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36

抑制剂 & 化合物

49

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19717	Cyclo-L-Trp-L-Trp	Antifungal	Microbiology/Virology
	Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。
T21358	Dalbavancin BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星	Antibacterial; Antibiotic	Microbiology/Virology
	Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。
T60093	CHEMBL1380345 N,N'-(Ethane-1,2-diyl)bis(3-methylbenzenesulfonamide)	Antibacterial	Microbiology/Virology
	CHEMBL1380345 对金黄色葡萄球菌、蜡状芽孢杆菌和大肠杆菌具有抗菌活性，pMIC 值分别为 3.64、3.56 和 3.70。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T61037	Glycosyltransferase-IN-1	Others	Others
	Glycosyltransferase-IN-1 是一种糖基转移酶 (glycosyltransferase) 抑制剂，具有抑菌活性，抑制 MSSA、MRSA 、枯草杆菌和肠杆菌。
T124635	Cyclo(L-Pro-L-Ile)
	Cyclo(L-Pro-L-Ile) 是一种来自苏云金芽孢杆菌双酮哌嗪，可诱发中度超敏反应，可用于研究松树枯萎病。
T77608	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-	Antifungal	Microbiology/Virology
	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 可作为一种广谱抗菌剂，对黑曲霉枯草芽孢杆菌、白假丝酵母、大肠杆菌和金黄色葡萄球菌有抑制作用。1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 在体外实验中显示出抗炎活性，可用于治疗细菌感染。
T25056	Alphostatin
	Alphostatin is an alkaline phosphatase inhibitor isolated from Bacillus megaterium.
T25686	Leuhistin Leuhistine
	Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.
T31603	Edeine D
	Edeine D is a bioactive chemical from Bacillus brevis Vm(4).
T34575	Schizokinen
	Schizokinen is a citrate-containing dihydroxamate and a siderophore produced by Bacillus megaterium and Anabaena sp.
T76009	Thermolysin
	Thermolysin 是由革兰氏阳性菌 Bacillus thermoproteolyticus 分泌的耐热的中性金属蛋白酶。Thermolysin 可催化含有疏水残基的肽键水解。
T69210	Chondrocurine
	Chondrocurine is a biochemical that Inhibits quick death of mice treated with bacillus Calmetta Guerin & elicited with lipopolysaccharide.
T36599	4-Epianhydrotetracycline hydrochloride
	Epianhydrotetracycline (EATC) is a degradation product of the antibiotic tetracycline .1 EATC is active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli (MIC50s = 0.75-16 mg/L).
T36436	Spergualin trihydrochloride
	Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1]. Spergualin trihydrochloride derivatives likely acts as Hsp70 modulators[1]. [1]. Srikanth Patury, et al. Pharmacological Targeting of the Hsp70 Chaperone. Curr Top Med Chem. 2009;9(15):1337-51.
T68203	Tuberine, (+)-
	Tuberine, (+)- is an alkaloid isolated from Haplophyllum tuberculatum that has high antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Saccharomyces cerevisiae. Tuberine, (+)- is also slightly inhibitory to Escherichia coli .
T33538	Mycobactin S
	Mycobactin S is made from metabolic products of the acid-resistant form of Mycobacterium phlei, a tuberculosis bacillus derived originally from the cold-blooded sea turtle. Importantly, it is not based on cell wall fragments or killed bacteria.
T80129	Baceridin	Proteasome	Proteases/Proteasome; Ubiquitination
	Baceridin是环状六肽类proteasome抑制剂，可从Epiphytic Bacillus培养基中提取。该化合物能够通过p53独立途径阻断细胞周期并促进肿瘤细胞凋亡，因而常用于癌症研究。
T82351	Gageotetrin A
	Gageotetrin A为源自海洋细菌Bacillus subtilis的抗菌肽，显示出抗真菌活性，同时对多种人类癌细胞无毒性。
TP1001	γ-Glu-Phe γ-Glutamylphenylalanine
	γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide found in sourdough.it is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commerc
TP2173	γ-Glu-Phe TFA (7432-24-8 free base) γ-Glutamylphenylalanine TFA,γ-Glu-Phe TFA	Others	Others
	γ-Glu-Phe TFA is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). It enhances the umami intensity of commercial soy sauce and model chicken broth.
T78310	Raxibacumab ABthrax
	Raxibacumab (ABthrax)是针对炭疽杆菌(Bacillus anthracis)保护性抗原(PA)的人类IgG1型单克隆抗体。该抗体能够防止保护性抗原与宿主细胞受体结合，有效阻断炭疽毒素的有毒效应，用于炭疽病防治研究。
T75253	Dalbavancin hydrochloride
	Dalbavancin hydrochloride (MDL-63397 hydrochloride)为半合成脂糖肽类抗生素，有效对抗革兰氏阳性菌。其对金黄色葡萄球菌与炭疽芽孢杆菌的MIC90分别为0.06 μg/mL与0.25 μg/mL。
T82350	Gageotetrin C
	Gageotetrin C是一种海洋细菌枯草芽孢杆菌产生的抗菌肽，其对真菌表现出较高的活性，具有MIC值为0.02-0.04 μM。
T68946	Antibiotic MA 144M1
	Antibiotic MA 144M1 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T68945	Antibiotic MA 144M2
	Antibiotic MA 144M2 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T78654	MraY-IN-3 hydrochloride
	MraY-IN-1（compound 12a）是一种针对细菌转位酶MraY的有效抑制剂，具有140 μM的IC50值。其对Escherichia coli K12、Bacillus subtilis W23和Pseudomonas fluorescens Pf-5展现出抗菌活性，相应的MIC50为7 µg/mL、12 µg/mL和46 µg/mL。MraY-IN-1适用于抗菌药物的研究领域。
T73635	γ-Glu-Phe TFA
	γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) 是由解淀粉芽孢杆菌 (GBA) 和米曲霉 (GAO) 合成的。γ-Glu-Phe TFA 或酶后反应混合物可增强商业酱油和模型鸡汤的鲜味强度。
T76108	Leucine dehydrogenase
	Leucine dehydrogenase 能够从球形芽孢杆菌中纯化得到。Leucine dehydrogenase 催化L-亮氨酸、L-缬氨酸、L-异亮氨酸、L-去甲缬氨酸、左旋α-氨基丁酸酯和L-去甲亮氨酸的氧化脱氨，以及它们的酮类似物的还原胺化。
T62278	Anticancer agent 36
	Anticancer agent 36 (compound 11) 是一种有效的抗微生物剂和抗癌剂，是一种磺酰脲类衍生物。Anticancer agent 36 对蕈状芽孢杆菌、大肠杆菌和白色念珠菌的微生物生长有抑制作用 (MIC: 0.156 - 0.039 mg/mL)。Anticancer agent 36 能够抑制 A549 细胞 (IC50: 19.7 μg/mL)、PC3 细胞 (IC50: 11.9 μg/mL) 生长。
T75509	Pulcherriminic acid
	Pulcherriminic acid 是环状二肽抗菌剂，对Fe3+有高亲和力，主要在芽孢杆菌和酵母中发现。该化合物通过非酶促反应与铁离子螯合，生成细胞外红色素pulcherrimin，通过竞争铁营养达到抗菌效果。Pulcherriminic acid 在食品、农业和医疗等领域具有广泛应用潜力。
T64172	MraY-IN-1
	MraY-IN-1 (compound 12a) 是细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-1 对大肠杆菌 K12 (MIC50: 7 μg/ml)、枯草芽孢杆菌 W23 (MIC50: 12 μg/ml) 和荧光假单胞杆菌 Pf-5 (MIC50: 46 μg/ml) 具有抗菌作用。MraY-IN-1 能够用于抗菌的研究。
T35425	β-Apooxytetracycline
	β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Baci...
T63552	FtsZ-IN-1
	FtsZ-IN-1 是有效的、具有喹啉环的 FtsZ 抑制剂，对革兰氏阳性菌具有较强的抑菌效果 (MIC: 0.5-8 μg/mL)。FtsZ-IN-1 能够提高 FtsZ 聚合作用，明显促进枯草芽孢杆菌 (B. subtilis) 的细胞伸长。FtsZ-IN-1 拥有低溶血毒性和低诱导耐药倾向，表现出抗耐药性细菌效果。
T80368	Im5
	Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性（MIC:10、2.5-5、0.5-1 μM)的抗菌肽，同时表现出溶血性（EC50: 28 μM）。
T83811	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium 2'(3')-ANT-ATP
	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate（2'-ANT-ATP）与3'-ANT-ATP是荧光ATP衍生物，可自发地进行异构化。在水中，2'(3')-ANT-ATP的激发波长为330 nm时，发射最大波长为428 nm。它对哺乳动物腺苷酸环化酶（AC1）、AC2及AC5显示出抑制作用，抑制常数(Kis)分别为130、640和120 nM。此外，它还能抑制百日咳杆菌腺苷酸环化酶毒素CyaA（在锰和镁存在下，Kis分别为1.3和20 µM）、炭疽杆菌腺苷酸环化酶毒素水肿因子（在锰和镁存在下，Kis分别为0.44和5.15 µM）以及大肠杆菌重组酶A（RecA；Ki = 6.3 µM）。

化合物

Cyclo-L-Trp-L-Trp

Cat.No: T19717

Target: Antifungal

Cat.No: T21358

Synonym: BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星

Target: Antibacterial, Antibiotic

Cat.No: T60093

Synonym: N,N'-(Ethane-1,2-diyl)bis(3-methylbenzenesulfonamide)

Target: Antibacterial

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

Glycosyltransferase-IN-1

Cat.No: T61037

Target: Others

Cyclo(L-Pro-L-Ile)

Cat.No: T124635

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-

Cat.No: T77608

Target: Antifungal

Cat.No: T25056

Cat.No: T25686

Synonym: Leuhistine

Cat.No: T31603

Cat.No: T34575

Cat.No: T76009

Cat.No: T69210

4-Epianhydrotetracycline hydrochloride

Cat.No: T36599

Spergualin trihydrochloride

Cat.No: T36436

Cat.No: T68203

Cat.No: T33538

Cat.No: T80129

Target: Proteasome

Cat.No: T82351

Cat.No: TP1001

Synonym: γ-Glutamylphenylalanine

γ-Glu-Phe TFA (7432-24-8 free base)

Cat.No: TP2173

Synonym: γ-Glutamylphenylalanine TFA,γ-Glu-Phe TFA

Target: Others

Cat.No: T78310

Synonym: ABthrax

Dalbavancin hydrochloride

Cat.No: T75253

Cat.No: T82350

Antibiotic MA 144M1

Cat.No: T68946

Antibiotic MA 144M2

Cat.No: T68945

MraY-IN-3 hydrochloride

Cat.No: T78654

Cat.No: T73635

Leucine dehydrogenase

Cat.No: T76108

Anticancer agent 36

Cat.No: T62278

Pulcherriminic acid

Cat.No: T75509

Cat.No: T64172

β-Apooxytetracycline

Cat.No: T35425

Cat.No: T63552

Cat.No: T80368

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

Cat.No: T83811

Synonym: 2'(3')-ANT-ATP

Cat. No.	Product Name	Target	Signaling Pathways
T21518	Colistin methanesulfonate sodium salt 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)	Cell wall; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Colistin methanesulfonate sodium salt (Colistimethate Sodium) 是一种来自 Bacillus colistinus 的环状多肽抗生素，由多粘菌素 E1 和 E2 组成。
T5084	Xanthosine dihydrate 黄苷二水合物	Others; Endogenous Metabolite	Metabolism; Others
	Xanthosine dihydrate 是衍生自黄嘌呤和核糖的核苷，能够提高牛和山羊的乳腺干细胞数量和产奶量。
T1130	Gramicidin 短杆菌肽,Gramicidinum,Gramicidine,Gramicidina	MRP; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Gramicidin (Gramicidine) 是一种抗菌肽。它通过组装成膜中的通道，增加其对阳离子的渗透性。
T21552	5-deoxy Thymidine 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione	Others	Others
	5-deoxy Thymidine (5'-Deoxythymidine) 是5'位被氢取代的胸苷形式。它对枯草芽孢杆菌和金黄色葡萄球菌的活性有效。
T1100	Polymyxin B Sulfate Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX	Antibacterial; Antibiotic	Microbiology/Virology
	Polymyxin B Sulfate (Poly-RX) 是一个阳离子型表面活性剂抗生素剂，能够提高细胞膜的渗透性。
T1245	Colistin sulfate Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素	Cell wall; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Colistin sulfate (Colistin sulfate (1066-17-7 free base)) 是抑制革兰氏阴性细菌的一种多肽抗生素，与革兰氏阴性细菌的外细胞膜中的脂多糖和磷脂结合起作用。
TN6675	Cyclo(Pro-Val) Cyclo(prolylvalyl)	Antibacterial; Antifungal	Microbiology/Virology
	Cyclo(Pro-Val) (Cyclo(prolylvalyl)) 是从海洋真菌中获得的，具有中等的抗真菌活性和较弱的抗肿瘤活性。 Cyclo(Pro-Val) 抑制枯草芽孢杆菌的生长，MIC 为 0.8 g/L。
T67731	Holomycin N-Demethylthiolutin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Holomycin (N-Demethylthiolutin) 是二硫代吡咯酮类的次级代谢产物。 HolomycinHolomycin 是一种抗生素次级代谢物，是天然产光杆菌galatheae S2753形成生物膜所必需的，也是一种广谱抗生素。holomycin 通过其烯-二硫基团促进S2753的生物膜形成。 Holomycin 具有抗肿瘤活性，可参与 RNA 合成。
T4788	L-Norvaline	Others; Endogenous Metabolite	Metabolism; Others
	L-Norvaline 是一种精氨酸酶抑制剂，也是一种非蛋白支链氨基酸。 L-Norvaline 先前已被报道为枯草芽孢杆菌抗真菌肽的天然成分。 L-Norvaline 和其他修饰的支链氨基酸在研究中受到了关注，因为它们似乎被掺入到大肠杆菌中发现的一些重组蛋白中。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
TN4028	Euchrestaflavanone B	PARP; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of
TN4851	Pterodondiol	Antifection	Microbiology/Virology
	Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
T25971	Polymyxin B2 Polymyxin-B2,PolymyxinB2
	Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.
T80357	Bombinin H7
	Bombinin H7 是一种抗菌肽，提取自铃蟾Bombina的皮肤分泌物。该化合物对Bacillus megateriumBm11显示出高效活性，其致死浓度达到25.2 μM。
T75549	(2E,4E)-Decadienoic acid
	(2E,4E)-Decadienoic acid 是一种抗卵菌脂肪族化合物，存在于 Bacillus subtilis 和 Trichoderma asperellum 的共培养物中。
TN4852	Pterodontic acid	Antifection	Microbiology/Virology
	Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.
TN7201	Lauric Acid Diethanolamide Lauric diethanolamide,N,N-二乙醇十二酰胺,Lauryl diethanolamide,N,N-Bis(2-hydroxyethyl)dodecanamide	Others	Others
	Lauric Acid Diethanolamide (Lauric diethanolamide) 是一种海洋来源的天然产物，存在于Bacillus sp.。
TN1695	Globulol	Antifection	Microbiology/Virology
	Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillus subtilis, the IC50 value of 158.0 microg/ mLand 737.2 microg/ mL, respectively.
T75578	Apigravin
	Apigravin 是一种有效的抗菌剂。Apigravin 对 Bacillus subtilis 具有抗菌活性，MIC 值为 61 μM。
TN1203	2,3,8-Tri-O-methylellagic acid 2,3,8-三邻甲基鞣花酸	Antifection	Microbiology/Virology
	2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
T81344	Pycnophorin
	碧萝芷以25μM的最小抑菌浓度（MIC）显著抑制枯草芽孢杆菌和金黄色葡萄球菌的生长。
TN2032	Pachypodol 霍香黃酮醇	Antifection	Microbiology/Virology
	Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
T15349	Fraxidin	Others	Others
	Fraxidin is a class of coumarin. It is isolated from the roots of Jatropha podagrica. It also shows antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.
T66935	1-Aminopropan-2-ol	Endogenous Metabolite	Metabolism
	1-Aminopropan-2-ol 参与枯草芽孢杆菌菌株中的苏氨酸代谢，可作为真菌培养基上的氮源。
T75467	Asperglaucin A
	Asperglaucin A 代表一种不寻常的类苯酞衍生物。Asperglaucin A 对两种植物病原体Pseudomonas syringae pv actinidae(Psa) 和Bacillus cereus 具有有效的抗菌活性，MIC 值为 6.25 μM。
T81051	Talaroenamine F
	Talaroenamine F显示了对蜡样芽胞杆菌的抗菌活性，其最小抑菌浓度(MIC)为0.85μg/mL。
TN3400	Altechromone A	Antifection	Microbiology/Virology
	Altechromone A has antimicrobial activity, it is active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 ug/ml, respectively.
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
T80349	Maximin H4
	Maximin H4是一种来自中华红腹蟾蜍(Bombina maxima)皮肤分泌物的抗菌肽，具有针对Escherichia coli ATCC25922、Staphylococcus aureus ATCC2592、Bacillus pyocyaneus CMCCB1010和Candida albicans ATCC2002的抗菌活性。其最小抑菌浓度(MIC)值依次为12、6、12、6 μg/ml。
T17185	Tyrothricin	Others	Others
	Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin displays activity against bacteria, fungi, and some viruses.
T80351	Maximin 28
	Maximin 28为源自蟾蜍大脑的抗菌肽，对金黄色葡萄球菌(Staphylococcus aureus)、大肠杆菌(Escherichia coli)及枯草芽孢杆菌(Bacillus subtilis)表现出抗菌活性，其MIC值分别为4.7、9.4、75 μg/mL。
T75468	Asperglaucin B
	Asperglaucin B 是一种来自真菌Aspergillus chevalieriSQ-8 的烷基化水杨醛衍生物，具有抗菌活性。Asperglaucin B 对两种植物病原体Pseudomonas syringae pv actinidae(Psa)和Bacillus cereus 显示出有效的抗菌活性，MIC 值为 6.25 μM。
T80335	Maximin H3
	Maximin H3，源自中华红腹蟾蜍Bombina maxima皮肤分泌，为一种抗菌肽。对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 2592、Bacillus pyocyaneus CMCC B1010 及Candida albicans ATCC 2002表现出显著抗性，其MIC值依次为20, 10, 20, 5 μg/ml。
T75684	Monascorubrin
	Monascorubrin 是一种从红曲菌菌丝体中纯化获得的化合物，对枯草芽孢杆菌和拟假丝酵母显示出显著的抗生素活性。
TN2626	14-Norpseurotin A	Antifection	Microbiology/Virology
	14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r
TN2392	9,17-Octadecadiene-12,14-diyne-1,11,16-triol	Antifection	Microbiology/Virology
	9,17-Octadecadiene-12,14-diyne-1,11,16-triol shows antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata at low concentratio
TN4594	Murraol	Antifection	Microbiology/Virology
	Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372.
T80334	Maximin H2
	Maximin H2，源自中华红腹蟾蜍(Bombina maxima)皮肤分泌物的抗菌肽，对Escherichia coli ATCC25922、Staphylococcus aureus ATCC2592、Bacillus pyocyaneus CMCCB1010及Candida albicans ATCC2002展示了明显的抗菌活性。其最小抑菌浓度(MIC)值依序为20、2、4、2 μg/ml。
T80332	Maximin H1
	Maximin H1是一种抗菌肽，由中华红腹蟾蜍(Bombina maxima)皮肤分泌物提取得到。该化合物对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 25923、Bacillus pyocyaneus CMCC B1010和Candida albicans ATCC 2002表现出抗菌活性，其最小抑菌浓度(MIC)值分别为9、4.5、9、4.5 μg/ml。
T80350	Maximin 15
	Maximin 15为源自蟾蜍大脑的抗菌肽，具有针对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌的活性，其最小抑菌浓度(MIC)值依次为9.4, 18.8, 75 μg/mL。
T82859	Blepharotriol
	Blepharotriol为Maytenus blepharodes中发现的一种酚类三萜化合物。该化合物具有抗菌特性，对Bacillus subtilis的最小抑菌浓度（MIC）为8-4 µg/ml。此外，Blepharotriol在HeLa、Hep-2、Vero细胞上的半数抑制浓度（IC50）分别为12.2、>20、>20 µM，表明其具有一定的细胞毒性。
TN4637	Neogrifolin	PARP; GSK-3; Akt; Caspase	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respe...
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...
T75686	Enfumafungin
	Enfumafungin，一种从Hormonema carpetanum菌提取的三萜糖苷，具有抗真菌特性，主要通过作为(1,3)-beta-D-葡聚糖合酶抑制剂影响真菌细胞壁发挥作用。其对酵母和多数真菌（除隐球菌外）有效，但不会抑制枯草芽孢杆菌的生长。
TN6674	Cyclo-(Pro-Gly) Cyclo(Pro-Gly)
	Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the concentration of 10 umol/L, it inhibit
TN4670	Norlichexanthone	Antibacterial; Parasite	Microbiology/Virology
	Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力，例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。它具有抗菌和抗疟活性，对枯草芽孢杆菌有很强的活性，IC50范围为1-5uM，对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用，IC50为20.95±1.56uM。
TN4168	Grifolin	Others	Others
	Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs
TN4402	Labd-13-ene-8,15-diol	Antifection	Microbiology/Virology
	13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer ac
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Colistin methanesulfonate sodium salt

Cat.No: T21518

Synonym: 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)

Target: Cell wall, Antibacterial

Xanthosine dihydrate

Cat.No: T5084

Synonym: 黄苷二水合物

Target: Others, Endogenous Metabolite

Cat.No: T1130

Synonym: 短杆菌肽,Gramicidinum,Gramicidine,Gramicidina

Target: MRP, Antibacterial, Antibiotic

5-deoxy Thymidine

Cat.No: T21552

Synonym: 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

Target: Others

Polymyxin B Sulfate

Cat.No: T1100

Synonym: Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX

Target: Antibacterial, Antibiotic

Colistin sulfate

Cat.No: T1245

Synonym: Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素

Target: Cell wall, Antibacterial, Antibiotic, Autophagy

Cat.No: TN6675

Synonym: Cyclo(prolylvalyl)

Target: Antibacterial, Antifungal

Cat.No: T67731

Synonym: N-Demethylthiolutin

Target: DNA/RNA Synthesis

Cat.No: T4788

Target: Others, Endogenous Metabolite

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

Euchrestaflavanone B

Cat.No: TN4028

Target: PARP, Antifection

Cat.No: TN4851

Target: Antifection

Cat.No: T25971

Synonym: Polymyxin-B2,PolymyxinB2

Cat.No: T80357

(2E,4E)-Decadienoic acid

Cat.No: T75549

Pterodontic acid

Cat.No: TN4852

Target: Antifection

Lauric Acid Diethanolamide

Cat.No: TN7201

Synonym: Lauric diethanolamide,N,N-二乙醇十二酰胺,Lauryl diethanolamide,N,N-Bis(2-hydroxyethyl)dodecanamide

Target: Others

Cat.No: TN1695

Target: Antifection

Cat.No: T75578

2,3,8-Tri-O-methylellagic acid

Cat.No: TN1203

Synonym: 2,3,8-三邻甲基鞣花酸

Target: Antifection

Cat.No: T81344

Cat.No: TN2032

Synonym: 霍香黃酮醇

Target: Antifection

Cat.No: T15349

Target: Others

1-Aminopropan-2-ol

Cat.No: T66935

Target: Endogenous Metabolite

Cat.No: T75467

Talaroenamine F

Cat.No: T81051

Cat.No: TN3400

Target: Antifection

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

Cat.No: T80349

Cat.No: T17185

Target: Others

Cat.No: T80351

Cat.No: T75468

Cat.No: T80335

Cat.No: T75684

14-Norpseurotin A

Cat.No: TN2626

Target: Antifection

9,17-Octadecadiene-12,14-diyne-1,11,16-triol

Cat.No: TN2392

Target: Antifection

Cat.No: TN4594

Target: Antifection

Cat.No: T80334

Cat.No: T80332

Cat.No: T80350

Cat.No: T82859

Cat.No: TN4637

Target: PARP, GSK-3, Akt, Caspase

Cat.No: T36961

Cat.No: T75686

Cyclo-(Pro-Gly)

Cat.No: TN6674

Synonym: Cyclo(Pro-Gly)

Norlichexanthone

Cat.No: TN4670

Target: Antibacterial, Parasite

Cat.No: TN4168

Target: Others

Labd-13-ene-8,15-diol

Cat.No: TN4402

Target: Antifection

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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