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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10860	Col003	HSP	Cytoskeletal Signaling; Metabolism
	Col003 是一种选择性和有效的 Hsp47 抑制剂，可竞争性结合 Hsp47 上的胶原蛋白结合位点，IC50为1.8 μM。它通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌，可用于肺纤维化的相关研究。
T38155	N-Acetyl-D-cysteine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	N-Acetyl-D-cysteine 具有抗氧化活性，机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。
T7726	Triadimefon	Antifungal	Microbiology/Virology
	Triadimefon 是一种三唑类杀菌剂，可抑制羊毛甾醇 14α-去甲基化酶，干扰真菌麦角甾醇生物合成途径的氧化去甲基化反应，并可阻断赤霉素的生物合成。用于防治白粉病。
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T0890	Mefenamic acid CN-35355,CI 473,甲芬那酸,甲灭酸	COX	Immunology/Inflammation; Neuroscience
	Mefenamic acid (CN-35355) 是一种非甾体抗炎剂，可竞争性抑制hCOX-1和hCOX-2，IC50值分别为 40 nM 和 3 μM。
T33272	Mefenidil McN-2378,McN 2378	Others	Others
	Mefenidil (McN-2378) 是一种选择性脑血管扩张剂，在狗麻醉模型中显示出在不刺激 O2 摄取的情况下增加健康大脑中的 CBF。
T1444	Lomefloxacin 洛美沙星,SC47111A	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Lomefloxacin (SC47111A) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。
T0860L	Mefloquine Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998	Others	Others
	Mefloquine (Ro 215998) 是一种喹啉抗疟药，是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂，IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T7593	Levomefolate calcium 左旋甲状腺素钙,L-5-甲基四氢叶酸钙	Antifolate	Cell Cycle/Checkpoint
	Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式，是膳食补充剂中生物利用度更高的替代品。
T1625	Lomefloxacin hydrochloride Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。
T11991	Mefentrifluconazole	P450; Antifungal	Metabolism; Microbiology/Virology
	Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂，但对人芳香酶的抑制活性较低，IC50值为0.92 μM。它是一种新型唑类衍生物，用作农用广谱抗真菌剂。
T0273	Mefexamide 美非沙胺盐酸盐,Mefaxadyne,美非沙胺,Timodyne,Mefexamide hydrochloride	Others	Others
	Mefexamide hydrochloride 是一种特殊的精神刺激剂。
T0860	Mefloquine hydrochloride Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹	Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB
	Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药，是抗 SARS-CoV-2进入抑制剂，可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂，IC50约为 1 μM。
T32705	Levomefolate magnesium L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th
T21110	Mefenacet
	Mefenacet is an herbicide for rice.
T33277	Mefway F-18 18F-Mefway
	Mefway F-18 is a PET radioligand specific to serotonin-1A receptors.
T38763	Mefenpyr-diethyl
	Mefenpyr-diethyl is an herbicide safener, which protects crops against herbicide injury.
T33275	Mefox (6RS)-Mefox
	Mefox is a bioactive chemical.
T70785	Mefuparib Free Base
	Mefuparib Free Base is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively. Mefuparib (CVL218), has been shown to have promising antiviral activity against the virus that causes COVID-19.
T33274	Mefeserpine Mefeserpinum,Mefeserpina
	Mefeserpine is a biochemical.
T27401	Garomefrine HCl PNO-49B,NS-49,ABT-232,ABT232,NS49,PNO49B
	Garomefrine HCl, a α1A-adrenoceptor agonist, is potential for the treatment of urinary incontinence.
T75689	Mumefural
	Mumefural，Prunus mumeSieb 加工果实中的一种生物活性成分，具有抑制血小板聚集、显示抗血栓作用及改善认知障碍的功能。
T31484	Dimefuron Pradone plus,Pradone TS,RP 23465,Vt 2809,Pradone kombi,恶唑隆	Others	Others
	Dimefuron (Vt 2809) 是一种苯基脲类化合物，具有杀虫活性，也可用作除草剂。
T32706	Levomefolate calcium pentahydrate
	Levomefolate calcium pentahydrate is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12. Levomefolate is included in formulations of certain oral contraceptives to ens
T19275	Desbutyl Lumefantrine D9 Desbutyl-benflumetol D9	Others	Others
	Desbutyl Lumefantrine D9, a deuterium-labeled metabolite of Lumefantrine, exhibits the incorporation of deuterium atoms.
T29314	Lumefantrine Impurity A 2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)-
	2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)- is a bioactive chemical.
T20971	Mefluidide VEL3973,VEL-3973,VEL 3973,MBR 12325
	Mefluidide is a biochemical.
T11992	Mefuparib hydrochloride MPH	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively.
T7593L	Levomefolate sodium L 5 MTHF sodium,L-5-MTHF sodium,L5MTHF sodium,
	Levomefolate calcium is a primary biologically active form of folate used at the cellular level for dna reproduction, the cysteine cycle and the regulation of homocysteine
T33276	Mefruside FDA1902,FDA-1902,FDA 1902,FBA-1500,FBA1500,FBA 1500
	Mefruside is a diuretic indicated for the treatment of edema and hypertension.
T63214	Lomefloxacin (aspartate)
	Lomefloxacin (SC47111A) aspartate 是广谱的喹诺酮类抗菌剂，能够用于呼吸道感染、胃肠道感染、泌尿生殖系统感染、耳鼻喉感染等疾病的研究。
T21352	Salmefamol AHR-3929,AHR3929,AHR 3929
	Salmefamol is a beta-adrenergic agonist. It may also be used as a bronchodilator.
T31374	Demethylchlordimeform Demethylchlorphenamidine
	Demethylchlordimeform is a biochemiacl.
T10999	Desbutyl Lumefantrine Desbutyl-benflumetol	Others	Others
	Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.
T11891	Lumefantrine-d18 Benflumetol D18,苯芴醇 D18,Lumefantrine D18	Others	Others
	Lumefantrine D18 is an antimalarial drug, and is the deuterium labeled Lumefantrine.
T36935	PKUMDL-LC-101-D04 GPX4-Activator-1d4,PKUMDL-LC-101-D04	GPX	oxidation-reduction
	PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4（GPX4）的异位激活剂，是一种铁死亡的调节剂。当在无细胞试验中使用浓度为20 μM 时，GPX4活性增加到对照水平的150%；在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时，GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04（200 μM）能减少胆固醇过氧化氢诱导的MEF 死亡。
T78170	Kras4B G12D-IN-1	Ras	GPCR/G Protein; MAPK
	Kras4B G12D-IN-1为Kras4B G12D的抑制剂，表现出抗癌活性。在降低Kras4B G12D表达的小鼠胚胎成纤维细胞(MEF)中减少Kras蛋白水平。
T82108	ICMT-IN-35
	ICMT-IN-35（即compound 10n），作为FTPA-triazole类ICMT抑制剂（IC50=0.8 μM），能被哺乳动物细胞吸收并阻断K-Ras膜定位，进而诱导K-Ras错定位。ICMT-IN-35对ICMT+/+MEF细胞表现出选择性细胞毒性，对转移性胰腺癌细胞系展示低微摩尔级别活性（IC50=0.8 μM）。
T69403	AZD-3409
	AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. The mean IC(50) for cytotoxicity of AZD3409 was 510 in MEF cells, 10,600 in A549 cells and 6,170 in MCF7 cells, respectively. In these cells, the IC(50) for FTase activity of AZD3409 ranged from 3.0 to 14.2 nM and of lonafarnib from 0.26 to 31.3 nM. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. Both inhibition of farnesylation and geranylgeranylation could not be corre...
T69195	UC-857993
	UC-857993 是一种选择性SOS1-Ras 抑制剂 (Kd=14.7 μM, His6-SOS1cat)，抑制其催化活性。UC-857993 还能抑制ERK 和Ras 激活，抑制小鼠胚胎成纤维细胞 (MEF) 的生长。

化合物

Cat.No: T10860

Target: HSP

N-Acetyl-D-cysteine

Cat.No: T38155

Target: Reactive Oxygen Species

Cat.No: T7726

Target: Antifungal

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Mefenamic acid

Cat.No: T0890

Synonym: CN-35355,CI 473,甲芬那酸,甲灭酸

Target: COX

Cat.No: T33272

Synonym: McN-2378,McN 2378

Target: Others

Cat.No: T1444

Synonym: 洛美沙星,SC47111A

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T0860L

Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Target: Others

Levomefolate calcium

Cat.No: T7593

Synonym: 左旋甲状腺素钙,L-5-甲基四氢叶酸钙

Target: Antifolate

Lomefloxacin hydrochloride

Cat.No: T1625

Synonym: Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin

Target: Topoisomerase, Antibacterial, Antibiotic

Mefentrifluconazole

Cat.No: T11991

Target: P450, Antifungal

Cat.No: T0273

Synonym: 美非沙胺盐酸盐,Mefaxadyne,美非沙胺,Timodyne,Mefexamide hydrochloride

Target: Others

Mefloquine hydrochloride

Cat.No: T0860

Synonym: Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹

Target: Potassium Channel, SARS-CoV, Reactive Oxygen Species, Parasite, Autophagy

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

Cat.No: T21110

Cat.No: T33277

Synonym: 18F-Mefway

Mefenpyr-diethyl

Cat.No: T38763

Cat.No: T33275

Synonym: (6RS)-Mefox

Mefuparib Free Base

Cat.No: T70785

Cat.No: T33274

Synonym: Mefeserpinum,Mefeserpina

Garomefrine HCl

Cat.No: T27401

Synonym: PNO-49B,NS-49,ABT-232,ABT232,NS49,PNO49B

Cat.No: T75689

Cat.No: T31484

Synonym: Pradone plus,Pradone TS,RP 23465,Vt 2809,Pradone kombi,恶唑隆

Target: Others

Levomefolate calcium pentahydrate

Cat.No: T32706

Desbutyl Lumefantrine D9

Cat.No: T19275

Synonym: Desbutyl-benflumetol D9

Target: Others

Lumefantrine Impurity A

Cat.No: T29314

Synonym: 2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)-

Cat.No: T20971

Synonym: VEL3973,VEL-3973,VEL 3973,MBR 12325

Mefuparib hydrochloride

Cat.No: T11992

Synonym: MPH

Target: PARP

Levomefolate sodium

Cat.No: T7593L

Synonym: L 5 MTHF sodium,L-5-MTHF sodium,L5MTHF sodium,

Cat.No: T33276

Synonym: FDA1902,FDA-1902,FDA 1902,FBA-1500,FBA1500,FBA 1500

Lomefloxacin (aspartate)

Cat.No: T63214

Cat.No: T21352

Synonym: AHR-3929,AHR3929,AHR 3929

Demethylchlordimeform

Cat.No: T31374

Synonym: Demethylchlorphenamidine

Desbutyl Lumefantrine

Cat.No: T10999

Synonym: Desbutyl-benflumetol

Target: Others

Lumefantrine-d18

Cat.No: T11891

Synonym: Benflumetol D18,苯芴醇 D18,Lumefantrine D18

Target: Others

PKUMDL-LC-101-D04

Cat.No: T36935

Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04

Target: GPX

Kras4B G12D-IN-1

Cat.No: T78170

Target: Ras

Cat.No: T82108

Cat.No: T69403

Cat.No: T69195

Cat. No.	Product Name	Target	Signaling Pathways
T7094	Levomefolic Acid L-5-甲基四氢叶酸,5-MTHF,5-甲基四氢叶酸	Reactive Oxygen Species; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB
	Levomefolic Acid (5-MTHF) 是一种具有口服活性、可穿过血脑屏障的天然活性叶酸，是广泛使用的叶酸食品补充剂。

天然产物

Levomefolic Acid

Cat.No: T7094

Synonym: L-5-甲基四氢叶酸,5-MTHF,5-甲基四氢叶酸

Target: Reactive Oxygen Species, Endogenous Metabolite

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