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44

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4197	HZ-1157 HZ1157,DHFR-inhibitor	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HZ-1157 (DHFR-inhibitor) 是一种丙型肝炎病毒抑制剂，对 HCV NS3/4A 蛋白酶具有抑制活性。
T9618	HeE1-2Tyr	SARS-CoV	Microbiology/Virology
	HeE1-2Tyr 是一种pyridobenzothiazole，抑制黄病毒 RNA 依赖性 RNA 聚合酶。HeE1-2Tyr 在体外对Dengue, West Nile 和 SARS-CoV-2 RdRps 有显著的抑制活性(IC50为 27.6 µM) 。
T23004	ML-SA1 Mucolipin synthetic agonist 1	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	ML-SA1 (Mucolipin synthetic agonist 1) 是一种选择性的TRPML 激动剂，通过促进溶酶体的酸化和蛋白酶活性抑制登格病毒 2 和寨卡病毒，抗 DENV2 RNA 和 ZIKV RNA 的IC50分别为 8.3 μM 和 52.99 μM。ML SA1可诱发自噬。ML SA1可用于广谱抗病毒研究。
T11760	KIN101 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene,3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯	HCV Protease; Influenza Virus; RSV; Antifection	Microbiology/Virology; Proteases/Proteasome
	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene) 是 IRF-3 依赖性信号传导的异黄酮激动剂，可诱导 IRF-3 核易位。它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。
T13397	ZINC03129319	Virus Protease	Microbiology/Virology
	ZINC03129319 是有效的登革病毒 NS2B-NS3蛋白酶抑制剂，抑制常数 Ki1和 Ki3分别为 92 μM 和 20 μM。
T64091	(-)-JNJ-A07	Others	Others
	(-)-JNJ-A07 是一种具有选择性和高效性的登革热病毒 (DENV) 抑制剂（EC50:31 nM),具有抗病毒活性，可用于研究登革热病毒感染。
T8886	NITD-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂，可抑制 DENV RdRp 介导的 RNA 延伸。
T16325	NITD008 7-Deaza-2'-C-acetylene-adenosine	Others	Others
	NITD008 (7-Deaza-2'-C-acetylene-adenosine) 是一种有效的和选择性的腺苷核苷抑制剂，是一种腺苷核苷类似物，具有广谱的抗病毒活性，抑制登革热病毒、动物杯状病毒和寨卡病毒。
T63143	DENV-IN-5	Virus Protease; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	DENV-IN-5 是一种有效且具有选择性的登革热病毒 (DENV) 抑制剂，对 DENV-I ∼ IV 的 EC50 值分别为 1.47、9.23、7.08、8.91 μM，对HIV-1IIIB 的EC50 为 0.1512 μM。
T16914	SP187 UV4,MON-DNJ	Others; Virus Protease; Influenza Virus	Microbiology/Virology; Others
	SP187 (MON-DNJ) 是一种靶向作用于宿主的亚氨基糖。它具有抗丝状病毒感染活性。SP187可用于治疗抗流感和登革热病毒。
T16702	QL47	Virus Protease; BTK	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	QL47 是一种宿主靶向的小分子抗病毒剂，具有抗病毒活性，对登革热病毒和其他 RNA 病毒有抑制作用。QL47 可作为病毒翻译的抑制抑制剂和 BTK 的共价抑制剂，可用于研究淋巴瘤。
T17190	U18666A	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	U18666A 是一种细胞渗透性药物，是一种胆固醇合成和转运抑制剂，抑制埃博拉病毒，登革热病毒和人类丙型肝炎病毒的复制。
T38960	QL-X-138	Virus Protease; MNK; BTK	Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors
	QL-X-138 是一种强效的选择性 BTK和 MNK 双激酶抑制剂，与 BTK 具有共价结合，与 MNK 具有非共价结合。QL-X-138 对 BTK、MNK1 和 MNK2 激酶的 IC 50 s 分别为 9.4 nM、107.4 nM 和 26 nM。QL-X-138 对登革病毒 2 具有抑制作用，其 IC 50 为 3.5 μM。QL-X-138 可用于 B 细胞恶性肿瘤的研究。
T76856	Andecaliximab GS-5745	MMP; Virus Protease	Microbiology/Virology; Proteases/Proteasome
	Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。
T11281L	FGI-106 tetrahydrochloride	Virus Protease; HCV Protease; Influenza Virus; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	FGI-106 tetrahydrochloride 对多种病毒具有抑制活性，有抗埃博拉病毒，裂谷病毒和登革热病毒的 EC50分别为 100 nM，800 nM 和 400-900 nM，抑制非失血性发热病毒HCV 和HIV-1的EC50分别为 200 nM 和 150 nM 。
T38960L	QL-X-138 HCl QL-X-138 HCl（1469988-63-3 Free base）	MNK; BTK	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	QL-X-138 HCl 是一种新型具有选择性和高效性的 BTK/MNK 双激酶抑制剂，具有抗癌活性，可与 BTK 共价结合，与 MNK 非共价结合。QL-X-138 HCl 对 BTK、MNK1 和 MNK2 激酶有抑制作用。QL-X-138 HCl 具有抗登革热病毒 2 活性，在急性髓系白血病细胞中显示抗增殖活性。QL-X-138 HCl 可用于研究淋巴瘤和白血病。
T25171	BP13944 BP 13944,BP-13944
	BP13944 is used as a potential dengue virus NS2B/NS3 protease inhibitor.
T24432	MB21 MB-21,MB 21
	MB21 is a dengue type 2 protease inhibitor that acts by inhibiting each one of the four serotypes of dengue viruses in infected cells in culture.
T69649	NITD-688
	NITD-688 是一种具有口服活性的登革病毒 (dengue virus)NS4B 蛋白的泛血清型抑制剂。 NITD-688 可用于登革热病毒 (DENV) 的研究。
T69186	CP26
	CP26 is a novel inhibitor of ER-to-cytosol protein dislocation, exhibiting anti-dengue and anti-Zika virus activity.
T73311	DENV-IN-7
	DENV-IN-7，一种黄酮类似物，作为登革病毒(DENV)的抑制剂，显示出70 nM的EC50值。该化合物对正常细胞具有低毒性，并展现了抗登革热的活性。
T71748	RK-0404678
	RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T82172	Hs-1
	Hs-1为具备针对登革热-2病毒80%保护效力的抗菌肽。
T28860	ST-148 ST148
	ST-148 is a potent inhibitor for Dengue virus capsid. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity.
T61703	GAK inhibitor 2
	GAK inhibitor 2 (Compound 14g) is a highly potent inhibitor of cyclin G-associated kinase (GAK) with an IC 50 of 0.024 μM. It exhibits remarkable antiviral activity against dengue virus (DENV), with an EC 50 of 1.049 μM [1].
T39783	DENV-IN-2
	DENV-IN-2 is a highly effective inhibitor of dengue viral replication with a potency indicated by an EC 50 of 0.016 nM. It exhibits significant activity against all four serotypes of the Dengue virus, with EC 50 values ranging from 0.013 to 0.029 nM.
T27498	GSK983 GSK-983,GSK 983
	GSK983, a potent broad-spectrum antiviral, blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH).
T27050	CM-10-18 CM-1018
	CM-10-18 is a potent inhibitor of ER α-glucosidase. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. CM-10-18 efficiently protected the lethality of dengue virus
T37870	Bz-Nle-Lys-Arg-Arg-AMC
	Substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. The kcat/Km value of Bz-NleKRR-AMC for the dengue virus type 4 (DEN4) enzyme is > 800 fold higher than that of Boc-Gly-Arg-Arg-AMC, a widely used NS3 substrate (kcat = 2.9 s 1, Km = 8.6 μM for DEN4). For yellow fever virus NS3 protease the kcat value was 0.111 s 1, the Km value 14.6 μM.
T15554	IHVR-19029	Others	Others
	IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift
T38818	Golgicide A-2 Golgicide A-2,GCA-2
	Golgicide A-2 (GCA-2), a derivative of Golgicide A (GCA), is the highly active enantiomer of GCA. It exhibits exceptional selectivity and efficiency in eradicating An. stephensi larvae, thus making it a valuable tool for researching dengue virus-related diseases.
T64044	SP-471
	SP-471 是登革病毒 (DENV) 蛋白酶的有效抑制剂 (IC50: 18 μM)，对登革病毒的分子间和分子内的蛋白酶过程具有抑制作用。
T11281	FGI-106	Others	Others
	FGI-106 is a potent, broad-spectrum inhibitor demonstrating activity against various viruses, including Ebola, Rift Valley Fever, and Dengue Fever, exhibiting EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. Furthermore, it effectively inhibits non-hemorrhagic fever viruses such as HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively.
T19740	Narasin Monteban,甲基盐霉素,A28086A,A 28086A,A-28086A
	Narasin is a novel agent that inhibits dengue virus replication in vitro through non-cytotoxic mechanisms. It is used for the treatment of coccidiosis from a class of protozoa. It has been shown to foster the apoptosis of tumor cells.
T25611	Lanatoside Lantoside,ABC lanatoside complex
	Lanatoside 是一种 FDA 批准的强心苷，已被确定为候选的抗登革热化合物。它也被发现可以促进脉粥样硬化，还具有抗肿瘤活性，可抑制结直肠癌细胞、肝癌细胞的生长。
T37463	CAY10704
	CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity. CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM).
T70954	SP-187 HCl
	SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium.
T62932	NS2B/NS3-IN-2
	NS2B/NS3-IN-2 是一种有效的、共价的登革病毒 (DENV)NS2B/NS3 抑制剂 (IC50: 6.0 nM，Ki: 0.66 μM)。NS2B/NS3-IN-2 可以明显提高细胞存活率，且没有细胞毒性。
T79141	Mosnodenvir JNJ-1802	Virus Protease	Microbiology/Virology
	Mosnodenvir（JNJ-1802）是一种泛血清型登革热抗病毒药物，表现出较高的耐药性屏障，同时安全性和耐受性均优良。它通过阻断NS3-NS4B相互作用来抑制病毒复制复合体。在小鼠模型中，Mosnodenvir展示了从皮摩尔到低纳摩尔量级的体外抗病毒效能。
T78562	FX-06 Fibrin-derived peptide Bβ15-42
	FX-06 (Fibrin-derived peptide Bβ15-42)为纤维蛋白Bbeta链衍生的肽类化合物。通过与VE-cadherin结合并阻断白细胞的迁移，FX-06激活了以VE-cadherin为中心的信号通路。该化合物主要应用于缺血/再灌注损伤和登革热休克综合征(DSS)的相关研究。
T73420	SP-471P
	SP-471P 是一种高效的登革热病毒 (DENV) 蛋白酶抑制剂，其对 DENV1、DENV2、DENV3 和 DENV4 的抑制半最大有效浓度（EC50）分别为 5.9 μM、1.4 μM、5.1 μM 和 1.7 μM。此化合物的细胞毒性浓度50%（CC50）超过 100 μM。SP-471P 能够有效减少 DENV 的病毒 RNA 合成 (RNA synthesis)。
T78700	DENV-IN-10
	DENV-IN-10为一种有效的四价登革热抑制剂，其对DENV-1-4血清型的EC50值分别为1.36、0.87、0.94和0.95 μM。DENV-IN-10作为后复制阶段的抑制剂，显示对源自灵长类动物细胞的特异性。
T79334	Antiviral agent 36	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Antiviralagent 36 (compound 27) 作为一种抗病毒化合物，对登革热病毒(DENV)和寨卡病毒(ZIKV)展现出高效的抑制作用。通过抑制这两种病毒的复制，Antiviralagent 36 对ZIKV-FLR、ZIKV-HN16、DENV-2和DENV-3的半数抑制浓度(EC50)分别达到100 nM、90 nM、210 nM和120 nM，表明其具有较强的抗病毒活性。
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...

化合物

Cat.No: T4197

Synonym: HZ1157,DHFR-inhibitor

Target: HCV Protease

Cat.No: T9618

Target: SARS-CoV

Cat.No: T23004

Synonym: Mucolipin synthetic agonist 1

Target: Others, TRP/TRPV Channel

Cat.No: T11760

Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene,3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯

Target: HCV Protease, Influenza Virus, RSV, Antifection

Cat.No: T13397

Target: Virus Protease

Cat.No: T64091

Target: Others

Cat.No: T8886

Target: DNA/RNA Synthesis

Cat.No: T16325

Synonym: 7-Deaza-2'-C-acetylene-adenosine

Target: Others

Cat.No: T63143

Target: Virus Protease, HIV Protease

Cat.No: T16914

Synonym: UV4,MON-DNJ

Target: Others, Virus Protease, Influenza Virus

Cat.No: T16702

Target: Virus Protease, BTK

Cat.No: T17190

Target: Others, HCV Protease

Cat.No: T38960

Target: Virus Protease, MNK, BTK

Cat.No: T76856

Synonym: GS-5745

Target: MMP, Virus Protease

FGI-106 tetrahydrochloride

Cat.No: T11281L

Target: Virus Protease, HCV Protease, Influenza Virus, HIV Protease

Cat.No: T38960L

Synonym: QL-X-138 HCl（1469988-63-3 Free base）

Target: MNK, BTK

Cat.No: T25171

Synonym: BP 13944,BP-13944

Cat.No: T24432

Synonym: MB-21,MB 21

Cat.No: T69649

Cat.No: T69186

Cat.No: T73311

Cat.No: T71748

Cat.No: T82172

Cat.No: T28860

Synonym: ST148

GAK inhibitor 2

Cat.No: T61703

Cat.No: T39783

Cat.No: T27498

Synonym: GSK-983,GSK 983

Cat.No: T27050

Synonym: CM-1018

Bz-Nle-Lys-Arg-Arg-AMC

Cat.No: T37870

Cat.No: T15554

Target: Others

Cat.No: T38818

Synonym: Golgicide A-2,GCA-2

Cat.No: T64044

Cat.No: T11281

Target: Others

Cat.No: T19740

Synonym: Monteban,甲基盐霉素,A28086A,A 28086A,A-28086A

Cat.No: T25611

Synonym: Lantoside,ABC lanatoside complex

Cat.No: T37463

Cat.No: T70954

Cat.No: T62932

Cat.No: T79141

Synonym: JNJ-1802

Target: Virus Protease

Cat.No: T78562

Synonym: Fibrin-derived peptide Bβ15-42

Cat.No: T73420

Cat.No: T78700

Antiviral agent 36

Cat.No: T79334

Target: DNA/RNA Synthesis

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Cat. No.	Product Name	Target	Signaling Pathways
TN2027	Oxysanguinarine 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine	Parasite	Microbiology/Virology
	Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T25789	Melianone NSC 302037,NSC-302037,NSC302037
	Melianone exhibits antiviral activity (EC50s: 3-11μM) against three important human pathogens, belonging to the Flaviviridae family, West Nile virus, Dengue virus, and Yellow Fever virus.
T23664	Agathisflavone 6,8'-Biapigenin
	Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.
T15703	Lactimidomycin	Others	Others
	Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i
TN2222	Sotetsuflavone	Others	Others
	Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series.
TN1689	Glabranine 光甘草宁,Glabranin	Antifection	Microbiology/Virology
	Glabranin has antimicrobial activity, it shows significant activities on DPPH free radical with the IC50 value of 240.20 ug/ml. Glabranin or a derivative thereof could be used to stimulate hair growth. Glabranine exerts a dose-dependent inhibitory effect

天然产物

Oxysanguinarine

Cat.No: TN2027

Synonym: 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine

Target: Parasite

Cat.No: TN1065

Target: Apoptosis

Cat.No: T25789

Synonym: NSC 302037,NSC-302037,NSC302037

Cat.No: T23664

Synonym: 6,8'-Biapigenin

Cat.No: T15703

Target: Others

Cat.No: TN2222

Target: Others

Cat.No: TN1689

Synonym: 光甘草宁,Glabranin

Target: Antifection

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