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FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)

产品编号 TMPY-02103

别名: HEL-S-104, fatty acid binding protein 4, adipocyte, A-FABP, AFABP, aP2, ALBP

FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090.

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FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090.

种属	Human
表达系统	E. coli
标签	N-His
蛋白编号	P15090
别名	HEL-S-104, fatty acid binding protein 4, adipocyte, A-FABP, AFABP, aP2, ALBP
蛋白构建	The Human FABP4 (P15090) (Cys 2-Ala 132) (29 Ala / Thr) was expressed, with a polyhistide tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	16 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 200 mM NaCl, 10% glycerol, pH 8.2. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

参考文献

1. van Dongen,M.J. et al., 2002, J Am Chem Soc. 124 (40): 11874-80. 2. Coll, B. et al., 2008, Atherosclerosis 199 (1):147-53. 3. Hoashi,S. et al., 2008, BMC Genet. 9 :84. 4. Cai,H. et al., 2010, Bioorg Med Chem Lett 20 (12):3675-9.

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Keywords

FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) HEL-S-104 fatty acid binding protein 4, adipocyte A-FABP HEL-S 104 AFABP aP2 ALBP HEL-S104 recombinant recombinant-proteins proteins protein

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