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Search Results for " regeneration "

42

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21632	Myoseverin	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Myoseverina 是多核肌管可逆分裂成单核片段的诱导剂，影响多种生长因子、免疫调节、细胞外基质重塑和应激反应基因的表达，与伤口愈合和组织再生相关通路的激活一致。
T2052	KY02111	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY02111 是典型的 WNT 信号抑制剂，能够促进人多潜能干细胞向心肌细胞分化，可用于研究人类心肌细胞再生。
T9820	GPI-1485 GM1485	Others	Others
	GPI-1485 (GM1485) 是一种免疫抑制的特异性亲免蛋白配体，可促进中风后的神经功能改善和神经再生。
T25284	DAC-2-25 DAC 225,DAC-225,DAC 2 25	Others	Others
	DAC-2-25是 Hydra 头部再生调节剂。它通过诱导 Hydra 的同源转化而起作用。
T64342	DC-TEADin02	YAP	Stem Cells
	DC-TEADin02 是 TEAD 自棕榈酰化抑制剂 (IC50 = 197 nM)。 DC-TEADin02 可用于有关发育、再生和组织稳态的研究。
T35559	SAG 21k	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG 21k 是一种可透过血脑屏障且具有口服生物活性和有效性的 Hedgehog 信号激活剂，可用于研究软骨再生。
TP2319	Thymosin β4 acetate(75591-33-4 free base)	Autophagy	Autophagy
	Thymosin β4 acetate(75591-33-4 free base) 是一种胸腺激素，具有多种不同的细胞内和细胞外活性，影响伤口愈合、炎症、纤维化和组织再生。
T60144	TDI-011536	Others	Others
	TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。
T72956	Darizmetinib HRX215	MAPK	MAPK
	Darizmetinib (HRX215) 是一种 MKK4 抑制剂，MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强，进而激活转录因子 ATF2 和 ELK1，促进细胞增殖和肝再生。
T11053	DJ001	Phosphatase	Metabolism
	DJ001 是一种高度特异性，选择性和非竞争性的蛋白酪氨酸磷酸酶-σ (PTPσ) 抑制剂，IC50 为 1.43 μM。DJ001 对其他磷酸酶无抑制活性，对蛋白质磷酸酶 5 仅有中等抑制活性。DJ001 促进造血干细胞再生。
T5030	Zofenopril calcium SQ26991,佐芬普利钙,Zofenopril (calcium)	RAAS; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Zofenopril calcium (SQ26991) 是一种抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T28866	Stemazole	Apoptosis	Apoptosis
	Stemazole 是一种新型小分子人类干/祖细胞增殖激活剂，可促进人类胚胎干细胞的存活并保持干性，促进少突胶质细胞前体细胞在体外的存活。Stemazole 能显著提高细胞存活率和克隆形成数，并呈剂量依赖性，降低细胞凋亡率，促进运动功能障碍的恢复和髓鞘的修复。Stemazole 可作为脱髓鞘疾病的治疗剂，促进OPC 体外存活和体内再生。
T71793	CDMG1
	CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population
T19280	Diethyl aminoethyl hexanoate citrate DA-6 citrate,胺鲜酯柠檬酸盐,2-Diethylaminoethyl hexanoate citrate	Others	Others
	Diethyl aminoethyl hexanoate citrate (2-Diethylaminoethyl hexanoate citrate) 是一种植物生长调节剂，能够刺激不定芽的再生。
T37506	MCTR2 MCTR2
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shor...
T82851	BMP2-derived peptide
	BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序，具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。
T62295	MEIS-IN-2
	MEIS-IN-2 是一种 MEIS1 抑制剂。MEIS-IN-2 能够用于心脏再生和造血干细胞（HSC）调节方面的研究。
T13691	Etifoxine HOE 36-801	Others	Others
	Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. GABAA receptor Etifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration. Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons.
T37505	MCTR1 MCTR1
	Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflam...
T78092	UCL-TRO-1938	PI3K	PI3K/Akt/mTOR signaling
	UCL-TRO-1938为一种有效的PI3Kα变构激活剂，EC50约60 μM。该化合物能够诱导细胞增殖，并具备心脏保护及神经再生功能。
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37507	MCTR3 MCTR3
	Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase. MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1. Pretreatment with MCTR3 pri...
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37490	11(R)-HETE
	11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T72950	15-PGDH-IN-1
	15-PGDH-IN-1 是一种有效的15-PGDH 抑制剂，具有口服活性。15-PGDH-IN-1 对重组人15-PGDH 具有抑制活性，IC50值为 3 nM。15-PGDH-IN-1 可用于组织修复和再生的研究。
T75393	Glucose 1-dehydrogenase
	Glucose 1-dehydrogenase，即葡萄糖脱氢酶 (FAD) 或称为假单胞菌葡萄糖脱氢酶。Glucose 1-dehydrogenase 是一种用于再生辅助因子的酶，将葡萄糖和 NAD(P) 转化为 NAD(P)H 和葡萄糖酸。
T75763	TP508 TFA
	TP508 TFA为含23个氨基酸的非蛋白质水解凝血酶肽, 属凝血酶分子受体结合结构域部分。该化合物能激活内皮NO synthase(eNOS)，促进人内皮细胞内NO生成，进而通过激活内皮细胞及干细胞，促进血管及组织再生。
T37300	PCTR1 PCTR1
	Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It als...
T78101	Zymosan A Zymosan A from Saccharomyces cerevisiae
	Zymosan A（来自酿酒酵母的Zymosan A）是一种针对TLR2的激动剂，能够预防及抑制由IR引起的肠道伤害。该化合物显著增强了对辐射的防护能力，并能够保护小鼠免受辐射引起的肠损伤。此外，Zymosan A还能促进受IR损伤的肠干细胞（ISCs）的再生。
T76207	Glucose dehydrogenase (GDH)
	Glucose dehydrogenase (GDH)是一种氧化还原酶，催化β-D-葡萄糖氧化成β-D-葡糖酸-1,5-内酯，同时将辅助因子NADP+还原至NADPH，或以较小程度还原NAD+至NADH。此酶能接收NAD+和NADP+作为辅助因子，适用于NADH与NADPH的再生。
T80420	TAT-NEP1-40 acetate	Apoptosis	Apoptosis
	TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤，并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用，保护大脑免受缺血再灌注伤害，并能有效传递至大鼠的脑内。
T78454	Lucifer Yellow CH dipotassium salt
	Lucifer Yellow CH dipotassium为一高亮度荧光探针，含有游离肼基。它能在室温条件下与脂肪醛发生作用，并被广泛应用于作为生物示踪剂，监测神经元分支、再生、间隙连接以及细胞特定区域损伤后的反应。该探针 Ex-max 和 Em-max 分别为 430 nm和540 nm。
T78024	Selcopintide acetate Cpne7-DP acetate
	Selcopintide acetate (Cpne7-DP) 是一种合成肽，其结构基于hCPNE7蛋白的10个氨基酸残基344-353片段。该化合物通过上调成牙本质细胞标记基因DSPP和巢蛋白，高度复现了CPNE7在体外的作用。Selcopintide acetate能够促进牙本质再生，对不同程度的牙本质缺损有治疗效果，再生的硬组织具有真牙本质的特性。
T80418	TAT-NEP1-40	Apoptosis	Apoptosis
	TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤，同时促进神经突的生长。此外，TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡，对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤，特别是中风后的轴突再生与功能恢复方面的研究。
TP1989	NEP(1-40) Nogo-66 (1-40)
	Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal
T80419	TAT-NEP1-40 TFA	Apoptosis	Apoptosis
	TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害，并促进神经突的生长。此外，TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡，以改善神经系统功能。该化合物在中枢神经系统损伤，包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。
T82379	FN-A208 fusion peptide
	FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维，并有助于促进肌动蛋白应力纤维的形成，进而介导成纤维细胞附着，显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用，而在 EDTA 存在下，其活性则会被破坏。
T83700	IRBP (651-670) (human) TFA IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)
	IRBP651-670（Interphotoreceptor retinoid-binding protein (651-670)）是IRBP（亦称为retinoid-binding protein 3）的肽段，参与色素再生，通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中，利用IRBP651-670诱导自身免疫性葡萄膜炎，这些小鼠携带H-2b单体型。用IRBP651-670（300 µg/动物）免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平，免疫细胞浸润及光感受器损伤。
T36847	Coelenterazine hcp
	Coelenterazine hcp is a synthetic bioluminescent luciferin that displays an emission maximum of 445 nm.1It has been used as a calcium indicator and substrate to quantifyRenillaluciferase activity.1,2,3 1.Sabnis, R.W.Handbook of biological dyes and stains: Synthesis and industrial applications(2010) 2.Shimomura, O., Kishi, Y., and Inouye, S.The relative rate of aequorin regeneration from apoaequorin and coelenterazine analoguesBiochemistry Journal296(Pt 3)549-551(1993) 3.Pichler, A., Prior, J.L.,...
T83681	IRBP (1-20) (human, rat) TFA IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	IRBP1-20（1-20）是IRBP的一个十二肽片段，亦称视黄醇结合蛋白3，负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮，参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中，IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20（3 µM）能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战，可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤，以及视网膜脱落。

化合物

Cat.No: T21632

Target: Others, Microtubule Associated

Cat.No: T2052

Target: Wnt/beta-catenin

Cat.No: T9820

Synonym: GM1485

Target: Others

Cat.No: T25284

Synonym: DAC 225,DAC-225,DAC 2 25

Target: Others

Cat.No: T64342

Target: YAP

Cat.No: T35559

Target: Hedgehog/Smoothened

Thymosin β4 acetate(75591-33-4 free base)

Cat.No: TP2319

Target: Autophagy

Cat.No: T60144

Target: Others

Cat.No: T72956

Synonym: HRX215

Target: MAPK

Cat.No: T11053

Target: Phosphatase

Zofenopril calcium

Cat.No: T5030

Synonym: SQ26991,佐芬普利钙,Zofenopril (calcium)

Target: RAAS, Reactive Oxygen Species

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

Cat.No: T28866

Target: Apoptosis

Cat.No: T71793

Diethyl aminoethyl hexanoate citrate

Cat.No: T19280

Synonym: DA-6 citrate,胺鲜酯柠檬酸盐,2-Diethylaminoethyl hexanoate citrate

Target: Others

Cat.No: T37506

Synonym: MCTR2

BMP2-derived peptide

Cat.No: T82851

Cat.No: T62295

Cat.No: T13691

Synonym: HOE 36-801

Target: Others

Cat.No: T37505

Synonym: MCTR1

Cat.No: T78092

Target: PI3K

Cat.No: T37166

Cat.No: T37301

Cat.No: T37507

Synonym: MCTR3

Cat.No: T37302

Cat.No: T37490

Cat.No: T72950

Glucose 1-dehydrogenase

Cat.No: T75393

Cat.No: T75763

Cat.No: T37300

Synonym: PCTR1

Cat.No: T78101

Synonym: Zymosan A from Saccharomyces cerevisiae

Glucose dehydrogenase (GDH)

Cat.No: T76207

TAT-NEP1-40 acetate

Cat.No: T80420

Target: Apoptosis

Lucifer Yellow CH dipotassium salt

Cat.No: T78454

Selcopintide acetate

Cat.No: T78024

Synonym: Cpne7-DP acetate

Cat.No: T80418

Target: Apoptosis

Cat.No: TP1989

Synonym: Nogo-66 (1-40)

TAT-NEP1-40 TFA

Cat.No: T80419

Target: Apoptosis

FN-A208 fusion peptide

Cat.No: T82379

IRBP (651-670) (human) TFA

Cat.No: T83700

Synonym: IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)

Coelenterazine hcp

Cat.No: T36847

IRBP (1-20) (human, rat) TFA

Cat.No: T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

Cat. No.	Product Name	Target	Signaling Pathways
TN7087	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone	Others	Others
	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio (Thermophillin) 是一种天然产物。它的氧化还原循环是木材褐腐真菌腐烂中Fe2+和H2O2再生的还原当量来源。
TN6908	Polyporusterone A (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one
	Polyporusterone A 是一种从 P. umbellatus 的子实体中提取出来的三萜羧酸。Polyporusterone A 抑制自由基诱导的红细胞裂解 (溶血) ，可用于研究头发再生和牛皮癣。
T4739	Sodium creatine phosphate dibasic tetrahydrate 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate	Others; Endogenous Metabolite	Metabolism; Others
	Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) 主要存在于脊椎动物的骨骼肌中，是测定肌酸激酶的底物，能够用于骨骼肌收缩过程中 ATP 的再生。
T6S2246	Alisol B 23-acetate Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯	Others	Others
	Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物，能够激活法尼醇受体，诱导受损的肝脏再生。
T19189	Allocholic acid	Others	Others
	Allocholic acid 是一种胆汁酸，在脊椎动物中发现，在肝脏再生和致癌过程中会重新出现，也是成熟嗅觉系统的特定性刺激物。
TN3552	Byzantionoside B	Others	Others
	Byzantionoside B shows stimulatory activity on human osteoblast cells, it may have the potential to stimulate bone formation and regeneration.

天然产物

2,5-dimethoxycyclohexa-2,5-diene-1,4-dio

Cat.No: TN7087

Synonym: 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone

Target: Others

Polyporusterone A

Cat.No: TN6908

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Sodium creatine phosphate dibasic tetrahydrate

Cat.No: T4739

Synonym: 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate

Target: Others, Endogenous Metabolite

Alisol B 23-acetate

Cat.No: T6S2246

Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯

Target: Others

Allocholic acid

Cat.No: T19189

Target: Others

Byzantionoside B

Cat.No: TN3552

Target: Others

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