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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product Name	CAS No.	Purity
T13584	BMVC-8C3O 化合物BMVC-8C3O	1301708-12-2	98%
T13584	BMVC-8C3O 是一种 DNA G-四链体 (G4) 配体，可诱导人类端粒 DNA G4 中的非平行到平行形式的拓扑转换
T36756	DMT-dG(ib) Phosphoramidite DMT-dG(ib)亚磷酰胺单体	93183-15-4	98%
T36756	DMT-dG(ib) Phosphoramidite 可用于 DNA 的合成。
T23974	DDRI-18 化合物DDRI-18	4402-18-0	98%
T23974	DDRI-18 是一种调节 DNA 损伤反应的新型小分子抑制剂，具有增敏活性和抗癌活性，抑制非同源末端连接 (NHEJ) DNA 修复过程，增强抗癌 DNA 损伤化合物的细胞毒性作用。
T37101	1-Hydroxyanthraquinone 1-羟基蒽醌	129-43-1	98%
T37101	1-Hydroxyanthraquinone 是口服有效的天然产物，来源于植物 Tabebuia avellanedae，显示出致癌活性。
T4470	Pyridostatin TFA 化合物Pyridostatin TFA	1472611-44-1	98%
T4470	Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。