Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,990 | 5日内发货 | ||
50 mg | ¥ 8,330 | 5日内发货 | ||
100 mg | ¥ 12,900 | 5日内发货 |
产品描述 | EHNA hydrochloride is a chemical compound recognized for its antiviral, antitumor, and antiarrhythmic properties. It functions as a potent and selective inhibitor of both cyclic nucleotide phosphodiesterase 2 (PDE2) with an IC50 of 4 μM and adenosine deaminase (ADA). Additionally, it effectively inhibits the activity of cGMP-stimulated PDE II (cGs-PDE) with IC50 values of 0.8 μM in humans and 2 μM in porcine myocardium, although its inhibitory effects on unstimulated PDE2 activity are less pronounced. |
靶点活性 | PDE2A (human):0.8 μM |
体外活性 | EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity. |
分子量 | 313.83 |
分子式 | C14H24ClN5O |
CAS No. | 58337-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
EHNA hydrochloride 58337-38-5 Others EHNA Hydrochloride Inhibitor inhibitor inhibit