Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sibrafiban (RO 48-3657) 是一种 Ro 44-3888 的口服非肽双前药,是一种选择性的糖蛋白 IIb/IIIa 受体 (glycoprotein IIb/IIIa receptor) 拮抗剂。Sibrafiban 能够抑制血小板聚集。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,670 | 5日内发货 | ||
25 mg | ¥ 8,750 | 6-8周 | ||
50 mg | ¥ 11,376 | 6-8周 | ||
100 mg | ¥ 16,996 | 6-8周 |
产品描述 | Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 which is a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation [1] [2] [3]. |
体外活性 | The effects of site occupancy by Sibrafiban on platelet activation are assessed using P-selectin expression, fibrinogen binding and microaggregate formation. Sibrafiban inhibits ADP and TRAP-stimulated fibrinogen binding and microaggregate formation in a concentration-dependent manner, whereas P-selectin expression is relatively unaltered. A decrease in site occupancy from peak to trough of Sibrafiban does not cause increased activation of platelets [3]. |
体内活性 | The effects of Ro 44-3888 on the platelet aggregation response to ADP (17 μmol) and on cutaneous bleeding times is determined in 8 rhesus monkeys given Sibrafiban 0.25 mg/kg/day or 0.5 mg/kg/day orally for 8 days. Ro 44-3888 showed a dose-dependent maximum inhibition of ex vivo platelet aggregation and prolongation of bleeding time [1]. |
别名 | RO-48-3657/001, RO-48-3657, RO 48-3657/001 |
分子量 | 420.46 |
分子式 | C20H28N4O6 |
CAS No. | 172927-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sibrafiban 172927-65-0 RO-48-3657/001 RO-48-3657 RO 48-3657/001 Inhibitor inhibitor inhibit