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Cat. No.	Product Name	Target	Signaling Pathways
T60005	CK1-IN-3	Casein Kinase	Metabolism; Stem Cells
	CK1-IN-3 是酪蛋白激酶 1 抑制剂，可用于治疗或预防与 circadiantiazol 节律相关的疾病、炎症性疾病的研究。
T5393	CK1-IN-1 PUN51207	p38 MAPK; Casein Kinase	MAPK; Metabolism; Stem Cells
	CK1-IN-1 (PUN51207) 是一种酪蛋白激酶 1 抑制剂，对 CK1δ、CK1ε和p38σ MAPK 的IC50值为 15 nM、16 nM 和73 nM。
T79145	CK1-IN-2	Casein Kinase	Metabolism; Stem Cells
	CK1-IN-2 (compound Nr.4) 作为CK1抑制剂展现出高效性，其对CK1a、CK1d、CK1e、p38a的IC50值依次为123、19.8、26.8、74.3 nM。
T9175	Casein Kinase inhibitor A51	Apoptosis; Casein Kinase	Apoptosis; Metabolism; Stem Cells
	Casein Kinase inhibitor A51 是一种具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，具有抗癌活性，可诱导白血病细胞凋亡 (apoptosis)，可用于研究颈部癌、急性髓系白血病、乳腺癌和前列腺癌。
T8987	Epiblastin A	Casein Kinase	Metabolism; Stem Cells
	Epiblastin A 是 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，能够抑制 CK1α (IC50:8.9 µM)、 CK1δ (IC50:0.5 µM)、CK1 ɛ (IC50:4.7 µM)。它能够抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。
T22884	JW 67	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	JW 67 是典型 Wnt 信号通路的抑制剂，IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，快速降低活性 β- 连环蛋白，随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
T19913	CKI-7 CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK; SGK; Casein Kinase; CDK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂，IC50为 6 μM，Ki 为 8.5 μM。它选择性抑制 Cdc7激酶，还抑制 SGK，S6K1以及 MSK1。
TP1971	Pseudo RACK1
	Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide i
T61843	CK156
	CK156 is a potent inhibitor of death-associated protein kinase (DAPK), demonstrating high selectivity. In the DRAK1 NanoBRET assay, CK156 exhibits IC50 values of 182 nM, 34 μM, and 39 μM for DRAK1, CK2a1, and CK2a2, respectively. This compound is valuable for studying autoimmune and inflammatory diseases [1].
T71654	APcK110
	APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling path...
T27030	CK176 HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34
	CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs).
T2449	D4476 D 4476,Casein Kinase I Inhibitor	Apoptosis; Casein Kinase; ALK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	D4476 (Casein Kinase I Inhibitor) 是一种选择性和细胞渗透性的CK1抑制剂，在体外实验的IC50值为0.3 μM。
T2440	IC261 SU-5607	Apoptosis; Casein Kinase; CDK	Apoptosis; Cell Cycle/Checkpoint; Metabolism; Stem Cells
	IC261 (SU-5607) 是一种选择性的，ATP 竞争性的CK1抑制剂，可触发有丝分裂检查点控制。对Ckiδ、Ckiε、 Ckiα1 和Cdk5的IC50值分别为 1 μM、1 μM 、16 μM 和4.5mM。
T6745	5-Iodotubercidin 5-碘代杀结核菌素,5-ITu,NSC 113939	Adenosine Receptor	GPCR/G Protein; Neuroscience
	5-Iodotubercidin (NSC-113939) 是一种 ATP 类似物，有效抑制腺苷激酶，IC50为 26 nM。它可以激活磷酸化酶和糖原合成酶，在离体肝细胞中启动糖原合成。它也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 。
T4645	TA-01	p38 MAPK; Casein Kinase; Autophagy	Autophagy; MAPK; Metabolism; Stem Cells
	TA01 是一种心源性抑制剂，有效抑制CK1和p38 MAPK，其对 CK1ε，CK1δ 和 p38 MAPK 的IC50值分别为 6.4 nM，6.8 nM 和 6.7 nM。
T21915	TBCA Casein Kinase II Inhibitor III, TBCA	Casein Kinase	Metabolism; Stem Cells
	TBCA (Casein Kinase II Inhibitor III, TBCA) 是高选择性的酪蛋白激酶II CK2 抑制剂，IC50 为 110 nM，Ki 为 77 nM。TBCA 对 CK1、DYRK1A 和其它 27 个激酶表现出选择性。
T23224	(R)-DRF053 dihydrochloride	Others	Others
	cdk/CK1 inhibitor,potent and ATP-competitive
T10829	CKI-7 free base CKI-7	Casein Kinase	Metabolism; Stem Cells
	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
T2695	TBB Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole	GSK-3; Casein Kinase; CDK	Cell Cycle/Checkpoint; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	TBB (NSC-231634) 是一种高选择性的 ATP/GTP 竞争性酪蛋白激酶 2 (CK2) 抑制剂，可抑制大鼠肝脏 CK2，IC50值为0.15 μM。
T16141	MRT00033659	Others	Others
	MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
T83684	Myelin Basic Protein Peptide (mouse, bovine) TFA Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
	Myelin基础蛋白(MBP)肽是PKC的肽底物，相比PKA、酪蛋白激酶1(CK1)、CK2、磷酸化酶激酶及钙/钙调蛋白依赖性蛋白激酶(CaMKII)，它对PKC有选择性。MBP肽已用于监测原发性人类肾动脉平滑肌细胞中的PKC活性。
T14069	A-3 hydrochloride	CaMK; Casein Kinase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors
	A-3 hydrochloride 是一种细胞可渗透的、可逆的、ATP 竞争性非选择性拮抗剂。它抑制 PKA 、酪蛋白激酶 II 和肌球蛋白轻链激酶，Ki 值分别为4.3 µM、5.1 µM 和7.4 µM。它还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。
T16507	PF-5006739	Casein Kinase	Metabolism; Stem Cells
	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selecti
T10298L	AMG-548	p38 MAPK	MAPK
	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM

化合物

Cat.No: T60005

Target: Casein Kinase

Cat.No: T5393

Synonym: PUN51207

Target: p38 MAPK, Casein Kinase

Cat.No: T79145

Target: Casein Kinase

Casein Kinase inhibitor A51

Cat.No: T9175

Target: Apoptosis, Casein Kinase

Cat.No: T8987

Target: Casein Kinase

Cat.No: T22884

Target: Wnt/beta-catenin

Cat.No: T19913

Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl

Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase

Cat.No: TP1971

Cat.No: T61843

Cat.No: T71654

Cat.No: T27030

Synonym: HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34

Cat.No: T2449

Synonym: D 4476,Casein Kinase I Inhibitor

Target: Apoptosis, Casein Kinase, ALK, Autophagy

Cat.No: T2440

Synonym: SU-5607

Target: Apoptosis, Casein Kinase, CDK

5-Iodotubercidin

Cat.No: T6745

Synonym: 5-碘代杀结核菌素,5-ITu,NSC 113939

Target: Adenosine Receptor

Cat.No: T4645

Target: p38 MAPK, Casein Kinase, Autophagy

Cat.No: T21915

Synonym: Casein Kinase II Inhibitor III, TBCA

Target: Casein Kinase

(R)-DRF053 dihydrochloride

Cat.No: T23224

Target: Others

CKI-7 free base

Cat.No: T10829

Synonym: CKI-7

Target: Casein Kinase

Cat.No: T2695

Synonym: Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole

Target: GSK-3, Casein Kinase, CDK

Cat.No: T16141

Target: Others

Myelin Basic Protein Peptide (mouse, bovine) TFA

Cat.No: T83684

Synonym: Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide

A-3 hydrochloride

Cat.No: T14069

Target: CaMK, Casein Kinase, PKA, PKC

Cat.No: T16507

Target: Casein Kinase

Cat.No: T10298L

Target: p38 MAPK

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