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5,6-dihydro-5-Fluorouracil

产品编号 T36870 CAS 696-06-0

别名: 5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione

5,6-dihydro-5-Fluorouracil (5-FUH2)是 5-FU 的无活性代谢产物，可用于用于研究机体代谢。

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5,6-dihydro-5-Fluorouracil Chemical Structure

5,6-dihydro-5-Fluorouracil, CAS 696-06-0

规格	价格/CNY	货期
5 mg	￥ 1,550	35日内发货
10 mg	￥ 2,950	35日内发货
25 mg	￥ 6,860	35日内发货
50 mg	￥ 13,200	35日内发货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.
靶点活性	MDA-MB-231 cells:0.25 μg/mL
体外活性	The combination of 5,6-dihydro-5-Fluorouracil (5-Fu) and NSC 123127 (Dox) demonstrates synergistic anticancer efficacy. The IC50 values for 5-Fu/Dox-DNM against human breast cancer (MDA-MB-231) cells are 0.25 μg/mL, with cytotoxicity increasing by 11.2-fold and 6.1-fold for Dox-DNM and 5-Fu-DNM, respectively [4]. In NFBD1-inhibited NPC cells treated with 5,6-dihydro-5-Fluorouracil (5-FU) and CDDP, lentivirus-mediated short hairpin RNA depletion of NFBD1 expression in NPC CNE1 cell line enhances sensitivity. Knockdown of NFBD1 significantly induces apoptosis in CNE1 cells treated with CDDP or 5,6-dihydro-5-Fluorouracil [2].
体内活性	Administered at a dose of 23 mg/kg three times a week for 14 days, 5,6-dihydro-5-Fluorouracil(5-FU) induces gastrointestinal transit acceleration associated with acute intestinal inflammation starting on the third day of treatment. This may lead to sustained changes in the enteric nervous system (ENS) observed beyond the 7th day, and the 14-day treatment results in delayed gastrointestinal transit and colonic motility disorders [1].

别名	5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione
分子量	132.09
分子式	C4H5FN2O2
CAS No.	696-06-0

存储

store at low temperature　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 43 mg/mL(325.53 mM), Sonication is recommended.

PBS (pH 7.2): 8 mg/mL

Ethanol: 0.8 mg/mL

DMF: 60 mg/mL

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	7.5706 mL	37.853 mL	75.706 mL	189.2649 mL
	5 mM	1.5141 mL	7.5706 mL	15.1412 mL	37.853 mL
	10 mM	0.7571 mL	3.7853 mL	7.5706 mL	18.9265 mL
	20 mM	0.3785 mL	1.8926 mL	3.7853 mL	9.4632 mL
	50 mM	0.1514 mL	0.7571 mL	1.5141 mL	3.7853 mL
	100 mM	0.0757 mL	0.3785 mL	0.7571 mL	1.8926 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. 2. Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to NSC 119875 or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. 3. Jones DH, et al. Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients. Dermatol Surg. 2019 Jul;45(7):941-948. 4. Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and NSC 123127 for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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