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14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16437 |
PC Biotin-PEG3-alkyne
|
Others | Others |
PC Biotin-PEG3-alkyne 是一种 ADC 连接剂,可裂解的 3 单元 PEG,还可以用于合成抗体药物共轭物 (ADC)。 | |||
T4949 |
1,2-Didecanoyl-sn-glycero-3-phosphocholi
1,2-Didecanoyl Phosphatidylcholine,1,2-Didecanoyl PC,L-A-癸酰磷脂酰胆碱 |
Others | Others |
1,2-Didecanoyl-sn-glycero-3-phosphocholi (1,2-Didecanoyl PC) 是一种合成的、疏水性较低的磷脂,已被发现可用于增强肽类药物和激素(如胰岛素)的吸收。 | |||
T37623 |
1,2-Dierucoyl-sn-glycero-3-PC
|
||
1,2-Dierucoyl-sn-glycero-3-PC is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. It has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP). | |||
T37043 |
1,2-Dihexadecyl-sn-glycero-3-PC
|
||
1,2-Dihexadecyl-sn-glycero-3-PC 可用于生命科学领域的相关研究。其产品编号为 T37043,CAS号为 36314-47-3。 | |||
T38356 |
1,2-Dipalmitoyl-13C-sn-glycero-3-PC
|
||
1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation... | |||
T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
|
||
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂,在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症(ALS)模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。 | |||
T37486 |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
|
||
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM. | |||
T37485 |
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
|
||
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). | |||
T4306 |
CCG-203971
CCG203971 |
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CCG-203971 是一种Rho/MRTF/SRF 通路抑制剂,具有潜在的抗转移作用。它有效靶向 RhoA/C 激活的 SRE 荧光素酶,IC50为 6.4 μM。它抑制 PC-3 细胞迁移,IC50为 4.2 μM。 | |||
T2014 |
CCG-1423
CCG1423 |
LRRK2; Rho; Ras | Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CCG-1423 是一种选择性 RhoA 通路抑制剂,可抑制 SRF 介导的转录,能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。 | |||
T81479 |
Phytochelatin 3
PC 3 |
||
Phytochelatin 3 (PC 3)是一种具有金属螯合能力的小型肽,主要用途为螯合重金属离子。 | |||
T18521 |
PC DBCO-PEG3-biotin
|
Others | Others |
PC DBCO-PEG3-biotin is a trimeric polyethylene glycol (PEG) linker, specifically designed for antibody-drug conjugate (ADC) synthesis, with a cleavable moiety consisting of a dibenzocyclooctyne (DBCO) group and a biotin molecule. This linker provides a platform for the efficient attachment of drugs to antibodies, facilitating the targeted delivery and controlled release of therapeutic agents in ADCs[1]. | |||
T16438 |
PC Biotin-PEG3-azide
|
Others | Others |
PC Biotin-PEG3-azide is a cleavable three-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker, employed in the synthesis of ADCs[1]. | |||
T81478 |
Phytochelatin 3 TFA
PC 3 TFA |
||
Phytochelatin 3 (PC 3) TFA,一小分子螯合肽,专用于重金属离子螯合。 | |||
T18518 | PC Biotin-PEG3-NHS ester | Others | Others |
PC Biotin-PEG3-NHS ester is a cleavable ADC linker comprising three PEG units. This linker is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T2617 |
SNS-314 Mesylate
SNS-314 |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
SNS-314 Mesylate (SNS-314) 是一种有效且特异性的极光激酶抑制剂,对极光激酶 A、B、C 的 IC50值分别为 9,31 和 3 nM。 | |||
T16961 |
Supinoxin
RX-5902 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂,是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长,IC50的范围为 10 nM 至 20 nM。 | |||
T67070 |
1,2-Diarachidoyl-sn-glycero-3-PC
|
||
1,2-Diarachidoyl-sn-glycero-3-PC 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67070,CAS号为 61596-53-0。 | |||
T64546 | 1-Stearoyl-2-myristoyl-sn-glycero-3-PC | ||
1-Stearoyl-2-myristoyl-sn-glycero-3-PC 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64546,CAS号为 20664-02-2。 | |||
T22062 |
CCG-100602
|
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达,IC50为 9.8 µM。 | |||
T60812 |
Cathepsin X-IN-1
|
Cysteine Protease | Proteases/Proteasome |
Cathepsin X-IN-1 (compound 25) 降低人前列腺癌细胞 PC-3 的迁移且具有较低的细胞毒性,它是组织蛋白酶 X 的有效抑制剂 (IC50 = 7.13 μM)。 | |||
T77526 |
Pim-1 kinase inhibitor 4
|
Apoptosis; Pim | Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling |
Pim-1 kinase inhibitor 4 是一种高效的 Pim-1 激酶 抑制剂,IC50 值为 17.01 nM。Pim-1 kinase inhibitor 4 还具有抗氧化活性和潜在的抗癌活性,对 DPPH 有抑制作用。Pim-1 kinase inhibitor 4 促进 PC-3 细胞凋亡 (apoptosis),对 PC-3 细胞生长有抑制作用,IC50 为 16 nM。Pim-1 kinase inhibitor 4 可用于研究前列腺癌。 | |||
T60357 |
NF-κB-IN-2
JEUD-38 |
||
NF-κB-IN-2 抑制 PC-3细胞中 TNF-α诱导的的经典 NF-κB 信号传导。 | |||
T27998 |
MDK-4204
Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I |
||
MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively. | |||
T83476 |
1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine
DHPC |
||
1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine (DHPC) 是生物活性磷脂化合物,属于磷脂酰胆碱 (PC) 的衍生物。 | |||
T63062 | Lepidozin G | ||
Lepidozin G 能够抑制癌细胞系的生长 (IC50=4.2±0.2 - 5.7±0.5 μM μM)。Lepidozin G 利用线粒体相关的凋亡,诱导 PC-3 细胞死亡。 | |||
T68209 |
Kopsoffinol
|
||
Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells. | |||
T36449 |
(S)-α-Methylbenzyl Ricinoleamide
|
||
(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM. | |||
T62523 |
Anticancer agent 40
|
||
Anticancer agent 40 (compound 3e) 是一种有效的抗癌剂。Anticancer agent 40 具有抗癌作用,能够作用于 SKBR-3 细胞 (IC50: 0.94 nM)、SKOV-3 细胞 (IC50: 0.98 nM)、PC-3 细胞 (IC50: 0.96 nM)、U-87 细胞 (IC50: 0.95 nM)、HDF 细胞 (IC50: 2.13 nM)。 | |||
T79495 |
VEGFR-2-IN-32
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-32(Comp 3a)作为一种VEGFR-2的抑制剂,其IC50值为8.93 nM。该化合物对PC-3细胞表现出细胞毒性,IC50为1.22 μM,适用于前列腺癌研究。 | |||
T61935 |
B-Raf IN 9
|
||
B-Raf IN 9 (compound 8b) 是有效的B-Raf 抑制剂(IC50= 24.79 nM)。B-Raf IN 9 将细胞周期阻滞于 G2/M 期,诱导凋亡。B-Raf IN 9 对人前列腺癌 PC-3 细胞表现出较强的抗肿瘤活性(IC50= 7.83 μM)。 | |||
T79558 |
fac-[Re(CO)3(L3)(H2O)][NO3]
|
||
fac-[Re(CO)3(L3)(H2O)][NO3](简称compound 3),是一种与线粒体功能障碍相关的抗前列腺癌剂。这种铼(I)三羰基水配合物对前列腺癌细胞系(PC-3)表现出显著的细胞毒性,其IC50值为0.32 μM。研究表明,fac-[Re(CO)3(L3)(H2O)][NO3]主要在线粒体中积聚,能够降低PC-3细胞的ATP生成,进而触发细胞副凋亡(paraptosis)机制,而不通过引发坏死、凋亡或自噬途径作用。 | |||
T36562 |
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid
|
||
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells. | |||
T36172 |
KOdiA-PC
|
||
Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave... | |||
T60727 |
B-Raf IN 8
|
||
B-Raf IN 8 (compound 7g) 是 B-Raf 的有效抑制剂 (IC50 = 70.65 nM)。B-Raf IN 8 显示出抗肿瘤活性,其对肝细胞癌 (HEPG-2)、结肠癌 (HCT-116),乳腺癌 (MCF-7) 和人前列腺癌 (PC-3) 细胞的 IC50值分别为9.78、13.78、18.52 和 29.85 μM。 | |||
T63391 |
Calpain Inhibitor-2
|
||
Calpain Inhibitor-2 是具有亲脂性的钙蛋白酶抑制剂,与黑色素瘤细胞系(A-375和B-16F1)和PC-3前列腺癌细胞相比,他们在体外具有中等到良好的抗增殖效果。Calpain Inhibitor-2 中的化合物3,在基质胶细胞侵袭测定中以2μM 浓度能够抑制了80%的DU-145细胞侵袭。 | |||
T74557 |
α1A-AR Degrader 9c
|
PROTACs | PROTAC |
α1A-AR Degrader 9c(化合物 9c)是一种高效、选择性且可逆的α1A-AR PROTAC降解剂,DC50值为2.86 μM。它通过蛋白酶体途径诱导α1A-AR的降解,并且在抑制PC-3细胞增殖方面表现出活性,IC50为6.12 μM。此外,α1A-AR Degrader 9c展现出在前列腺癌研究中的抗肿瘤潜力。 | |||
T79557 |
fac-[Re(CO)3(L6)(H2O)][NO3]
|
Apoptosis | Apoptosis |
fac-[Re(CO)3(L6)(H2O)][NO3](compound 6)是一种具有针对线粒体功能失调的抗癌活性的铼(I)三羰基水配合物。该化合物对前列腺癌细胞展现出显著的细胞毒性,具有50 nM的IC50值(PC-3细胞)。fac-[Re(CO)3(L6)(H2O)][NO3]能够主要集中在细胞核,抑制PC3细胞的ATP生成并诱导细胞凋亡,而不触发坏死、焦亡或自噬过程。 | |||
T80173 |
BDS-I
|
Potassium Channel | Membrane transporter/Ion channel |
BDS-I,又名降血物质,源自苏卡达银莲花的海洋毒素。它作为钾通道特异性抑制剂,针对Kv3.4。BDS-I能够抑制由Aβ1-42诱导的Kv3.4活性增强,减少caspase-3的激活,阻止NGF诱导的PC-12细胞分化以及异常核形态的出现,并可逆转Aβ肽引发的细胞死亡。 | |||
T82493 | EGFR/HER2/DHFR-IN-2 | EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR/HER2/DHFR-IN-2 (Compound 4b) 是针对EGFR、HER2和DHFR的三重抑制剂,IC50分别为0.248、0.156、0.138 μM。该化合物对包括Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7在内的多种癌细胞系展现出显著的抗癌活性(IC50分别为9.14、7.33、14.18、24.87、20.07、6.16 μM),并能有效减缓乳腺癌肿瘤的生长。 | |||
T60933 |
B-Raf IN 7
|
||
B-Raf IN 7 (compound 6a) 是 B-Raf 的有效抑制剂,IC50值为 110.23 nM。B-Raf IN 7 对结肠癌细胞(HCT-116)、乳腺癌细胞 (MCF-7)、肝癌细胞 (HEPG-2)、人宫颈癌细胞 (Hela) 和人前列腺癌细胞 (PC-3) 具有抗肿瘤活性。其 IC50值分别为 7.50、9.87、10.57、11.63 和 12.83 μM。 | |||
T81469 | PI3Kα-IN-14 | PI3K | PI3K/Akt/mTOR signaling |
PI3Kα-IN-14(复合物F8)是一款高度选择性的PI3Kα抑制剂,其IC50值为0.14 nM 。此化合物能显著降低线粒体膜的完整性,并在U87-MG细胞中引起G1期细胞周期的停滞以及凋亡现象。此外,PI3Kα-IN-14在不同来源的肿瘤细胞系中均展现出明显的抗增殖能力,其中PC-3的IC50为0.28 μM,HCT-116的IC50为0.57 μM,以及U87-MG的IC50为1.37 μM。 | |||
T68861 |
MS-0022
|
||
MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low µM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo. | |||
T83757 |
RG33 TFA
|
||
RG33是一种33个氨基酸的合成肽,与apolipoprotein A1 (ApoA1)的C-末端域中两个Y类螺旋的209-219和220-241氨基酸相对应。它能溶解含有1,2-dimyristoyl-sn-glycero-3-PC (DMPC)的多层囊泡(MLVs),形成重组HDL。与脂质结合的RG33在J774巨噬细胞中诱导胆固醇外流。RG33 (12 mg/kg)可降低胰岛素抵抗性小鼠的血糖水平。 | |||
T69685 |
AGPS-IN-2i
|
MMP | Proteases/Proteasome |
AGPS-IN-2i 是一种高效且具有很高亲和力的烷基甘油磷酸酯合成酶抑制剂的,可控制着细胞中醚脂的利用和代谢,降低了醚类脂质水平和细胞迁移率,促进癌细胞的增殖和运动。AGPS-IN-2i 在 PC-3和 MDA-MB-231癌细胞中测试时通过调节 E-cadherin、Snail 和 MMP2的表达水平,特异性地损害了上皮向间质转化(EMT)。AGPS-IN-2i 对癌细胞增殖具有抑制作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19085 |
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC
POPC,2-油酰-1-棕榈锡甘油-3-磷酸胆碱,1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,Palmitoyloleoylphosphatidylcholine |
Others | Others |
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) 是生物膜的主要成分,是一种磷脂。它用于脂质体的制备以及脂质双层的特性的研究。 | |||
T9510 |
1,2-Distearoyl-sn-glycero-3-phosphorylcholine
DSPC,L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL,1,2-Distearoyl-sn-glycero-3-PC,二硬脂酰磷脂酰胆碱 |
Others | Others |
1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) 是一种脂质纳米颗粒(LNP) 系统中的脂质成分,可用于合成脂质体。 | |||
T74236 |
1-Oleoyl-2-palmitoyl-sn-glycero-3-PC
|
||
1-Oleoyl-2-palmitoyl-sn-glycero-3-PC,由油酸衍生,用于脂质体合成。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
TN3465 |
Atalantoflavone
|
Antifection | Microbiology/Virology |
Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3. | |||
TN1872 |
Linderone
|
Others | Others |
Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line. | |||
TN3737 |
Cycloartane-3,24,25-triol
|
ATPase | Membrane transporter/Ion channel |
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. | |||
T81529 | Peganumine A | ||
Peganumine A,一种天然产物,源自Peganum harmala,具备对HL-60、MCF-7、PC-3、HepG2细胞线显示出细胞毒性作用,其IC50值依次为5.8、38.5、40.2、55.4 µM[1]< /sup>。 | |||
TN2273 |
Tigloylgomisin P
巴豆酰戈米辛 P,巴豆酰戈米辛P |
Others | Others |
Tigloylgomisin P shows moderate to marginal cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines. | |||
T83471 | 10-Deacetyl-13-oxobaccatin III | ||
10-Deacetyl-13-oxobaccatin III是一款从Taxus sumatrana分离的紫杉烷。在30 μg/mL的浓度下,对A498、NCI-H226、A549、PC-3细胞系展现细胞毒性作用,其抑制率分别达到29.7%、49.2%、43.9%、65.3%。 | |||
TN6394 | Alisol B acetate | ||
Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B aceta | |||
TN3125 |
5-Methoxycanthin-6-one
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Others | Others |
5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi | |||
T36791 |
Lysophosphatidylcholine 18:2
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1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ... | |||
T36845 |
Isogarcinol
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Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... |