44
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38612 |
Linaprazan glurate
|
Others | Others |
Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。 | |||
T5051 |
Isopropamide Iodide
|
AChR | Neuroscience |
Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病,尤其是胃酸过多和运动过度。 | |||
T15500 |
HPi1
|
Others; Antibacterial | Microbiology/Virology; Others |
HPi1 是一种有口服活性的,针对幽门螺杆菌的选择性抗菌剂,IC50为 0.24 μM,MIC 为 0.08-0.16 μg/mL。 | |||
T4981 |
Anisotropine Methylbromide
|
Prostaglandin Receptor; AChR | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Anisotropine Methylbromide 是一种抗胆碱能药物,已用于缓解胃肠道痉挛和抑制胃酸分泌。 | |||
T0044 |
Oxethazaine
奥昔卡因,Oxetacaine |
HBV; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Oxethazaine (Oxetacaine) 是一种具有耐酸性和口服活性试剂,是芬特明的酸性前体,有潜力缓解消化性溃疡疾病或食管炎引起的疼痛。 | |||
T1734 |
Rabeprazole Sulfide
雷贝拉唑相关物质E,Rabeprazole Related Compound E |
Proton pump; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物,有效抑制幽门螺旋杆菌的活性,可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌,可研究各种消化系统疾病。 | |||
T0992 |
Carbenoxolone disodium
Biogastrone,Duogastrone,甘珀酸钠,Bioral |
Gap Junction Protein | Cytoskeletal Signaling |
Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂,可抑制牛痘病毒生长,用于消化性、食道和口腔溃疡和炎症的相关研究。 | |||
T8388 |
Vonoprazan
TAK-438 (free base),沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T25939 | Pepticinnamin E | ||
Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor. | |||
T29015 |
Trithiozine
Tresanil,Sulmetozine,Tritiozinum,舒美吗啉,Tritiozine,Tritiozina |
Others | Others |
Trithiozine (Tritiozinum) 具有抗分泌和抗溃疡能力。 Trithiozine 可用于治疗消化性溃疡病和高分泌障碍的研究。 | |||
T23667 |
AGN-201904
AGN201904,AGN 201904 |
ATPase | Membrane transporter/Ion channel |
AGN-201904 是质子泵抑制剂,是一种奥美拉唑前药,可延缓衰老,可用于预防和治疗消化性溃疡。 | |||
T25737 |
Linetastine
TMK 688,TMK-688,TMK688 |
Lipoxygenase; LTR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Linetastine (TMK-688) 是一种 5-脂氧合酶抑制剂(5-LOX),能抑制白三烯的产生,并能拮抗组胺的作用。Linetastine可用于研究哮喘、动脉粥样硬化和消化性溃疡。 | |||
T10221 |
Abeprazan hydrochloride
DWP14012 hydrochloride,Fexuprazan hydrochloride |
Proton pump | Membrane transporter/Ion channel |
Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂,通过竞争性的与钾离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI),通过减少胃酸的产生而起作用,可用于治疗胃酸相关疾病,如胃食管反流病(GERD)和消化性溃疡。 | |||
T4195 |
Betahistine
PT 9 base,倍他司汀,Vasomotal,Serc base |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T0786 |
Clidinium bromide
克利溴铵,Ro 2-3773 |
AChR | Neuroscience |
Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 | |||
T34936 |
Tridihexethyl chloride
Propethonum,Pathilon,Tridihexethyl |
||
Tridihexethyl is an anticholinergic, antimuscarinic, and antispasmolytic drug, which can be used to treat acquired nystagmus or peptic ulcer disease. | |||
T70090 |
Nizatidine amide
|
||
Nizatidine amide is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T70127 |
Famotine
|
||
Famotine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T71049 | Famotidine disulfide | ||
Famotidine disulfide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T78237 |
Urease-IN-6
|
||
Urease-IN-6为一种高效Urease抑制剂,IC50值为14.2 μM,适用于消化性溃疡和胃溃疡研究。 | |||
T2138L |
Oxyphencyclimine
Oxiphencycliminum,Antulcus,Zamanil,Manir,Caridan,Naridan |
||
Oxyphencyclimine is a muscarinic receptor antagonist (MRA) anticholinergic drug used to treat peptic ulcers. | |||
T12914 | Siltenzepine | Others | Others |
Siltenzepine is an agent of anti-acid agent,and used in the treatment of peptic ulcers. | |||
T27640 |
Itriglumide
CR-2945,CR2945,CR 2945 |
||
Itriglumide, a CCK2 receptor antagonist, is used potentially for the treatment of peptic ulcers, dyspepsia, and gastroesophageal reflux disease (GERD). | |||
T31743 |
Famotine hydrochloride
Famotine HCl,UK-2054 |
||
Famotine Hydrochloride is a histamine H2 receptor antagonist that suppresses acid production in the stomach and commonly treats peptic ulcer disease and gastroesophageal reflux disease. | |||
T32224 |
Isopropamide
Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid |
||
Isopropamide (R5) is a long-acting anticholinergic drug. It is used to treat peptic ulcers and other gastrointestinal disorders involving excess gastric acid (gastrointestinal acidosis) and hyperactivity. | |||
T19929 |
Ranitidine-S-oxide
|
||
Ranitidine-S-oxide is a metabolite of Ranitidine. It is commonly used in the treatment of peptic ulcer disease, Zollinger–Ellison syndrome,and gastroesophageal reflux disease. | |||
T68725 |
Famotidine propanamide
|
||
Famotidine propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T71509 |
Famotidine sulfamoyl propanamide
|
||
Famotidine sulfamoyl propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T38058 |
Cimetidine sulfoxide
|
||
Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage[1]. | |||
T71485 |
Famotidine propionic acid
|
||
Famotidine propionic acid is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T33314 |
Methantheline Bromide
Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide |
||
Methantheline Bromide is a synthetic spasmolytic used to relieve cramps or spasms of the stomach, bowel, and bladder. It is also useful for intestinal or gastric ulcers (peptic ulcer disease), intestinal problems, pancreatitis, gastritis, biliary dysmotil | |||
T25104 |
Aprofene
aprophen,Aprofenum |
||
Aprofene (Aprophen) is an antagonist of muscarinic and nicotinic acetylcholine receptors. It may be used in the therapy of peptic ulcers, endarteritis (inflammation of the inner shell of the artery), cholecystitis (inflammation of the gallbladder), and sp | |||
T14051 |
5-Hydroxylansoprazole
AG1908 |
Proton pump | Membrane transporter/Ion channel |
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole. | |||
T68206 | Arbortristoside A | ||
Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and may facilitate healing of peptic ulcers. | |||
T61228 |
Pirenzepine
|
||
Pirenzepine (LS 519 free base) is a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). It effectively inhibits gastric acid secretion and reduces muscle spasm, making it a valuable compound for investigating peptic ulcers. Additionally, Pirenzepine exhibits anti-proliferative activity against cancer cells [1] [2]. | |||
T71980 |
Omeprazole acid
|
||
Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid. | |||
T71801 |
Arbaprostil
|
||
Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2. | |||
T0246L |
Betahistine mesylate
Extovyl,甲磺酸倍他司汀,Melopat,Meginalisk |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Betahistine mesylate (Extovyl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T79656 | Urease-IN-8 | ||
Urease-IN-8 (Compound 5e) 为一竞争性脲酶 (Urease) 抑制剂,具IC50值为3.51 μM,Ki值为3.11 μM,主要用于消化性溃疡与胃溃疡研究。 | |||
T79652 | Urease-IN-7 | ||
Urease-IN-7 (Compound 5k),作为竞争性Urease抑制剂,具有IC50为3.33 μM和Ki值为3.62μM。该化合物可用于消化性溃疡和胃溃疡研究。 | |||
T70428 |
Nepaprazole sodium
|
||
Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes; and the inhibitory effect was enhanced under weak acid conditions, the IC50 (concentrations that inhibit the enzyme activity by 50%) being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively. TY-11345 should be useful for the clinical tre... | |||
T36714 |
Sucrose octasulfate (potassium salt)
|
||
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr... | |||
T61643 | Vonoprazan hydrochloride | ||
Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB),展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下,该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性,呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究,包括胃食管反流病和消化性溃疡,并可用于根除幽门螺杆菌。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3605 |
Gastrodenol
Bismuth tripotassium dicitrate,枸橼酸铋钾,Bismuth subcitrate |
Others | Others |
Gastrodenol (Bismuth tripotassium dicitrate) 是一种对溃疡和胃不适具有潜在的应用价值的药物。 | |||
T7908 |
DL-Methionine Methylsulfonium Chloride
DL-蛋氨酸甲基氯化锍,维生素U |
Others | Others |
DL-methionine methylsulfonium chloride 是天然的蛋氨酸衍生物。它能够有效保护胃粘膜,避免其受到乙醇诱导的损伤。 | |||
T21651 |
Lansoprazole sodium
兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium |
Proton pump; Phospholipase; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂,是中性鞘磷脂酶的外泌体抑制剂,能抑制胃酸生成。 | |||
TN3852 |
Dihydrolicoisoflavone
|
Antifection | Microbiology/Virology |
Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN1302 |
6,8-Diprenylorobol
6,8-二异戊烯基香豌豆苷元 |
Others; HIV Protease; Antifection | Microbiology/Virology; Others; Proteases/Proteasome |
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN4659 |
Nimbin
|
COX | Immunology/Inflammation; Neuroscience |
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydroxylase activity in the three insect |