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Search Results for " leishmania "

59

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2331	Leishmania peptide 183 Peptide 183,p183,Leishmania
	Leishmania peptide 183 is an antigen.
T12909	SID 26681509	Cysteine Protease; Parasite	Microbiology/Virology; Proteases/Proteasome
	SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。
T62330	Antileishmanial agent-12
	Antileishmanial agent-12 (compound 5a) 是一种有效的抗利什曼原虫剂，对 Leishmania brazilensis (IC50: 14.9 μM)、Leishmania infantum (IC50: 21.3 μM) 和 T. cruzi (IC50: 9.3 μM) 具有抗原虫作用。
T63281	Antileishmanial agent-11
	Antileishmanial agent-11 是有效的抗利什曼原虫剂，能够作用于 Leishmania brazilensis (IC50: 28.3 μM)、Leishmania infantum (IC50: 24.8 μM) 和T. cruzi(IC50: 13.0 μM) 具有出抗原虫作用。
T61391	Antileishmanial agent-3
	Antileishmanial agent-3 (Compound 13) 是一种很有前景的Leishmania major 的生长抑制剂。
T78963	Antileishmanial agent-16	Parasite	Microbiology/Virology
	Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂，表现出针对Leishmaniamajor前鞭毛体的高效活性（IC50=0.59 µM）以及对Leishmaniamajor无鞭毛体的有效活性（IC50=0.81 µM）。此外，Antileishmanial agent-16对哺乳动物细胞（VERO 细胞）的毒性低，说明其具有较好的安全性。
T61710	Antileishmanial agent-7
	Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1].
T61416	Antileishmanial agent-9
	Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity in L-6 cells, with an IC50 value of 40.1 μM [1].
T62574	Antileishmanial agent-6
	Antileishmanial agent-6 是一种有效的抗利什曼虫剂。Antileishmanial agent-6 对Leishmania donovani 和 L-6 具有抗利什曼虫活性 (IC50: 0.54 μM) 和细胞毒性 (IC50: 10.2 μM) 作用。
T78680	Antileishmanial agent-14	Parasite	Microbiology/Virology
	Antileishmanial agent-14，一种磺胺类类似物，展现了对Leishmaniadonovani promastigotes的潜在活性(IC50=4.1 μM)。该化合物同时对L. donovani amastigotes的感染也具有抑制作用(IC50=11.1 μM)。
T79471	Antileishmanial agent-20	Parasite	Microbiology/Virology
	Antileishmanial agent-20 显示对利什曼原虫的选择性抑制作用，其针对L. infantum和L. braziliensis的IC50值分别为2.8 μM 和0.2 μM，适用于寄生虫研究领域。
T60638	Antileishmanial agent-8
	Antileishmanial agent-8 (compound 18) 对杜氏利什曼原虫 (L. donovani) 显示出有效的和选择性的杀伤活性(IC50 = 5.64 μM)，并且对 L-6 细胞显示相对较低的细胞毒性 (IC50=73.9 μM)。
T72260	Antileishmanial agent-13
	Antileishmanial agent-13 是一种喹啉-靛蓝杂交物，可作为抗利什曼病试剂，抑制L. MajorLeishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用，IC50分别为 0.604 μM 和 0.508 μM。
T79390	Antileishmanial agent-23	Parasite	Microbiology/Virology
	Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著，展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。
T79632	Antileishmanial agent-21	Parasite	Microbiology/Virology
	Antileishmanial agent-21 (compound 4e)，是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用，且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9)，IC50 范围为0.0198-0.096 μM。
T79449	Antileishmanial agent-19	Parasite	Microbiology/Virology
	Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂，其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶，并干预宿主PI3K/Akt/CREB轴，从而抑制IL-10的分泌。此外，Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程，并在感染的动物体内显著减少寄生虫负担。
T79633	Antileishmanial agent-22	Parasite	Microbiology/Virology
	Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物，展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫（IC50=0.408 μM）。在100 μM浓度时，Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内，以48.4 μM/kg/day剂量对伯氏疟原虫展示96.67%的抑制效果；在体外，其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌，MIC值为28.44 μM。
T79419	Antileishmanial agent-24	Parasite	Microbiology/Virology
	Antileishmanial agent-24 (compound 33) Exhibiting an IC50 of 5.39 μM against the amastigote form.
T40117	Antileishmanial agent-1
	Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).
T62210	Antileishmanial agent-10
	Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。
T61100	Antileishmanial agent-4
	Antileishmanial agent-4 是一种核糖核苷类似物，作为抗黑热病试剂。
T83045	Antileishmanial agent-25	Parasite	Microbiology/Virology
	Antileishmanial agent-25（compound 24）展现了对胞内无尾线虫的选择性抗力士曼体活性，其半抑制浓度（IC50）为6.63 μM。
T61560	Antileishmanial agent-5
	Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T78962	Antileishmanial agent-15	Parasite	Microbiology/Virology
	Antileishmanial agent-15 (compound 13c) 是针对L. major前鞭毛体和无鞭毛体的高效抗利什曼原虫分子，展现出显著的抗原虫活性和细胞毒性，其IC50值分别为0.78 μM和0.99 μM。
T78964	Antileishmanial agent-17	Parasite	Microbiology/Virology
	Antileishmanial agent-17是香豆素杂化化合物，展现出优越的抗利什曼原虫活性(IC50<0.78 μM)，同时对VERO细胞具备安全性。该化合物通过抑制叶酸代谢途径发挥效用，且在对抗利什曼原虫不同生长阶段表现显著，其IC50值分别对前鞭毛体为0.40 μM，对无鞭毛体为0.68 μM。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T60531	2'-C-Methyladenosine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	2'-C-Methyladenosine 是丙型肝炎病毒(HCV)复制的抑制剂，分离自肾棒状杆菌。2'-C-Methyladenosine 抑制 HCV 复制子和 NS5B 催化的 RNA 合成，IC50值分别为 0.3 μM 和 1.9 μM。2'-C-Methyladenosine 还对Leishmania guyanensis (Lgy)和Leishmania braziliensis中的 LRV1有抑制作用。
T1654	Pentamidine isethionate Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine isethionate (Pentamidine diisethionate) 是抗微生物剂，会干扰 DNA 的生物合成。它抑制寄生虫Leishmania infantum，IC50为 2.5 μM。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它有抗肿瘤和抗菌活性。
T60092	CHEMBL1276927 N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide,N-[3-(1H-苯并[d]咪唑-2-基)苯基]-3-甲基苯甲酰胺	Antibacterial; Parasite	Microbiology/Virology
	CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) 对肺炎衣原体和多诺瓦尼利什曼原虫具有抗菌和抗寄生虫活性。
T15095	Dehydroemetine	Others; Parasite	Microbiology/Virology; Others
	Dehydroemetine 是一种有效的抗原虫剂，是二盐酸艾美汀的合成类似物，可用于预防和治疗阿米巴感染和疾病，具有治疗伴有皮肤损伤的利什曼原虫感染和耐甲硝唑阿米巴病的作用。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T68109	Moxipraquine	Antibiotic	Microbiology/Virology
	Moxipraquine 是一种新型的8-氨基喹诺酮类化合物，对克氏锥虫具有抗感染活性。Moxipraquine 能有效抑制寄生虫血症，但不能根除小鼠或豚鼠的感染。Moxipraquine 对重度利什曼原虫、墨西哥乳杆菌和巴西乳杆菌的实验性感染有效，但对巴西乳杆菌无效。
T2112	Fexinidazole 非昔硝唑,HOE 239	Others; Parasite	Microbiology/Virology; Others
	Fexinidazole (HOE 239) 是具有口服活性的硝基咪唑抗锥虫药物。它显示出对布鲁氏杆菌亚种和菌株的杀锥虫活性，IC50值为 0.7-3.3 μM (0.2-0.9 μg/ml)。它具有用于因感染布鲁氏菌引起的人类昏睡病的潜力。
T15546	ICA N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine	Potassium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) 是有效的 SK 通道抑制剂。ICA 显示出抗利什曼原虫的活性，IC50为2.1 µM。
T23133	Pentamidine	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine 是抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T15110	DHQZ 36	Others	Others
	DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).
T69511	Diospyrin
	Diospyrin is a plant product that has significant inhibitory effect on the growth of Leishmania donovani promastigotes.
T20303	Dibenzalacetone AI3-00896,AI3 00896,AI300896
	Dibenzylideneacetone is a synthetic curcumin analog. It leads to apoptotic cell death in Leishmania donovani.
T40652	Meclizine Meclozine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meclizine (Meclozine) (Meclozine)具有抗组胺作用，可可逆地抑制组胺与H1受体的相互作用。Meclizine 是哌嗪类H1拮抗剂的一个成员。Meclizine 是一种有效的抗运动病剂。Meclizine 可通过血脑屏障。Meclizine 是小鼠组成型雄烷受体(CAR)的激动剂配体，也是人CAR 的反向激动剂。Meclizine 可用于polyQ 毒性疾病的研究，如亨廷顿病。
T61245	Antiparasitic agent-7
	Antiparasitic agent-7 (compound 5d) displays specific antiparasitic activity against Leishmania infantum (L. infantum), exhibiting an IC50 value of 2.85 μM. Additionally, Antiparasitic agent-7 demonstrates cytotoxicity against HepG2 cells with a CC50 value of 10.61 μM [1].
T69891	CGP 40215
	CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes
T16546	PK 11195 RP 52028	Others	Others
	PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively).
T61364	LmCPB-IN-1
	LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1].
T72925	Naloxonazine
	Naloxonazine为高效选择性μ-1阿片类拮抗剂，亦可通过调控宿主编码功能作用于利什曼原虫。
T61641	Antiparasitic agent-5
	Antiparasitic agent-5 (compound 8h) exhibits potent selectivity as an antiparasitic agent against Leishmania infantum (L. infantum), with an IC50 value of 2.50 μM. Additionally, this compound displays cytotoxic effects on HepG2 cells with a CC50 value of 6.78 μM [1].
T83025	Antiparasitic agent-19
	Antiparasitic agent-19 (compound 40) 是一种化合物，具备广泛的抗寄生虫活性，且对布氏锥虫、婴儿利什曼原虫和克氏锥虫具有较低的毒性。
T80648	Eugenitin	Parasite	Microbiology/Virology
	Eugenitin，一种可从南美药用植物中的真菌Mycoleptodiscus indicus分离的聚酮化合物，对大利士曼原虫（Leishmania major）具有抑制作用，LD50为39.9 μM。该化合物对多种人癌细胞系表现出较低的细胞毒性（IC50 >131 μM）。
T63831	SID 26681509 quarterhydrate
	SID 26681509 quarterhydrate 是可逆的、有效的、选择性的、竞争性的人组织蛋白酶 L (human cathepsin L) 抑制剂 (IC50: 56 nM)。SID 26681509 quarterhydrate 能够抑制Plasmodium falciparum 的体外繁殖 (IC50: 15.4 μM)，并抑制Leishmania major (IC50: 12.5 μM)，且不抑制组织蛋白酶 G 的活性。
T74932	Trypanothione synthetase-IN-1
	Trypanothione synthetase-IN-1 (Compound 1) 为一竞争性婴儿利什曼虫锥体胱甘肽合成酶(TryS)抑制剂，以三胺亚精胺为多胺S时，IC50值为14.8 μM。
T61001	Antiparasitic agent-6
	Antiparasitic agent-6 (compound 5b) 对婴儿利什曼原虫表现出选择性抗寄生活性 (IC50 = 3.89 μM)。Antiparasitic agent-6 还对 HepG2 细胞表现出一定的细胞毒性，CC50值为 13.64 μM。

化合物

Leishmania peptide 183

Cat.No: TP2331

Synonym: Peptide 183,p183,Leishmania

Cat.No: T12909

Target: Cysteine Protease, Parasite

Antileishmanial agent-12

Cat.No: T62330

Antileishmanial agent-11

Cat.No: T63281

Antileishmanial agent-3

Cat.No: T61391

Antileishmanial agent-16

Cat.No: T78963

Target: Parasite

Antileishmanial agent-7

Cat.No: T61710

Antileishmanial agent-9

Cat.No: T61416

Antileishmanial agent-6

Cat.No: T62574

Antileishmanial agent-14

Cat.No: T78680

Target: Parasite

Antileishmanial agent-20

Cat.No: T79471

Target: Parasite

Antileishmanial agent-8

Cat.No: T60638

Antileishmanial agent-13

Cat.No: T72260

Antileishmanial agent-23

Cat.No: T79390

Target: Parasite

Antileishmanial agent-21

Cat.No: T79632

Target: Parasite

Antileishmanial agent-19

Cat.No: T79449

Target: Parasite

Antileishmanial agent-22

Cat.No: T79633

Target: Parasite

Antileishmanial agent-24

Cat.No: T79419

Target: Parasite

Antileishmanial agent-1

Cat.No: T40117

Antileishmanial agent-10

Cat.No: T62210

Antileishmanial agent-4

Cat.No: T61100

Antileishmanial agent-25

Cat.No: T83045

Target: Parasite

Antileishmanial agent-5

Cat.No: T61560

Antileishmanial agent-15

Cat.No: T78962

Target: Parasite

Antileishmanial agent-17

Cat.No: T78964

Target: Parasite

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

2'-C-Methyladenosine

Cat.No: T60531

Target: HCV Protease

Pentamidine isethionate

Cat.No: T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T60092

Synonym: N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide,N-[3-(1H-苯并[d]咪唑-2-基)苯基]-3-甲基苯甲酰胺

Target: Antibacterial, Parasite

Cat.No: T15095

Target: Others, Parasite

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

Cat.No: T68109

Target: Antibiotic

Cat.No: T2112

Synonym: 非昔硝唑,HOE 239

Target: Others, Parasite

Cat.No: T15546

Synonym: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine

Target: Potassium Channel, Parasite

Cat.No: T23133

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T15110

Target: Others

Cat.No: T69511

Dibenzalacetone

Cat.No: T20303

Synonym: AI3-00896,AI3 00896,AI300896

Cat.No: T40652

Synonym: Meclozine

Target: Histamine Receptor

Antiparasitic agent-7

Cat.No: T61245

Cat.No: T69891

Cat.No: T16546

Synonym: RP 52028

Target: Others

Cat.No: T61364

Cat.No: T72925

Antiparasitic agent-5

Cat.No: T61641

Antiparasitic agent-19

Cat.No: T83025

Cat.No: T80648

Target: Parasite

SID 26681509 quarterhydrate

Cat.No: T63831

Trypanothione synthetase-IN-1

Cat.No: T74932

Antiparasitic agent-6

Cat.No: T61001

Cat. No.	Product Name	Target	Signaling Pathways
TN1961	Myricetin 3-O-glucoside Myricetin 3-O-beta-D-glucopyranoside	Immunology/Inflammation related	Immunology/Inflammation
	Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) 是一种从Tibouchina paratropica 提取的黄酮醇。Myricetin 3-O-glucoside 具有很多活性，包括抗利什曼原虫、抗炎和抗菌活性。
T4861	trans-Aconitic acid	ATPase; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	trans-Aconitic acid 是反式丙酮酸2-甲基转移酶的底物，存在于正常人尿液中，大量存在于 Reye 综合征和有机酸尿症。
TN2101	Primin	Antifection	Microbiology/Virology
	Primin 是存在于 Primula obconica 叶和茎毛状体中的天然产物，显示出抗菌和抗癌活性。
TN5092	Tagitinin F	Antifection	Microbiology/Virology
	Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
T19876	Simiarenol UNII-6OU4M247SJ,Simiaren-3beta-ol,beta-Simiarenol
	Simiarenol may have leishmanicidal activity against Leishmania donovani promastigotes in vitro.
TN5872	Phebalosin Alosin
	Phebalosin displays 50% effective concentrations (EC(50)) of 14.1 microg/mL against axenic amastigote forms of Leishmania panamensis. It also displays cytotoxicity (IC(50)) at concentrations of 20.7 microg/mL on human promonocytic U-937 cells.
TN4653	Niazinin	Antifection	Microbiology/Virology
	Niazinin shows antileishmanial activity against promastigotes of Leishmania donavani, with an IC50 value of 5.25 microM.
TN2697	2,3-Dihydrohinokiflavone	MMP; Parasite; Antifection	Microbiology/Virology; Proteases/Proteasome
	2,3-Dihydrohinokiflavone 是基质金属蛋白酶 (MMP) 基因表达的抑制剂，对利什曼原虫具有很强的活性，IC50 为 1.6 μM。
TN4733	Pancixanthone A 胡桐，海棠木	Antifection	Microbiology/Virology
	Pancixanthone A may have antimalarial activity, it also shows a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.
TN3721	Cryptofolione	Antifection	Microbiology/Virology
	Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp.
T72234	3β-Hydroxy-hop-22(29)-ene
	3β-Hydroxy-hop-22(29)-ene 是一种有效的抗寄生虫剂 (antiparasiticagent)。3β-Hydroxy-hop-22(29)-ene 对克氏锥虫和墨西哥利什曼原虫具有一定的抑制活性。
T73949	Isatropolone A
	Isatropolone A，一种含有1,5-二酮部分的天然产物，源自链霉菌Gö66。该化合物在抑制利什曼原虫(Leishmaniadonovani)方面表现出良好的活性，IC50值为0.5 μM。
TN4683	Nyasol	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly
TN4778	Physalin H	gp120/CD4; Antifection; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both

天然产物

Myricetin 3-O-glucoside

Cat.No: TN1961

Synonym: Myricetin 3-O-beta-D-glucopyranoside

Target: Immunology/Inflammation related

trans-Aconitic acid

Cat.No: T4861

Target: ATPase, Endogenous Metabolite

Cat.No: TN2101

Target: Antifection

Cat.No: TN5092

Target: Antifection

Cat.No: T19876

Synonym: UNII-6OU4M247SJ,Simiaren-3beta-ol,beta-Simiarenol

Cat.No: TN5872

Synonym: Alosin

Cat.No: TN4653

Target: Antifection

2,3-Dihydrohinokiflavone

Cat.No: TN2697

Target: MMP, Parasite, Antifection

Pancixanthone A

Cat.No: TN4733

Synonym: 胡桐，海棠木

Target: Antifection

Cat.No: TN3721

Target: Antifection

3β-Hydroxy-hop-22(29)-ene

Cat.No: T72234

Cat.No: T73949

Cat.No: TN4683

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

Cat.No: TN4778

Target: gp120/CD4, Antifection, Autophagy

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