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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T60749 Autophagy-IN-2

Autophagy-IN-2 (Compound 7h) 是自噬通量的抑制剂,可诱导癌细胞凋亡,具有研究三阴性乳腺的潜力。
T5485 OSU-T315

OSU-T315 (1,5-regioisomer),ILK-IN-2

Apoptosis; Integrin; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling
OSU-T315 (OSU-T315 (1,5-regioisomer)) 是一种整联蛋白连接激酶抑制剂,通过去磷酸化 AKT-Ser473 和其他 ILK 靶标抑制 PI3K/AKT 信号传导。它阻止 AKT 转位到脂筏消除 AKT 的活化,并以 ILK 非依赖性方式触发 Caspase 依赖性细胞凋亡。它通过自噬和凋亡导致细胞死亡。
T15268 FAAH-IN-2

O-Desmorpholinopropyl Gefitinib,4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇

FAAH; Autophagy Autophagy; Metabolism; Neuroscience
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) 是一种脂肪酸酰胺水解酶的有效抑制剂。
T60967 Atg4B-IN-2

Phospholipase; Autophagy Autophagy; Metabolism
Atg4B-IN-2 是一种具有有效性的选择性的Atg4B 抑制剂,具有抗癌活性,对 Atg4B 和 PLA2 的活性有抑制作用。Atg4B-IN-2 通过细胞自噬 (autophagy) 来抵抗抗去势抗性前列腺癌药物的抗癌活性。
T71961 TUN-92046

DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate

Others Others
TUN-92046 (Dimethyl 2-oxoglutarate)是一种膜渗透性α酮戊二酸类似物,抑制压力过载诱导的心肌病中适应不良的自噬。
T77611 DAPK-IN-2

WAY-380496

DAPK Apoptosis
DAPK-IN-2 (WAY-380496) 是一种 DAPK 抑制剂。 DAPK-IN-2 具有潜在的抗癌活性,可调节细胞发生自噬反应,可用于研究脑梗死和缺血性疾病。
T24167 Inflachromene

ICM

Others Others
Inflachromene(ICM) 是一种 HMGB1 和 HMGB 表达抑制剂,具有抗炎活性。Inflachromene 通过抑制 HMGB1 易位来减轻小鼠癫痫模型的癫痫发作严重程度,通过 HMGB1/2 调节的 TLR4-NF-κB 通路抑制内膜增生,通过调节 Beclin 1 活性来抑制自噬。Inflachromene 可用于研究癫痫。
T14091 AC-73

Autophagy Autophagy
AC-73 是一种可口服的 Cluster of Differentiation 147 (CD147) 抑制剂,具有很高的生物利用,可选择性破坏 CD147 的二聚化 (结合位点在 CD147 的 N 端 IgC2 域中包括 Glu64 和 Glu73),从而对 CD147/ERK1/2/STAT3/MMP-2 途径产生抑制,并抑制肝癌细胞的运动和侵袭。AC-73 具有抗增殖活性,诱导白血病细胞自噬。
T60202 MMRi62

7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Ferroptosis Apoptosis
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂,靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性,并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡,伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解,并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
T2310L CHIR-99021 HCl

CT99021 HCl,Laduviglusib HCl

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T61547 ATG7-IN-2

ATG7-IN-2 (compound 1) is a highly potent inhibitor of the ATG7 protein, displaying an IC 50 value of 0.089 μM. This compound effectively suppresses the activity of autophagy marker LC3B, thereby regulating the autophagy process [1].
T26973 Cefatrizine

Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640

Cefatrizine is an inhibitor of eukaryotic elongation factor-2 kinase, a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers.
T61659 CC214-2

CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the duration of tuberculosis (TB) [1].
T74304 C16 PEG-Ceramide

C16 PEG-Ceramide为一种聚乙二醇化神经酰胺,具备脂质载体传递功能,并能诱导自噬(autophagy),在癌症研究中有应用。
T60760 HDAC10-IN-2

HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。
T61344 VO-OHPic

VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].
T36991 Monascuspiloin

Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T37085 Luxeptinib

Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].
T39459 THZ-P1-2

THZ-P1-2

THZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kα. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kα by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kα/β/γ. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications.
T22034 ARP 101

ARP101 是一种有效的选择性基质金属蛋白酶-2 (MMP-2)抑制剂,在癌细胞中诱导自噬相关的细胞死亡。ARP101可有效诱导自噬体形成和LC3I 转化为LC3II。
T78145 HDAC10-IN-2 hydrochloride

Autophagy Autophagy
HDAC10-IN-2 hydrochloride(化合物10c)是一种对HDAC10具有高效性和高选择性的抑制剂,IC50值为20 nM。该化合物能够调控FLT3-ITD阳性急性髓系白血病细胞的自噬过程。
T78404 Pyridinium bisretinoid A2E TFA

A2E TFA

Apoptosis Apoptosis
Pyridinium bisretinoid A2E TFA作为一种荧光团,能从视网膜色素上皮(RPE)的脂褐素中分离得到,是蓝光诱导的细胞凋亡(apoptosis)诱导剂。该化合物具有光活化特性,可介导自噬(autophagy)和活性氧(reactive oxygen species)的产生,常用于视网膜退行性疾病的研究。
T79653 VISTA-IN-2

Autophagy Autophagy
VISTA-IN-2(Compound 1)是一种抑制V结构域Ig抑制因子(VISTA)的化合物,能够诱导通过自噬(Autophagy)机制的VISTA降解。该化合物在克制VISTA介导的免疫抑制方面有效,提升免疫细胞对抗肿瘤的活性,并在CT26小鼠肿瘤模型中激发抗肿瘤免疫响应,进而抑止肿瘤生长。
T73183 SMYD3-IN-2

SMYD3-IN-2为一种针对SMYD3的抑制剂,具备通过诱导程序性自噬来抑制胃癌的能力。其对SMYD3及BGC823细胞展现出显著的抑制效果,IC50值分别达到0.81 μM与0.75 μM。因此,SMYD3-IN-2主要适用于癌症相关研究领域。
T79770 FB49

Autophagy Autophagy
FB49是一种针对Bcl-2-associated athanogene 3 (BAG3)的高选择性抑制剂,具有Ki值为45 μM。在人类肿瘤细胞系中,FB49能够有效抑制细胞生长,同时对人外周单核细胞无明显毒性。此外,FB49能够在HD-MB03成神经管细胞瘤细胞中阻碍G1期的细胞周期进程,并诱导细胞凋亡(apoptosis)和自噬(autophagy)。
T1181L Gefitinib hydrochloride

Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效,选择性和具有口服活性的EGFR 酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib hydrochloride 也诱导细胞自噬 (autophagy),具有抗肿瘤活性。
T61949 Evogliptin

Evogliptin (DA-1229) 是具有口服活性的DPP4抑制剂。Evogliptin 在小鼠模型中具有显著而持久的降糖效果。Evogliptin 通过诱导自噬抑制肝细胞的纤维化和炎症信号的产生。Evogliptin 可用于 2 型糖尿病、慢性肝脏炎症,骨质疏松症及肾功能损害的研究。
T74284 SH379

SH379为2-甲基嘧啶-稠合三环二萜衍生物,是具有口服活性的有效抗迟发性性腺机能减退剂。它显著促进StAR与3β-HSD等关键睾酮合成相关酶的表达,并通过调节AMPK/mTOR信号通路刺激自噬。
T73651 Forigerimod TFA

Forigerimod TFA (IPP-201101 TFA) 为 CD4T 细胞调节剂,属于 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段,并在 Ser140 位点磷酸化。它能有效抑制自噬,适用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。
T63991 BRD4/CK2-IN-1

BRD4/CK2-IN-1 是高效的、口服具有活力的 BRD4/CK2 (含溴结构域蛋白 4/酪蛋白激酶 2) 双靶点抑制剂,能够作用于 BRD4 (IC50: 180 nM) 和 CK2 (IC50: 230 nM)。在三阴性乳腺癌 (TNBC) 中,BRD4/CK2-IN-1 能够诱导细胞凋亡和自噬相关的细胞死亡。BRD4/CK2-IN-1 表现出显著的抗癌效果,且没有明显毒性。
T73650 Forigerimod

Forigerimod (IPP-201101) 是一种 CD4T 细胞调节剂。Forigerimod 是 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段,在 Ser140 位点被磷酸化。Forigerimod 可以有效抑制自噬。Forigerimod 可用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。
TMIH-0146 Chloroquine-d5

Chloroquine-d5 是 Chloroquine 的氘代化合物。Chloroquine 的 CAS 号为 54-05-7。Chloroquine 是一种自噬和 Toll 样受体抑制剂。 氯喹是一种抗疟疾和抗炎剂,广泛用于治疗疟疾和类风湿性关节炎。它在体外控制 SARS-CoV-2 (COVID-19) 感染方面非常有效,EC50 为 1.13 μM。
T62072 HDAC-IN-47

HDAC-IN-47 是一种口服具有活力的组蛋白去乙酰化酶 (HDAC) 的抑制剂,对 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8 的 IC50 值分别为 19.75 nM、57.8 nM、40.27 nM、5.63 nM、302.73 nM。HDAC-IN-47 可以将细胞周期阻滞在 G2/M 期,抑制细胞自噬,能够利用 Bax/Bcl-2 和 caspase-3 通路诱导凋亡,在体内具有抗癌活性。
T35519 Aflatoxin B2-13C17

Aflatoxin B2-13C17

Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen...
T78371 Ac2-26 ammonium

Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。
T35775 HT-2 Toxin-13C22

HT-2 Toxin-13C22

HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...
T36882 CAY10773

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ...
T38381 CAY17c

CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,...
T36107 YW3-56

YW3-56

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...
T36974 D-threo-PPMP hydrochloride

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201...
T36108 YW3-56 (hydrochloride) (technical grade)

YW3-56 (hydrochloride) (technical grade)

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept...

化合物

Autophagy-IN-2
Cat.No: T60749
Synonym:
Target:
OSU-T315
Cat.No: T5485
Synonym: OSU-T315 (1,5-regioisomer),ILK-IN-2
Target: Apoptosis, Integrin, Autophagy
FAAH-IN-2
Cat.No: T15268
Synonym: O-Desmorpholinopropyl Gefitinib,4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇
Target: FAAH, Autophagy
Atg4B-IN-2
Cat.No: T60967
Synonym:
Target: Phospholipase, Autophagy
TUN-92046
Cat.No: T71961
Synonym: DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate
Target: Others
DAPK-IN-2
Cat.No: T77611
Synonym: WAY-380496
Target: DAPK
Inflachromene
Cat.No: T24167
Synonym: ICM
Target: Others
AC-73
Cat.No: T14091
Synonym:
Target: Autophagy
MMRi62
Cat.No: T60202
Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
Target: Ferroptosis
CHIR-99021 HCl
Cat.No: T2310L
Synonym: CT99021 HCl,Laduviglusib HCl
Target: GSK-3
ATG7-IN-2
Cat.No: T61547
Synonym:
Target:
Cefatrizine
Cat.No: T26973
Synonym: Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640
Target:
CC214-2
Cat.No: T61659
Synonym:
Target:
C16 PEG-Ceramide
Cat.No: T74304
Synonym:
Target:
HDAC10-IN-2
Cat.No: T60760
Synonym:
Target:
VO-OHPic
Cat.No: T61344
Synonym:
Target:
Monascuspiloin
Cat.No: T36991
Synonym:
Target:
Luxeptinib
Cat.No: T37085
Synonym:
Target:
THZ-P1-2
Cat.No: T39459
Synonym: THZ-P1-2
Target:
ARP 101
Cat.No: T22034
Synonym:
Target:
HDAC10-IN-2 hydrochloride
Cat.No: T78145
Synonym:
Target: Autophagy
Pyridinium bisretinoid A2E TFA
Cat.No: T78404
Synonym: A2E TFA
Target: Apoptosis
VISTA-IN-2
Cat.No: T79653
Synonym:
Target: Autophagy
SMYD3-IN-2
Cat.No: T73183
Synonym:
Target:
FB49
Cat.No: T79770
Synonym:
Target: Autophagy
Gefitinib hydrochloride
Cat.No: T1181L
Synonym:
Target:
Evogliptin
Cat.No: T61949
Synonym:
Target:
SH379
Cat.No: T74284
Synonym:
Target:
Forigerimod TFA
Cat.No: T73651
Synonym:
Target:
BRD4/CK2-IN-1
Cat.No: T63991
Synonym:
Target:
Forigerimod
Cat.No: T73650
Synonym:
Target:
Chloroquine-d5
Cat.No: TMIH-0146
Synonym:
Target:
HDAC-IN-47
Cat.No: T62072
Synonym:
Target:
Aflatoxin B2-13C17
Cat.No: T35519
Synonym: Aflatoxin B2-13C17
Target:
Ac2-26 ammonium
Cat.No: T78371
Synonym:
Target:
HT-2 Toxin-13C22
Cat.No: T35775
Synonym: HT-2 Toxin-13C22
Target:
CAY10773
Cat.No: T36882
Synonym:
Target:
CAY17c
Cat.No: T38381
Synonym:
Target:
YW3-56
Cat.No: T36107
Synonym: YW3-56
Target:
D-threo-PPMP hydrochloride
Cat.No: T36974
Synonym:
Target:
YW3-56 (hydrochloride) (technical grade)
Cat.No: T36108
Synonym: YW3-56 (hydrochloride) (technical grade)
Target:
Cat. No. Product Name Target Signaling Pathways
TN6705 Graveoline

1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine

Autophagy Autophagy
Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) 是皮肤黑色素瘤癌细胞的凋亡和自噬诱导剂。
T4S1962 beta-Asarone

β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

NF-κB; JNK MAPK; NF-κB
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。
T8689 Chloroquine

CQ,氯喹

SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Chloroquine 是一种 Toll 样受体抑制剂,可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性,广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。
T3S1471 Cucurbitacin IIA

葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Apoptosis; Survivin Apoptosis
Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯,可诱导细胞凋亡和增强自噬,有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。
T36489 Malformin A

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...
T37452 Stephacidin B

Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...

天然产物

Graveoline
Cat.No: TN6705
Synonym: 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine
Target: Autophagy
beta-Asarone
Cat.No: T4S1962
Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin
Target: NF-κB, JNK
Chloroquine
Cat.No: T8689
Synonym: CQ,氯喹
Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy
Cucurbitacin IIA
Cat.No: T3S1471
Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA
Target: Apoptosis, Survivin
Malformin A
Cat.No: T36489
Synonym:
Target:
Stephacidin B
Cat.No: T37452
Synonym:
Target:
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