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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11696 |
Ivachtin
Caspase-3 Inhibitor VII |
Caspase | Apoptosis; Proteases/Proteasome |
Ivachtin (Caspase-3 Inhibitor VII) 是一种非肽,非竞争性和可逆的caspase-3抑制剂,IC50为 23 nM。它是其余胱天蛋白酶的适度抑制剂。 | |||
T11857 |
LIT-001
|
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
LIT-001 是非肽类催产素受体激动剂,EC50为55 nM,Ki 为226 nM。它可改善孤独症小鼠模型的社交互动。 | |||
T16850 |
SB-265610
GSK-CXCR2 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂,可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性,IC50分别为 3.7 和 70 nM。 | |||
T12870 |
SCH79797 dihydrochloride
|
Apoptosis; Others; Protease-activated Receptor | Apoptosis; GPCR/G Protein; Others |
SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂,IC50 为 70 nM,Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。 | |||
T6288 |
Mozavaptan
莫扎伐坦,OPC31260l,OPC-31260 |
Vasopressin Receptor | GPCR/G Protein |
Mozavaptan (OPC-31260) 是 benzazepine 衍生物,是一种竞争性加压素受体拮抗剂,作用于 V1 和 V2 受体,IC50 分别为 1.2 μM 和 14 nM。它可在体内拮抗精氨酸加压素的抗利尿作用,可用于低钠血症、抗利尿激素不适当综合征和充血性心力衰竭的研究。 | |||
T21790 |
BMS 182874 hydrochloride
|
Endothelin Receptor | GPCR/G Protein |
BMS 182874 hydrochloride 是一种非肽内皮素 (El) 受体拮抗剂。 | |||
T26594 |
Allisartan Isoproxil
|
RAAS | Endocrinology/Hormones |
Allisartan Isoproxil 是一种非肽类的血管紧张素 II 受体拮抗剂,可用于有关高血压和心脏疾病的研究。 | |||
T1520 |
Aliskiren hemifumarate
阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂,IC50为1.5 nM,具有抗高血压活性。 | |||
T3525 |
PD150606
|
Cysteine Protease | Proteases/Proteasome |
PD150606 是一种具有选择性的非肽 calpain 抑制剂,具有神经保护活性,抑制 μ-calpains 和 m-calpains ,抑制红藻氨酸诱导的 Ca2+ 内流,干扰兴奋性毒性依赖性运动神经元死亡。 | |||
T27762 |
L-162,313
L-162313,L 162,313,L162,313 |
RAAS | Endocrinology/Hormones |
L-162,313是一种ANG II受体激动剂,是一种模仿血管紧张素II生物学作用的非肽,可诱导MAP增加。 | |||
T3347 |
PF3274167
PF 3274167,Cligosiban,PF-3274167 |
OX Receptor | GPCR/G Protein; Neuroscience |
PF3274167 (Cligosiban) 是一种有效的、选择性的、高亲和力的非肽催产素受体拮抗剂。 | |||
TQ0057 |
AVE 0991
|
Others | Others |
AVE 0991 是血管紧张素-(1-7) [Ang-(1-7)] 的非肽类似物,是一种具有口服活性的 Mas 激动剂,对 [125I]-Ang-(1-7) 结合到牛主动脉内皮细胞膜有抑制作用,通过增强自噬来抑制星形胶质细胞介导的阿尔茨海默病神经炎症。 | |||
T6281 |
TW-37
TW 37 |
BCL | Apoptosis |
TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂,Ki 值分别为 0.26、0.29和1.11μM | |||
TQ0075 |
ML314
|
Neurotensin Receptor | GPCR/G Protein |
ML314 是一种具有脑渗透性非肽 β-抑制素偏向神经降压素 NTR1 受体激动剂(EC50:1.9 μM),是一种用于甲基苯丙胺滥用的偏向神经降压素受体配体,抑制 NTR2 和 GPR35。 | |||
T8691 |
PD 168368
PD168368 |
Bombesin Receptor | GPCR/G Protein |
PD 168368 是一种新型有效且具有竞争性和选择性的非肽类神经调节蛋白 B 受体 (NMB-R) 拮抗剂,对胃泌素释放肽受体 (GRPR)具有抑制作用。PD 168368 是一种高效的 FPR1/FPR2/FPR3 的混合激动剂。 | |||
T25615 |
Lanepitant
LY303870,LY-303870,LY 303870 |
Others | Others |
Lanepitant (LY303870) 是一种非肽类神经激肽-1(NK-1)拮抗剂,具有镇痛活性,可抑制神经源性硬脑膜炎症,可用于预防偏头痛。 | |||
T9692 |
Paltusotine
|
Somatostatin | GPCR/G Protein |
Paltusotine 是一种口服有效的,非肽选择性生长抑素 2 型受体激动剂。在长效生长抑素受体配体作用后,Paltusotine 仍可维持 GH 和 IGF-1 水平。 | |||
T11174 |
(R)-Elagolix
恶拉戈利,NBI-56418 |
GNRH Receptor | GPCR/G Protein |
(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。 | |||
T39229 |
YNT-185
|
OX Receptor | GPCR/G Protein; Neuroscience |
YNT-185 是一种非肽类、选择性的俄睾丸激素2型受体(OX2R)激动剂,对 OX2 R和 OX1R 的 EC50 值分别为 0.028 μM 和 2.75 μM。此外,YNT-185 在小鼠模型中有效缓解了嗜睡症-猝倒症的症状。 | |||
T6825 |
Eltrombopag Olamine
Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR |
Thrombin | Proteases/Proteasome |
Eltrombopag Olamine (Eltrombopag diethanolamine salt) 是 Eltrombopag 的口服活性乙醇胺盐,是一种血小板生成素(TPO)受体激动剂,用于血小板减少的某些病症研究。 | |||
T2531L |
Eprosartan
KF-108566J free base,Teveten |
RAAS | Endocrinology/Hormones |
Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂,对AT1受体亚型具有高亲和力,可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用,在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。 | |||
T29177 |
YM 218
YM218,YM-218 |
||
YM 218 is a novel, potent, selective antagonist of nonpeptide vasopressin V1A receptor. | |||
T70225 |
L-159884
|
||
L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging | |||
T29234 |
ZM 253270
ZM253270,ZM-253270 |
||
ZM 253270 is an nonpeptide neurokinin A antagonist. | |||
T27940 |
LY301875
LY 301875,LY-301875 |
||
LY301875 is an antagonist of nonpeptide angiotensin receptor. | |||
T70137 | CAM 4515 | ||
CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist. | |||
T70136 |
CAM 4750
|
||
CAM 4750 is a nonpeptide tachykinin NK1 receptor antagonist. | |||
T12331 |
OT-R antagonist 2
Oxytocin receptor antagonist 2 |
Others | Others |
OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R . | |||
T28322 |
PD 123177
PD-123177,PD123177,Exp-655,Exp655,Exp 655 |
||
PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2. | |||
T70272 |
L-162782
|
||
L-162782 is a nonpeptide agonist of angiotensin AT1 receptor. | |||
T69097 | ARD-353 | ||
ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects. | |||
T16895 |
SL910102
|
Others | Others |
SL910102 is a nonpeptide angiotensin antagonist of the AT1 receptor. | |||
T25895 |
NVP-SAA164
SAA 164,SAA164,SAA-164,NVP SAA164 |
||
NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent. | |||
T28813 |
SM19712 sodium
SM 19712,SM19712,SM-19712 |
||
SM19712 sodium is an inhibitor of nonpeptide endothelin converting enzyme. | |||
T28814 |
SM19712 free acid
SM 19712,SM-19712,SM19712 |
||
SM19712 free acid is an inhibitor of nonpeptide endothelin converting enzyme. | |||
T68486 |
Fasitibant
|
||
Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist. | |||
T16935 | SR 146131 | Others | Others |
SR 146131 is a potent and selective agonist of the nonpeptide receptor. | |||
T11862 |
LMD-009
|
Others | Others |
LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 nonpeptide agonist. | |||
T16085 |
MK-0429
L-000845704 |
Others | Others |
MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM). | |||
T25608 |
Lamifiban trifluoroacetate
Lamifiban trifluoroacetate salt |
||
Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa). | |||
T70295 |
MDL-105212A HCl
|
||
MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist. | |||
T14354 | AVE 0991 sodium salt | Others | Others |
AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes, with IC50 of 21±35 nM. AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. | |||
T3178 | BIBS 39 | RAAS | Endocrinology/Hormones |
BIBS 39是新型的非肽类血管紧张素II(AII)受体拮抗剂。 | |||
T61079 |
RXFP3 agonist 1
|
||
RXFP3 agonist 1 是一种非肽的RXFP3激动剂 (EC50=6937 nM)。 | |||
T25607 |
Lamifiban
Ro-44-9883/000,Ro 44-9883/000,Ro44-9883/000 |
||
Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass. | |||
T70658 |
Ici D8731
|
||
Ici D8731 is a nonpeptide angiotensin II antagonist with potential as a treatment for hypertension and heart failure. | |||
T11856 |
LIT-001 free base
|
Others | Others |
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). | |||
T36481 | BIIE 0246 hydrochloride | ||
Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo. | |||
T16772 |
Ro 64-6198
|
Others | Others |
Ro 64-6198 is a nonpeptide, high-affinity, and brain penetration N/OFQ receptor (NOP) agonist (EC50: 25.6 nM). Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. | |||
T16358 |
NTRC-824
|
Others | Others |
NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4954L |
Smilagenin
PYM50028,Cogane,AI3-44895,PYM 50028 |
||
Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease. |