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Search Results for " ap2 "

Targets Recommended: AAK1 (AP2 associated kinase 1) AAK1 (AP2 associated kinase 1)

21

抑制剂 & 化合物

1

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12885	SGC-AAK1-1	AAK1 (AP2 associated kinase 1)	Neuroscience
	SGC-AAK1-1 是选择性的 AAK1(AP2 相关的激酶 1) 抑制剂，IC50=270 nM，Ki=9 nM，也抑制 BMP2K。它用于与 AAK1 相关的 Wnt 途径的研究。
T15781	LP-935509	Serine/threonin kinase; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; Metabolism; Neuroscience
	LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂，其 IC50=3.3 nM，Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。
T68455	AP23846 AP-23846	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	AP23846 是一种新型高效的 Src 家族激酶抑制剂，可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达，并消除下游血管生成过程。
T14299	AP20187 B/B Homodimerizer	Others	Others
	AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体，用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27 是一种生物活性肽，对应于主要的血管连接蛋白Cx40第二个细胞外环的GAP27结构域（40Gap27）。该化合物在研究氧化应激所致的损伤以及间隙连接通讯机制中有应用。40Gap27能够在给药后减少内皮依赖性的内膜下平滑肌的超极化现象。
T69700	BAP2
	BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).
T68607	AP23848
	AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.
T78129	MetAP2-IN-1	Others	Others
	MetAP2-IN-1为MetAP2抑制剂，用于血管生成介导疾病研究。
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.
T68325	AP24163
	AP24163 is an inhibitor of the gatekeeper mutant of BCR-ABL, thereby suppressing in vitro resistance.
T63986	SAP2-IN-1
	SAP2-IN-1 是分泌型天冬氨酸蛋白酶 2 (SAP2) 抑制剂，表现出有效的 SAP2 抑制作用 (IC50: 0.92 μM)。SAP2-IN-1 也是一种毒力因子抑制剂，在体外不具有活性。SAP2-IN-1 能够用于研究感染。
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26是一种生物活性肽，对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域，命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富，而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。
TP2123	ShK-Dap22
	Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >1000
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo...
T62861	ERAP2-IN-1
	ERAP2-IN-1 (compound 61) 是一种 ERAP2 的非竞争性抑制剂。ERAP2-IN-1 特异性抑制 ERAP2 肽水解活性，抑制 Arg-AMC 水解作用 (IC50: 27 μM) 和模型肽的水解活性 (IC50: 44 μM)。
T7621	6-Thioinosine 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	6-Thioinosine (6TI) 是一种嘌呤抗代谢物，是抗脂肪形成剂，能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。
T15506	HTS01037	Others	Others
	HTS01037 is an inhibitor of fatty acid-binding. HTS01037 is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).
T77333L	(Iso)-BMT-124110 Formate (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)	Neuroscience
	(Iso)-BMT-124110 Formate 对蛋白丝氨酸/苏氨酸激酶AAK 有抑制作用，可用于治疗帕金森病、精神分裂症、神经性疼痛和阿尔茨海默病。
T34630	SGC-AAK1-1N SGCAAK11N,SGCAAK1-1N,SGC-AAK11N
	SGC-AAK1-1N 是一种有效且选择性的 AAK1(AP2 相关激酶 1)小分子抑制剂(IC50=1.8 μM)。
T63355	BMS-309403 sodium
	BMS-309403 sodium 是一种有效的选择性脂肪细胞脂肪酸结合蛋白aFABP, 也称为FABP4，aP2抑制剂，对 FABP4，FABP3 和 FABP5 的Ki 分别为 <2 nM，250 nM，350 nM。BMS-309403 sodium 与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。BMS-309403 sodium 可改善载脂蛋白E 缺乏症小鼠和培养的人内皮细胞的内皮功能。
T14072	A-443654	ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-443654 是 pan-Akt 抑制剂，对Akt1，Akt2，和Akt3具有同等效力的抑制作用，Ki=均为 160 pM。

化合物

Cat.No: T12885

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T15781

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

Cat.No: T68455

Synonym: AP-23846

Target: Src

Cat.No: T14299

Synonym: B/B Homodimerizer

Target: Others

Connexin mimetic peptide 40GAP27

Cat.No: T82683

Cat.No: T69700

Cat.No: T68607

Cat.No: T78129

Target: Others

Cat.No: T36240

Cat.No: T68325

Cat.No: T63986

Connexin mimetic peptide 40,37GAP26

Cat.No: T82684

Cat.No: TP2123

Cat.No: T68581

Cat.No: T62861

Cat.No: T7621

Synonym: 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI

Target: Nucleoside Antimetabolite/Analog

Cat.No: T15506

Target: Others

(Iso)-BMT-124110 Formate

Cat.No: T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T34630

Synonym: SGCAAK11N,SGCAAK1-1N,SGC-AAK11N

BMS-309403 sodium

Cat.No: T63355

Cat.No: T14072

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Cat. No.	Product Name	Target	Signaling Pathways
TN3882	Dodoviscin A	cAMP; Tyrosinase; transporter	GPCR/G Protein; Metabolism; Proteases/Proteasome
	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact

天然产物

Cat.No: TN3882

Target: cAMP, Tyrosinase, transporter

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02949	AP2 Gamma/TFAP2C Protein, Human, Recombinant (His) ERF1,hAP-2g,transcription factor AP	Human	E. coli
	TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested fo...
TMPY-01482	FABP4 Protein, Mouse, Recombinant (His) ALBP/Ap2,Lbpl,422/aP...	Mouse	HEK293 Cells
	FABP4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P04117.
TMPY-02103	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) HEL-S-104,fatty acid binding protein 4, adipocyte,A-FABP,AFA...	Human	E. coli
	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090.
TMPY-00018	METAP2 Protein, Human, Recombinant (His) MAP2,MNPEP,p67eIF2,methionyl amin...	Human	Baculovirus Insect Cells
	METAP2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is A0A140VJE3.
TMPY-00992	ERAP2 Protein, Human, Recombinant (His) L-RAP,endoplasmic reticulum aminopeptidase 2	Human	HEK293 Cells
	Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 96-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyz...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His) DOC-1R,p14,cyclin-dependent kinase 2 associated pro...	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las...
TMPY-02727	METAP2 Protein, Mouse, Recombinant (His) Amp2,methionyl aminopeptidase 2,A930035J	Mouse	Baculovirus Insect Cells
	METAP2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is O08663.
TMPH-01250	MAP2K3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. MAP2K3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession numbe...
TMPJ-01356	NECAP2 Protein, Human, Recombinant (His) NECAP endocytosis associated protein 2,Ad<...	Human	E. coli
	NECAP2 belongs to the NECAP family. The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Adaptin ear-binding coat-associated protein 2 can interacts with AP1G1 and AP2A1 components of the adapter protein complex AP-1 and AP-2. It also interacts with the GAE domain proteins GGA1, GGA2 and GGA3.
TMPH-00943	AP2M1 Protein, Human, Recombinant (His) AP-2 complex subunit mu,AP2	Human	E. coli
	AP2M1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02162	Synaptotagmin-1 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas...

重组蛋白

AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

Cat.No: TMPY-02949

Species: Human

Expression System: E. coli

FABP4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01482

Species: Mouse

Expression System: HEK293 Cells

FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)

Cat.No: TMPY-02103

Species: Human

Expression System: E. coli

METAP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00018

Species: Human

Expression System: Baculovirus Insect Cells

ERAP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00992

Species: Human

Expression System: HEK293 Cells

CDK2AP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02921

Species: Human

Expression System: E. coli

METAP2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02727

Species: Mouse

Expression System: Baculovirus Insect Cells

MAP2K3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01250

Species: Human

Expression System: E. coli

NECAP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01356

Species: Human

Expression System: E. coli

AP2M1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00943

Species: Human

Expression System: E. coli

Synaptotagmin-1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02162

Species: Human

Expression System: E. coli

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