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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5513	RO-3	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	RO3 是一种能透过大脑的P2X3和P2X2/3拮抗剂，口服有活性。它对人同型多聚体 P2X3和异型多聚体 P2X2/3受体的 pIC50分别为 5.9 和 7.0。
T34360	Ro 3-7410 Ro-3-7410
	Ro 3-7410 is an active hydroxy metabolite of bufuralol.
T34359	Ro 3-5940 HCl Ro 3 5940 HCl
	Ro 3-5940 HCl is a psychoactive agent, increasing in production of serotonin in central nervous system tissue.
T6312	R547 Ro 4584820	Apoptosis; GSK-3; PKA; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	R547 (Ro 4584820) 是一种口服有效，选择性， ATP 竞争性CDK 抑制剂，对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki 值分别为 2 nM、3 nM、1 nM。
T0110	Zalcitabine Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Zalcitabine (Dideoxycytidine) 是一种核苷类似物逆转录酶抑制剂，用于HIV 感染相关研究。
T0860L	Mefloquine Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998	Others	Others
	Mefloquine (Ro 215998) 是一种喹啉抗疟药，是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂，IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T30611	Bufuralol Ro3-4787,Ro 3-4787,Ro-3-4787
	Bufuralol is a Adrenergic Agent.
T10119	3-O-Methyltolcapone Ro 40-7591	Transferase	Metabolism
	3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease.
T19706	Ro 20-1724 Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE	Metabolism
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其 Ki=1930 nM，具有神经保护作用。
T12571	PSI-6206 13C,d3 Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3	Others	Others
	PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.
T2087	AF-353 Ro-4	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	AF-353 (Ro-4) 是一种选择性、可口服的 P2X3/P2X2/3 受体拮抗剂，抑制人和大鼠 P2X3 的 pIC50值为 8.0，抑制人 P2X2/3 的 pIC50值为 7.3。
T1896	Ro 61-8048	Hydroxylase	Metabolism
	Ro 61-8048 是一种选择性的、口服有效的犬尿氨酸 3-羟化酶抑制剂(IC50:37 nM)。它能够导致细胞喹啉酸浓度的显著增加。
T6643	Ro 31-8220 Mesylate Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) 是PKC 抑制剂，对 PKCα、PKCβI、PKCβII、PKCγ、PKCε 和大鼠大脑 PKC 的IC50值为 5、24、14、27、24 和 23 nM。它还抑制 MAPKAP-K1b、MSK1、S6K1 和 GSK3β，IC50为3、8、15 和 38 nM。
T10118	3-O-Methyltolcapone D7 Ro 40-7591 D7	Transferase	Metabolism
	3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P
T28598	Ro-23-9424 Ro 239424,Ro23-9424
	Ro-23-9424 is a dual-action cephalosporin with a fleroxacin esterified at the 3' position and aminothiazolylmethoxyimino-type side chain at the 7 position. Ro-23-9424 has broad and potent antibacterial activity in vitro and in vivo.
T28775	Sibrafiban RO-48-3657/001,RO-48-3657,RO 48-3657/001
	Sibrafiban (RO 48-3657) 是一种 Ro 44-3888 的口服非肽双前药，是一种选择性的糖蛋白 IIb/IIIa 受体 (glycoprotein IIb/IIIa receptor) 拮抗剂。Sibrafiban 能够抑制血小板聚集。
T21684	Bufuralol (hydrochloride)
	Bufuralol hydrochloride (Ro 3-4787 hydrochloride) 是一种有效的非选择性，口服活性的 β-肾上腺素受体 (β-adrenoreceptor) 拮抗剂，具有部分激动剂活性。Bufuralol hydrochloride 是CYP2D6 探针的底物。
T6643L	Ro 31-8220
	Ro 31-8220 是一种有效的PKC 抑制剂，对 PKCα，PKCβI，PKCβII，PKCγ，PKCε 和大鼠大脑 PKC 的IC50值为 5，24，14，27，24 和 23 nM。Ro 31-8220还显著抑制 MAPKAP-K1b，MSK1，S6K1 和 GSK3β，IC50值分别为3，8，15，38 nM，对 MKK3，MKK4，MKK6 和 MKK7 无作用。
T71000	RO-5328673
	RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g...

化合物

Cat.No: T5513

Target: P2X Receptor

Cat.No: T34360

Synonym: Ro-3-7410

Cat.No: T34359

Synonym: Ro 3 5940 HCl

Cat.No: T6312

Synonym: Ro 4584820

Target: Apoptosis, GSK-3, PKA, CDK

Cat.No: T0110

Synonym: Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine

Target: HIV Protease, Reverse Transcriptase

Cat.No: T0860L

Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Target: Others

Cat.No: T30611

Synonym: Ro3-4787,Ro 3-4787,Ro-3-4787

3-O-Methyltolcapone

Cat.No: T10119

Synonym: Ro 40-7591

Target: Transferase

Cat.No: T19706

Synonym: Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724

Target: PDE

PSI-6206 13C,d3

Cat.No: T12571

Synonym: Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3

Target: Others

Cat.No: T2087

Synonym: Ro-4

Target: P2X Receptor

Cat.No: T1896

Target: Hydroxylase

Ro 31-8220 Mesylate

Cat.No: T6643

Synonym: Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate

Target: PKC

3-O-Methyltolcapone D7

Cat.No: T10118

Synonym: Ro 40-7591 D7

Target: Transferase

Cat.No: T28598

Synonym: Ro 239424,Ro23-9424

Cat.No: T28775

Synonym: RO-48-3657/001,RO-48-3657,RO 48-3657/001

Bufuralol (hydrochloride)

Cat.No: T21684

Cat.No: T6643L

Cat.No: T71000

Cat. No.	Product Name	Target	Signaling Pathways
T3915	Ginsenoside Ro 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V	Calcium Channel; Reductase; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量，较弱降低 COX-1 和 TXAS 活性，具有 Ca2+拮抗剂的抗血小板作用，IC50为 155 μM。

天然产物

Cat.No: T3915

Synonym: 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V

Target: Calcium Channel, Reductase, Prostaglandin Receptor

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