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36

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0042	Xylometazoline hydrochloride 盐酸赛洛唑啉,Xylometazoline HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Xylometazoline hydrochloride (Xylometazoline HCl) 是一种 α- 肾上腺素受体激动剂，是一种鼻血管收缩药。
T38236	2′-Deoxy-2′-fluoroguanosine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2′-Deoxy-2′-fluoroguanosine 是一种核苷类似物，有效抑制流感病毒，抑制A 型和B 型流感病毒的EC90值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 显著抑制流感病毒在上呼吸道中的复制，从而改善鼻腔炎症和发烧。
T4563	Thonzylamine neohetramine,松齐拉敏	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂，具有抗组胺和抗过敏特性，可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。
T0397	Tetrahydrozoline 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，广泛用于研究鼻充血、结膜充血。
T22033	ARC 239 dihydrochloride	Norepinephrine	Neuroscience
	ARC 239 dihydrochloride 是一种选择性 α2B 肾上腺素受体拮抗剂。
T6703	Tetrahydrozoline hydrochloride Murine Plus,盐酸四氢萘咪唑,Tetryzoline hydrochloride,Tyzine,Tetrahydrozoline HCl,盐酸四氢唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydrozoline hydrochloride (Murine Plus) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，常用于研究鼻充血、结膜充血。
T26009	Quazolast RHC-3988,RHC 3988,RHC3988	Others	Others
	Quazolast (RHC 3988) 是一种有效的介质释放抑制剂，是对豚草抗原鼻腔挑战的对照。Quazolast 在防止猪笼草鼻腔挑战后的鼻塞和鼻痒方面优于安慰剂。
T71012	Nemazoline Free Base
	Nemazoline Free Base is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal administration to dogs, the compound was devoid of systemic effects up to a concentration 1000 times that needed for local decongestant effect (1.65 micrograms, atomized from a 1 microgram mL-1 solution) suggesting limited mucosal absorption. After nasal administration to rats for 1...
T3612	Carbocisteine Carbocysteine,羧甲司坦,Broncodeterge,Mucodyne,S-Carboxymethyl-L-cysteine	Others	Others
	Carbocisteine (Mucodyne) 常被用作具有粘液溶解和祛痰作用的抗感染鼻喷雾剂。
T0113	Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。
T21404	Fluticasone furoate Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
T21390	Fexofenadine Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine (Carboxyterfenadine) 是一种抗组胺药物，用于治疗过敏症状，如鼻塞、花粉热和荨麻疹。与第一代抗组胺药相比，它通过血脑屏障并引起镇静的能力较差。
T0900	Cetylpyridinium chloride monohydrate Hexadecylpyridinium chloride monohydrate,十六烷基氯化吡啶	Antibacterial; Antibiotic	Microbiology/Virology
	Cetylpyridinium chloride monohydrate (Hexadecylpyridinium chloride monohydrate) 是阳离子季铵, 是一种能杀死细菌和其他微生物的防腐剂, 用于某些类型的漱口水, 牙膏, 咽喉和鼻腔喷雾剂中, 可有效预防牙斑和减少牙龈炎。
T25199	Cafaminol Cafaminolum,G1,G-1,G 1
	Cafaminol (methylcoffanolamine) is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant.
T69341	Tramazoline hydrochloride
	Tramazoline hydrochloride is commonly used in nasal spray as a nasal decongestant by acting as an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.
T69670	Clonazoline HCl
	Clonazoline HCl is the salt form of Clonazoline, a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor.
T70216	Clonazoline
	Clonazoline is a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor.
T32656	Lerimazoline ST-71,Trimizoline,Trimazoline,ST 71,ST71
	Lerimazoline(Trimazoline, Trimizoline, ST-71) is used in the form of tramazoline hydrochloride in nasal decongestant preparations. It is used to inhibits the secretion of nasal mucus as an α-adrenergic receptor agonist.
T68997	L-Phenylephrine
	L-Phenylephrine is an alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
T36709	N’-Nitrosonornicotine
	N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S....
T14035	3M-011	TLR	Immunology/Inflammation
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
T38350	TAS 205
	TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens...
T25618	Laninamivir trifluoroacetate
	Laninamivir trifluoroacetate 是一种抗病毒化合物，用于治疗和预防甲型流感病毒和乙型流感病毒。它是一种通过鼻吸入给药的长效神经氨酸酶抑制物。
T37860	T 26c disodium salt
	Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810"
T26770	Bencycloquidium Bromide BCQB
	Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M
T60263	Povafonidine
	Povafonidine (PGE-6201204) 是一种有效的 α-2 肾上腺素受体激动剂。Povafonidine 可以收缩血管，减轻粘膜充血，可用于鼻塞研究。
T60425	Tetrahydrozoline nitrate
	Tetrahydrozoline (Tetryzoline) nitrate 是咪唑啉的衍生物。它是一种引起血管收缩的α-肾上腺素能 (α-adrenergic) 激动剂。Tetrahydrozoline 广泛用于鼻充血和结膜充血的研究。
T64314	OxyMetazoline
	OxyMetazoline 是一种 α-肾上腺素受体 (α-adrenoceptor) 激动剂，能够作用于 α1A (IC50: 0.02 μM)、α1B (IC50: 0.25 μM)、α2A (IC50: 0.58 μM) 和 α2C (IC50: 0.13 μM)。OxyMetazoline 能够用于研究缓解鼻黏膜充血。
T78112	Voxvoganan trihydrochloride LTX-109 trihydrochloride
	Voxvoganan (LTX-109) trihydrochloride为有效的局部抗菌剂，特别是针对S. aureus，其MIC为2-4 μg/mL。该化合物主要用于研究细菌性皮肤感染和真菌感染。
T14359	AVX 13616	Others	Others
	AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i
T83840	Uridine-5'-O-(3-thiotriphosphate) sodium UTP-γ-S
	Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) 是UTP的一种抗水解衍生物，是嘌呤P2Y2受体的激动剂。在表达人类P2Y2受体的1321N1星形胶质瘤细胞中，其可诱导肌醇磷酸盐的形成（EC50 = 240 nM），并且在来自囊性纤维化患者的原代鼻上皮细胞中以浓度依赖的方式诱导氯离子分泌。UTP-γ-S在分离的人类冠状动脉中诱导血管收缩（EC50 = 25.1 µM）。
T37262	14,15-Leukotriene E4 14,15-Leukotriene E4
	Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils...
T80090	Lugdunin	Antibiotic	Microbiology/Virology
	Lugdunin是一种具有抗菌活性的肽类抗生素。该化合物能够通过破坏细菌细胞膜的电位来抑制革兰氏阳性菌的生长，特别是对金黄色葡萄球菌（Staphylococcus aureus）表现出高效能，有效降低其在皮肤和鼻腔的定植能力。此外，Lugdunin还能在人类角质形成细胞和小鼠皮肤中促进LL-37和CXCL8/MIP-2的表达。
T37261	14,15-Leukotriene D4 14,15-Leukotriene D4
	14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both ...
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T65252	Pepsin
	Pepsin is an endopeptidase that breaks down proteins into smaller peptides and amino acids that can be easily absorbed in the small intestine[1]. Pepsin is stable at pH ranges as high as pH 6. Above this pH, pepsin is rapidly irreversibly inactivated and elevation of pH of the reaction mixture to pH 8 results in complete inactivation of pepsin[2]. Pepsin has been posited to be a reliable biological marker of EER. An immunologic pepsin assay of combined sputum and saliva was determined to be 100%...

化合物

Xylometazoline hydrochloride

Cat.No: T0042

Synonym: 盐酸赛洛唑啉,Xylometazoline HCl

Target: Adrenergic Receptor

2′-Deoxy-2′-fluoroguanosine

Cat.No: T38236

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Cat.No: T4563

Synonym: neohetramine,松齐拉敏

Target: Histamine Receptor

Tetrahydrozoline

Cat.No: T0397

Synonym: 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline

Target: Adrenergic Receptor

ARC 239 dihydrochloride

Cat.No: T22033

Target: Norepinephrine

Tetrahydrozoline hydrochloride

Cat.No: T6703

Synonym: Murine Plus,盐酸四氢萘咪唑,Tetryzoline hydrochloride,Tyzine,Tetrahydrozoline HCl,盐酸四氢唑林

Target: Adrenergic Receptor

Cat.No: T26009

Synonym: RHC-3988,RHC 3988,RHC3988

Target: Others

Nemazoline Free Base

Cat.No: T71012

Cat.No: T3612

Synonym: Carbocysteine,羧甲司坦,Broncodeterge,Mucodyne,S-Carboxymethyl-L-cysteine

Target: Others

Mebhydrolin napadisylate

Cat.No: T0113

Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline

Target: 5-HT Receptor, AChR, Histamine Receptor

Fluticasone furoate

Cat.No: T21404

Synonym: Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate

Target: Glucocorticoid Receptor

Cat.No: T21390

Synonym: Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra

Target: Histamine Receptor

Cetylpyridinium chloride monohydrate

Cat.No: T0900

Synonym: Hexadecylpyridinium chloride monohydrate,十六烷基氯化吡啶

Target: Antibacterial, Antibiotic

Cat.No: T25199

Synonym: Cafaminolum,G1,G-1,G 1

Tramazoline hydrochloride

Cat.No: T69341

Clonazoline HCl

Cat.No: T69670

Cat.No: T70216

Cat.No: T32656

Synonym: ST-71,Trimizoline,Trimazoline,ST 71,ST71

L-Phenylephrine

Cat.No: T68997

N’-Nitrosonornicotine

Cat.No: T36709

Cat.No: T14035

Target: TLR

Cat.No: T38350

Laninamivir trifluoroacetate

Cat.No: T25618

T 26c disodium salt

Cat.No: T37860

Bencycloquidium Bromide

Cat.No: T26770

Synonym: BCQB

Cat.No: T60263

Tetrahydrozoline nitrate

Cat.No: T60425

Cat.No: T64314

Voxvoganan trihydrochloride

Cat.No: T78112

Synonym: LTX-109 trihydrochloride

Cat.No: T14359

Target: Others

Uridine-5'-O-(3-thiotriphosphate) sodium

Cat.No: T83840

Synonym: UTP-γ-S

14,15-Leukotriene E4

Cat.No: T37262

Synonym: 14,15-Leukotriene E4

Cat.No: T80090

Target: Antibiotic

14,15-Leukotriene D4

Cat.No: T37261

Synonym: 14,15-Leukotriene D4

Nafarelin acetate hydrate

Cat.No: T68525

Cat.No: T65252

Cat. No.	Product Name	Target	Signaling Pathways
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T0335	Sodium salicylate 水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt	Apoptosis; NF-κB; COX; S6 Kinase; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; MAPK; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Sodium salicylate (2-Hydroxybenzoic acid sodium salt) 是一种S6K 的抑制剂，可抑制COX-2活性。它还是一种NF-κB 抑制剂，可降低炎症基因的表达，促进老化肌肉的修复。
T1287	Synephrine 辛弗林,Oxedrine	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂，是一种生物碱。它也是一种拟交感神经化合物，能够用于减肥。
TN1610	Epimagnolin A	Parasite	Microbiology/Virology
	Epimagnolin A 是一种糠醛木脂素，具有中等的抗疟原虫活性，IC50值为5.7 μg/mL。
T4764	5-Methoxy-5-oxopentanoic acid 戊二酸单乙酯,mono-Methyl glutarate,METHYL HYDROGEN GLUTARATE	Others; Endogenous Metabolite	Metabolism; Others
	5-Methoxy-5-oxopentanoic acid (mono-Methyl glutarate) 是内源性代谢产物的一种。
T35455	N-Nitrosodiethylamine Diethylnitrosamine,NDEA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	N-Nitrosodiethylamine (NDEA) 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与 DNA 修复/复制相关的核酶的变化相关。
TN6646	Fargesol
	(-)-Fargesol is a nartural product from the flowers buds of Magnolia fargesii,the dried flower buds of M. fargesii, has been used as therapy for nasal empyema and headache.
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Sodium salicylate

Cat.No: T0335

Synonym: 水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt

Target: Apoptosis, NF-κB, COX, S6 Kinase, Autophagy

Cat.No: T1287

Synonym: 辛弗林,Oxedrine

Target: Endogenous Metabolite, Adrenergic Receptor

Cat.No: TN1610

Target: Parasite

5-Methoxy-5-oxopentanoic acid

Cat.No: T4764

Synonym: 戊二酸单乙酯,mono-Methyl glutarate,METHYL HYDROGEN GLUTARATE

Target: Others, Endogenous Metabolite

N-Nitrosodiethylamine

Cat.No: T35455

Synonym: Diethylnitrosamine,NDEA

Target: DNA/RNA Synthesis

Cat.No: TN6646

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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