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8

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T7461	2,4-Diamino-6-hydroxypyrimidine DAHP,2,4-二氨基-6-羟基嘧啶	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	2,4-Diamino-6-hydroxypyrimidine (DAHP) 是GTP cyclohydrolase I(蛋白从头合成中的限速酶) 的选择性抑制剂。它能够抑制NO 的产生以及阻断 Tetrahydrobiopterin (BH4) 的合成。
T11742	K-7174	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	K-7174 是一种新型细胞粘附抑制剂，抑制由 IL-1β 或 TNF-α 诱导的血管细胞粘附分子 1 (VCAM-1) 的表达。
T71722	Angiogenesis inhibitor BT2
	Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, angiogenesis, and inflammation, interacting with MEK1, suppressing retinal CD31, pERK, VCAM-1, and VEGF-A165 expression.
T31072	CP-664511 UNII-W1AEF8025F,CP664511
	CP-664511 is an alpha4beta1/ vascular cell adhesion molecule-1 (VCAM-1) inhibitor with therapeutic potential for allergic airway disease.
T11742L	K-7174 dihydrochloride	mTOR	PI3K/Akt/mTOR signaling
	K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
T69203	HMR1031
	HMR1031 is a potent and specific integrin α4ß1 or very late antigen 4 (VLA-4) receptor antagonist which binds to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin.
T62111	Antioxidant agent-5
	Antioxidant agent-5 (compound D-6) 是一种有效的抗氧化剂。Antioxidant agent-5 能够抑制 oxLDL 诱导的 ROS 水平升高和 NF-κB 核转位。Antioxidant agent-5 对 oxLDL (氧化型低密度脂蛋白)诱导的 VECs 细胞凋亡 (apoptosis) 及 ICAM-1 和 VCAM-1 的表达表现出抑制作用。Antioxidant agent-5 可以激活 Nrf2/HO-1 抗氧化通路，对 oxLDL 诱导的内皮损伤表现出保护活性。

化合物

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

2,4-Diamino-6-hydroxypyrimidine

Cat.No: T7461

Synonym: DAHP,2,4-二氨基-6-羟基嘧啶

Target: Reactive Oxygen Species, NO Synthase

Cat.No: T11742

Target: IL Receptor, TNF

Angiogenesis inhibitor BT2

Cat.No: T71722

Cat.No: T31072

Synonym: UNII-W1AEF8025F,CP664511

K-7174 dihydrochloride

Cat.No: T11742L

Target: mTOR

Cat.No: T69203

Antioxidant agent-5

Cat.No: T62111

Cat. No.	Product Name	Target	Signaling Pathways
T3927	Phellopterin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Phellopterin 是一种分离自P. trifoliata 中的天然产物。它能够调节 Akt 和 PKC 通路，抑制 TNF-alpha 诱导的 VCAM-1 表达，进而减少单核细胞与内皮细胞的粘附。
TN6951	Ethyl linoleate 亚油酸乙酯	Others	Others
	Ethyl linoleate 对动脉粥样硬化病变的发展和炎症介质的表达有抑制作用。
TN1163	2'-Hydroxychalcone	Others	Others
	2'-Hydroxychalcone 是一种药物合成中间体，可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1，VCAM-1和E-选择素的稳态转录水平，因此可能会干扰其基因的转录。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T2873	Ginsenoside Rg2 Chikusetsusaponin I,Panaxoside Rg2,人参皂苷Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2,人参皂苷 Rg2	Beta Amyloid; GSK-3; NF-κB	Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Stem Cells
	Ginsenoside Rg2 (Chikusetsusaponin I) 是一种人参的主要活性成分。它能够降低Aβ1-42积聚，抑制脂多糖介导的VCAM-1和ICAM-1表达的增加。
T4S1615	Sanggenon C 桑根酮C,桑根酮 C,Sanggenone C	NF-κB	NF-κB
	Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。它具有抗氧化和抗炎作用，也有抑制胰脂肪酶作用。
T2985	Gypenoside XLIX 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX	PPAR	DNA Damage/DNA Repair; Metabolism
	Gypenoside XLIX 是一种达玛烷型糖苷，是绞股蓝的主要成分。它是选择性过氧化物酶体增殖物激活受体 (PPAR)-α激活剂，可抑制细胞因子诱导的血管细胞粘附分子-1 (VCAM-1) 在人体内皮细胞中过度活跃和表达。
TN3219	7,8-Didehydrocimigenol	ERK; IκB/IKK; TNF; NF-κB; Akt; PPAR	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.
T36513	Pyranonigrin A
	Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH;) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
TN3655	Cimiside E	ERK; TNF; ROS; Akt; PI3K; PKC; PPAR	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen

天然产物

Cat.No: T3927

Target: GABA Receptor

Ethyl linoleate

Cat.No: TN6951

Synonym: 亚油酸乙酯

Target: Others

2'-Hydroxychalcone

Cat.No: TN1163

Target: Others

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Ginsenoside Rg2

Cat.No: T2873

Synonym: Chikusetsusaponin I,Panaxoside Rg2,人参皂苷Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2,人参皂苷 Rg2

Target: Beta Amyloid, GSK-3, NF-κB

Cat.No: T4S1615

Synonym: 桑根酮C,桑根酮 C,Sanggenone C

Target: NF-κB

Gypenoside XLIX

Cat.No: T2985

Synonym: 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX

Target: PPAR

7,8-Didehydrocimigenol

Cat.No: TN3219

Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR

Cat.No: T36513

Cat.No: TN3655

Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR

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