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Search Results for " nrf2-dependent "

6

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1487	Fluvastatin sodium XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Fluvastatin sodium (Fluvastatin sodium salt) salt 是羟甲基戊二酰辅酶 A 还原酶的竞争性抑制剂，IC50为 8 nM。它通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激，是一种常用的降胆固醇剂。
T21405	Fluvastatin Canef,XU-62320,Vastin,Cranoc,Lescol	HMG-CoA Reductase	Metabolism
	Fluvastatin (XU-62320) 是一种具有高效性和竞争性的 HMG-CoA 还原酶抑制剂（IC50 ：8 nM），可通过依赖 Nrf2 通路抑制血管平滑肌细胞免受氧化应激，用于降低血浆胆固醇水平和预防心血管疾病。
T39036	(3R,5S)-Fluvastatin (3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid
	(3R,5S)-Fluvastatin, the 3R,5S-isomer of Fluvastatin (XU 62-320 free acid), stands as the inaugural fully synthetic, competitive inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It safeguards vascular smooth muscle cells from oxidative stress by activating the Nrf2-dependent antioxidant pathway.
T10129	(3S,5R)-Fluvastatin sodium (3S,5R)-XU 62-320	Others	Others
	(3S,5R)-Fluvastatin sodium is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor (IC50: 8 nM). Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-
T37633	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T37634	17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

化合物

Fluvastatin sodium

Cat.No: T1487

Synonym: XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T21405

Synonym: Canef,XU-62320,Vastin,Cranoc,Lescol

Target: HMG-CoA Reductase

(3R,5S)-Fluvastatin

Cat.No: T39036

Synonym: (3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid

(3S,5R)-Fluvastatin sodium

Cat.No: T10129

Synonym: (3S,5R)-XU 62-320

Target: Others

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

Cat.No: T37633

17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T37634

Cat. No.	Product Name	Target	Signaling Pathways
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
T3385	Gypenoside XVII GP-17,Gynosaponin S,七叶胆苷XVII	Estrogen Receptor/ERR; GSK-3; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Gypenoside XVII (Gynosaponin S) 是一种绞股蓝皂甙类的新型植物雌激素，能够激活雌激素受体。
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
TN1674	Garcinone D 伽升沃 D	Reactive Oxygen Species; Nrf2; STAT	Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Stem Cells
	Garcinone D 是来自山竹的一种呫吨酮，可促进 C17.2 神经干细胞的增殖。它以浓度和时间依赖的方式增加磷酸化信号转导和转录激活因子 3 (p-STAT3)、Cyclin D1 和核因子红细胞 2 相关因子 (Nrf2)、以及血红素加氧酶-1 (HO-1) 的蛋白质水平。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
TN6711	toralactone	Others; Nrf2	Immunology/Inflammation; Others
	Toralactone 是一种分离自决明子中的天然产物，通过 Nrf2 依赖性抗氧化机制介导肝脏保护作用。
T13670L	(Z)-Ligustilide 藁本内酯,cis-Ligustilide,Ligustilide A,蒿本内酯 A	Antibacterial	Microbiology/Virology
	(Z)-Ligustilide (Ligustilide A) 是从川芎中提取的天然产物，具有抗菌和抗真菌活性。它抑制 FATP5 和 DGAT 的表达，抑制小鼠脂肪酸的摄取和酯化，有潜力研究非酒精性脂肪性肝病。

天然产物

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Gypenoside XVII

Cat.No: T3385

Synonym: GP-17,Gynosaponin S,七叶胆苷XVII

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Cat.No: TN1674

Synonym: 伽升沃 D

Target: Reactive Oxygen Species, Nrf2, STAT

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: TN6711

Target: Others, Nrf2

(Z)-Ligustilide

Cat.No: T13670L

Synonym: 藁本内酯,cis-Ligustilide,Ligustilide A,蒿本内酯 A

Target: Antibacterial

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