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代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
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类药性化合物库 多样性核心库Part2 多样性核心库Part1 药物靶点库 多样性核心预制库 Golden骨架库 Mini骨架库 化合物库深度定制
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基于表型筛选实体化合物活性筛选 细胞增殖检测 细胞周期检测 细胞凋亡检测 药代动力学研究
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细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体
CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白
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Search Results for " mdk "
Targets Recommended: Autophagy

41

抑制剂 & 化合物

8

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T28001 MDK-6983

MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

 Autophagy Autophagy
MDK-6983 (MDK-6983) 是一种自噬抑制剂，可破坏人黑色素瘤细胞中肌动蛋白细胞骨架的动力学。
T19765 MDK-4025

Calcium Channel Membrane transporter/Ion channel; Metabolism
MDK-4025 是锥体神经元中高压激活 (HVA) Ca2+ 电流的抑制剂。
T5310 TR-14035

MDK-1191

 Integrin Cytoskeletal Signaling
TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂，对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM，可用于炎症和自体免疫疾病的研究。
T25779 MDK-4683

MDK 4683,CA IX/XII Inhibitor
MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T33261 MDK-5432

AMPA stabilizer (R,R)-2a,MDK 5432
MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.
T25780 MDK-4823

LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in obesity.
T27998 MDK-4204

Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I
MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.
T27997 MDK-3345

MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T5093 Pim1/AKK1-IN-1

LKB1/AAK1 dual inhibitor,MDK-2275

 Pim; Hippo pathway Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) 是多种酶抑制剂，能够作用于Pim1、AKK1、MST2 和 LKB1，Kd 值分别为 35、53、75 和 380 nM，还抑制 MPSK1 和 TNIK。
T9033 BTYNB

MDK6620,BTYNB IMP1 Inhibitor

 Others; c-Myc; NF-κB Cell Cycle/Checkpoint; NF-κB; Others
BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂，IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能，可用于癌症研究。
T8412 (S,R,S)-AHPC

VH032-NH2,MDK7526,VHL ligand 1

 Others; Ligand for E3 Ligase Others; PROTAC
(S,R,S)-AHPC (VH032-NH2) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T27991 MDK-0757

Hsp90-IN-89,MDK0757
MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).
T27995 MDK-3046

HK-inhibitor-2,MDK3046,HK inhibitor 2
MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T27990 MDK-0738

AKR1C3-IN-14a,AKR1C3 IN 14a
MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
T27999 MDK-4624

AMPKα1 activator C13,C13, Compound 13
MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation
T27994 MDK-2959

PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2
MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).
T27996 MDK-3298

Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T27992 MDK08445

MDK-08445,MDK 08445
MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.
T28000 MDK49781

MDK-49781,MDK 49781
MDK49781 is a useful chemical intermediate for drug synthesis.
T28004 MDK8228

PF-CBP/BRD4,MDK-8228,MDK 8228
MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.
T1772 MDK83190

Apoptosis Activator 2

 Apoptosis; Caspase Apoptosis; Proteases/Proteasome
MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂，可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。
T28002 MDK71803

MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803
MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.
T24438 MDK5466

MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
T70601 MDK03855

MDK03855, also known as A2AR antagonist 19, is an adenosine A2A receptor (A2AR) antagonist. MDK03855 has CAS#1454903-85-5. The last five digit of CAS# was used for name.
T70141 MDK80908

MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.
T70069 MDK6465

MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name.
T28003 MDK7677

Cathepsin B Inhinitor-17,MDK 7677
MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T69916 MDK3673

MDK3673, also known as Olfr895-Agonist-10, is a novel specific agonist of odorant receptor 895 (Olfr895).
T9460 iMDK

PI3K PI3K/Akt/mTOR signaling
iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。
T16529 BEBT-908

PI3Kα inhibitor 1,MDK9521

 PI3K; HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
BEBT-908 (PI3Kα inhibitor 1) 是一种选择性的PI3Kα抑制剂(IC50<0.1 μM)，也抑制 HDAC (0.1 μM≤IC50≤1 μM)。
T27989 MDK0734

Cathepsin B Inhinitor-42
MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T70599 Asem F-18

Asem F-18 is a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET .
T69915 GX-585

GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.
T70068 AT-1015 hydrochloride monohydrate

AT-1015 hydrochloride monohydrate is a serotonin (5-HT)2 receptor antagonist that blocks vascular and platelet 5-HT2A receptors.
T68559 OUN58101

OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-​protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T3190 PIK-inhibitors

MDK34597

 PI3K PI3K/Akt/mTOR signaling
PIK-inhibitors (MDK34597) 是一种泛 PI3K 抑制剂，是 PI-103 的类似物。
T70140 D 22888

D 22888 is a PDE4 inhibitor.
T4198 T.cruzi-IN-1

MDK1088,T.cruzi Inhibitor

 Antibiotic; Parasite Microbiology/Virology
T.cruzi-IN-1 (MDK1088) 是一种克氏锥虫抑制剂，IC50为 8 nM。它是一种 4-三氟甲基取代的类似物，有潜力治疗南美锥虫病的急性和慢性阶段。
T24439 MDK6204

CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2
MDK6204 is a selective inhibitor of CLK1 and CLK2.
T61627 iMDK quarterhydrate

iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC without causing harm to normal cells and mice [1].
T7082 HDAC8-IN-1

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
HDAC8-IN-1 是一种 HDAC8 抑制剂，在癌细胞系中的 IC50 为 27.2 nM，有抗增殖作用。

化合物

MDK-6983
Cat.No: T28001
Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983
Target: Autophagy
MDK-4025
Cat.No: T19765
Synonym:
Target: Calcium Channel
TR-14035
Cat.No: T5310
Synonym: MDK-1191
Target: Integrin
MDK-4683
Cat.No: T25779
Synonym: MDK 4683,CA IX/XII Inhibitor
Target:
MDK-5432
Cat.No: T33261
Synonym: AMPA stabilizer (R,R)-2a,MDK 5432
Target:
MDK-4823
Cat.No: T25780
Synonym: LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
Target:
MDK-4204
Cat.No: T27998
Synonym: Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I
Target:
MDK-3345
Cat.No: T27997
Synonym: MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
Target:
Pim1/AKK1-IN-1
Cat.No: T5093
Synonym: LKB1/AAK1 dual inhibitor,MDK-2275
Target: Pim, Hippo pathway
BTYNB
Cat.No: T9033
Synonym: MDK6620,BTYNB IMP1 Inhibitor
Target: Others, c-Myc, NF-κB
(S,R,S)-AHPC
Cat.No: T8412
Synonym: VH032-NH2,MDK7526,VHL ligand 1
Target: Others, Ligand for E3 Ligase
MDK-0757
Cat.No: T27991
Synonym: Hsp90-IN-89,MDK0757
Target:
MDK-3046
Cat.No: T27995
Synonym: HK-inhibitor-2,MDK3046,HK inhibitor 2
Target:
MDK-0738
Cat.No: T27990
Synonym: AKR1C3-IN-14a,AKR1C3 IN 14a
Target:
MDK-4624
Cat.No: T27999
Synonym: AMPKα1 activator C13,C13, Compound 13
Target:
MDK-2959
Cat.No: T27994
Synonym: PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2
Target:
MDK-3298
Cat.No: T27996
Synonym: Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
Target:
MDK08445
Cat.No: T27992
Synonym: MDK-08445,MDK 08445
Target:
MDK49781
Cat.No: T28000
Synonym: MDK-49781,MDK 49781
Target:
MDK8228
Cat.No: T28004
Synonym: PF-CBP/BRD4,MDK-8228,MDK 8228
Target:
MDK83190
Cat.No: T1772
Synonym: Apoptosis Activator 2
Target: Apoptosis, Caspase
MDK71803
Cat.No: T28002
Synonym: MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803
Target:
MDK5466
Cat.No: T24438
Synonym: MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
Target:
MDK03855
Cat.No: T70601
Synonym:
Target:
MDK80908
Cat.No: T70141
Synonym:
Target:
MDK6465
Cat.No: T70069
Synonym:
Target:
MDK7677
Cat.No: T28003
Synonym: Cathepsin B Inhinitor-17,MDK 7677
Target:
MDK3673
Cat.No: T69916
Synonym:
Target:
iMDK
Cat.No: T9460
Synonym:
Target: PI3K
BEBT-908
Cat.No: T16529
Synonym: PI3Kα inhibitor 1,MDK9521
Target: PI3K, HDAC
MDK0734
Cat.No: T27989
Synonym: Cathepsin B Inhinitor-42
Target:
Asem F-18
Cat.No: T70599
Synonym:
Target:
GX-585
Cat.No: T69915
Synonym:
Target:
AT-1015 hydrochloride monohydrate
Cat.No: T70068
Synonym:
Target:
OUN58101
Cat.No: T68559
Synonym:
Target:
PIK-inhibitors
Cat.No: T3190
Synonym: MDK34597
Target: PI3K
D 22888
Cat.No: T70140
Synonym:
Target:
T.cruzi-IN-1
Cat.No: T4198
Synonym: MDK1088,T.cruzi Inhibitor
Target: Antibiotic, Parasite
MDK6204
Cat.No: T24439
Synonym: CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2
Target:
iMDK quarterhydrate
Cat.No: T61627
Synonym:
Target:
HDAC8-IN-1
Cat.No: T7082
Synonym:
Target: HDAC
Species：
Human (4)
Mouse (4)
Expression System：
HEK293 Cells (4)
E. coli (3)
Baculovirus Insect Cells (1)
Tag：
His (2)
N-His-Avi (2)
C-His (1)
N-His (1)
Tag Free (1)
hFc (1)
Cat. No. Product Name Species Expression System
TMPK-00024 Midkine Protein, Human, Recombinant (His & Avi), Biotinylated

MK1,MK,MDK,NEGF2,MKARAP,MEK,ARAP

 Human E. coli
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu...
TMPK-00023 Midkine Protein, Human, Recombinant (His & Avi)

MDK,MEK,MK1,MKARAP,ARAP,MK,NEGF2

 Human E. coli
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu...
TMPK-00812 Midkine Protein, Mouse, Recombinant (His)

MK1,ARAP,MKARAP,MEK,MK,NEGF2,MDK

 Mouse E. coli
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Mo...
TMPY-01786 EphB4 Protein, Mouse, Recombinant (hFc)

MDK2,Htk,Myk1,AI042935,Tyro11,EPH receptor B4

 Mouse HEK293 Cells
EphB4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.7 kDa and the accession number is P54761-1.
TMPY-01787 EphB4 Protein, Mouse, Recombinant (His)

Myk1,Htk,Tyro11,MDK2,AI042935,EPH receptor B4

 Mouse HEK293 Cells
EphB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P54761-1.
TMPY-01784 EphB3 Protein, Mouse, Recombinant (His)

MDK5,Tyro6,Etk2,HEK2,EPH receptor B3,Cek10,Sek4,AW4...

 Mouse HEK293 Cells
EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754.
TMPK-00898 EphB3 Protein, Human, Recombinant (His)

EC 2.7.10.1,EPHB3,ETK2,EK2,HEK2,AW456895,Sek4,MDK5,...

 Human HEK293 Cells
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC.
TMPY-02172 Midkine Protein, Human, Recombinant

midkine (neurite growth-promoting factor 2),NEGF2,MK,ARAP

 Human Baculovirus Insect Cells
Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angio...

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Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
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Species: Human
Expression System: E. coli
Midkine Protein, Human, Recombinant (His & Avi)
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Species: Human
Expression System: E. coli
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Species: Mouse
Expression System: E. coli
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Species: Mouse
Expression System: HEK293 Cells
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Species: Mouse
Expression System: HEK293 Cells
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Species: Mouse
Expression System: HEK293 Cells
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Cat.No: TMPK-00898
Species: Human
Expression System: HEK293 Cells
Midkine Protein, Human, Recombinant
Cat.No: TMPY-02172
Species: Human
Expression System: Baculovirus Insect Cells
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