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37

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40115	GAD65 (206-220) GAD65 (206-220)
	GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus.
T2200	Hydroxyzine dihydrochloride Hydroxyzine 2HCl,盐酸羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) 是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T8318	BNC210 H-Ile-Trp-OH,IW-2143	AChR	Neuroscience
	BNC210 (IW-2143) 是一种α7 nAChR 负变构调节剂，在焦虑和抑郁动物模型中有活性。
T82354	GAD65 (524-543)
	GAD65 (524-543) 是具有生物活性的肽，属于谷氨酸脱羧酶 65 (GAD65) 氨基酸片段 524-543。作为胰岛抗原的关键片段之一，该肽在自发性自身免疫性糖尿病非肥胖糖尿病 (NOD) 小鼠模型中，可诱导增殖性 T 细胞反应。GAD65 (524-543) 对T细胞克隆BDC2.5具有特异性刺激作用，但可能存在亲和力较低的问题。此外，p524-543免疫可增强NOD小鼠对通过BDC2.5 T细胞过继转移诱导的1型糖尿病的敏感性。
T80218	GAD65(247-266) epitope TFA	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	GAD65(247-266) epitope TFA 为T细胞表位，与I-Ag7（I型糖尿病相关分子）竞争性结合，亲和力较低。该表位源自胰岛抗原，GAD65 是谷氨酸脱羧酶 65，涉及将谷氨酸转换为γ-氨基丁酸（GABA）。
T5161	Gadodiamide	Others	Others
	Gadodiamide 是一种含钆造影剂，可用于医学成像。
T13111	Tegadifur 40497S,FD 1	Others	Others
	Tegadifur (40497S) 是一种可口服的抗肿瘤化合物，具有抗新陈代谢作用，常与尿嘧啶林和治疗直肠腺癌。
T8406	Gadobutrol ZK 135079,钆布醇	Others	Others
	Gadobutrol 是一种非离子的顺磁造影剂，可用于磁共振成象（MRI）。
T15367	Gadoxetate Disodium Gd-EOB-DTPA Disodium,钆塞酸二钠,ZK 139834	Others	Others
	Gadoxetate Disodium 是一种肝胆系统中磁共振成像 (MRI) 中的造影剂，能够在正常的功能性肝细胞中累积，可用于局灶性肝脏病变（如肝细胞癌或 T1 加权成像的肝转移）的研究。
T22795	Gadolinium chloride	CaSR	GPCR/G Protein
	Gadolinium chloride 是特殊的钙敏感受体激动剂，可用于研究心血管疾病。
T4506	Gadopentetate dimeglumine Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt	Others	Others
	Gadopentetate dimeglumine (Gd-DTPA) 可用于核磁共振成像 (MRI) 中，使血管、器官和其他非骨组织能够更清晰地被看到。
T19333	Gadoteridol ProHance,SQ-32692,钆特醇,Gd-HP-DO3A	Others	Others
	Gadoteridol (Gd-HP-DO3A) 是含钆基的 MRI 造影剂，可用于中枢神经系统成像。
T19332	Gadopentetic acid gadolinium complex,钆喷酸,Gd-DTPA	Others	Others
	Gadopentetic acid (gadolinium complex) 是一种顺磁性造影剂，通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。
T2671	Regadenoson CVT-3146,瑞加德松,Lexiscan	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。
T8406L	Gadobutrol Monohydrate Gd-DO3A-butrol
	Gadobutrol is a medicinal product used in diagnostic magnetic resonance imaging (MRI) in adults and children. It provides contrast enhancement during cranial, spinal, breast, or other investigations. In the central nervous system, Gadobutrol works by high
T78094	Eglumegad hydrochloride LY354740 hydrochloride,Eglumetad hydrochloride
	Eglumegad (LY354740) hydrochloride是一种高效且选择性的group II (mGlu2/3) receptor激动剂，其对人mGlu2和mGlu3受体的IC50值分别是5和24 nM。该化合物能够保护神经元不受NMDA毒性影响，并表现出抗焦虑及抗精神病样作用。
T82353	GADGVGKSA
	GADGVGKSA, 作为KRAS G12D 9mer肽的变体，充当免疫原性新抗原，在癌症免疫疗法研究中具有潜在应用价值。
T70255	Elapegademase
	Elapegademase is an Adenosine Deaminase Inhibitor
T13160	Timegadine 替美加定,SR1368	COX	Immunology/Inflammation; Neuroscience
	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
TP1460	NH2-KLGADTDGEQDQHMTYGGQ-COOH
	NH2-QGGYTMHQDQEGDTDAGLK-COOH is a synthetic peptide chain consisting of a primary amine group attached to lysine and a carboxyl group attached to glutamine.
T82352	GADGVGKSAL
	GADGVGKSAL为KRAS G12D突变型10mer肽，具有免疫原性，常用作癌症免疫疗法研究中的新型抗原。
T33487	Motexafin gadolinium PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3
	Motexafin gadolinium, also known as PCI 0120, is a synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating rea
T6508	Gadodiamide Hydrate Omniscan,钆双胺	Others	Others
	Gadodiamide Hydrate (Omniscan) 是一种造影剂，用于MR 中血管成像。它是非离子 Gd3+ 螯合物，经常静脉注射。进入磁共振成像以增强对比度。
T77294	1-epi-Regadenoson
	1-epi-Regadenoson为Regadenoson的α异构体杂质，后者是具有高选择性的腺苷A2A受体(adenosine A2A receptor)拮抗剂。
T76261	Argadin
	Argadin 是一种环五肽几丁质酶抑制剂。Argadin 抑制几丁质酶 B (ChiB)，Ki 值为 20 nM。Argadin 可用于杀菌剂和杀虫剂的研究。
T37904	Gadoleic Acid
	Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of ...
T38213	1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
	1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher'...
T15817	Eglumegad Eglumetad,LY354740	Others	Others
	Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).
T66961	Gadolinium(III) chloride hexahydrate
	Gadolinium(III) chloride hexahydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66961，CAS号为 13450-84-5。
T26054	Regadenoson hydrate Regadenoson,CVT3146,CVT 3146,Lexiscan,CVT-3146
	Regadenoson is an A2A adenosine receptor agonist, a coronary vasodilator commonly used in pharmacologic stress testing.
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T2132	Buspirone hydrochloride Buspirone HCl,盐酸丁螺环酮,Narol,Buspar	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Buspirone hydrochloride (Buspar) 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。
T37190	L-Allylglycine	Dehydrogenase; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。
T5884	Chelidamic acid 4-氧代-1,4-二氢-2,6-吡啶二甲酸,白屈氨酸	GluR	Neuroscience
	Chelidamic acid 是一种有效的谷氨酸脱羧酶抑制剂(Ki:33 μM)，也是含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。
T22509	3-Methyl-GABA	Others	Others
	3-Methyl-GABA 是一种有效的GABA 氨基转移酶激活剂。3-Methyl-GABA 能与 GABAA 受体 (GABAaR) 结合。3-Methyl-GABA 能够激活 L-谷氨酸脱羧酶 (GAD)，表现出抗惊厥作用。
T11113	Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride	Others	Others
	Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].

化合物

GAD65 (206-220)

Cat.No: T40115

Synonym: GAD65 (206-220)

Hydroxyzine dihydrochloride

Cat.No: T2200

Synonym: Hydroxyzine 2HCl,盐酸羟嗪

Target: Histamine Receptor

Cat.No: T8318

Synonym: H-Ile-Trp-OH,IW-2143

Target: AChR

GAD65 (524-543)

Cat.No: T82354

GAD65(247-266) epitope TFA

Cat.No: T80218

Target: GABA Receptor

Cat.No: T5161

Target: Others

Cat.No: T13111

Synonym: 40497S,FD 1

Target: Others

Cat.No: T8406

Synonym: ZK 135079,钆布醇

Target: Others

Gadoxetate Disodium

Cat.No: T15367

Synonym: Gd-EOB-DTPA Disodium,钆塞酸二钠,ZK 139834

Target: Others

Gadolinium chloride

Cat.No: T22795

Target: CaSR

Gadopentetate dimeglumine

Cat.No: T4506

Synonym: Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt

Target: Others

Cat.No: T19333

Synonym: ProHance,SQ-32692,钆特醇,Gd-HP-DO3A

Target: Others

Gadopentetic acid

Cat.No: T19332

Synonym: gadolinium complex,钆喷酸,Gd-DTPA

Target: Others

Cat.No: T2671

Synonym: CVT-3146,瑞加德松,Lexiscan

Target: Adenosine Receptor

Gadobutrol Monohydrate

Cat.No: T8406L

Synonym: Gd-DO3A-butrol

Eglumegad hydrochloride

Cat.No: T78094

Synonym: LY354740 hydrochloride,Eglumetad hydrochloride

Cat.No: T82353

Cat.No: T70255

Cat.No: T13160

Synonym: 替美加定,SR1368

Target: COX

NH2-KLGADTDGEQDQHMTYGGQ-COOH

Cat.No: TP1460

Cat.No: T82352

Motexafin gadolinium

Cat.No: T33487

Synonym: PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3

Gadodiamide Hydrate

Cat.No: T6508

Synonym: Omniscan,钆双胺

Target: Others

1-epi-Regadenoson

Cat.No: T77294

Cat.No: T76261

Gadoleic Acid

Cat.No: T37904

1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))

Cat.No: T38213

Synonym: 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))

Cat.No: T15817

Synonym: Eglumetad,LY354740

Target: Others

Gadolinium(III) chloride hexahydrate

Cat.No: T66961

Regadenoson hydrate

Cat.No: T26054

Synonym: Regadenoson,CVT3146,CVT 3146,Lexiscan,CVT-3146

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Buspirone hydrochloride

Cat.No: T2132

Synonym: Buspirone HCl,盐酸丁螺环酮,Narol,Buspar

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T37190

Target: Dehydrogenase, GABA Receptor

Chelidamic acid

Cat.No: T5884

Synonym: 4-氧代-1,4-二氢-2,6-吡啶二甲酸,白屈氨酸

Target: GluR

Cat.No: T22509

Target: Others

Duloxetine D3 hydrochloride

Cat.No: T11113

Synonym: (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride

Target: Others

Cat.No: T61376

Cat. No.	Product Name	Target	Signaling Pathways
T20884	Hydroxyzine Hydroxyzine free base,羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine (Hydroxyzine free base) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。
T0508	γ-Aminobutyric acid Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质，能够与离子移变 GABA 受体(GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。
T4913	Maleic acid	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	Maleic Acid 是大肠杆菌和单核细胞增生李斯特菌的谷氨酸脱羧酶抑制剂。
T5739	Paederosidic acid 鸡屎藤苷酸,异戊二酸紫草酸	Apoptosis; BCL	Apoptosis
	Paederosidic acid 是从鸡矢藤分离出的一种天然产物，通过诱导线粒体介导的凋亡抑制肺癌细胞，具有显着的抗肿瘤、抗惊厥和镇静作用。
T5558	Chelidonic acid Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质，用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂，Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。

天然产物

Cat.No: T20884

Synonym: Hydroxyzine free base,羟嗪

Target: Histamine Receptor

γ-Aminobutyric acid

Cat.No: T0508

Synonym: Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid

Target: GABA Receptor, Endogenous Metabolite

Cat.No: T4913

Target: Endogenous Metabolite, Antibacterial

Paederosidic acid

Cat.No: T5739

Synonym: 鸡屎藤苷酸,异戊二酸紫草酸

Target: Apoptosis, BCL

Chelidonic acid

Cat.No: T5558

Synonym: Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

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