55
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T33858 |
PACA
N-Propargyl Caffeamide |
||
PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor (NGF). | |||
T60028 |
MM41
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
MM41 是一种人类端粒和基因启动子 DNA 四链体稳定剂,对 MIA PaCa-2 胰腺癌细胞系的 IC50 <10 nM。 | |||
T4671 |
BN82002
CDC25 Phosphatase Inhibitor I |
Phosphatase | Metabolism |
BN82002 (CDC25 Phosphatase Inhibitor I) 是一种CDC25 phosphatase 家族的有效的、不可逆的、选择性的泛抑制剂。它显示出比 CD45 酪氨酸磷酸酶高约 20 倍的选择性。 | |||
T11898 |
LXH254
|
Raf | MAPK |
LXH254 是B/C RAF 抑制剂。 | |||
T8369 |
Adagrasib
MRTX849 |
Ras | GPCR/G Protein; MAPK |
Adagrasib (MRTX849) 是一种 KRAS G12C 共价抑制剂,具有口服活性和选择性。Adagrasib 与 KRAS G12C 非活性构象的 GDP 状态结合,抑制 KRAS 及其下游信号的传导。Adagrasib 对 KRAS G12C 突变肿瘤具有抑制活性。 | |||
T7610 |
GW284543
UNC10225170 |
MEK | MAPK |
GW284543 (UNC10225170) 是一个选择性的MEK5抑制剂,可降低 pERK5,并下调内源性 MYC 蛋白。 | |||
TP1878L |
PACAP 1-38 acetate
|
PACAP | GPCR/G Protein |
PACAP 1-38 acetate 是一种垂体腺苷酸环化酶激活多肽 (PACAP) 类似物。它与 PACAP I 型受体 (IC50 = 4 nM) 和 PACAP II 型 VIP2 受体 (IC50 = 1 nM) 结合,但不与 PACAP II 型 VIP1 受体结合。 | |||
T3548 |
Epacadostat
INCB 024360,艾卡哚司他,IDO Inhibitor 1 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Epacadostat (INCB 024360) 是选择性的IDO1抑制剂,IC50=71.8 nM。 | |||
TP1722L |
PACAP (6-38), human, ovine, rat acetate
|
PACAP | GPCR/G Protein |
PACAP (6-38), human, ovine, rat acetate 是一种有效的 PACAP 受体拮抗剂。PACAP (6-38) 作用于 PACAP I 型受体,PACAP II 型受体 VIP1 和 PACAP II 型受体 VIP2,IC50 分别为 30 nM,600 nM 和 40 nM。 | |||
TP1618L |
PACAP-38 (31-38), human, mouse, rat acetate
PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) |
PACAP | GPCR/G Protein |
PACAP-38 (31-38), human, mouse, rat acetate 是 PAC1 受体的激活剂。PACAP-38 (31-38), human, mouse, rat acetate 对交感神经元 NPY 和儿茶酚胺的产生具有强效、有效和持续的刺激作用,可用于神经营养和神经保护研究。 | |||
TP1070L |
PACAP (1-27), human, ovine, rat acetate
PACAP 1-27 acetate,PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base) |
PACAP | GPCR/G Protein |
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate)(127317-03-7 free base) 是一种新的神经肽,最初从牛下丘脑中分离出来,也存在于人和大鼠中。 | |||
TP1069 |
PACAP (1-27), human, ovine, rat TFA
PACAP 1-27 TFA |
||
PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) is an N-terminal fragment of pacap-38 and an effective PACAP receptor antagonist. The IC50s for rat PAC1, rat VPAC1 and human VPAC2 are 3nm, 2nm and 5nm respectively. | |||
T80069 |
PACAP (6-27) (human, ovine, rat)
Pituitary adenylate cyclase-activating peptide (6-27) |
||
PACAP (6-27) (human, ovine, rat) 是一种对PACAP受体具有拮抗作用的化合物,可以抑制犬肾上腺对外源性VIP的反应。此化合物在心血管疾病和神经系统疾病研究中展现出应用潜力。 | |||
T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
|
PACAP | GPCR/G Protein |
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ... | |||
TP1878 |
PACAP (1-38), human, ovine, rat
Pituitary Adenylate Cyclase Activating Polypeptide 38,腺苷酸环化酶激活肽-38(抗原),PACAP 1-38 |
PACAP | GPCR/G Protein |
PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) 是含有 38 个氨基酸残基的神经肽。它能够结合 PACAP I 型受体(IC50:4 nM)、PACAP II 型受体 VIP1(IC50:2 nM)、PACAP II 型受体 VIP2(IC50:1 nM)。 | |||
TP1054 |
PACAP (1-38), human, ovine, rat TFA
Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA) |
||
PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP), | |||
T36428 |
PACAP-related Peptide (human) (trifluoroacetate salt)
|
PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP. | |||
TP1619 |
PACAP-38 (16-38), human, mouse, rat
|
||
PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... | |||
TP1414 |
PACAP-38 (31-38), human, mouse, rat TFA
|
||
PACAP-38 (31-38), human, mouse, rat (TFA) demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal. | |||
T81571 |
PACAP (1-38) free acid TFA
|
||
PACAP (1-38) free acid TFA,一种内源性神经肽,能有效促进胃窦运动,增强体液蛋白分泌,同时抑制胃泌素释放。此外,它刺激血管活性肠肽、胃泌素释放肽和P物质的释放,并通过RACK1增强N-甲基-D-天门冬氨酸受体功能及脑源性神经营养因子表达。 | |||
T77127 |
Pacanalotamab
|
||
Pacanalotamab (AMG 420;BI-836909) 是一种双特异性 T 细胞接合剂 (BiTE),靶向 BCMA 和 CD3ɛ。BCMA 是指 B 细胞成熟抗原,而 Pacanalotamab 会将 T 细胞重定向到细胞表面的 BCMA 表达细胞。Pacanalotamab 可对人多发性骨髓瘤 (MM) 细胞系进行 T 细胞重定向裂解。 | |||
T83510 |
[Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2
BM-PACAP |
||
[Arg-15,-20,-21,Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) 为合成PACAP 1-27 类似物,展现出明显的松弛效应。 | |||
T81572 |
PACAP (1-38) free acid
|
||
PACAP (1-38) free acid 是一种具有多重生物功能的内源性神经肽,主要作用包括刺激胃窦运动、增进体液蛋白分泌、抑制胃泌素分泌,以及促进血管活性肠肽、胃泌素释放肽和P 物质的释放。此外,PACAP (1-38) free acid 通过与RACK1互作,可以增强N-甲基-D-天门冬氨酸受体的功能并促进脑源性神经营养因子的表达。 | |||
TP1618 |
PACAP-38 (31-38), human, mouse, rat
|
||
PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. | |||
TP1850 |
PACAP-Related Peptide (PRP), human
|
||
PACAP-Related Peptide (PRP), human,a 29 amino-acid region of the PACAP precursor protein, is synthesized in quantities sufficient for biological and structural studies. | |||
TP1438 |
PACAP (6-38), human, ovine, rat TFA
|
||
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. | |||
TP1722 |
PACAP (6-38), human, ovine, rat
|
||
PACAP (6-38), human, ovine, rat is a potent antagonist of PACAP 38. PACAP (6-38) is much more potent and selective than PACAP (6-27) in the inhibition of PACAP-27-stimulated pituitary adenylate cyclase. | |||
T32150 |
Impacarzine
V 5531,V-5531,V5531 |
||
Impacarzine is a biochemical. | |||
TP1070 |
PACAP (1-27), human, ovine, rat
PACAP 1-27 |
||
PACAP (1-27) (the N-terminal fragment of PACAP-38) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats. | |||
T72576 |
Transketolase-IN-4
|
Antibacterial | Microbiology/Virology |
Transketolase-IN-4 是一种转酮酶抑制剂 ,IC50值为3.9 μM。Transketolase-IN-4 对结核分枝杆菌 DXS 有抑制作用,IC50 为 114.1 μM。 Transketolase-IN-4 抑制 SW620、LS174T 和 MIA PaCa-2 的肿瘤细胞增殖。 | |||
T63136 |
DX3-213B
|
OXPHOS | Apoptosis |
DX3-213B 是一种高效的、口服具有活力的氧化磷酸化 (OXPHOS) 复合物 I 抑制剂,其 IC50 值为 3.6 nM。DX3-213B 能够阻断 ATP 的生成 (IC50: 11 nM),抑制 MIA PaCa-2 细胞生长 (GI50: 11 nM)。DX3-213B 能够用于研究胰腺癌。 | |||
T79287 |
SB-1295
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
SB-1295是一种口服活性CDK9/T1抑制剂,其IC50为0.17 μM。在HCT 116和MIA PaCa-2细胞中表现出抗增殖效应,并能诱导MIA PaCa-2细胞死亡,机制包括ROS生成增加、线粒体膜电位下降及细胞凋亡启动。SB-1295具备作为癌症研究工具的潜力。 | |||
T36514 |
QD-394
|
||
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin ... | |||
T79808 |
KRAS G12C inhibitor 61
|
ERK | MAPK |
KRAS G12C inhibitor 61 (Example 3) 在 MIA PaCa-2 细胞中抑制 ERK1/2 磷酸化,其 IC50 为 9 nM。此化合物适用于胰腺癌、结直肠癌和肺癌的研究。 | |||
T81850 |
MASTL-IN-2
|
||
MASTL-IN-2为MASTL(microtubule-associated Ser/Thr kinase-like)抑制剂,能够抑制人上皮MIA PaCa癌细胞的增殖,其IC50值为2.8 nM。 | |||
T63863 |
KRAS G12C inhibitor 47
|
||
KRAS G12C inhibitor 47 是 KRAS G12C 的有效抑制剂 (IC50: 0.172 μM)。KRAS G12C inhibitor 47 在 MIA PaCA-2 细胞、A549 细胞中表现出 p-ERK 抑制作用,他们的 IC50 值分别为 0.046 μM、69.8 μM。KRAS G12C inhibitor 47 对胰腺癌,结直肠癌和肺癌表现出研究潜力。 | |||
T64150 | CX-5461 dihydrochloride | ||
CX-5461 dihydrochloride 是一种有效的、口服具有活力的 Pol I 介导的 rRNA synthesis 抑制剂,能够作用于 HCT-116 细胞 (IC50: 142 nM),A375 细胞 (IC50: 113 nM) 和 MIA PaCa-2 细胞 (IC50: 54 nM),对 Pol II 作用较小 (IC50≥25 μM)。 | |||
T62737 |
KRAS inhibitor-15
|
||
KRAS inhibitor-15 (compound 3-19) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.954 μM)。KRAS inhibitor-15 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 2.03,>33.3 μM。KRAS inhibitor-15 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。 | |||
T62890 |
OXPHOS-IN-1
|
||
OXPHOS-IN-1 (compound 2) 是一种氧化磷酸化 (OXPHOS) 抑制剂。OXPHOS-IN-1 能够抑制 MIA PaCa-2 细胞 (IC50: 2.34 μM) 和 BxPC-3 细胞 (IC50: 13.82 μM) 的生长。 | |||
T63164 | KRAS inhibitor-13 | ||
KRAS inhibitor-13 (compound 5-6) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.883 μM)。KRAS inhibitor-13 在 MIA PaCA-2,A549 细胞中具有 p-ERK 抑制效果,其 IC50 值分别为 5.9,>100 μM。 KRAS inhibitor-13 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。 | |||
T73255 |
Akt1-IN-1
|
||
Akt1-IN-1 是一种有效的 Akt1抑制剂,对 MIA Paca-2 细胞的 IC50为 18.79 nM。Akt1-IN-1 不具有明显的致畸性、肝毒性和心脏毒性 (有害作用剂量大于 100 µM)。Akt1-IN-1 可用于抗癌研究。 | |||
T78896 |
SHP2-IN-22
|
||
SHP2-IN-22 作为变构抑制剂,靶向SHP2,具有 17.7 nM 的 IC50。该化合物能够有效抑制MIA PaCa-2胰腺癌细胞的增殖、迁移和侵袭行为。SHP2-IN-22 主要用于研究含Kirsten大鼠肉瘤病毒癌基因(KRAS)突变型的癌症。 | |||
T63235 |
KRAS inhibitor-14
|
||
KRAS inhibitor-14 是 KRAS G12C 的有效抑制剂(IC50: 0.249 μM)。KRAS inhibitor-14 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 1.12,>33.3 μM。KRAS inhibitor-14 对胰腺癌、结直肠癌和肺癌的具有研究潜力。 | |||
T62752 | KRAS inhibitor-16 | ||
KRAS inhibitor-16 (compound 3-11) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.457 μM)。KRAS inhibitor-16 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 3.06,11.1 μM。 KRAS inhibitor-16 具有潜力进行胰腺癌,结直肠癌和肺癌的研究。 | |||
T62784 |
KRAS inhibitor-18
|
||
KRAS inhibitor-18 (compound 3-10) 是一种 KRAS G12C 的有效抑制剂 (IC50: 4.74 μM)。KRAS inhibitor-18 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 66.4,11.1 μM。KRAS inhibitor-18 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。 | |||
T64093 | KRAS G12C inhibitor 44 | ||
KRAS G12C inhibitor 44 是一种有效的、口服具有活力的 KRAS G12C 抑制剂。KRAS G12C inhibitor 44 在 MIA PaCA-2 (IC50: 0.016 μM)、H358 细胞 (IC50: 0.028 μM) 中表现出抗增殖作用。KRAS G12C inhibitor 44 在体内具有抗肿瘤活性。 | |||
T78844 |
MET/PDGFRA-IN-2
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
MET/PDGFRA-IN-2(化合物8h)是一种针对MET和PDGFRA蛋白的抑制剂,具有诱导细胞凋亡(apoptosis)的功能。该化合物能有效抑制多种MET表达细胞系的增殖,包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562细胞,其IC50分别为9.7、6.1、12.0、11.5、8.6和34.4μM。 | |||
T62751 | KRAS inhibitor-12 | ||
KRAS inhibitor-12 (compound 6-1) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.537 μM)。KRAS inhibitor-12 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,其 IC50 值分别为 1.3,3.7 μM。 KRAS inhibitor-12 具有潜力进行胰腺癌,结直肠癌和肺癌的研究。 | |||
T62981 |
KRAS inhibitor-17
|
||
KRAS inhibitor-17 (compound 3-9) 是一种 KRAS G12C 的有效抑制剂 (IC50: 3.37 μM)。KRAS inhibitor-17 具有 p-ERK 抑制作用,在 MIA PaCA-2 细胞的 IC50=9.25 μM,在 A549 细胞中的 IC50 >33.3 μM。KRAS inhibitor-17 具有潜力进行胰腺癌,结直肠癌和肺癌的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN5789 |
Royleanone
|
||
Royleanone possesses cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2. | |||
T36797 |
1-Alaninechlamydocin
|
||
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively). | |||
T36954 |
Nemorosone
|
||
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... | |||
T36489 |
Malformin A
|
||
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati... |