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42

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21652	RN-1 dihydrochloride	Histone Demethylase; MAO	Chromatin/Epigenetic; Metabolism; Neuroscience
	RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T2445	FG-2216 YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。
T35044	Velaresol BW 12C79,BW 12C,BW-12C79,BW12C79,BW-12C
	Velaresol (BW12C, BW12C79) is an oxygenated hemoglobin stabilizer that, in addition to stabilizing oxygenated hemoglobin, protects sickle cells from calcium-mediated dehydration.
T19583	TN1	Others	Others
	TN1 是一种有效的胎儿型血红蛋白 (HbF) 诱导剂。
T19889	L-5-BromoTryptophan L-5-溴色氨酸,5-BrW,5 BrW	Others	Others
	L-5-BromoTryptophan (5-BrW) 是色氨酸(Trp) 效应物的类似物，可抑制血红蛋白 S 的凝胶化。
T7581	voxelotor GBT 440	Others	Others
	Voxelotor (GBT 440) 是镰状血红蛋白 (HbS) 聚合抑制剂，有用于镰状细胞贫血病研究的潜力。
T6482	Efaproxiral Sodium 乙丙昔罗钠,RSR13 sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Efaproxiral Sodium (RSR13 sodium) 是血红蛋白 (Hb) 合成变构调节剂，能够减少血红蛋白氧 (O2) 的结合亲和力。
TP1404L	Hemorphin-7 acetate(152685-85-3 free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Hemorphin-7 acetate(152685-85-3 free base) 是一种 hemorphin 肽，一种源自血红蛋白 β 链的内源性阿片肽。 Hemorphin 肽具有镇痛和抗高血压活性，可激活阿片受体并抑制血管紧张素转换酶 (ACE)。
TP1900L1	Hemopressin (human, mouse) acetate Hemopressin (human, mouse) acetate(1314035-51-2 free base)	Cannabinoid Receptor	GPCR/G Protein
	Hemopressin (human, mouse) acetate(1314035-51-2 free base) 是一种衍生自血红蛋白 α1 链的九肽，是从大鼠脑匀浆中分离出来的。 Hemopressin 是 CB1 大麻素受体的口服活性、选择性和反向激动剂。 Hemopressin 在炎性疼痛模型中发挥镇痛作用。
TP1901L1	Hemopressin (rat) acetate(568588-77-2 free base)	Cannabinoid Receptor	GPCR/G Protein
	Hemopressin (rat) acetate(568588-77-2 free base) 是一种衍生自血红蛋白 α1 链的九肽，起初是从大鼠脑匀浆中分离出来的。 Hemopressin 是 CB2 大麻素受体的口服活性、选择性和反向激动剂。 Hemopressin 在炎性疼痛模型中发挥镇痛作用。
T3695	Pepstatin 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂，可抑制 HIV 蛋白酶的活性。
T12407	Pepstatin Ammonium Pepstatin A Ammonium	Others	Others
	Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM
T32313	JP7 JP-7,JP 7
	JP7 is a hemoglobin allosteric modifier.
T21318	Efaproxiral RSR13,Efaproxyn,RSR 13,RSR-13
	Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity, increasing tumor
T34421	RSR4 RSR 4,RSR-4
	RSR4 is one of the most effective allosteric effectors of hemoglobin.
T32057	Hemorphin 5 Tyr-pro-trp-thr-gln
	Hemorphin 5 is an opioid peptide obtained from bovine hemoglobin.
T25768	Lysylphenylalanine Lys-phe
	Lysylphenylalanine is a cell sickling and a gelatin inhibitor of hemoglobin S.
T32439	L 35 L-35,L35
	L 35 is kind of a negative effector of hemoglobin.
T60313	Sucistil
	Sucistil 是一种活性生化物质。hemoglobin sucistil (bovine) 是一种氧载体。
T32892	LR 16 LR16,LR-16
	LR 16 has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein.
T39809	PRMT5-IN-14 PRMT5-IN-14
	PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
T60898	HbF inducer-1
	HbF inducer-1 是一种胎儿血红蛋白诱导剂，具有口服生物活性。
T25490	Hemorphin 4 Tyr-pro-trp-thr
	Hemorphin 4 is an endogenous opioid peptide of the hemorphin family which has antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.
T78074	Osivelotor GBT-601,GBT-021601	Others	Others
	Osivelotor 是一种血红蛋白 S (HbS) 变构调节剂，用于调整其结构特性。
T78075	GBT1118	Others	Others
	GBT1118是一种有效的口服血红蛋白氧亲和力变构调节剂，可增强对严重缺氧的耐受性。
T78356	Fructosyl amino acid oxidase
	Fructosyl amino acid oxidase是测量糖化蛋白的重要试剂，特别是用于评估糖尿病指标糖化血红蛋白A1c。
T35774	HC Toxin
	HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.
T83193	Acetyl-Heme-Binding Protein 1 (1-21) (human)
	Acetyl-Heme-Binding Protein 1 (1-21) (human)为一种由Acetyl-Heme-Binding Protein 1前21个氨基酸组成的短肽。该肽具有与血红素结合的能力，参与血红素代谢及血红蛋白释放过程。
T80278	Hb 98–114
	Hb 98-114，为牛血红蛋白α亚基98至114号氨基酸片段，属于抗菌肽类。此肽段对各类酵母及丝状真菌显示出显著的抗菌效果（MIC：2.1 μM-12.5 μM）。
T81500	PF-07059013
	PF-07059013是口服活性的镰状血红蛋白(HbS)非共价调制剂，具有纳摩尔级别的亲和力特异性结合Hb，展现出显著的红细胞(RBCs)分裂作用，适用于镰状细胞病(SCD)的研究。
T75799	Hemopressin(human, mouse) TFA	Cannabinoid Receptor	GPCR/G Protein
	Hemopressin TFA，一种衍生自血红蛋白α1链的九肽，最初自大鼠脑匀浆分离。作为口服活性且选择性的CB1大麻素受体反向激动剂，Hemopressin TFA在炎性疼痛模型中具有抗伤害感受效应。
T80374	HBA(111–142)	HSV	Microbiology/Virology
	HBA(111-142) 是一种源于 α-血红蛋白 C 端的32-聚体抗菌肽片段，对 ESKAPE 病原体展示出了抗菌效果。它能形成淀粉样原纤维结构，并表现出针对多种病毒，包括麻疹病毒和疱疹病毒（HSV-1、HSV-2、HCMV）的抗病毒活性。
TP1404	Hemorphin-7
	Hemorphin-7 binds to the angiotensin IV receptor, triggering multiple effects including cellular proliferation and memory enhancement. Hemorphins are endogenous peptides belonging to the family of atypical opioid peptides released from hydrolyzed hemoglob
T78446	Phenosafranine
	Phenosafranine是一种吩嗪染料，具有较高的三链RNA结合亲和力，相较于双链RNA。该染料通过嵌入机制与这两种RNA结合。Phenosafranine用途包括植物细胞染色，以及血红蛋白、多巴胺、血清素等的检测。
T75798	Hemopressin(rat) TFA
	Hemopressin(rat) TFA，一种衍生自α1-珠蛋白九肽，最初分离自大鼠脑匀浆。该化合物通过口服能有效选择性地作为CB1大麻素受体的反向激动剂，并在炎性疼痛模型中表现出抗伤害感受活性。
T73694	Albiglutide TFA
	Albiglutide TFA 是一种胰高血糖素样肽GLP-1模拟物，是长效的GLP-1受体激动剂。Albiglutide TFA 可显著降低糖化血红蛋白 (A1C)。Albiglutide TFA 可用于研究 2 型糖尿病 (T2D)。Albiglutide TFA 是由抗DPP-4的GLP-1二聚体与人白蛋白的基因融合产生的。
T28542	Rivoglitazone HCl CI-1037,CI1037,CS011,CS-011,CI 1037
	Rivoglitazone, also known as CI-1037; CS-011; DE-101; R-119702; Rivo, is a peroxisome proliferator-activated receptor γ agonist (PARPγ agonist) potentially for the treatment of type 2 diabetes. Rivoglitazone has been shown, through small clinical studies,
T83406	2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt
	2,3-Diphospho-D-glyceric acid pentasodium salt 是一种聚磷化合物，具有明显的阴离子性质。它在红细胞的凹中心起作用，通过结合血红蛋白降低氧亲和力。作为血管钙化 (VC) 的内源性选择性抑制剂，2,3-Diphospho-D-glyceric acid 能显著推迟结晶钙蛋白颗粒 (CPP) 的生成，并在小鼠血管平滑肌细胞系 (MOVAS) 中抑制钙化作用，同时不引起细胞毒性。
T78571	Albiglutide fragment TFA GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA
	Albiglutide fragment (GLP-1 (7-36) analog) TFA为Albiglutide活性片段，代表胰高血糖素样肽-1(GLP-1)模拟物，属长效GLP-1受体激动剂。由GLP-1二聚体抗DPP-4特性与人白蛋白基因融合而成，本化合物在降低糖化血红蛋白(A1C)方面表现显著，主要应用于2型糖尿病(T2D)的相关研究。
T37323	Succinyl-Coenzyme A sodium salt Succinyl-CoA sodium salt,Succinyl-Coenzyme A (sodium salt),Succinyl-CoA	Endogenous Metabolite	Metabolism
	Succinyl-Coenzyme A sodium salt(Succinyl-CoA sodium salt) 参与柠檬酸循环，在柠檬酸循环中转化为琥珀酸。Succinyl-Coenzyme A (sodium salt) 在生物体内参与多种代谢反应，在体内有着举足轻重的作用 Succinyl-Coenzyme A sodium salt 参与血红素的合成，可用于研究由营养性维生素 B12 缺乏症 (致使 Succinyl-Coenzyme A 合成缺乏) 所引起的代谢疾病、神经疾病和血液学异常导致的疾病。
T37053	Z-(L-Arg)-AMC (hydrochloride)
	Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrat...

化合物

RN-1 dihydrochloride

Cat.No: T21652

Target: Histone Demethylase, MAO

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

Cat.No: T2445

Synonym: YM-311,FG2216,FG 2216

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T35044

Synonym: BW 12C79,BW 12C,BW-12C79,BW12C79,BW-12C

Cat.No: T19583

Target: Others

L-5-BromoTryptophan

Cat.No: T19889

Synonym: L-5-溴色氨酸,5-BrW,5 BrW

Target: Others

Cat.No: T7581

Synonym: GBT 440

Target: Others

Efaproxiral Sodium

Cat.No: T6482

Synonym: 乙丙昔罗钠,RSR13 sodium

Target: Reactive Oxygen Species

Hemorphin-7 acetate(152685-85-3 free base)

Cat.No: TP1404L

Target: Opioid Receptor

Hemopressin (human, mouse) acetate

Cat.No: TP1900L1

Synonym: Hemopressin (human, mouse) acetate(1314035-51-2 free base)

Target: Cannabinoid Receptor

Hemopressin (rat) acetate(568588-77-2 free base)

Cat.No: TP1901L1

Target: Cannabinoid Receptor

Cat.No: T3695

Synonym: 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C

Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy

Pepstatin Ammonium

Cat.No: T12407

Synonym: Pepstatin A Ammonium

Target: Others

Cat.No: T32313

Synonym: JP-7,JP 7

Cat.No: T21318

Synonym: RSR13,Efaproxyn,RSR 13,RSR-13

Cat.No: T34421

Synonym: RSR 4,RSR-4

Cat.No: T32057

Synonym: Tyr-pro-trp-thr-gln

Lysylphenylalanine

Cat.No: T25768

Synonym: Lys-phe

Cat.No: T32439

Synonym: L-35,L35

Cat.No: T60313

Cat.No: T32892

Synonym: LR16,LR-16

Cat.No: T39809

Synonym: PRMT5-IN-14

Cat.No: T60898

Cat.No: T25490

Synonym: Tyr-pro-trp-thr

Cat.No: T78074

Synonym: GBT-601,GBT-021601

Target: Others

Cat.No: T78075

Target: Others

Fructosyl amino acid oxidase

Cat.No: T78356

Cat.No: T35774

Acetyl-Heme-Binding Protein 1 (1-21) (human)

Cat.No: T83193

Cat.No: T80278

Cat.No: T81500

Hemopressin(human, mouse) TFA

Cat.No: T75799

Target: Cannabinoid Receptor

Cat.No: T80374

Target: HSV

Cat.No: TP1404

Cat.No: T78446

Hemopressin(rat) TFA

Cat.No: T75798

Albiglutide TFA

Cat.No: T73694

Rivoglitazone HCl

Cat.No: T28542

Synonym: CI-1037,CI1037,CS011,CS-011,CI 1037

2,3-Diphospho-D-glyceric acid pentasodium salt

Cat.No: T83406

Synonym: 2,3-DPG pentasodium salt

Albiglutide fragment TFA

Cat.No: T78571

Synonym: GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA

Succinyl-Coenzyme A sodium salt

Cat.No: T37323

Synonym: Succinyl-CoA sodium salt,Succinyl-Coenzyme A (sodium salt),Succinyl-CoA

Target: Endogenous Metabolite

Z-(L-Arg)-AMC (hydrochloride)

Cat.No: T37053

Cat. No.	Product Name	Target	Signaling Pathways
T2934	Bilirubin 胆红素,Bilibubin,Principal bile pigment,Hematoidin,Hemetoidin	Endogenous Metabolite	Metabolism
	Bilirubin (Principal bile pigment) 是血红素分解代谢产生的黄色产物，是肝功能的重要指标。Bilirubin 具有抗诱变和抗氧化作用。
T0063	L-Isoleucine 异亮氨酸,isoleucine,Ile,L-异亮氨酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-Isoleucine (Ile) 是一种非极性疏水性氨基酸。它是必需氨基酸。
T41335	cis-Vaccenic acid cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid	Antiviral	Immunology/Inflammation
	cis-Vaccenic acid (Asclepic acid) 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。
T8948	Ferroheme protoheme,Hematin,heme	Others	Others
	Ferroheme (protoheme) 是一种亚铁离子和卟啉的复合物，也是脂肪酸结合大鼠肝脏脂肪酸结合蛋白的同位异构抑制剂。
T6480	D-Pantothenic acid vitamin B5,pantothenate,D-泛酸	Others	Others
	D-Pantothenic acid (vitamin B5) 是必需的微量营养素，是辅酶 A 的前体，在很多生物过程中发挥关键作用，如调节碳水化合物，脂质，蛋白和核酸代谢。
T10933	D-Cysteine	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	D-Cysteine 是一种大肠杆菌生长的有力抑制剂，是半胱氨酸的 D 型异构体。它由 D-氨基酸氧化酶介导产生 H2S，是一种对抗小脑共济失调的神经保护剂。 D-半胱氨酸可以抑制由变形链球菌和链球菌血红蛋白形成的两种生物膜的生长和致龋性。
T75705	Pepstatin Trifluoroacetate
	Pepstatin (Pepstatin A) Trifluoroacetate 是一种由放线菌产生的特异性天冬氨酸蛋白酶(aspartic proteases)抑制剂，口服活性强。该化合物能有效抑制hemoglobin-pepsin、hemoglobin-proctase、casein-pepsin、casein-proctase、casein-acid protease和hemoglobin-acid protease的活性，其IC50值分别为4.5 nM、6.2 nM、150 nM、290 nM、520 nM和260 nM。此外，对HIV protease也有抑制作用。
T83405	2,3-Diphosphoglyceric acid 2,3-DPG
	2,3-Diphosphoglyceric acid (2,3-DPG) 是一种糖酵解途径的中间产物，能够通过变构作用结合并稳定脱氧血红蛋白，从而促进氧气在组织部位的释放。此外，2,3-Diphosphoglyceric acid 与血红蛋白结合，有效降低了其对氧的亲和力。

天然产物

Cat.No: T2934

Synonym: 胆红素,Bilibubin,Principal bile pigment,Hematoidin,Hemetoidin

Target: Endogenous Metabolite

Cat.No: T0063

Synonym: 异亮氨酸,isoleucine,Ile,L-异亮氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

cis-Vaccenic acid

Cat.No: T41335

Synonym: cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid

Target: Antiviral

Cat.No: T8948

Synonym: protoheme,Hematin,heme

Target: Others

D-Pantothenic acid

Cat.No: T6480

Synonym: vitamin B5,pantothenate,D-泛酸

Target: Others

Cat.No: T10933

Target: Endogenous Metabolite, Antibacterial

Pepstatin Trifluoroacetate

Cat.No: T75705

2,3-Diphosphoglyceric acid

Cat.No: T83405

Synonym: 2,3-DPG

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