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5
Cat. No. | Product Name | Target | Signaling Pathways |
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T0984 |
5-Fluorouracil
5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶 |
Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; DNA/RNA Synthesis; Endogenous Metabolite | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome |
5-Fluorouracil (5-FU) 是一种尿嘧啶类似物,一种 DNA 合成抑制剂。5-Fluorouracil 具有抗肿瘤活性,通过抑制胸苷酸合成酶影响嘧啶的合成。5-Fluorouracil 可以引起细胞凋亡和自噬。 | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
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5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | |||
T0964 |
Floxuridine
氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640 |
Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Floxuridine (FUDR) 是一种嘧啶类似物,也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶,导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂 ,具有抗HSV 和CMV 病毒的作用。 | |||
T36870 |
5,6-dihydro-5-Fluorouracil
5-fluorodihydrouracil,5-Fluoro-dihydro-pyrimidine-2,4-dione |
Others | Others |
5,6-dihydro-5-Fluorouracil (5-FUH2)是 5-FU 的无活性代谢产物,可用于用于研究机体代谢。 | |||
T10013 |
1-Acetyl-3-o-toluyl-5-fluorouracil
A-OT-Fu |
Others | Others |
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent. | |||
T7614 |
Eniluracil
GW776C85,5-Ethynyluracil |
Others | Others |
Eniluracil (GW776C85) 是不可逆的二氢嘧啶脱氢酶(DPD)抑制剂,是一种尿嘧啶类似物,能够使 5-FU 的口服生物利用度提高到 100%,促进均匀吸收和可预测的毒性。 | |||
TNU1053 |
5-Fluorouracil-1-yl acetic acid
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5-Fluorouracil-1-yl acetic acid is a PNA-related Derivative. | |||
TNU1481 |
1-(b-D-Xylofuranosyl)-5-fluorouracil
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1-(b-D-Xylofuranosyl)-5-fluorouracil is a Nucleoside Derivative - Xylo-nucleoside, Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside. | |||
T1307 |
Carmofur
HCFU,卡莫氟 |
Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物,是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂,用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶,还抑制 Vero E6 细胞 SARS-CoV-2,EC50为 24.3 μM。 | |||
TNU1052 |
5-Fluorouracil-1-yl acetic acid methyl ester
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5-Fluorouracil-1-yl acetic acid methyl ester is a PNA-related Derivative. | |||
T33762 |
Fosifloxuridine nafalbenamide
NUC-3373,NUC3373,NUC 3373 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Fosifloxuridine nafalbenamide (NUC 3373) 是一种胸腺嘧啶合酶抑制剂,属于嘧啶核苷酸类似物,具有抗癌活性。它能诱发宿主免疫反应,有潜力增强免疫治疗。 | |||
T1378 |
Tegafur
Fluorafur,替加氟,FT-207,NSC 148958,FT 207 |
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Tegafur (FT 207) 是一种前药,在肝脏中被细胞色素 P-450 酶逐渐转化为氟尿嘧啶。它是抗代谢物氟尿嘧啶的同源物,具有抗肿瘤活性。 | |||
T27342L |
Flurocitabine HCl
Flurocitabine HCl(37717-21-8 Free base) |
Others | Others |
Flurocitabine HCl 是阿糖胞苷的氟化酸酐类似物,在体内部分水解成两种活性抗肿瘤物质 (阿拉伯糖基-氟尿嘧啶 (ara-FC) 和阿拉伯糖基-氟尿嘧啶 (ara-FU))。Flurocitabine HCl 在急性白血病和实体瘤的 I 期研究中具显示出抗肿瘤活性。 | |||
T27259 |
Emitefur
BOFA2,BOF A2,BOF-A2 |
Others | Others |
Emitefur (BOF-A 2)是一种有口服活性和有效性的 5-氟尿嘧啶衍生物,具有抗癌和抗肿瘤活性。Emitefur 可用于研究晚期胃癌、乳腺癌和代谢相关疾病。 | |||
T1349 |
5-Fluorouridine
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Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
5-Fluorouridine 是一种 5-fluorouracil 的代谢物,具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用,其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。 | |||
T9936 |
ZX-J-19J
N-(2,3-Diphenyl-6-quinoxalinyl)octanamide |
Others | Others |
ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide) 是 Cyclophilin J 的抑制剂,对肿瘤细胞生长有显着的抑制作用,与环孢素 A 相当,但比 5-氟尿嘧啶强得多。 | |||
T1408 |
Capecitabine
Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978 |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Capecitabine (Capecitibine) 是一种可口服的前药,可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。 | |||
T1600 |
Doxifluridine
Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷 |
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂,对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。 | |||
T4374 |
Edoxudine
依度尿苷,Aedurid,EUDR,Epoxudine,乙去氧尿啶 |
Antiviral; Antibacterial | Immunology/Inflammation; Microbiology/Virology |
Edoxudine (Epoxudine) 是胸苷的类似物,是一种抗病毒药物,对单纯疱疹病毒有效。 | |||
T21327 |
Uridine triacetate
RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate |
Others | Others |
Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收,在循环中迅速脱乙酰,生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性,或早发性心脏或中枢神经系统 (CNS) 毒性。 | |||
T33686 |
Nitrocaphane
AT 1258,AT-1258,AT1258 |
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Nitrocaphane, in combination with 5-FU (fluorouracil), chemotherapy is considered as a protocol of choice in the treatment of malignant trophoblastic tumor. | |||
T28831 |
Sparfosate sodium
CI882,CI-882,CI 882 |
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Sparfosate is a 5-fluorouracil biomodulator. | |||
T68906 | Miliusol | ||
Miliusol is a natural anti-tumor agent, demonstrating with tumor inhibitory efficacy comparable or even superior to the mainstay chemotherapeutics paclitaxel or fluorouracil. | |||
T40932 |
Benzylacyclouridine
5-Benzylacyclouridine,BAU |
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Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives. | |||
T31837 |
FOLFIRI Regimen
FOLFIRI |
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FOLFIRI Regimen is a chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used during the treatment of advanced-stage and metastatic colorectal cancer. | |||
T21315 |
Folitixorin
ANX-510 |
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ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituen | |||
T74046 |
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine
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D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine,即1-磷酸核糖,作为核苷酸合成的关键中间体,在5-氟尿嘧啶(FUra)的磷酸化过程中,被尿苷磷酸化酶催化转化为核苷。 | |||
T72991 | Bis-Pro-5FU | ||
Bis-Pro-5FU 是一种 5-FU 前体,可增强5-氟尿嘧啶 (5-FU) 的口服生物利用度并提高其疗效。5-FU 是一种抗肿瘤抗代谢物,广泛用于结直肠癌和胰腺癌的研究。 | |||
T63074 | Ivaltinostat formic | ||
Ivaltinostat (CG-200745) formic 是一种口服具有活力的泛 HDAC 抑制剂,具有异羟肟酸部分,能够在催化袋底部结合锌。Ivaltinostat formic 对组蛋白 H3 和微管蛋白的脱乙酰作用具有抑制效果。Ivaltinostat formic 能够促使 p53 的积累,诱导 p53 依赖性反式激活,并提高 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。Ivaltinostat formic 增加 Gemcitabine 耐药细胞对 Gemcitabine 和 5-Fluorouracil (5-FU) 的敏感性。Ivaltinostat formic 诱导凋亡,并具有抗肿瘤效果。 | |||
T36385 |
Ansatrienin A
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Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl... | |||
T35439 |
(E)-5-(2-Bromovinyl)uracil
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(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time. | |||
T36650 |
Ansatrienin B
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Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul... | |||
T83881 |
4-(3,4-Difluorobenzo)curcumin
CDF |
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4-(3,4-Difluorobenzo)curcumin(CDF)是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量(EC50s分别为0.8和0.37 µM)。CDF(4和8 µM)通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。 | |||
T36424 |
DSPE-PEG(2000)-amine (sodium salt)
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DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-cont... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6431 |
Levoleucovorin Calcium
左亚叶酸钙,Calcium Levofolinate,CL307782 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。 | |||
T4720 |
6-Hydroxypyridin-2(1H)-one hydrochloride
2,6-二羟基吡啶盐酸盐,2,6-Dihydroxypyridine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) 是内源性代谢产物的一种。 | |||
T4919 |
Ureidopropionic acid
Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid |
Endogenous Metabolite | Metabolism |
Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说,它是二氢尿嘧啶的分解产物,由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN3152 |
6-Acetonyldihydrochelerythrine
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ERK; BCL; Akt; HIV Protease; PPAR; p53 | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is |