24
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5023 |
Propiverine hydrochloride
|
Others; Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
Propiverine hydrochloride 是一种痉挛剂,具有钙拮抗和抗胆碱能特性,用于研究膀胱过度活动和尿失禁。 | |||
T9419 |
Fesoterodine
(R) Fesoterodine,弗斯特罗定 |
AChR | Neuroscience |
Fesoterodine ((R) Fesoterodine) 是可口服的,非亚型选择性的竞争性毒蕈碱受体拮抗剂,用于膀胱过度活动症,对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。 | |||
T19723 |
AMTB hydrochloride
AMTB |
TRP/TRPV Channel | Membrane transporter/Ion channel |
AMTB hydrochloride (AMTB HCl) 是TRPM8通道的选择性阻滞剂。它抑制 icilin 诱导的 TRPM8 通道激活,pIC50为 6.23。它在膀胱过度活动和膀胱疼痛综合征中有研究的价值。它是电压门控钠通道的非选择性抑制剂 (NaV)。 | |||
T4612 |
NS309
|
EGFR; Potassium Channel; HER | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。 | |||
T1472 |
Trospium chloride
Spasmex,Sanctura,曲司氯铵,曲司氯胺 |
AChR | Neuroscience |
Trospium chloride (Spasmex) 是一种可口服的特异竞争性毒蕈碱胆碱能受体拮抗剂,可与毒蕈碱受体 M1、M2 和 M3 高亲和力结合,具有抗毒蕈碱活性。 | |||
T1475 |
Fesoterodine fumarate
Toviaz,SPM 907,富马酸非索罗定 |
AChR | Neuroscience |
Fesoterodine fumarate (Toviaz) 是可口服的,非亚型选择性的竞争性毒蕈碱受体拮抗剂,用于膀胱过度活动症,对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。 | |||
T0703 |
Flavoxate hydrochloride
Flavoxate HCl,盐酸黄酮哌酯,NSC-114649,DW61,Rec-7-0040 |
AChR | Neuroscience |
Flavoxate hydrochloride (DW61) 是一种毒蕈碱受体 AChR 拮抗剂, IC50为 12.2 μM。 | |||
T1534 |
Darifenacin hydrobromide
氢溴酸达非那新,Darifenacin HBr,UK-88525 |
AChR | Neuroscience |
Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂,pKi 为 8.9。 | |||
T15273 |
Fedovapagon
VA483,A106483 |
Vasopressin Receptor | GPCR/G Protein |
Fedovapagon (VA106483) 是一种具有选择性和高效性的加压素 V2 受体 (V2R) 激动剂,可抑制斑马鱼节间血管的生长。Fedovapagon 可用于研究膀胱过度活动症、夜尿症和膀胱疼痛综合征。 | |||
T1671 |
Mirabegron
YM178,米拉贝隆 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Mirabegron (YM178) 是选择性的肾上腺素受体激动剂,EC50=22.4 nM。 | |||
T1049L |
Oxybutynin
Oxytrol,奥昔布宁,Ditropan,Oxibutyninum |
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Oxybutynin (Ditropan) 是一种抗胆碱能药,抑制血管 Kv 通道,IC50为 11.51 μM,可用于治疗尿失禁和膀胱过度活动症。 | |||
T12970 |
Solabegron
GW 427353,3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Solabegron (GW 427353) 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得 EC50=22 nM,可用于研究膀胱过度活跃和肠易激综合征。 | |||
T76690 |
Mavrilimumab
CAM 3001 |
Virus Protease; CSF-1R | Microbiology/Virology; Tyrosine Kinase/Adaptors |
Mavrilimumab (CAM 3001) 是一种单克隆抗体,具有抗病毒活性,对粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 受体的 α 亚基有亲和力,并阻止 GM-CSF 下游细胞内信号传导。GM-CSF 可能与呼吸衰竭和死亡相关的过度活跃炎症反应有关,可用于研究类风湿性关节炎。 | |||
T11275 | Fesoterodine L-mandelate | Others | Others |
Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB). | |||
T68548 |
Tolterodine Dimer
|
||
Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder. | |||
T28465 |
PSD-506
PSD 506,RO 3202904,RO3202904,RO-3202904 |
||
PSD-506, a muscarinic M2/M3 antagonist, is used potentially for the treatment of overactive bladder, and urinary incontinence. | |||
T35052 |
Vibegron
MK4618,MK 4618,MK-4618 |
||
Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB). | |||
T29208 |
ZD-0947
AZD0947,AZD-0947,ZD 0947,AZD 0947 |
||
ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB). | |||
T28125 |
N-5984
N5984,KRP-204,KRP 204,KRP204 |
||
N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes. | |||
T70338 | Lu AF58786 | ||
Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively. | |||
T61438 |
Propiverine
|
||
Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2]. | |||
T61357 |
EP3 antagonist 3
|
||
EP3 antagonist 3 (compound 2) is a highly effective and specific antagonist of the EP3 receptor. It displays significant oral bioavailability and exhibits a strong pKi value of 8.3. Furthermore, EP3 antagonist 3 possesses excellent pharmacokinetic characteristics, making it a suitable candidate for experimental investigations involving overactive bladder (OAB) research [1]. | |||
T40161 |
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride,(Rac)-PNU-200577hydrochloride,(Rac)-Desfesoterodine hydrochloride |
||
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions. | |||
T72091 |
ADRA1D receptor antagonist 1 free base
|
||
ADRA1D receptor antagonist 1 (free base) (化合物 (R)-9s),是口服高效、强效及选择性的人类α1D-肾上腺素受体(α1D-AR)拮抗剂,具有Ki值为1.6 nM。该化合物能剂量依赖性降低膀胱收缩,IC30值为15 nM,适用于膀胱过度活动症(包括尿急、尿频和尿失禁)的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4342 | Izalpinine | Others | Others |
Izalpinin exhibits potent antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Izalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promising lead compound to treat overactiv |