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29

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0023	Valethamate bromide Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan	Others	Others
	Valethamate bromide (Resitan) 是快速作用的抗胆碱能解痉和肌萎缩剂，是一种酯，能够改善宫颈扩张加速分娩。
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T20570	Labetalol Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Labetalol (Apo-Labetalol) 是一种抗高血压药物，可用于心血管疾病的研究，如妊娠期高血压。它是一种口服具有活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。
T22285	Carboprost 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α,卡前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) 是一种前列腺素 F2α 的代谢稳定的合成类似物。它能够刺激子宫收缩并引起流产，可用于子宫收缩乏力引起的产后出血，以及在妊娠中期终止妊娠。
T31213	Dazmegrel UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485	PPAR	DNA Damage/DNA Repair; Metabolism
	Dazmegrel (UK 38,485) 是一种强效特异性血栓素 A2（TXA2）合成酶抑制剂，可用于预防正常妊娠中全血小板聚集增加。
T61864	Melengestrol acetate	Progesterone Receptor	Others
	Melengestrol acetate 是孕酮的衍生物，充当皮质类固醇激素。 Melengestrol acetate 可以促进月经活动和妊娠维持的子宫内膜增殖延迟。
T1110	Meclizine dihydrochloride Meclozine dihydrochloride,NSC28728,Meclizine 2HCl,盐酸美克洛嗪	Apoptosis; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meclizine dihydrochloride (NSC28728) 是一种组胺 H1 拮抗剂，用于治疗妊娠期间的晕动病、眩晕和恶心以及放射病。它是小鼠组成型雄甾烷受体激动剂，是人 CAR 的反向激动剂。它可透过血脑屏障，可用于多聚谷氨酰胺毒性障碍方面的研究。
T24415	Lotrifen Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta	Others	Others
	Lotrifen (Privaprol) 是一种非激素抗生育药物，Lotrifen 引起妊娠停止和复旧。在胚泡着床后，它直接作用于受精卵，受精卵经历一个缓慢而逐渐的退化过程，并以受精卵的再吸收或排出而结束。
T4616	Metoclopramide 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T34165	Prostalene RS 9390,RS9390,RS-9390,Synchrocept
	Prostalene is a prostaglandin F(2)alpha analogue used in pregnancy.
T27108	Cymipristone ZXH951,ZXH 951,ZXH-951
	Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
T31756	Fe-Cap folic
	Fe-Cap folic is an encapsulated dosage for use as an iron supplement in pregnancy.
T33326	Methotrexate-alpha glutamate Meapa-glu-glu
	Methotrexate-alpha glutamate is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.
T31851	Formiminoglutamic acid NSC-334078,NSC334078,NSC 334078
	Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine.
T20855	Gemeprost SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin
	Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone.
T36829	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimes...
T29486	7-Methotrexate 7-Mtx
	7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.
T29391	3'-Chloromethotrexate NSC 29631,NSC29631,SKI 23338,NSC-29631,AI3-50533
	3'-Chloromethotrexate is a chemotherapy agent and immune system suppressant. It can be used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.
T34302	Retroprogesterone
	Retroprogesterone, a progestin, may be used for menstrual irregularities in adolescence, for the maintenance of threatened pregnancy, and possibly as an ovulation stimulant.
T70570	Erlosiban
	Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).
T73761	Estriol 16α-(β-D-glucuronide)
	Estriol 16α-(β-D-glucuronide) 是存在于尿中的内源代谢物，可用于研究妊娠。
T74179	1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine
	1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine，一种血液中的内源性代谢物，主要用于妊娠和败血症的研究。
T37327	Prostaglandin F2α 1,15-lactone Prostaglandin F2α 1,15-lactone
	PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective.
T37230	(+)-5-trans Cloprostenol
	Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster.
T37122	1,2-Dilinoleoyl-sn-glycerol
	1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy.
T28685	SB236057 SB-236057,SB 236057
	SB236057 is a potent and selective inverse agonist for the 5-HT receptor, acting especially at 5-HT autoreceptors on nerve terminals. It produces a rapid increase in 5-HT levels in the brain. SB236057 also acts as a potent teratogen, producing severe musc
T37231	(+)-Cloprostenol methyl ester
	(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprosteno...
T73734	Acetoacetic acid
	Acetoacetic acid是一种存在于脑脊液中的内源代谢物，主要应用于脑膜炎、妊娠、3-羟基-3-甲基戊二酰辅酶A裂解酶缺乏症、子痫前期/子痫、2型糖尿病、1型葡萄糖转运蛋白缺乏综合征及琥珀酰辅酶A:3-氧酸辅酶A转移酶缺乏症的研究中。
T64294	Succinic acid sodium
	Succinic acid sodium 是一种口服具有活力的抗焦虑剂。Succinic acid sodium 能够下调 KCNMB1 (钾通道亚基 β1) 和TET1(10-11 易位 1) 的表达。Succinic acid sodium 可抑制体内的结肠上皮细胞的增殖。Succinic acid sodium 能够用于研究妊娠期高血压。

化合物

Valethamate bromide

Cat.No: T0023

Synonym: Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan

Target: Others

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

Cat.No: T20570

Synonym: Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne

Target: Adrenergic Receptor

Cat.No: T22285

Synonym: 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α,卡前列素

Target: Prostaglandin Receptor

Cat.No: T31213

Synonym: UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485

Target: PPAR

Melengestrol acetate

Cat.No: T61864

Target: Progesterone Receptor

Meclizine dihydrochloride

Cat.No: T1110

Synonym: Meclozine dihydrochloride,NSC28728,Meclizine 2HCl,盐酸美克洛嗪

Target: Apoptosis, Histamine Receptor

Cat.No: T24415

Synonym: Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta

Target: Others

Cat.No: T4616

Synonym: 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T34165

Synonym: RS 9390,RS9390,RS-9390,Synchrocept

Cat.No: T27108

Synonym: ZXH951,ZXH 951,ZXH-951

Cat.No: T31756

Methotrexate-alpha glutamate

Cat.No: T33326

Synonym: Meapa-glu-glu

Formiminoglutamic acid

Cat.No: T31851

Synonym: NSC-334078,NSC334078,NSC 334078

Cat.No: T20855

Synonym: SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

Cat.No: T36829

Synonym: 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

Cat.No: T29486

Synonym: 7-Mtx

3'-Chloromethotrexate

Cat.No: T29391

Synonym: NSC 29631,NSC29631,SKI 23338,NSC-29631,AI3-50533

Retroprogesterone

Cat.No: T34302

Cat.No: T70570

Estriol 16α-(β-D-glucuronide)

Cat.No: T73761

1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

Cat.No: T74179

Prostaglandin F2α 1,15-lactone

Cat.No: T37327

Synonym: Prostaglandin F2α 1,15-lactone

(+)-5-trans Cloprostenol

Cat.No: T37230

1,2-Dilinoleoyl-sn-glycerol

Cat.No: T37122

Cat.No: T28685

Synonym: SB-236057,SB 236057

(+)-Cloprostenol methyl ester

Cat.No: T37231

Acetoacetic acid

Cat.No: T73734

Succinic acid sodium

Cat.No: T64294

Cat. No.	Product Name	Target	Signaling Pathways
T3894	Polyphyllin II 重楼皂苷 II,Chonglou Saponin II	Apoptosis; Others	Apoptosis; Others
	Polyphyllin II (Chonglou Saponin II) 是重楼中重要的一种皂苷，具有止血、祛痰、抑菌、抗细胞毒和抗孕杀精作用。它通过 caspases 激活和细胞周期停滞诱导细胞凋亡。
T3O2784	Vitamin B6 维生素B6	Others	Others
	Vitamin B6 是人体某些辅酶的成分，参与多种代谢反应，特别是与氨基酸代谢有关。维生素B6在防治妊娠和放射病呕吐中的临床应用。
T6S2315	Polyphyllin VI	Apoptosis; Antibacterial; Pyroptosis	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Polyphyllin VI 是一种活性皂甙，诱导 G2/M 细胞周期停滞并引发细胞凋亡，具有抗癌活性。它通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡。
T0478	Progesterone 孕酮,Pregn-4-ene-3,20-dione	Estrogen/progestogen Receptor; Progesterone Receptor; Opioid Receptor; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience; Others
	Progesterone (Pregn-4-ene-3,20-dione) 是类固醇激素，能够调节月经周期。
T1429	17α-Hydroxyprogesterone Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮	Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	17α-Hydroxyprogesterone (17-OHP) 是一种内源性孕激素，其他类固醇激素（包括糖皮质激素，雌激素，和雄激素）生物合成的化学中间体。
T1571	Estriol NSC-12169,Oestriol,雌三醇	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; MRP; Endogenous Metabolite	Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Estriol (Oestriol) 是G 蛋白偶联雌激素受体拮抗剂，能够作用于雌激素受体阴性乳腺癌细胞。
T1688	Pregnanediol 5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇	Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) 是一种黄体酮的主要代谢物 (metabolite)，能够通过尿液排出。它提供了一种间接测定体内孕激素水平的方法。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
TN5961	Gardenolic acid B
	Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.
T37499	Estriol 3-glucuronide
	Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].

天然产物

Cat.No: T3894

Synonym: 重楼皂苷 II,Chonglou Saponin II

Target: Apoptosis, Others

Cat.No: T3O2784

Synonym: 维生素B6

Target: Others

Cat.No: T6S2315

Target: Apoptosis, Antibacterial, Pyroptosis

Cat.No: T0478

Synonym: 孕酮,Pregn-4-ene-3,20-dione

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Opioid Receptor, Endogenous Metabolite

17α-Hydroxyprogesterone

Cat.No: T1429

Synonym: Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Cat.No: T1571

Synonym: NSC-12169,Oestriol,雌三醇

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, MRP, Endogenous Metabolite

Cat.No: T1688

Synonym: 5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇

Target: Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Gardenolic acid B

Cat.No: TN5961

Estriol 3-glucuronide

Cat.No: T37499

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