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Targets Recommended: ROCK Serine/threonin kinase Calcium Channel PKA PKC Autophagy

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1606	Fasudil HA-1077,AT877,法舒地尔	ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂，也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用，ROCK1 的 Ki 值为 0.33 μM，ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。
T3060	Fasudil hydrochloride Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂，也抑制蛋白激酶，对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。
T15647	Tipelukast MN 001,KCA 757	Leukotriene Receptor	GPCR/G Protein
	Tipelukast (KCA 757) 是一种新型可口服的白三烯受体 (leukotriene receptor) 拮抗剂，是具有抗炎活性，可减少纤维化，下调 TIMP-1、1 型胶原蛋白。Tipelukast 可用于研究哮喘疾病。

Cat. No.	Product Name	Target	Signaling Pathways
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T2A2481	Taurochenodeoxycholic Acid Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸	Apoptosis; TNF; Caspase; Endogenous Metabolite	Apoptosis; Metabolism; Proteases/Proteasome
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一，可诱导细胞凋亡，具有明显的抗炎和免疫调节作用。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

Cat. No.	Product Name	Species	Expression System
TMPY-01107	TIMP-1 Protein, Human, Recombinant EPO,TIMP metallopeptidase inhibitor 1,TIMP...	Human	HEK293 Cells
	TIMP-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P01033.
TMPY-01485	TIMP-1 Protein, Mouse, Recombinant Timp,EPA,Clgi,TIMP-1,TPA-S1,TIMP ...	Mouse	HEK293 Cells
	TIMP-1 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P12032.
TMPY-02912	TIMP-1 Protein, Rat, Recombinant TIMP metallopeptidase inhibitor 1	Rat	HEK293 Cells
	TIMP-1 Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21.5 kDa and the accession number is P01860.
TMPY-00154	TIMP-1 Protein, Human, Recombinant (hFc) TIMP-1,TIMP metallopeptidase inhibitor 1,E...	Human	HEK293 Cells
	TIMP-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is P01033.
TMPY-00932	TIMP-1 Protein, Human, Recombinant (His) CLGI,EPA,TIMP,TIMP-1,EPO,TIMP met...	Human	HEK293 Cells
	TIMP-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P01033.
TMPK-00093	TIMP-1 Protein, Mouse, Recombinant (hFc) TPA-S1,CLGI,TIMP-1,EPO,TIMP,EPA,EPATIM...	Mouse	HEK293 Cells
	Tissue inhibitor of metalloprotease-1 (TIMP-1) is a tissue inhibitor of matrix metalloproteinases (MMPs). It however exerts multiple effects on biological processes, such as cell growth, proliferation, differentiation and apoptosis, in an MMP-independent manner.
TMPJ-00101	TIMP-2 Protein, Human, Recombinant (His) Tissue Inhibitor of Metalloproteinases 2,TIMP2,CSC-...	Human	HEK293 Cells
	Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and i...
TMPY-01868	TIMP-2 Protein, Human, Recombinant CSC-21K,DDC8,TIMP metallopeptidase inhibitor 2	Human	HEK293 Cells
	TIMP-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22 kDa and the accession number is A0A140VK57.
TMPJ-00916	TIMP-2 Protein, Mouse, Recombinant (His) metalloproteinase inhibitor 2,Tissue inhibitor of metallopro...	Mouse	HEK293 Cells
	Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi...
TMPY-00933	TIMP-2 Protein, Human, Recombinant (hFc) TIMP metallopeptidase inhibitor 2,DDC8,CSC-21K	Human	HEK293 Cells
	TIMP-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is A0A140VK57.
TMPJ-01289	TIMP-4 Protein, Human, Recombinant (His) TIMP4,TIMP-4,Metalloproteinase inhibitor 4...	Human	HEK293 Cells
	Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
TMPH-01665	TIMP3 Protein, Human, Recombinant (His)	Human	E. coli
	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
TMPH-02782	TIMP4 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	TIMP4 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
TMPK-01286	MMP-8 Protein, Cynomolgus, Recombinant (His) Collagenase 2,HNC,CLG1,MMP8,PMNL-CL	Cynomolgus	HEK293 Cells
	Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was signifi...
TMPJ-00157	CD82 Protein, Human, Recombinant (hFc) Tetraspanin-27,KAI1,ST6,TSPAN27,TSPAN274F9,CD82 molecule,Tsp...	Human	HEK293 Cells
	CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signaling. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential. CD82/Kai-1...

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