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112

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3978	Linerixibat GSK2330672,Iinerixibat	HBV	Microbiology/Virology
	Linerixibat (GSK2330672) 是高效的、不可吸收的、具有口服活性的顶端钠依赖性胆汁酸转运蛋白 (ASBT) 抑制剂，对人ASBT 的IC50为 42 nM。它是一种降脂剂，具有用于 2 型糖尿病和原发性胆源性胆管炎的研究潜力。
T24493	Monoelaidin
	Monoelaidin is a poorly water-soluble drug enhancer of solubility and oral bioavailability.
T8238	Fosamprenavir Calcium Salt 福沙那伟钙,Diallyl Trisulfide,GW433908G	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药，具有改善的溶解性和抗HIV 感染作用。
T6538	Hydroxypropyl Cellulose	Others	Others
	Hydroxypropyl Cellulose 是纤维素的衍生物，兼具水溶性和有机溶解性，用作食品添加剂和 DNA 分离的筛分基质。
T20331	Sodium lauroyl glutamate Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11	Others	Others
	Sodium lauroyl glutamate (Acylglutamate LS-11) 是一种氨基酸去污剂，可增加长链没食子酸烷基酯(如没食子酸烷基酯)的溶解度。
T20075	Sodium dodecyl sulfate Laurylsulfuric acid sodium salt,NSC 402488,Anticerumen,NSC-402488,NSC402488,Natrium laurylsulfuricum,Sodium dodecylsulfate,Sodium lauryl sulfate	Others	Others
	Sodium dodecyl sulfate(Sodium lauryl sulfate) 是一种作药用辅料，无生物活性，单能提高药物制剂的稳定性、溶解性和加工性。
T50013	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid	Others	Others
	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid 是一种合成化合物，具有强大的抗肿瘤活性，对肿瘤细胞有高效性和选择性，但其在水中的溶解性差且在高浓度下有潜在毒性。
TP1809	TAT	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	TAT 源自人免疫缺陷病毒的转录反式激活因子，是一种细胞穿透肽。它可以增加异源蛋白质的产量和溶解度。
T24047	Etilevodopa hydrochloride Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester	Others; Dopamine Receptor; Drug Metabolite	GPCR/G Protein; Metabolism; Neuroscience; Others
	Etilevodopa hydrochloride (L-DOPA ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解产生 Levodopa 和乙醇。Levodopa 是多巴胺的前体，有助于中枢神经系统的渗透和传递多巴胺。Etilevodopa HCl 可用于帕金森病 (PD)的相关研究。
T4545	Propacetamol Hydrochloride 盐酸丙帕他莫,Propacetamol HCL	Others	Others
	Propacetamol Hydrochloride (Propacetamol HCL) 是 paracetamol(acetaminophen) 的前药，具有改善的水溶性。当口服非甾体抗炎药不合适或矛盾时，丙帕西莫是一种静脉给药的镇痛药。
T5593	L-Alanyl-L-glutamine L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln	Others; Endogenous Metabolite	Metabolism; Others
	L-Alanyl-L-glutamine (Ala-Gln) 是一种由丙氨酸和谷氨酰胺组成的二肽，对抗氧化系统有益，能够减轻炎症，并能够在分解代谢情况下调节热休克蛋白 (HSP) 的反应。
T8947	dasiglucagon acetate dasiglucagon acetate(1544300-84-6 free base)	Others	Others
	dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明，与传统的重组胰高血糖素相比，它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T14050	5-FAM 5-羧基荧光素,5-Carboxyfluorescein	Others	Others
	5-FAM (5-Carboxyfluorescein) 是一种绿色荧光探针(Ex/Em 为 490 nm/520 nm)，可用于肽，蛋白质和核苷酸的标记。
T25124	AZ599 AZ-599,AZ 599
	AZ599 is a full agonist of CB1 with good solubility and low CNS penetration.
T34119	PPS Silent Surfactant PPS
	PPS Silent Surfactant is a cleavable detergent used in biochemistry, and especially in proteomics, to enhance protein denaturation and solubility.
T68426	Dipfluzine
	Dipfluzine is a diphenylpiperazine calcium channel blocker with poor solubility.
T33606	NBI-30545
	NBI-30545 is a potent corticotropin-releasing factor-1 antagonist with sufficient lipophilicity and water solubility for the treatment of stress disorders.
T68337	PLX647(OMe)
	PLX647(OMe) is a slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility.
T30477	Bis-PEG5-thiol
	Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.
T24668	Propargyl-PEG4-CH2CO2-NHS
	Propargyl-PEG4-CH2CO2-NHS is a PEG derivative containing a propargyl group and an NHS group. The hydrophilic PEG spacer increases solubility in aqueous media.
T20978	S-acetyl-PEG6 S-acetyl-PEG6-alcohol
	S-acetyl-PEG6-alcohol is a PEG Linker, which is used to synthesize compounds and increases solubility in aqueous media.
T80936	Trisulfo-Cy3-acid disodium
	Trisulfo-Cy3-acid disodium, 作为一种Cy3（Cyanine3）染料衍生物，具备三个磺酸根离子（sulfonate），从而提供了优化的水溶性特征。
T35309	ZL004 ZL 004,ZL-004
	ZL-004可增加白细胞计数，专为缓释纳米混悬剂而开发，以改善低溶解度和患者的依从性。
T39700	Ga(III) protoporphyrin IX
	Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in methanol (MeOH) and serves as a malarial pigment analogue for drug development, as well as a potential antibacterial agent.
T31835	Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP
	Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP is a peptide reagent for ADC conjugation that possesses a cleavable peptide sequence. The hydrophilic PEG spacer increases solubility in aqueous media.
T19167	8pyDTZ	Others	Others
	8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission and improved water solubility. It can be used for in vivo luminescence imaging.
TP1500	β-Amyloid (1-17) β-Amyloid 1-17
	This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.
T16875	SF1126	Others	Others
	SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment.
T73394	BAY-7081
	BAY-7081 是一种有效的、选择性的、具有口服活性的可溶性氰吡啶基 PDE9A 抑制剂，其IC50为 15 nM。
T30274	Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
	Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a PEG derivative conjugated with a peptide via an amide bond. The azide group on the PEG end enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
T20849	Hydroxy-PEG3-acid
	Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functi
T20973	Thiol-C2-PEG2-OH Thiol-PEG3-alcohol,HS-PEG3-OH
	Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
T20903	m-PEG12-Mal
	M-PEG12-Mal is a PEG derivative containing a maleimide group. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group could form a covalent bond with a thiol group , enabling the further connection of biomolecule with a thiol
T22376	NCGC1481	Others	Others
	NCGC1481 is a potent inhibitor of FLT3 and IRAK1/4 with improved stability, solubility, and permeability properties.
T25819	ML350 SR-2311,SR 2311,SR2311,ML-350,ML 350
	ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting pharmacodynamic effects observed wi
T20901	m-PEG12-NHS ester
	M-PEG12-NHS ester is a PEG derivative containing an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label amine-modified oligonucleotides, the primary amines (-NH2) of proteins, and other amine-con
T71953	Thiol-PEG2-acid
	Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
T20904	m-PEG11-Tos
	M-PEG11-Tos is a PEG derivative containing a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. For nucleophilic substitution reactions, the tosyl group is a good leaving group.
T39634	GSK097
	GSK097 is a highly potent and selective inhibitor of the second bromodomain (BD2) found in bromodomain and extra-terminal domain (BET) proteins. It exhibits a remarkable 2000-fold selectivity for BD2 over BD1, as indicated by BRD4 data. Additionally, GSK097 demonstrates solubility of over 1 mg/mL in FaSSIF media.
T25826	MMV024101 MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101
	MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incu
T32120	Hydroxy-PEG1-methylamine
	Hydroxy-PEG1-methylamine is a PEG derivative containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct
T20850	Hydroxy-PEG14-acid
	Hydroxy-PEG14-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct
T30273	Azido-PEG4-acrylate
	Azido-PEG4-acrylate is a crosslinker containing an azide group and an acrylate group. The azide group enables Click Chemistry and the acrylate group enables Michael addition. The hydrophilic PEG spacer increases solubility in aqueous media.
T20328	Biotin-PEG7-amine
	Biotin-PEG7-amine is a PEG derivative containing a biotin group and a terminal primary amine group. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound.
T79018	GSK217	Epigenetic Reader Domain	Chromatin/Epigenetic
	GSK217为一种针对(BET)第二溴化结构域(BD2)的强效、选择性及高溶解度抑制剂，应用于肿瘤及免疫炎症研究领域。
T32121	Hydroxy-PEG3-NHS
	Hydroxy-PEG3-NHS is a PEG derivative containing a hydroxyl group with an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. T
T20915	Azido-PEG2-t-butyl ester
	Azido-PEG2-t-butyl ester is a PEG derivative containing a t-butyl ester and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. Under acidic conditions, the t-butyl protected carboxyl group can be deprotected.
T30272	Azido-PEG12-t-butyl ester
	Azido-PEG12-t-butyl ester is a PEG derivative containing an azide group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole
T20899	m-PEG1-acid
	M-PEG1-acid is a PEG derivative containing a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. In the presence of activators (e.g. EDC, DCC), the terminal carboxylic acid can be reacted with primary amine groups t

化合物

Cat.No: T3978

Synonym: GSK2330672,Iinerixibat

Target: HBV

Cat.No: T24493

Fosamprenavir Calcium Salt

Cat.No: T8238

Synonym: 福沙那伟钙,Diallyl Trisulfide,GW433908G

Target: HIV Protease

Hydroxypropyl Cellulose

Cat.No: T6538

Target: Others

Sodium lauroyl glutamate

Cat.No: T20331

Synonym: Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11

Target: Others

Sodium dodecyl sulfate

Cat.No: T20075

Synonym: Laurylsulfuric acid sodium salt,NSC 402488,Anticerumen,NSC-402488,NSC402488,Natrium laurylsulfuricum,Sodium dodecylsulfate,Sodium lauryl sulfate

Target: Others

4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid

Cat.No: T50013

Target: Others

Cat.No: TP1809

Target: HIV Protease

Etilevodopa hydrochloride

Cat.No: T24047

Synonym: Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester

Target: Others, Dopamine Receptor, Drug Metabolite

Propacetamol Hydrochloride

Cat.No: T4545

Synonym: 盐酸丙帕他莫,Propacetamol HCL

Target: Others

L-Alanyl-L-glutamine

Cat.No: T5593

Synonym: L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln

Target: Others, Endogenous Metabolite

dasiglucagon acetate

Cat.No: T8947

Synonym: dasiglucagon acetate(1544300-84-6 free base)

Target: Others

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

Cat.No: T14050

Synonym: 5-羧基荧光素,5-Carboxyfluorescein

Target: Others

Cat.No: T25124

Synonym: AZ-599,AZ 599

PPS Silent Surfactant

Cat.No: T34119

Synonym: PPS

Cat.No: T68426

Cat.No: T33606

Cat.No: T68337

Cat.No: T30477

Propargyl-PEG4-CH2CO2-NHS

Cat.No: T24668

Cat.No: T20978

Synonym: S-acetyl-PEG6-alcohol

Trisulfo-Cy3-acid disodium

Cat.No: T80936

Cat.No: T35309

Synonym: ZL 004,ZL-004

Ga(III) protoporphyrin IX

Cat.No: T39700

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP

Cat.No: T31835

Cat.No: T19167

Target: Others

β-Amyloid (1-17)

Cat.No: TP1500

Synonym: β-Amyloid 1-17

Cat.No: T16875

Target: Others

Cat.No: T73394

Azido-PEG4-Ala-Ala-Asn(Trt)-PAB

Cat.No: T30274

Hydroxy-PEG3-acid

Cat.No: T20849

Thiol-C2-PEG2-OH

Cat.No: T20973

Synonym: Thiol-PEG3-alcohol,HS-PEG3-OH

Cat.No: T20903

Cat.No: T22376

Target: Others

Cat.No: T25819

Synonym: SR-2311,SR 2311,SR2311,ML-350,ML 350

m-PEG12-NHS ester

Cat.No: T20901

Thiol-PEG2-acid

Cat.No: T71953

Cat.No: T20904

Cat.No: T39634

Cat.No: T25826

Synonym: MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101

Hydroxy-PEG1-methylamine

Cat.No: T32120

Hydroxy-PEG14-acid

Cat.No: T20850

Azido-PEG4-acrylate

Cat.No: T30273

Biotin-PEG7-amine

Cat.No: T20328

Cat.No: T79018

Target: Epigenetic Reader Domain

Hydroxy-PEG3-NHS

Cat.No: T32121

Azido-PEG2-t-butyl ester

Cat.No: T20915

Azido-PEG12-t-butyl ester

Cat.No: T30272

Cat.No: T20899

Cat. No.	Product Name	Target	Signaling Pathways
T20597	Alginic acid Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine	Apoptosis; Autophagy; Histamine Receptor	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Alginic acid (Snow acid algin G) 是一种从褐海藻中提取的天然多糖，具有抗过敏和抗炎活性。 Alginic acid 抑制组胺释放，可用于食品工业。
T2P2898	Neodiosmin 新地奥斯明,Diosmetin-7-neohesperidoside,新地奥司明,Diosmetin-7-O-neohesperidoside	Antioxidant	oxidation-reduction
	Neodiosmin (Diosmetin-7-O-neohesperidoside) 是一种黄酮苷，分离自柑桔叶中。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T81026	Tectorigenin sodium sulfonate
	Tectorigenin sodium sulfonate，一种经鸢尾黄素磺化并与饱和盐水混合得到的化合物，拥有高水溶性及优良抗氧化特性。
T82148	Hydrogenated soya phosphatidylcholines
	Hydrogenated soya phosphatidylcholines 是一种用于提升水溶性药物口服给药效果的天然产物，它能够增加药物负荷和溶解度，从而延长药物释放时间。
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。

天然产物

Cat.No: T20597

Synonym: Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine

Target: Apoptosis, Autophagy, Histamine Receptor

Cat.No: T2P2898

Synonym: 新地奥斯明,Diosmetin-7-neohesperidoside,新地奥司明,Diosmetin-7-O-neohesperidoside

Target: Antioxidant

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Tectorigenin sodium sulfonate

Cat.No: T81026

Hydrogenated soya phosphatidylcholines

Cat.No: T82148

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

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