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78

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12019	Methylproamine	Others	Others
	Methylproamine 是一种与DNA 结合的辐射保护剂，可以修复辐射诱导的短暂活性氧。
T5363	Tempo 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。
T9168	NSC 617145 NSC617145,NSC-617145	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
T24925	UNC-2170 UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others	Others
	UNC-2170 (UNC2170 Maleate) 是53BP1(IC50=29 µM;Kd=22 µM) 选择性的、功能活性的片段状配体，对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白，在 DNA 损伤修复途径中起核心作用，并被招募到双链断裂位点。
T14858	Calicheamicin Calicheamicin γ1,卡奇霉素	Others	Others
	Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素，可引起DNA 双链断裂，抑制DNA 合成。
T3353	Niraparib hydrochloride 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis; Others; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂，IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复，诱导凋亡并具有抗肿瘤活性。
T1798	RITA NSC 652287,RITA (NSC 652287)	Mdm2; DNA Alkylator/Crosslinker; p53; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair
	RITA (NSC-652287) 是 p53-HDM-2相互作用抑制剂，可诱导 DNA-DNA 和 DNA-蛋白质的交联，可与 p53dN 结合，Kd 值为 1.5 nM。
T6336	Amonafide NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed	Topoisomerase	DNA Damage/DNA Repair
	Amonafide (NSC-308847,AS1413) 是一种拓扑异构酶 II 的抑制剂和 DNA 的嵌入剂，通过拓扑异构酶 II 介导的反应产生蛋白质相关的 DNA 链断裂
T9497	Niraparib tosylate monohyrate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib tosylate monohyrate 也称为 MK-4827，是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性，增强 DNA 链断裂的积累，促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。
T6588	Mitoxantrone 米托蒽醌,mitozantrone	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II 的抑制剂，也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。
T9760	IC 86621	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂，IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性，其 EC50 为 68 µM，用于 DNA-PK 介导的细胞 DSB 修复。
T1055	Ifosfamide NSC109724,Isophosphamide,异环磷酰胺	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ifosfamide (NSC-109724) 是一种烷化剂，具有抗肿瘤活性。它烷基化并形成 DNA 交联，从而防止 DNA 链分离和 DNA 复制。它是一种前药，必须通过肝微粒体酶的羟基化来激活。
T11332	FUBP1-IN-1 FUBP1–IN-1	Others	Others
	FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence.
T4047	Bisantrene CL216942,比生群	Topoisomerase	DNA Damage/DNA Repair
	Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T9430	Venadaparib NOV140101,IDX-1197	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂，对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复，可研究实体瘤。
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T50098	TIQ-A	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TIQ-A 是一种 PARP1 抑制剂，通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发，其过度激活已被认为是许多病理状况的致病因素，包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。
T63228	Simmiparib SMOCL-9112	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Simmiparib (SMOCL-9112) 是一种新型有效的 PARP1 和 PARP2 抑制剂，是一种Olaparib 衍生物。Simmiparib 在同源重组修复 (HR) 缺陷细胞中诱导 DNA 双链断裂 (DSB) 和细胞周期阻滞，从而促使细胞凋亡 (apoptosis)。Simmiparib 可用于研究帕金森病、阿尔茨海默病、乳腺癌和黑色素瘤。
T21320	Methoxyamine HCl 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102	Others	Others
	Methoxyamine HCl (Methoxyamine) 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER)，这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂。该药剂可增强烷化剂的抗肿瘤活性。
T3615	Evofosfamide 艾伏磷酰胺,TH-302	Apoptosis; Others	Apoptosis; Others
	Evofosfamide (TH-302) 是一种缺氧激活前药，在缺氧 (N2) 和常氧 (21% O2) 环境下，IC50分别为 10 μM 和 1000 μM。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T15826	Lometrexol LY 264618,DDATHF	DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Lometrexol (LY 264618) 是一种抗嘌呤类抗叶酸 (Antifolate) 药，可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性，但不会引起可检测水平的 DNA 链断裂。Lometrexol 可以进一步抑制嘌呤从头合成，导致异常的细胞增殖，凋亡 (Apoptosis) 和细胞周期停滞。Lometrexol 具有抗癌活性。Lometrexol 还是一种有效的人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 抑制剂。
T1600	Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂，对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。
T0893	Tinidazole 替硝唑,CP12574	Antibacterial; Antibiotic	Microbiology/Virology
	Tinidazole (CP12574) 是一种对厌氧菌和原生动物具有选择性抗菌活性的 5-硝基咪唑，是一种具有口服活性的抗菌剂。
T1408	Capecitabine Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Capecitabine (Capecitibine) 是一种可口服的前药，可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。
T24555	NSC666715 NSC 666715,NSC-666715
	NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.
T71482	Penclomedine
	Penclomedine is an antineoplastic agent which alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis.
T21303	Etoposide Phosphate Eposin Etopophos Vepesid VP16,磷酸依托泊苷
	Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.
T28293	Pamiparib maleate BGB290,BGB 290,BGB-29 maleat 0
	Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, pro
T15200	Edotecarin PF 804950,J 107088	Topoisomerase	DNA Damage/DNA Repair
	Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T20907	DBC 3,4,5,6-Dibenzocarbazole
	DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells.
T23654	Afeletecan free base BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
	Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis
T70115	Pamiparib hydrate
	Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo...
T70533	Amonafide dihydrochloride
	Amonafide dihydrochloride is the dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.
T21323	Picoplatin NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473
	Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition of DNA replication and transcriptio
T68985	Amonafide L-malate
	Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.
T16283	Neocarzinostatin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potential for EpCAM-positive cancer treatment.
T69862	Afeletecan HCl
	Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA repli...
T19149	5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.
T76109	Nuclease S1
	Nuclease S1 是一种特异性的核酸内切酶，可降解单链 DNA (ssDNA) 和 RNA。Nuclease S1 还可以去除双链 DNA 中突出的单链末端。
T79330	PARP-1-IN-13	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-13 (Compound 19c) 为一种高效PARP-1抑制剂，其IC50值为26 nM。该化合物能够抑制DNA单链断裂修复并增强DNA双链断裂效应。此外，PARP-1-IN-13通过激活线粒体凋亡(apoptosis)途径来促进癌细胞死亡。
T68671	Amsacrine Isothionate
	Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T40345	AV-153
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
T68675	Porfiromycin
	Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
T72467	5-Iminodaunorubicin 5-亚氨基柔红霉素
	5-Iminodaunorubicin 是一种醌改性蒽环类药物，具有抗肿瘤活性。5-Iminodaunorubicin 在癌细胞中可诱导 DNA 链断裂。
T38962	MC-SN38 MC-SN38
	MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks.
T68971	Ormaplatin
	Ormaplatin is a platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
T68207	Elsamitrucin
	Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
T70229	Laromustine
	Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair.

化合物

Cat.No: T12019

Target: Others

Cat.No: T5363

Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

Cat.No: T9168

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

Cat.No: T24925

Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate

Target: Others

Cat.No: T14858

Synonym: Calicheamicin γ1,卡奇霉素

Target: Others

Niraparib hydrochloride

Cat.No: T3353

Synonym: 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Cat.No: T1798

Synonym: NSC 652287,RITA (NSC 652287)

Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy

Cat.No: T6336

Synonym: NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed

Target: Topoisomerase

Niraparib tosylate monohyrate

Cat.No: T9497

Target: PARP

Cat.No: T6588

Synonym: 米托蒽醌,mitozantrone

Target: Topoisomerase, PKC

Cat.No: T9760

Target: DNA-PK

Cat.No: T1055

Synonym: NSC109724,Isophosphamide,异环磷酰胺

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T11332

Synonym: FUBP1–IN-1

Target: Others

Cat.No: T4047

Synonym: CL216942,比生群

Target: Topoisomerase

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cat.No: T9430

Synonym: NOV140101,IDX-1197

Target: PARP

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Cat.No: T50098

Target: PARP

Cat.No: T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

Methoxyamine HCl

Cat.No: T21320

Synonym: 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102

Target: Others

Cat.No: T3615

Synonym: 艾伏磷酰胺,TH-302

Target: Apoptosis, Others

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat.No: T15826

Synonym: LY 264618,DDATHF

Target: DHFR

Cat.No: T1600

Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T0893

Synonym: 替硝唑,CP12574

Target: Antibacterial, Antibiotic

Cat.No: T1408

Synonym: Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T24555

Synonym: NSC 666715,NSC-666715

Cat.No: T71482

Etoposide Phosphate

Cat.No: T21303

Synonym: Eposin Etopophos Vepesid VP16,磷酸依托泊苷

Pamiparib maleate

Cat.No: T28293

Synonym: BGB290,BGB 290,BGB-29 maleat 0

Cat.No: T15200

Synonym: PF 804950,J 107088

Target: Topoisomerase

Cat.No: T20907

Synonym: 3,4,5,6-Dibenzocarbazole

Afeletecan free base

Cat.No: T23654

Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan

Pamiparib hydrate

Cat.No: T70115

Amonafide dihydrochloride

Cat.No: T70533

Cat.No: T21323

Synonym: NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473

Amonafide L-malate

Cat.No: T68985

Neocarzinostatin

Cat.No: T16283

Target: 5-HT Receptor

Cat.No: T69862

5-BrdUTP sodium salt

Cat.No: T19149

Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Target: Others

Cat.No: T76109

Cat.No: T79330

Target: PARP

Amsacrine Isothionate

Cat.No: T68671

Cat.No: T40345

Cat.No: T68675

5-Iminodaunorubicin

Cat.No: T72467

Synonym: 5-亚氨基柔红霉素

Cat.No: T38962

Synonym: MC-SN38

Cat.No: T68971

Cat.No: T68207

Cat.No: T70229

Cat. No.	Product Name	Target	Signaling Pathways
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T6116	Bleomycin Sulfate Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066	DNA/RNA Synthesis; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Bleomycin Sulfate (Blenoxane) 是一种糖肽抗生素，一种 DNA 合成抑制剂。Bleomycin Sulfate 可以引起 DNA 链断裂而不引起 RNA 链断裂。Bleomycin Sulfate 具有抗肿瘤活性。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
TN1170	1-Cinnamoylpyrrolidine	Platelet aggregation	Others
	1-Cinnamoylpyrrolidine 是从 Piper caninum 制备的天然产物，可作为一种 DNA 链断裂剂，在Cu2+ 存在下诱导质粒 pBR322 DNA 超螺旋的松弛。1-Cinnamoylpyrrolidine 对 PAF 诱导的血小板聚集有抑制作用，IC50 值为 37.3 μM。
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
T2S2172	nerolidol (±)-Nerolidol,Peruviol,橙花叔醇	Others; Endogenous Metabolite; Antibacterial; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Nerolidol (Peruviol) 是天然膜活性倍半萜，有抗肿瘤、抗细菌、抗真菌和抗寄生虫活性。它对动物有镇静作用，氧化过程对神经元病理后果起关键作用。
T82046	Irisquinone
	Irisquinone，一种具有抗癌活性的天然产物，同时作为癌症放射增敏剂。该化合物通过降低GSH水平并抑制DNA单链断裂修复，展现其药理作用。
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...

天然产物

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

Bleomycin Sulfate

Cat.No: T6116

Synonym: Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066

Target: DNA/RNA Synthesis, Antibiotic

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

1-Cinnamoylpyrrolidine

Cat.No: TN1170

Target: Platelet aggregation

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: T2S2172

Synonym: (±)-Nerolidol,Peruviol,橙花叔醇

Target: Others, Endogenous Metabolite, Antibacterial, Parasite, Antifungal

Cat.No: T82046

Cylindrospermopsin

Cat.No: T35770

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