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Mefenidil

产品编号 T33272 CAS 58261-91-9

别名: McN-2378, McN 2378

Mefenidil (McN-2378) 是一种选择性脑血管扩张剂，在狗麻醉模型中显示出在不刺激 O2 摄取的情况下增加健康大脑中的 CBF。

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Mefenidil, CAS 58261-91-9

规格	价格/CNY	货期
1 mg	￥ 2,350	现货
5 mg	￥ 5,630	现货
10 mg	￥ 7,790	现货
25 mg	￥ 11,200	现货
50 mg	￥ 13,800	现货
100 mg	￥ 17,500	现货
500 mg	￥ 34,800	现货

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选择批次

纯度: 98.17%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.

体内活性

Mefenidil (0.025, 0.25, and 2.5 mg/min/kg; i.v. infusion for 10 min; dogs) decreased systemic vascular resistance at 0.25 mg/min/kg without a change in CBF. At the highest infusion rate, CBF increased by 54 +/- 15% (+/- S.E.; n = 9) accompanied by a 9-mm Hg rise in intracranial pressure and a 14-mm Hg fall in mean aortic pressure. However, cardiac output increased by 68 +/- 8%, which was distributed primarily to right ventricle (541 +/- 95%), left ventricle (488 +/- 109%), small intestine (136 +/- 31%) and large intestine (57 +/- 15%). Within the brain, the thalamic and brainstem regions had larger increases in blood flow than the cerebellum and cerebrum. The caudate nucleus had a greater percentage of response than white matter. Using the cerebral venous outflow technique in another series of seven dogs, mefenidil (40-mg/kg i.v. bolus) produced a 20 +/- 8% increase in CBF with no change in O2 uptake. These data show that mefenidil is capable of increasing CBF in healthy brains without stimulating O2 uptake. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in the heart and gut.[1]

别名	McN-2378, McN 2378
分子量	197.24
分子式	C12H11N3
CAS No.	58261-91-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (253.5 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.07 mL	25.3498 mL	50.6997 mL	126.7491 mL
	5 mM	1.014 mL	5.07 mL	10.1399 mL	25.3498 mL
	10 mM	0.507 mL	2.535 mL	5.07 mL	12.6749 mL
	20 mM	0.2535 mL	1.2675 mL	2.535 mL	6.3375 mL
	50 mM	0.1014 mL	0.507 mL	1.014 mL	2.535 mL
	100 mM	0.0507 mL	0.2535 mL	0.507 mL	1.2675 mL

计算器

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参考文献

1. Koehler RC, et al. Effect of mefenidil on cerebral and peripheral hemodynamics in dogs. J Pharmacol Exp Ther. 1985 May;233(2):327-32. 2. Flaim SF, et al. Effects of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat. Pharmacology. 1986;33(3):167-80.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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