Tax. derivatives to an exposed site. J.Bio...
TP2051	CTCE-9908 CTCE 9908
	CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol. Enhances the efficacy of docetaxel in a mouse model.
TP2249	Flutax 1	Others	Others
	A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton
TP1904	FSLLRY-NH2
	Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of derm
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.

化合物

Paclitaxel-SMCC

Cat.No: T28289

Synonym: SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate.

Cat.No: T70005

Betaxolol hydrochloride

Cat.No: T0226

Synonym: 盐酸倍他洛尔,SL75212,SL 75212 HCl,Betaxolol HCl

Target: Adrenergic Receptor

Levobetaxolol hydrochloride

Cat.No: T6565

Synonym: Betaxon,左旋倍他洛尔,(S)-Betaxolol hydrochloride,AL-1577A,Levobetaxolol HCl

Target: Adrenergic Receptor

Cat.No: T6408

Synonym: Kerlone,SL 75212,Betoptic,倍他洛尔

Target: Adrenergic Receptor

Cat.No: T19682

Synonym: (S)-(-)-Betaxolol,(S)-Betaxolol

FSLLRY-NH2 TFA(245329-02-6 free base)

Cat.No: TP1904L

Target: Protease-activated Receptor

Cat.No: T36364

Cat.No: TP2051

Synonym: CTCE 9908

Cat.No: TP2249

Target: Others

Cat.No: TP1904

OB 24 hydrochloride

Cat.No: T41175

Cat. No.	Product Name	Target	Signaling Pathways
TN5118	Taxol C	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxol C 可以减少与 P-糖蛋白转运蛋白的相互作用，从而增加紫杉烷类向大脑的渗透。
T3S2372	7-epi-Taxol 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	7-epi-Taxol (7-Epitaxol) 是在细胞中发现的紫杉醇的主要衍生物，在抑制细胞增殖、微管解离和诱导微管聚合等方面与紫杉醇作用相当。
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T7054	N-Benzoyl-(2R,3S)-3-phenylisoserine N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain	Antiviral	Immunology/Inflammation
	N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) 是一种制备用于研究结合位点位置的强效抗癌药物紫杉醇的中间体。它显示出细胞毒性、抗病毒和免疫调节活性。
T5165	10-Deacetyltaxol 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyltaxol (10-DAT) 是从红豆杉中分离得到的一种紫杉醇衍生物，对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。它能促进微管蛋白的聚合，在体外抑制由钙离子诱导的微管解聚。
T2S2378	7-Xylosyltaxol	Others	Others
	7-xylosyltaxol is a taxol (Paclitaxel) derivative, has antineoplastic activity.
TN1335	7-Xylosyl-10-deacetyltaxol B 7-xylosyl-10-Deacetylpaclitaxel B	Others	Others
	7-Xylosyl-10-deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) 是一种来自红豆杉科植物东北红豆杉的紫杉醇衍生物，具有抗肿瘤活性，可用于合成紫杉醇。
TN1336	7-Xylosyl-10-deacetyltaxol C	Others	Others
	7-Xylosyl-10-deacetyltaxol C is a natural product from Taxus wallichiana Zucc.
TN5606	7-Xylosyltaxol B 7-Xylosylcephalomannine
	7-Xylosyltaxol B is a natural product from Taxus wallichiana var.mairei.
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
T2217	Cephalomannine Baccatin III,三尖杉宁碱	Microtubule Associated	Cytoskeletal Signaling
	Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物，具有抗肿瘤活性，可用于癌症研究。
T2197	10-Deacetylbaccatin III 10-脱乙酰巴卡丁 III,10-脱乙酰基巴卡丁III	Others	Others
	10-Deacetylbaccatin-III 是一种紫杉醇类似物制剂的中间体，具有抗癌活性。
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Cat.No: TN5118

Target: P-gp

Cat.No: T3S2372

Synonym: 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel

Target: Others, Microtubule Associated

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

N-Benzoyl-(2R,3S)-3-phenylisoserine

Cat.No: T7054

Synonym: N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain

Target: Antiviral

10-Deacetyltaxol

Cat.No: T5165

Synonym: 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel

Target: Others, Microtubule Associated

Cat.No: T2S2378

Target: Others

7-Xylosyl-10-deacetyltaxol B

Cat.No: TN1335

Synonym: 7-xylosyl-10-Deacetylpaclitaxel B

Target: Others

7-Xylosyl-10-deacetyltaxol C

Cat.No: TN1336

Target: Others

7-Xylosyltaxol B

Cat.No: TN5606

Synonym: 7-Xylosylcephalomannine

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Cat.No: T2217

Synonym: Baccatin III,三尖杉宁碱

Target: Microtubule Associated

10-Deacetylbaccatin III

Cat.No: T2197

Synonym: 10-脱乙酰巴卡丁 III,10-脱乙酰基巴卡丁III

Target: Others

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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