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Search Results for " beta-secretase "

21

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12188	NB-360	BACE	Neuroscience
	NB-360 是一种有效的脑穿透性 BACE1 和 BACE2 抑制剂，对小鼠和人源 BACE1 和 BACE2 的 IC50 分别为 5、5 和 6 nM。 NB-360 对相关的天冬氨酰蛋白酶、胃蛋白酶、组织蛋白酶 E 和组织蛋白酶 D 具有出色的特异性。
T2639	LY2811376	Beta Amyloid; Beta-Secretase; BACE	Neuroscience
	LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂，IC50=239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50=300 nM。
T13253	Umibecestat CNP520	BACE	Neuroscience
	Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂，对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM，可用于阿尔茨海默病的研究。
T6058	LY2886721	Beta-Secretase; BACE	Neuroscience
	LY2886721 是选择性的，口服活性的 β 位淀粉样蛋白前体蛋白裂解酶 1 抑制剂，对重组人 BACE1的 IC50=20.3 nM。它对 BACE1的选择性高于对组织蛋白酶 D、胃蛋白酶、肾素的选择性，但缺乏对 BACE2的选择性。它可透过血脑屏障，并可用于研究阿尔茨海默氏病。
T11175	Elenbecestat E2609	Beta-Secretase; BACE	Neuroscience
	Elenbecestat (E2609) 是一种高效、有口服活性的，能透过 CNS 的 BACE-1抑制剂，它有用于阿尔茨海默病 (AD) 的研究潜力。
T6772	AZD3839 free base AZD3839	Beta-Secretase; BACE	Neuroscience
	AZD3839 free base 是一种具有口服活性的、选择性的、可透过大脑屏障的BACE1抑制剂 (Ki=26 nM)，对 BACE2 和组织蛋白酶 D 的选择性分别为 14 倍和 >1000 倍。在小鼠、豚鼠和非人灵长类动物中，它剂量和时间依赖性的降低血浆、脑和脑脊液 Aβ 水平，可用于研究阿尔茨海默病。
T4398	LX2343	Beta Amyloid; Beta-Secretase; BACE; PI3K; Autophagy	Autophagy; Neuroscience; PI3K/Akt/mTOR signaling
	LX2343 是一种非 ATP 竞争性 PI3K 抑制剂，IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂，IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T7011	Verubecestat MK-8931,维罗司他	Beta-Secretase; BACE	Neuroscience
	Verubecestat (MK-8931) 是一种高亲和力的、具有口服活性的BACE1和BACE2抑制剂，Ki 分别为 2.2 nM 和 0.38 nM。它可以有效降低 Aβ40，并具有潜力用于阿尔茨海默氏病。
T3285	Eslicarbazepine Acetate Zebinix,Aptiom,BIA 2-093,Exalief,艾司利卡西平醋酸酯,Stedesa	Beta-Secretase; Sodium Channel	Membrane transporter/Ion channel; Neuroscience
	Eslicarbazepine Acetate (Zebinix) 是一种抗癫痫药物。Eslicarbazepine acetate 也是 β-内分泌酶(β-Secretase)和电压门控钠离子通道的双抑制剂。
T13434	β-Secretase Inhibitor IV	Others	Others
	β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T40260	β-Secretase Inhibitor II
	β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specifically against Aβ 1-42. This compound is particularly useful in research related to Alzheimer's disease.
T3161	β-Secretase inhibitor-STA	Beta-Secretase	Neuroscience
	BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。
T39251	β-Secretase Inhibitor I
	β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity.
T11362	gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor	Others	Others
	gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T83616	SEW06622	BACE; AChE	Neuroscience
	SEW06622 是一种有效的乙酰胆碱酯酶(AChE)和β-分泌酶-1(BACE-1)抑制剂，是治疗阿尔茨海默病的潜在候选化合物。
T6870	L-685458 L-685,458	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂，抑制淀粉样 β-蛋白前体 γ-分泌酶活性，选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解，可研究阿尔茨海默病和癌症。
T28390	PF9238 PF 9238,PF-9238
	PF9238 is an inhibitor of beta-secretase I. PF9238 has a CatD potency of 12 uM in vivo.
T24924	Umibecestat HCl (1387560-01-1 free base) CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520
	Umibecestat is a beta-secretase inhibitor. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies.
T70104	Verubecestat tosylate
	Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.
T71899	Verubecestat TFA
	Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.
T69664	Umibecestat HCl
	Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice

化合物

Cat.No: T12188

Target: BACE

Cat.No: T2639

Target: Beta Amyloid, Beta-Secretase, BACE

Cat.No: T13253

Synonym: CNP520

Target: BACE

Cat.No: T6058

Target: Beta-Secretase, BACE

Cat.No: T11175

Synonym: E2609

Target: Beta-Secretase, BACE

AZD3839 free base

Cat.No: T6772

Synonym: AZD3839

Target: Beta-Secretase, BACE

Cat.No: T4398

Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy

Cat.No: T7011

Synonym: MK-8931,维罗司他

Target: Beta-Secretase, BACE

Eslicarbazepine Acetate

Cat.No: T3285

Synonym: Zebinix,Aptiom,BIA 2-093,Exalief,艾司利卡西平醋酸酯,Stedesa

Target: Beta-Secretase, Sodium Channel

β-Secretase Inhibitor IV

Cat.No: T13434

Target: Others

β-Secretase Inhibitor II

Cat.No: T40260

β-Secretase inhibitor-STA

Cat.No: T3161

Target: Beta-Secretase

β-Secretase Inhibitor I

Cat.No: T39251

gamma-Secretase Modulators

Cat.No: T11362

Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor

Target: Others

Cat.No: T83616

Target: BACE, AChE

Cat.No: T6870

Synonym: L-685,458

Target: Apoptosis, Gamma-secretase

Cat.No: T28390

Synonym: PF 9238,PF-9238

Umibecestat HCl (1387560-01-1 free base)

Cat.No: T24924

Synonym: CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520

Verubecestat tosylate

Cat.No: T70104

Verubecestat TFA

Cat.No: T71899

Umibecestat HCl

Cat.No: T69664

Cat. No.	Product Name	Target	Signaling Pathways
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
T3769	Tenuifolin	Others; Beta-Secretase; AChE	Neuroscience; Others
	Tenuifolin 是一种从远志中分离出的三萜，能够抑制β-secretase 以减少 Aβ 蛋白分泌，具有神经保护作用。它可通过降低 AChE 活性来改善衰老小鼠的学习和记忆能力，有潜力用于阿尔茨海默氏病的研究。
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。
T8179	Aloeresin D 芦荟新甙D,芦荟新苷 D	Beta-Secretase; BACE	Neuroscience
	Aloeresin D 是一种从芦荟中分离得到的色原酮苷，能够抑制 β-分泌酶活性，IC50=39 μM。
T2S1181	Aloenin Aloenin A,Aloearbonaside,芦荟宁	Beta-Secretase; AChR	Neuroscience
	Aloenin (Aloenin A) A 是一种具有清除过氧自由基作用的天然产物，对 β-分泌酶 (BACE) 具有中等抑制活性。
TN2217	Sophoflavescenol 槐苦参醇,槐黄醇	Others; Beta-Secretase; BACE; PDE; AChR; AChE	Metabolism; Neuroscience; Others
	Sophoflavescenol 是异戊烯基黄酮类化合物，能够抑制PDE5的活性，IC50=0.013 μM。它也抑制 RLAR，HRAR，BACE1，AChE 和 BChE，IC50值分别为 0.30 µM，0.17 µM，10.98 µM，8.37 µM 和 8.21 µM。
T8306	Epiberberine chloride 表小檗碱氯化物,Epiberberine (chloride),盐酸表小檗碱	Reactive Oxygen Species; Beta-Secretase; BACE; AChR; AChE	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱，是一种AChE 和BChE 抑制剂，和非竞争性的BACE1抑制剂。它具有抗氧化作用，能够清除 ONOO-，可用于研究阿尔滋海默症和糖尿病。
T3682	(-)-Catechin gallate (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate	Others; COX	Immunology/Inflammation; Neuroscience; Others
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) 是绿茶儿茶素中的微量组分，可抑制COX-1和COX-2活性。它抑制人 Beta-secretase，对氯喹敏感的恶性疟原虫 NF54 和耐氯喹的恶性疟原虫 K1 具有抗疟原虫活性。

天然产物

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

Cat.No: T3769

Target: Others, Beta-Secretase, AChE

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Cat.No: T8179

Synonym: 芦荟新甙D,芦荟新苷 D

Target: Beta-Secretase, BACE

Cat.No: T2S1181

Synonym: Aloenin A,Aloearbonaside,芦荟宁

Target: Beta-Secretase, AChR

Sophoflavescenol

Cat.No: TN2217

Synonym: 槐苦参醇,槐黄醇

Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE

Epiberberine chloride

Cat.No: T8306

Synonym: 表小檗碱氯化物,Epiberberine (chloride),盐酸表小檗碱

Target: Reactive Oxygen Species, Beta-Secretase, BACE, AChR, AChE

(-)-Catechin gallate

Cat.No: T3682

Synonym: (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate

Target: Others, COX

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