65
11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36018 |
Phosphodiesterase 4 Inhibitor
|
||
Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme. | |||
T27172 |
Difamilast
|
PDE | Metabolism |
Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂,对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。 | |||
T7954 |
YM976
|
PDE | Metabolism |
YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应,并有抗炎的作用。 | |||
T2923 |
Apremilast
阿普斯特,CC-10004,阿普司特 |
Apoptosis; TNF; PDE | Apoptosis; Metabolism |
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂,IC50为 74 nM。它抑制脂多糖释放TNF-α,IC50为 104 nM。 | |||
T16164 |
MY-5445
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE | Metabolism |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂,其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂,具有抗增殖活性。它能抑制人血小板凝集。 | |||
T19706 |
Ro 20-1724
Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724 |
PDE | Metabolism |
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV),其 Ki=1930 nM,具有神经保护作用。 | |||
T33422 |
MK-0873
MK 0873,MK0873 |
PDE | Metabolism |
MK-0873 是一种新型且有效的选择性磷酸二酯酶 4 (PDE4) 抑制剂。 | |||
T4695 |
CP671305
|
PDE | Metabolism |
CP671305 是口服具有活力的 phosphodiesterase-4-D 选择性抑制剂,具有很高的活性。 | |||
T19865 |
GEBR-7b
3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde |
PDE | Metabolism |
GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) 是一种磷酸二酯酶 4 (PDE4) 抑制剂。 | |||
T3987 |
Lotamilast
E6005,RVT-501 |
PDE | Metabolism |
Lotamilast (RVT-501) 是一种磷酸二酯酶4(PDE4) 选择性抑制剂,IC50=2.8 nM。 | |||
T30232 |
AWD 12-281
GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470 |
PDE | Metabolism |
AWD 12-281 是一种选择性磷酸二酯酶 4 (PDE4) 抑制剂,具有抗炎活性和支气管扩张活性,用于研究慢性阻塞性肺疾病(COPD)。 | |||
T6644 |
Rolipram
SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram |
HIV Protease; Antibacterial; PDE | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Rolipram (SB 95952) 是一种磷酸二酯酶 PDE4的选择性抑制剂,抑制 PDE4A,PDE4B 和 PDE4D 的 IC50分别为 3 nM,130 nM 和 240 nM。 | |||
T27475 |
GSK356278
GSK-356278,GSK 356278 |
PDE | Metabolism |
GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂,对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。 | |||
T4285 |
Crisaborole
克立硼罗,AN-2728,PF-06930164 |
PDE | Metabolism |
Crisaborole (AN-2728) 是一种有效的 PDE4和 cytokine 释放抑制剂,能够抑制 PDE4(IC50=0.49 μM)。 | |||
T67815 |
uk-50001
|
PDE | Metabolism |
uk-50001是一种磷酸二酯酶(PDE4) 4抑制剂,可用于许多疾病,特别是炎症、过敏、呼吸系统疾病、失调和病症以及伤口。 | |||
T12103 |
MR-L2
|
PDE | Metabolism |
MR-L2 是可逆的、非竞争性的长型异构体磷酸二酯酶 -4激活剂,可以激活代表性的 PDE4 长型异构体 (PDE4A4、PDE4B1、PDE4C3、PDE4D5)。它可抑制 PGE2- 诱导的 MDCK 细胞囊肿形成,其EC50=1.2 µM。 | |||
T23256 |
RS-25344 hydrochloride
|
PDE | Metabolism |
RS 25344 hydrochloride 是 cAMP-磷酸二酯酶 4 的选择性抑制剂,在人淋巴细胞中的 IC50为 0.28 nM,对 PDE I、II、III 仅具有微弱的抑制作用,IC50分别为 >100 μM、160 μM、330 μM。它具有抗炎、增强记忆力和认知能力以及抗肿瘤活性。 | |||
T31792 |
Filaminast
UNII-CDD69JC61J,Way-pda-641,WAY-PDA 641,CDD69JC61J |
PDE | Metabolism |
Filaminast (UNII-CDD69JC61J) 是磷酸二酯酶4抑制剂(PDE4抑制剂)和罗利普兰的类似物,罗利普兰被用作抗哮喘药物。 | |||
T39341 |
FCPR03
|
PDE | Metabolism |
FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂,对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。 | |||
T9239 |
RS-25344
|
PDE | Metabolism |
RS-25344 是一种有效的选择性磷酸二酯酶 (PDE) 4 抑制剂。它在体外抑制嗜酸性粒细胞趋化性并增加精子的进行性运动。 | |||
T10201 |
PDE IV-IN-1
|
PDE | Metabolism |
PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂,具有抗炎活性,可用于治疗哮喘,慢性阻塞性肺病和其他炎症性疾病,是研究抑郁症的潜在化合物。 | |||
T38625 |
Tanimilast
CHF-6001 |
PDE | Metabolism |
Tanimilast (CHF-6001) 是一种新型的高效选择性磷酸二酯酶 4 抑制剂,IC 50值为0.026 ± 0.006 nM。Tanimilast 具有强大的抗炎活性,适用于肺部局部用药。Tanimilast 用于研究阻塞性肺病。 | |||
T16379 |
Oglemilast
GRC 3886 |
PDE | Metabolism |
Oglemilast (GRC 3886) 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂,对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润,包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。 | |||
T63056 |
Dovramilast
|
||
Dovramilast (CC-11050) 是一种口服具有活力的磷酸二酯酶 4 (PDE4) 抑制剂,可以降低炎症反应,改善 INH 介导的肺部细菌清除。Dovramilast (CC-11050) 能够作为辅助试剂,用于研究结核病。 | |||
T1024 |
Roflumilast
罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217 |
PDE; RSV | Metabolism; Microbiology/Virology |
Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。 | |||
T24382 |
L-826141
L826141,L826,141,L 826141,L-826,141,L 826,141 |
||
L-826141 is an inhibitor of phosphodiesterase 4. | |||
T28969 | THPP-4 | ||
THPP-4 inhibits phosphodiesterase 10A (PDE10A). | |||
T19824 |
Drotaverine
Drotaverine Hydrochloride |
||
Drotaverine Hydrochloride is a selective inhibitor of phosphodiesterase 4. | |||
T24772 |
SCH-351591
SCH351591,SCH 351591,D4396,D 4396,D-4396 |
||
SCH-351591 is an orally active inhibitor of phosphodiesterase 4. | |||
T69399 | MK-0359 besylate | ||
MK-0359 besylate is a Phosphodiesterase-4 (PDE4) inhibitor. | |||
T21043 |
Apremilast, (+/-)-
Apremilast (+/-)-, |
||
Apremilast, (+/-)-, is a small molecule inhibitor of phosphodiesterase 4 (PDE4) with oral activity. It is used to treat psoriatic arthritis. | |||
T26767 |
Benafentrine dimaleate
Benafentrine |
||
Benafentrine dimaleate is a platelet activating factor receptor (PAFR) antagonists and phosphodiesterase (PDE) 3/4 inhibitors. | |||
T26132 |
RS 14203
RS-14203,RS14203 |
||
RS 14203 is a selective type 4 phosphodiesterase (PDE4) inhibitor. | |||
T27557 |
HT-0712
IPL455903,IPL-455903,IPL 455903,HT0712 |
||
HT-0712是一种磷酸二酯酶4 (PDE4)抑制剂。 | |||
T11810 |
L791943
|
Others | Others |
L791943 is a selective, potent) inhibitor of Phosphodiesterase-4 (PDE4,IC50 of 4.2 nM). | |||
T62988 |
Mufemilast
|
||
Mufemilast 是一种磷酸二酯酶 4(PDE4) 的抑制剂。 | |||
T70925 |
GS-5759
|
||
GS-5759 is a bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action. | |||
T11483 |
GSK256066 Trifluoroacetate
GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid) |
PDE | Metabolism |
GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease. | |||
T38944 |
Tetomilast
OPC-6535,Tetomilast |
||
Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). | |||
T15766 |
Lirimilast
BAY 19-8004 |
PDE | Metabolism |
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease. | |||
T61208 | PDE4-IN-11 | ||
PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3]. | |||
T62367 |
Enpp-1-IN-4
|
||
Enpp-1-IN-4 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。Enpp-1-IN-4 具有潜力进行癌症疾病的研究。 | |||
T40356 |
PDE4-IN-3
PDE4-IN-3 |
||
PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM. | |||
T69491 |
(E/Z)-Ensifentrine
|
||
(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials. | |||
T60417 |
Fenspiride
|
||
Fenspiride 是 H1-组胺受体的拮抗剂。 Fenspiride 是一种具有口服活性的非甾体类抗炎药,可用于治疗呼吸道感染和中耳炎。 Fenspiride 抑制磷酸二酯酶 4 和磷酸二酯酶 3 的活性,-logIC50 值分别为 4.16+/-0.09 和 3.44+/-0.12。 磷酸二酯酶 5 活性也受到抑制,-logIC50 值约为 3.8。 | |||
T79538 |
PDE4-IN-13
|
||
PDE4-IN-13 is a phosphodiesterase 4 inhibitor with an IC50 value of 1.56 μM, exhibiting anti-inflammatory and antioxidative properties. It is utilized in the study of chronic obstructive pulmonary disease (COPD). | |||
T69223 | CC-1088 | ||
CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). | |||
T71561 | LEO-29102 | ||
LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis. | |||
T73240 |
PDE5-IN-4
|
||
PDE5-IN-4为磷酸二酯酶5(PDE5)抑制剂,应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。 | |||
T11168 | EHNA hydrochloride | Others | Others |
EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2159 |
Robustine
大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇 |
PDE | Metabolism |
Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱,在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。 | |||
T4S0792 |
Pinoresinol 4-O-β-D-glucopyranoside
(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside |
Others | Others |
(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。 | |||
T17199 |
Udenafil
3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非 |
PDE | Metabolism |
Udenafil 是一种选择性的,有效的,具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解,可用于研究勃起功能障碍的。 | |||
T8787 |
Drotaverine hydrochloride
|
PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
TN1950 |
Moracin M
|
PDE | Metabolism |
Moracin M 是桑白皮中的一种酚类成分,有效的磷酸二酯酶 4 (PDE4) 抑制剂,对于 PDE4D2,PDE4B2,PDE5A1 和 PDE9A2 的 IC50 分别为 2.9 μM,4.5 μM,> 40 μM 和 > 100 μM。Moracin M 具有抗炎活性。 | |||
T28019 |
(-)-Mesembrine
Mesembrin,Mesembrine,Mesembranone |
||
Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4). | |||
TN2974 |
3-O-Methylquercetin tetraacetate
|
IL Receptor; TNF; PDE | Apoptosis; Immunology/Inflammation; Metabolism |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness. | |||
T79957 |
4'-Methoxyisoagarotetrol
|
||
4'-Methoxyisoagarotetrol 是一种色素衍生物,表现出中等强度的PDE3A抑制活性,其半抑制浓度(IC50)为54 μM。 | |||
T4700 |
1,3,5-Trihydroxy-4-prenylxanthone
|
||
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu | |||
TN3537 |
Braylin
|
IL Receptor; TNF; NF-κB | Apoptosis; Immunology/Inflammation; NF-κB |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects. | |||
T75486 | Toddacoumalone | ||
Toddacoumalone 是一种天然PDE4 (磷酸二酯酶 4) 抑制剂,效力中等,活性分子特性不完善。具有研究银屑病等炎症性疾病潜力。 |