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Search Results for " dlk "

Targets Recommended: DNA Alkylation

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11056	DLK-IN-1	DNA Alkylation	DNA Damage/DNA Repair
	DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration
T3707	GNE-3511 GNE3511	DNA Alkylation; MAPK	DNA Damage/DNA Repair; MAPK
	GNE-3511是双亮氨酸拉链激酶 (DLK)抑制剂(Ki:0.5 nM)。
T6057	URMC-099	ROCK; MLK; VEGFR; SGK; DNA Alkylation; Trk receptor; c-Met/HGFR; LRRK2; MEK; IGF-1R; Syk; Bcr-Abl; CDK; Src; Aurora Kinase; Autophagy	Angiogenesis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	URMC-099 是一种具有优异的血脑屏障穿透性的，可口服的混合谱系激酶 3 抑制剂，IC50为14 nM。
T73457	DN-1289	DNA Alkylation	DNA Damage/DNA Repair
	DN-1289 是一种可口服可通过血脑屏障且具有选择性高效性的抑制剂，对双亮氨酸拉链激酶 (DLK）的 IC50 值为17 nM，对亮氨酸拉链轴承激酶 (LZK）的 IC50 值为 40 nM。DN-1289 对小鼠模型中视神经挤压 (ONC) 诱导的 p-c-Jun 有显著的抑制作用。
T11440	GNE-8505	DNA Alkylation	DNA Damage/DNA Repair
	GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T79303	IACS-52825
	IACS-52825是一种选择性DLK抑制剂，具有1.3 nM的Kd值，适用于研究化疗引起的周围神经病变。

化合物

DLK-IN-1

Cat.No: T11056

Synonym:

Target: DNA Alkylation

GNE-3511

Cat.No: T3707

Synonym: GNE3511

Target: DNA Alkylation, MAPK

URMC-099

Cat.No: T6057

Synonym:

Target: ROCK, MLK, VEGFR, SGK, DNA Alkylation, Trk receptor, c-Met/HGFR, LRRK2, MEK, IGF-1R, Syk, Bcr-Abl, CDK, Src, Aurora Kinase, Autophagy

DN-1289

Cat.No: T73457

Synonym:

Target: DNA Alkylation

GNE-8505

Cat.No: T11440

Synonym:

Target: DNA Alkylation

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00942	DLK1 Protein, Mouse, Recombinant (His) DLK1,DLK,pG2,secredeltin,ZOG,Pref1,DLK...	Mouse	HEK293 Cells
	paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neurogenesis and is located in the imprinted chromosome 14q32 region associated with Temple syndrome. DLK1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 30.9 kDa and the accession number is Q09163-1.
TMPK-00921	DLK1 Protein, Human, Recombinant (hFc) DLK1,FA1,pG2,ZOG,secredeltin,DLK,Pref1,	Human	HEK293 Cells
	paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neurogenesis and is located in the imprinted chromosome 14q32 region associated with Temple syndrome. DLK1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 56.58 kDa and the accession number is P80370-1.
TMPK-00922	DLK1 Protein, Human, Recombinant (aa 24-303, His) FA1,Pref1,DLK1,pG2,DLK,secredeltin,ZOG,	Human	HEK293 Cells
	paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neurogenesis and is located in the imprinted chromosome 14q32 region associated with Temple syndrome. DLK1 Protein, Human, Recombinant (aa 24-303, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 30.9 kDa and the accession number is P8037...
TMPK-01274	DLK1 Protein, Cynomolgus, Recombinant (His) FA1,DLK-1,secredeltin,DLK1,ZOG,DLK	Cynomolgus	HEK293 Cells
	paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neurogenesis and is located in the imprinted chromosome 14q32 region associated with Temple syndrome. DLK1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 31.26 kDa and the accession number is A0A2K5TMQ6...
TMPJ-00509	DLK1 Protein, Human, Recombinant (His) pG2,Protein Delta Homolog 1,Protein δ Homolog 1,DLK...	Human	HEK293 Cells
	Protein Delta Homolog 1 (DLK-1) is a transmembrane protein which contains a signal peptide, an extracellular domain with six tandem epidermai growth factor (EGF)-like domains, a single pass transmembrane domain, and a short cytoplasmic tail. It is found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. In addition, it is detected in som...
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) death-associated protein kinase 3,DLK,ZIP,ZIPK	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT...